1,2-dichloroethane
1,2-ethylidene dichloride
 
Notes:
Solvent used in food processing The chemical compound 1,2-dichloroethane, commonly known by its old name of ethylene dichloride (EDC), is a chlorinated hydrocarbon, mainly used to produce vinyl chloride monomer (VCM, chloroethene), the major precursor for PVC production. It is a colourless liquid with a chloroform-like odour. 1,2-Dichloroethane is also used generally as an intermediate for other organic chemical compounds, and as a solvent.
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CAS Number: 107-06-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 203-458-1
FDA UNII: 55163IJI47
Nikkaji Web: J4.049E
Beilstein Number: 605264
MDL: MFCD00000963
XlogP3: 1.50 (est)
Molecular Weight: 98.95788000
Formula: C2 H4 Cl2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: extraction solvents
 
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FDA Mainterm (SATF):107-06-2 ; ETHYLENE DICHLORIDE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart D--Special Dietary and Nutritional Additives
Sec. 172.385 Whole fish protein concentrate.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.560 Modified hop extract.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
H--Other Specific Usage Additives
Sec. 172.710 Adjuvants for pesticide use dilutions.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart C--Solvents, Lubricants, Release Agents and Related Substances
Sec. 173.230 Ethylene dichloride.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.315 Chemicals used in washing or to assist in the peeling of fruits and vegetables.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.170 Components of paper and paperboard in contact with aqueous and fatty foods.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact Surfaces
Sec. 177.1580 Polycarbonate resins.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact Surfaces
Sec. 177.1585 Polyestercarbonate resins.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2550 Reverse osmosis membranes.


FDA PART 573 -- FOOD ADDITIVES PERMITTED IN FEED AND DRINKING WATER OF ANIMALS
Subpart B--Food Additive Listing
Sec. 573.440 Ethylene dichloride.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.30 Annatto extract.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.345 Paprika oleoresin.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.615 Turmeric oleoresin.
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Physical Properties:
Food Chemicals Codex Listed: No
Specific Gravity: 1.25600 @  25.00 °C.
Boiling Point: 83.00 to  84.00 °C. @ 760.00 mm Hg
Vapor Pressure: 78.900000 mmHg @ 25.00 °C.
Flash Point: 60.00 °F. TCC ( 15.56 °C. )
logP (o/w): 1.480
Soluble in:
 water, 8600 mg/L @ 25 °C (exp)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: not used anymore
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Suppliers:
Covalent Chemical
Ethylene Dichloride
Shandong Luyue Chemical
Dichloroethane(EDC)
Sigma-Aldrich
For experimental / research use only.
1,2-Dichloroethane anhydrous, 99.8%
Wedor Corporation
ETHYLENE DICHLORIDE
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  670 mg/kg
Farm Chemicals Handbook. Vol. -, Pg. C130, 1991.

oral-dog LD50  5700 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: ATAXIA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 91, 1970.

intravenous-dog LDLo  175 mg/kg
Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.

intraperitoneal-guinea pig LDLo  600 mg/kg
American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974.

oral-human LDLo  286 mg/kg
LIVER: FATTY LIVER DEGERATION GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Casopis Lekaru Ceskych. Journal of Czech Physicians. Vol. 86, Pg. 203, 1947.

oral-human TDLo  428 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: COUGH BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Sovetskaia Meditsina. Vol. 22(10), Pg. 132, 1958.

oral-man LDLo  714 mg/kg
LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: CHANGE IN RATE
Klinische Wochenscrift. Vol. 48, Pg. 822, 1970.

oral-man TDLo  892 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Wiadomosci Lekarskie. Medical News. Vol. 28, Pg. 983, 1975.

intraperitoneal-mouse LD50  470 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 902, 1961.

oral-mouse LD50  413 mg/kg
LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
EHP, Environmental Health Perspectives. Vol. 43, Pg. 41, 1982.

oral-rabbit LD50  860 mg/kg
Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 264, 1973.

intraperitoneal-rat LD50  807 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(4), Pg. 26, 1982.

intratracheal-rat LDLo  120 mg/kg
National Technical Information Service. Vol. OTS0520615

Dermal Toxicity:
skin-rabbit LD50 2800 mg/kg
BEHAVIORAL: ATAXIA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: GENERAL ANESTHETIC
FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 91, 1970.

subcutaneous-mouse LDLo 380 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 53, 1945.

subcutaneous-rabbit LDLo 1200 mg/kg
Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.

subcutaneous-rat LD50 1000 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA
FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 91, 1970.

Inhalation Toxicity:
inhalation-rat LC50 1000 ppm/7H
BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 482, 1951.

inhalation-cat LC > 3000 ppm/7H
Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 53, 1945.

inhalation-guinea pig LCLo 1500 ppm/7H
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 53, 1945.

inhalation-mammal (species unspecified) LC > 3000 ppm/7H
Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 53, 1945.

inhalation-man TCLo 4000 ppm/1H
BEHAVIORAL: COMA PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) GASTROINTESTINAL: NAUSEA OR VOMITING
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 500, 1966.

inhalation-mouse LCLo 5000 mg/m3/2H
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 141, Pg. 19, 1929.

inhalation-rabbit LCLo 3000 ppm/7H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 53, 1945.

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Safety in Use Information:
Category: extraction solvents
Recommendation for 1,2-dichloroethane usage levels up to:
 not for fragrance use.
 
Recommendation for 1,2-dichloroethane flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
EPA-Iris: IRIS
NIOSH International Chemical Safety Cards: search
NIOSH Pocket Guide: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA GENetic TOXicology: Search
EPA Substance Registry Services (TSCA): 107-06-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 11
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 1,2-dichloroethane
Chemidplus: 0000107062
EPA/NOAA CAMEO: hazardous materials
RTECS: 107-06-2
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References:
 1,2-dichloroethane
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 107-06-2
Pubchem (cid): 11
Pubchem (sid): 134972247
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI: View
CHEMBL: View
Metabolomics Database: Search
UM BBD: Search
KEGG (GenomeNet): C06752
HMDB (The Human Metabolome Database): HMDB29571
FooDB: FDB000726
Export Tariff Code: 2903.15.0000
FDA Listing of Food Additive Status: View
Wikipedia: View
Formulations/Preparations:
•usepaopp pesticide code 042003; trade names: ent-1656; borer sol; brocide; destruxol borer-sol; dichloremulsion; dowfume; dutch liquid; dutch oil; freon 150. •granosan: disinfectant composed of 30% carbon tetrachloride and 70% ethylene dichloride. •grades: technical, spectrophotometric. •ethylene dichloride - carbon tetrachloride (dowfume 75). principal ingredient: 1,2-dichloroethane, commercial formulation, 70% active ingredient; & tetrachloromethane, commercial formulation, 30% active ingredient .
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
1,2-bichloroethane
alpha,beta-dichloroethane
 ethylene dichloride
1,2-ethylene dichloride
1,2-ethylidene dichloride
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