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Category: humectants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 92.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 224.61 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 210.00 °F. TCC ( 99.00 °C. ) (est)
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| logP (o/w): | -0.800 (est) |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
Odor Description:
| cotton candy |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | humectants |
| Recommendation for (R)-(-)-pantolactone usage levels up to: | | | not for fragrance use.
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| Recommendation for (R)-(-)-pantolactone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (3R)- | dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone | | 2(3H)- | furanone, dihydro-3-hydroxy-4,4-dimethyl-, (3R)- | | (3R)- | hydroxy-4,4-dimethyloxolan-2-one | | alpha- | hydroxy-beta,beta-dimethyl-gamma-butyrolactone | | | pantolactone | | | pantoyl lactone |
Articles:
| PubMed: | Elucidation of key aroma compounds in traditional dry fermented sausages using different extraction techniques. |
| PubMed: | Total synthesis of an anticancer norsesquiterpene alkaloid isolated from the fungus Flammulina velutipes. |
| PubMed: | Effect of alcohol aggregation on the retention factors of chiral solutes with an amylose-based sorbent: modeling and implications for the adsorption mechanism. |
| PubMed: | Biochemical studies on a versatile esterase that is most catalytically active with polyaromatic esters. |
| PubMed: | Chiral recognition mechanism of acyloin-containing chiral solutes by amylose tris[(S)-α-methylbenzylcarbamate]. |
| PubMed: | Structure of conjugated polyketone reductase from Candida parapsilosis IFO 0708 reveals conformational changes for substrate recognition upon NADPH binding. |
| PubMed: | PanG, a new ketopantoate reductase involved in pantothenate synthesis. |
| PubMed: | LplR, a repressor belonging to the TetR family, regulates expression of the L-pantoyl lactone dehydrogenase gene in Rhodococcus erythropolis. |
| PubMed: | L-pantoyl lactone dehydrogenase from Rhodococcus erythropolis: genetic analyses and application to the stereospecific oxidation of L-pantoyl lactone. |
| PubMed: | Production of Quorum Sensing Inhibitors in Growing Onion Bulbs Infected with Pseudomonas aeruginosa E (HQ324110). |
| PubMed: | Total synthesis of isofregenedadiol. |
| PubMed: | Synthesis of molluscicidal agent cyanolide a macrolactone from D-(-)-pantolactone. |
| PubMed: | A striking exception to the chelate model for acyclic diastereocontrol: efficient access to a versatile propargyl alcohol for chemical synthesis. |
| PubMed: | Asymmetric histidine-catalyzed cross-aldol reactions of enolizable aldehydes: access to defined configured quaternary stereogenic centers. |
| PubMed: | Biocatalytic properties of a recombinant Fusarium proliferatum lactonase with significantly enhanced production by optimal expression in Escherichia coli. |
| PubMed: | Catalyzed addition of diazoacetoacetates to imines: synthesis of highly functionalized aziridines. |
| PubMed: | Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent. |
| PubMed: | [Studies on chemical constituents of Ranunculus ternatus]. |
| PubMed: | Enantiomer-selective carbamoylation of racemic alpha-hydroxy gamma-lactones with chiral Cu(II) Catalysts: an example of a highly active Lewis acid catalyzed reaction. |
| PubMed: | Enantioselective interactions at the solid-liquid interface of an HPLC column under working conditions. |
| PubMed: | Isolation and properties of a levo-lactonase from Fusarium proliferatum ECU2002: a robust biocatalyst for production of chiral lactones. |
| PubMed: | Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development. |
| PubMed: | Directed evolution and characterization of a novel D-pantonohydrolase from Fusarium moniliforme. |
| PubMed: | Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors. |
| PubMed: | [Directed evolution of D-lactonohydrolase by error prone PCR and DNA shuffling]. |
| PubMed: | Total synthesis of polycavernoside A, a lethal toxin of the red alga Polycavernosa tsudai. |
| PubMed: | Practical resolution system for DL-pantoyl lactone using the lactonase from Fusarium oxysporum. |
| PubMed: | Oxoester oxidoreductase activities in new isolates of Pichia anomala from apple, grape and cane juices. |
| PubMed: | Exogenous supply of pantoyl lactone to excised leaves increases their pantothenate levels. |
