(S)-(+)-camptothecin, 7689-03-4

Articles:

PubMed:	Preparation of camptothecin-loaded targeting nanoparticles and their antitumor effects on hepatocellular carcinoma cell line H22.
PubMed:	Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency.
PubMed:	SN38 polymeric nanoparticles: in vitro cytotoxicity and in vivo antitumor efficacy in xenograft balb/c model with breast cancer versus irinotecan.
PubMed:	Salivary α-amylase, serum albumin, and myoglobin protect against DNA-damaging activities of ingested dietary agents in vitro.
PubMed:	A Simple HPLC Method with Fluorescence Detection for Simultaneous Determination of 10-methoxycamptothecin and its Metabolite 10-hydroxycamptothecin in Rat Liver Tissue.
PubMed:	Chemotherapy usage patterns in a US-wide cohort of patients with metastatic colorectal cancer.
PubMed:	The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats.
PubMed:	Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs.
PubMed:	Free radical scavenging, antiproliferative activities and profiling of variations in the level of phytochemicals in different parts of broccoli (Brassica oleracea italica).
PubMed:	Comparison of KRAS genotype: therascreen assay vs. LNA-mediated qPCR clamping assay.
PubMed:	Design, modeling, synthesis and biological activity evaluation of camptothecin-linked platinum anticancer agents.
PubMed:	Graphene oxide as a nanocarrier for loading and delivery of medicinal drugs and as a biosensor for detection of serum albumin.
PubMed:	Aflibercept.
PubMed:	TNFα and Fas/FasL pathways are involved in 9-Methoxycamptothecin-induced apoptosis in cancer cells with oxidative stress and G2/M cell cycle arrest.
PubMed:	Anthocyanins suppress the cleavable complex formation by irinotecan and diminish its DNA-strand-breaking activity in the colon of Wistar rats.
PubMed:	Food and Drug Administration approval of cetuximab and a new KRAS genetic test for metastatic colorectal cancer: major advance but just the tip of the biomarker iceberg.
PubMed:	Colon cancer cell chemosensitisation by fish oil emulsion involves apoptotic mitochondria pathway.
PubMed:	Irinotecan (CPT-11) chemotherapy alters intestinal microbiota in tumour bearing rats.
PubMed:	Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors.
PubMed:	Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.
PubMed:	Modulation of irinotecan-induced genomic DNA damage by theanine.
PubMed:	When do you need a validated assay?
PubMed:	Early dissemination of bevacizumab for advanced colorectal cancer: a prospective cohort study.
PubMed:	In vitro cytotoxic effect of ethanol extract prepared from sporophyll of Undaria pinnatifida on human colorectal cancer cells.
PubMed:	Anthocyanin-rich blackberry extract suppresses the DNA-damaging properties of topoisomerase I and II poisons in colon carcinoma cells.
PubMed:	Obacunone and obacunone glucoside inhibit human colon cancer (SW480) cells by the induction of apoptosis.
PubMed:	Prospective phase II study of FOLFIRI for mCRC in Japan, including the analysis of UGT1A1 28/6 polymorphisms.
PubMed:	Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells.
PubMed:	Plant-derived bioactive compounds produced by endophytic fungi.
PubMed:	Bevacizumab and glioblastomas, a single-centre experience: how disease history and characteristics may affect clinical outcome.
PubMed:	Bevacizumab plus irinotecan-based regimens in the treatment of metastatic colorectal cancer.
PubMed:	Effects of camptothecin, etoposide and Ca2+ on caspase-3 activity and myofibrillar disruption of chicken during postmortem ageing.
PubMed:	Repair of DNA damage induced by the mycotoxin alternariol involves tyrosyl-DNA phosphodiesterase 1.
PubMed:	Leveraging learning from a phase III colorectal cancer clinical trial: outcomes, methodology, meta-analysis and pharmacogenetics.
PubMed:	Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT) on human leukemia HL-60 cells.
