|
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 260.00 °C. @ 760.00 mm Hg (est)
|
| Vapor Pressure: | 0.603000 mmHg (est) |
| Flash Point: | 282.00 °F. TCC ( 139.10 °C. ) (est)
|
| logP (o/w): | -0.580 |
| Soluble in: |
| | water, 4.244e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| 1H-1, 2, 4Triazole
Odor: characteristic Use: 1H-1, 2, 4 Triazole is a C14-demethylase-inhibitor that is commonly used in fungicides. It is also used as an ingredient in the preparation of Rizatriptan, Letrozole, Vorozolea and Posaconazole. |
| Charkit Chemical |
| TRIAZOLE, 1,2,4-
|
| Glentham Life Sciences |
| 1,2,4-Triazole
|
| Penta International |
| 1,2,4-TRIAZOLE
|
| Shiva Chemicals and Pharmaceuticals |
| 1-H,1,2,4 triazole
|
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| 1,2,4-Triazole 98%
|
| TCI AMERICA |
| For experimental / research use only. |
| 1,2,4-Triazole >99.0%(GC)
|
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 1350 mg/kg BEHAVIORAL: TREMOR
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: EXCITEMENT Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(11), Pg. 65, 1986.
oral-quail LD50 > 316 mg/kg Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
oral-rat LD50 1750 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: TREMOR Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(11), Pg. 65, 1986.
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for 1,2,4-triazole usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for 1,2,4-triazole flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment for triazole derivative metabolites in light of confirmatory data View page or View pdf |
Peer review of the pesticide risk assessment for the triazole derivative metabolites in light of confirmatory data submitted View page or View pdf |
| EPI System: | View |
| NIOSH International Chemical Safety Cards: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 288-88-0 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 9257 |
| National Institute of Allergy and Infectious Diseases: | Data |
| SCCNFP: | opinion |
| WGK Germany: | 2 |
| | 1H-1,2,4-triazole |
| Chemidplus: | 0000288880 |
| RTECS: | 288-88-0 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | pyrrodiazole | | 1H-1,2,4- | triazol | | 1H-1,2,4- | triazole |
Articles:
| PubMed: | Triazole GHS-R1a antagonists JMV4208 and JMV3002 attenuate food intake, body weight, and adipose tissue mass in mice. |
| PubMed: | Access to a new class of biologically active quinoline based 1,2,4-triazoles. |
| PubMed: | Combined repeated-dose and reproductive/developmental toxicity screening test of 3-amino-5-mercapto-1,2,4-triazole in rats. |
| PubMed: | The involvement of several enzymes in methanol detoxification in Drosophila melanogaster adults. |
| PubMed: | Ghrelin-induced orexigenic effect in rats depends on the metabolic status and is counteracted by peripheral CB1 receptor antagonism. |
| PubMed: | Synthesis, fungicidal activity, and sterol 14α-demethylase binding interaction of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum. |
| PubMed: | Synthesis, crystal structure, in vitro acetohydroxyacid synthase inhibition, in vivo herbicidal activity, and 3D-QSAR of new asymmetric aryl disulfides. |
| PubMed: | The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist. |
| PubMed: | Synthesis and fungicidal activity of novel 3-(substituted/unsubstituted phenylselenonyl)-1-ribosyl/deoxyribosyl-1H-1,2,4-triazole. |
| PubMed: | The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae. |
| PubMed: | Separation and preconcentration of Cd(II), Cu(II), Ni(II), and Pb(II) in water and food samples using Amberlite XAD-2 functionalized with 3-(2-nitrophenyl)-1H-1,2,4-triazole-5(4H)-thione and determination by inductively coupled plasma-atomic emission spectrometry. |
| PubMed: | Efficient synthesis of novel 1,2,4-triazole fused acyclic and 21-28 membered macrocyclic and/or lariat macrocyclic oxaazathia crown compounds with potential antimicrobial activity. |
| PubMed: | β-ODAP accumulation could be related to low levels of superoxide anion and hydrogen peroxide in Lathyrus sativus L. |
| PubMed: | Synthesis and biological activity of some novel trifluoromethyl-substituted 1,2,4-triazole and bis(1,2,4-triazole) Mannich bases containing piperazine rings. |
| PubMed: | Synthesis, crystal structure, and biological activity of 4-methyl-1,2,3-thiadiazole-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. |