| PubMed: | Modular synthesis of pantetheine and phosphopantetheine. |
| PubMed: | Theoretical study of the stereoselective additions of chiral alcohols to ketenes. |
| PubMed: | Changes in volatile compounds and aromatic series in sherry wine with high gluconic acid levels subjected to aging by submerged flor yeast cultures. |
| PubMed: | A formal synthesis of (-)-mycalamide A. |
| PubMed: | Optical rotation of noncovalent aggregates. |
| PubMed: | Gene cloning and overexpression of two conjugated polyketone reductases, novel aldo-keto reductase family enzymes, of Candida parapsilosis. |
| PubMed: | Novel use of N-benzoyl-N,O-acetals as N-acylimine equivalents in asymmetric heterocycloaddition: an extended enantioselective pathway to beta-benzamido aldehydes. |
| PubMed: | Practical asymmetric synthesis of a potent Cathepsin K inhibitor. Efficient palladium removal following Suzuki coupling. |
| PubMed: | [Production of D-pantolactone hydrolase by Fusarium moniliforme SW-902]. |
| PubMed: | (R)-2,4-Dihydroxybutyramide seco-pseudonucleosides: new versatile homochiral synthons for synthesis of modified oligonucleotides. |
| PubMed: | The synthesis of deoxyfusapyrone. 1. An approach to the pyrone moiety. |
| PubMed: | A general method for the enantioselective synthesis of pantolactone derivatives. |
| PubMed: | Synthesis of (+/-)-5-epi-citreoviral and (+/-)-citreoviral and the kinetic resolution of an allylic silane by a [3 + 2] annulation. |
| PubMed: | A screening system for enantioselective enzymes based on differential cell growth. |
| PubMed: | Double diastereoselective intramolecular cyclopropanation to P-chiral [3.1.0]-bicyclic phosphonates. |
| PubMed: | Asymmetric Synthesis of 2,3-Dihydrofurans by Reaction of Rhodium-Stabilized Vinylcarbenoids with Vinyl Ethers. |
| PubMed: | An Enantioselective Synthesis of Cis Perhydroisoquinoline LY235959. |
| PubMed: | Lactone-ring-cleaving enzymes of microorganisms: their diversity and applications. |
| PubMed: | Synthesis of diastereomerically enriched 2-bromoesters and their reaction with nucleophiles. |
| PubMed: | Enantioselective synthesis of (S)-(+)-pantolactone |
| PubMed: | Microbial enzymes: new industrial applications from traditional screening methods. |
| PubMed: | Pantothenol protects rats against some deleterious effects of gamma radiation. |
| PubMed: | Optical resolution of pantolactone by a novel fungal enzyme, lactonohydrolase. |
| PubMed: | Investigation of Dienophile-TiCl(4) Complexation by Means of X-ray Absorption and (13)C-NMR Spectroscopies. |
| PubMed: | Potentially prebiotic syntheses of condensed phosphates. |
| PubMed: | A possible prebiotic synthesis of pantetheine, a precursor to coenzyme A. |
| PubMed: | Effect of cyclodextrin on improvement of enantioselectivity in the reduction of ketopantolactone with baker's yeast. |
| PubMed: | Prebiotic syntheses of vitamin coenzymes: II. Pantoic acid, pantothenic acid, and the composition of coenzyme A. |
| PubMed: | Pantothenases from pseudomonads produce either pantoyl lactone or pantoic acid. |
| PubMed: | Separation and determination of the enantiomers of pantolactone by gas-liquid chromatography. |
| PubMed: | [Quantitative gas chromatographic determination of pantolactone]. |
| PubMed: | Apparent antimutagenic effect of ultraviolet irradiation. |
| PubMed: | Effects of pantolactone and butyrolactone on the pleiotropic phenotypes of lon mutants and on thermal induction of the SOS phenomena in a tif mutant of Escherichia coli K12. |
| PubMed: | [Effect of pantoyl lactone on the growth of Mycobacterium lepraemurium in cell-free liquid medium (author's transl)]. |
| PubMed: | Analysis of stereochemistry of enzymically formed pantoyl lactone or pantoic acid by gas chromatography and circular dichroism. |
| PubMed: | Chemicals which promote survival of ultraviolet-irradiated lon and ruv mutants of Escherichia coli K12. |
| PubMed: | Modification of cell membrane lipids in Micrococcus lysodeikticus induced by pantoyl lactone. |
| PubMed: | D-pantolactone as a circular dichromism (CD) calibration. |
| PubMed: | [Improvement of the determination of pantothenates by photocolorimetry of pantolactone]. |
| PubMed: | Synthesis of pantolactone phosphate and its effect on growth of microorganisms. |
| PubMed: | Antagonism of Salicylate by Pantoyltaurine. |
| PubMed: | The biological activity of pantolactone and pantoic acid. |
| PubMed: | Observations on the effects of gamma-valero-lactone upon experimental animals. |
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