PubMed:	Ongoing challenges in drug interaction safety: from exposure to pharmacogenomics.
PubMed:	Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.
PubMed:	The evolving role of monoclonal antibodies in colorectal cancer: early presumptions and impact on clinical trial development.
PubMed:	[A case of advanced gastric cancer that a medical therapy effect was provided grade 3 by a histopathological diagnosis after long-term chemotherapy].
PubMed:	[Intestinal absorption and secretion mechanism of carboxylate drugs].
PubMed:	Attenuation of cytogenetic effects by erythropoietin in human lymphocytes in vitro and P388 ascites tumor cells in vivo treated with irinotecan (CPT-11).
PubMed:	Cytoprotective activity of amifostine on cultured human lymphocytes exposed to irinotecan.
PubMed:	FDA review of a panitumumab (Vectibix) clinical trial for first-line treatment of metastatic colorectal cancer.
PubMed:	Single and combined supplementation of glutamine and n-3 polyunsaturated fatty acids on host tolerance and tumour response to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11)/5-fluorouracil chemotherapy in rats bearing Ward colon tumour.
PubMed:	Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival in selected patients with peritoneal carcinomatosis from abdominal and pelvic malignancies: results of 21 cases.
PubMed:	Effects of nutritional support in patients with colorectal cancer during chemotherapy.
PubMed:	[The study of dynamic acccumulation of camptothecin in Camptotheca acuminata fruit by TLCS].
PubMed:	[Prevention of irinotecan hydrochloride-induced diarrhea by oral administration of Lactobacillus casei strain Shirota in rats].
PubMed:	Food-drug interaction of (-)-epigallocatechin-3-gallate on the pharmacokinetics of irinotecan and the metabolite SN-38.
PubMed:	Pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 polymorphisms: are we there yet?
PubMed:	U.S. Food and Drug Administration approval: panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens.
PubMed:	Synergy between cetuximab and chemotherapy in tumors of the gastrointestinal tract.
PubMed:	Proteome response in HT-29 human colorectal cancer cells to two apoptosis-inducing compounds with different mode of action.
PubMed:	Nutritional modulation of antitumor efficacy and diarrhea toxicity related to irinotecan chemotherapy in rats bearing the ward colon tumor.
PubMed:	Photochemical properties of camptothecin in the presence of copper(II) ions: the role of radicals as prospective species in photodynamic therapy.
PubMed:	UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters.
PubMed:	[Bevacizumab (Avastin)].
PubMed:	Insights, challenges, and future directions in irinogenetics.
PubMed:	[A case report of small cell carcinoma of the esophagus successfully treated by irinotecan and cisplatin].
PubMed:	The role of SN-38 exposure, UGT1A1*28 polymorphism, and baseline bilirubin level in predicting severe irinotecan toxicity.
PubMed:	Topotecan in combination with cisplatin for the treatment of stage IVB, recurrent, or persistent cervical cancer.
PubMed:	Adding pharmacogenetics information to drug labels: lessons learned.
PubMed:	Reproductive toxicity evaluation of a new camptothecin anticancer agent, CKD-602, in pregnant/lactating female rats and their offspring.
PubMed:	TPMT, UGT1A1 and DPYD: genotyping to ensure safer cancer therapy?
PubMed:	Evaluation of the toxic potentials of a new camptothecin anticancer agent CKD-602 on fertility and early embryonic development in rats.
PubMed:	Clinical and pharmacokinetic study evaluating the effect of food on the disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in patients with solid tumors.
PubMed:	Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity.
PubMed:	Critical evaluation of current treatments in metastatic colorectal cancer.
PubMed:	Embryotoxic effects of CKD-602, a new camptothecin anticancer agent, in rats.
PubMed:	4-Week repeated intravenous dose toxicity study of a new camptothecin anticancer agent CKD-602 in dogs.
