Articles:
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tetramethylene diamine
Notes:
Putrescine is an organic chemical compound related to cadaverine; both are produced by the breakdown of amino acids in living and dead organisms and both are toxic in large doses. The two compounds are largely responsible for the foul odor of putrefying flesh, but also contribute to the odor of such processes as bad breath and bacterial vaginosis. They are also found in semen and some microalgae, together with related molecules like spermine and spermidine.
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| CAS Number: | 110-60-1 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 203-782-3 | |
| FDA UNII: | V10TVZ52E4 | |
| Nikkaji Web: | J1.979H | |
| Beilstein Number: | 0605282 | |
| MDL: | MFCD00008235 | |
| XlogP3-AA: | -0.90 (est) | |
| Molecular Weight: | 88.15364000 | |
| Formula: | C4 H12 N2 | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: indirect food additives: adhesives and components of coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| DG SANTE Food Contact Materials: | 1,4-diaminobutane |
| FDA Mainterm (IAUFC): | 110-60-1 ; 1,4-BUTANEDIAMINE |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.87700 @ 25.00 °C. |
| Refractive Index: | 1.45690 @ 20.00 °C. |
| Flash Point: | 125.00 °F. TCC ( 51.67 °C. ) |
| Soluble in: | |
| water, 1e+006 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor Description: | animal rotting fish |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| EMD Millipore |
| For experimental / research use only. |
| 1,4-Diaminobutane |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 1,4-Diaminobutane >98% |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| 1,4-Diaminobutane 99% |
| TCI AMERICA |
| For experimental / research use only. |
| 1,4-Diaminobutane >98.0%(GC)(T) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-mouse LD50 1750 mg/kg BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Farmakologiya i Toksikologiya Vol. 18(6), Pg. 9, 1955. oral-mouse LDLo 1600 mg/kg Archives of Environmental Contamination and Toxicology. Vol. 14, Pg. 111, 1985. intravenous-rabbit LDLo 80 mg/kg Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 83, Pg. 481, 1920. oral-rabbit LDLo 1600 mg/kg Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 83, Pg. 481, 1920. oral-rat LD50 463 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) National Technical Information Service. Vol. OTS0538638 | |
| Dermal Toxicity: | |
|
skin-rabbit LD50 1576 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION National Technical Information Service. Vol. OTS0538638 subcutaneous-rabbit LDLo 1000 mg/kg Zeitschrift fuer Experimentelle Pathologie und Therapie. Vol. 17, Pg. 59, 1915. subcutaneous-rat LDLo 1000 mg/kg Zeitschrift fuer Experimentelle Pathologie und Therapie. Vol. 17, Pg. 59, 1915. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | indirect food additives: adhesives and components of coatings | ||
| Recommendation for 1,4-diaminobutane usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for 1,4-diaminobutane flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| European Food Safety Authority (EFSA) reference(s): | |
| Conclusion on the peer review of the pesticide risk assessment of the active substance 1,4-diaminobutane (putrescine) View page or View pdf | |
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 110-60-1 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 1045 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| butane-1,4-diamine | |
| Chemidplus: | 0000110601 |
| RTECS: | EJ6800000 for cas# 110-60-1 |
References:
| butane-1,4-diamine | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 1045 |
| Pubchem (sid): | 134974518 |
| Pherobase: | View |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C00134 |
| HMDB (The Human Metabolome Database): | HMDB01414 |
| FooDB: | FDB001494 |
| YMDB (Yeast Metabolome Database): | YMDB00132 |
| Export Tariff Code: | 2921.29.0055 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
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Synonyms:
| butane-1,4-diamine | |
| putrescine | |
| tetramethylene diamine |