| PubMed: | The effects of buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on propyl gallate-treated HeLa cells in relation to cell growth, reactive oxygen species and glutathione. |
| PubMed: | Determination of stereoselective interaction between enantiomers of chiral gamma-aryl-1H-1,2,4-triazole derivatives and Penicillium digitatum. |
| PubMed: | Resistance to cadmium as a function of Caco-2 cell differentiation: role of reactive oxygen species in cadmium- but not zinc-induced adaptation mechanisms. |
| PubMed: | Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor drug. |
| PubMed: | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| PubMed: | Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats. |
| PubMed: | Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor. |
| PubMed: | New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations. |
| PubMed: | Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations. |
| PubMed: | Development of potential manufacturing routes for substituted thiophenes--preparation of halogenated 2-thiophenecarboxylic acid derivatives as building blocks for a new family of 2,6-dihaloaryl 1,2,4-triazole insecticides. |
| PubMed: | First synthesis and antimicrobial activity Of N- and S-alpha-L-arabinopyranosyl-1,2,4-triazoles. |
| PubMed: | Synthesis and pharmacological in vitro and in vivo evaluations of novel triazole derivatives as ligands of the ghrelin receptor. 1. |
| PubMed: | Sterol demethylation inhibitor fungicides as disruptors of insect development and inducers of glutathione S-transferase activities in Mamestra brassicae. |
| PubMed: | Contributions of pro-oxidant and anti-oxidant conditions to the actions of 24,25-dihydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on phosphate uptake in intestinal cells. |
| PubMed: | Synthesis and herbicidal activity of N,N-diethyl-3-(arylselenonyl)-1H-1,2,4-triazole-1-carboxamide. |
| PubMed: | Efficient synthesis, structure, and antimicrobial activity of some novel N- and S-beta-D-glucosides of 5-pyridin-3-yl-1,2,4-triazoles. |
| PubMed: | Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21. |
| PubMed: | Determination of 22 triazole compounds including parent fungicides and metabolites in apples, peaches, flour, and water by liquid chromatography/tandem mass spectrometry. |
| PubMed: | Determination of Fe(II) and Zn(II) by spectrophotometry, atomic absorption spectrometry and ions chromatography methods in Vitrum. |
| PubMed: | Kinetics and products of photo-Fenton degradation of triazophos. |
| PubMed: | Spectrophotometric determination of Fe(II) and Zn(II) in the pharmaceutical multivitamin preparations with microelements. |
| PubMed: | Comparison of three colorimetric reagents in the determination of methanol with alcohol oxidase. Application to the assay of pectin methylesterase. |
| PubMed: | Sorption behavior of triazole fungicides in Indian soils and its correlation with soil properties. |
| PubMed: | Liquid chromatographic determination of ampicillin residues in porcine muscle tissue by a multipenicillin analytical method: European Collaborative Study. |
| PubMed: | Role of acetaldehyde in the discriminative stimulus effects of ethanol. |
| PubMed: | A specific and potent inhibitor of brassinosteroid biosynthesis possessing a dioxolane ring. |
| PubMed: | Acetylation of 5-amino-1H-[1,2,4]triazole revisited. |
| PubMed: | Characterization of a catalase-peroxidase from the hyperthermophilic archaeon Archaeoglobus fulgidus. |
| PubMed: | Metabolism of [(14)C]flusilazole in the goat. |
| PubMed: | Purification and some properties of catalase from wheat germ (Triticum aestivum L.). |
| PubMed: | Multi-residue analysis of penicillin residues in porcine tissue using matrix solid phase dispersion. |
| PubMed: | Multiresidue liquid chromatographic method for determining residues of mono- and dibasic penicillins in bovine muscle tissues. |
| PubMed: | The catalase-peroxidase of Synechococcus PCC 7942: purification, nucleotide sequence analysis and expression in Escherichia coli. |
| PubMed: | Effects of 3-amino-1,2,4-triazole on brain catalase in the mediation of ethanol consumption in mice. |
| PubMed: | Analysis of penicillin G in milk by liquid chromatography. |
| PubMed: | Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum. |
| PubMed: | Molecular mechanisms of action of ribavirin. |
| PubMed: | Extraction of 3-amino-1,2,4-triazole (amitrole) and 2,6-dichloro-4-nitroaniline (DCNA) from soils. |
|