PubMed:	Effect of yerba mate (Ilex paraguariensis) tea on topoisomerase inhibition and oral carcinoma cell proliferation.
PubMed:	Phase I pharmacokinetic, food effect, and pharmacogenetic study of oral irinotecan given as semisolid matrix capsules in patients with solid tumors.
PubMed:	Future directions of liposome- and immunoliposome-based cancer therapeutics.
PubMed:	Antifungal activity of camptothecin, trifolin, and hyperoside isolated from Camptotheca acuminata.
PubMed:	Bevacizumab for advanced colorectal cancer.
PubMed:	Subacute toxicity evaluation of a new camptothecin anticancer agent CKD-602 administered by intravenous injection to rats.
PubMed:	A novel mouse model of rectal cancer established by orthotopic implantation of colon cancer cells.
PubMed:	Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells.
PubMed:	FDA drug approval summaries: oxaliplatin.
PubMed:	Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.
PubMed:	Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives.
PubMed:	Nitric oxide levels in human preneoplastic colonocytes determine their susceptibility toward antineoplastic agents.
PubMed:	Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.
PubMed:	Antiproliferative activity of apples is not due to phenolic-induced hydrogen peroxide formation.
PubMed:	Erbitux trial flawed from the beginning, committee finds.
PubMed:	Lessons learned from the Saltz and Mayo Clinic regimens.
PubMed:	Postmarketing re-evaluation of irinotecan plus 5-fluorouracil/leucovorin for first-line treatment of metastatic colorectal cancer.
PubMed:	Irinotecan/5-fluorouracil/leucovorin in advanced colorectal cancer: Oncologic Drugs Advisory committee summary.
PubMed:	Review of the role of CPT-11 in the treatment of colorectal cancer.
PubMed:	In vitro pharmacodynamics of CKD-602 in HT-29 cells.
PubMed:	9-nitrocamptothecin liposome aerosol: lack of subacute toxicity in dogs.
PubMed:	Release of annexin V-binding membrane microparticles from cultured human umbilical vein endothelial cells after treatment with camptothecin.
PubMed:	Cellular prion protein is expressed on endothelial cells and is released during apoptosis on membrane microparticles found in human plasma.
PubMed:	Clinical phase II study and pharmacological evaluation of rubitecan in non-pretreated patients with metastatic colorectal cancer-significant effect of food intake on the bioavailability of the oral camptothecin analogue.
PubMed:	Promising drug is victim of bad business.
PubMed:	ImClone BLA is declined.
PubMed:	[A case of esophageal small-cell carcinoma responding to chemotherapy with CTP-11].
PubMed:	Oxaliplatin: a new agent for colorectal cancer.
PubMed:	Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells.
PubMed:	From the Food and Drug Administration.
PubMed:	FDA approves irinotecan as first-line therapy for colorectal cancer.
PubMed:	Irinotecan (CPT-11) induced colitis: report of a case and review of Food and Drug Administration MEDWATCH reporting.
PubMed:	New agents in gastrointestinal malignancies: Part 1: Irinotecan in clinical practice.
PubMed:	Irinotecan hydrochloride: drug profile and nursing implications of a topoisomerase I inhibitor in patients with advanced colorectal cancer.
PubMed:	Cell cycle-dependent chronotoxicity of irinotecan hydrochloride in mice.
PubMed:	9-Nitrocamptothecin inhibits tumor recrosis factor-mediated activation of human immunodeficiency virus type 1 and enhances apoptosis in a latently infected T cell clone.
PubMed:	Topotecan in the treatment of gynecologic cancer.
PubMed:	Annexin-V and TUNEL use in monitoring the progression of apoptosis in plants.
PubMed:	The current status of irinotecan (CPT-11) in the United States.
PubMed:	Basic research plays a key role in new patient treatments.
PubMed:	Topotecan: after FDA and ASCO, what's next?
PubMed:	FDA approve bark-derived drug.
PubMed:	Camptothecin, a selective plant growth regulator.