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(1R,2S)-2-(methylamino)-1-phenyl-1-propanol hydrochloride (1:1)
Notes:
a phenethylamine found in ephedra sinica. pseudoephedrine is an isomer. it is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. it has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. it has become less extensively used with the advent of more selective agonists. a phenethylamine found in ephedra sinica. pseudoephedrine is an isomer. it is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. it has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. it has become less extensively used with the advent of more selective agonists.
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 50-98-6 (-)-Ephedrine hydrochloride 97 % (TLC). alpha and beta Adrenoreceptors subtypes agonist; MAO inhibitor. Alkaloid derivative of l-Ephedrine from plants of the Ephedra genus, Ephedraceae. ADCs Cytotoxin
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 05-04290 EPHEDRINE HYDROCHLORIDE
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| CAS Number: | 50-98-6 |  3D/inchi
|
| Other(deleted CASRN): | 14992-57-5 | |
| ECHA EINECS - REACH Pre-Reg: | 200-074-6 | |
| FDA UNII: | NLJ6390P1Z | |
| Beilstein Number: | 3630391 | |
| MDL: | MFCD00066127 | |
| Molecular Weight: | 201.69572000 | |
| Formula: | C10 H16 Cl N O | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 218.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 255.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 0.008650 mmHg @ 25.00 °C. (est) |
| Flash Point: | 186.00 °F. TCC ( 85.60 °C. ) (est) |
| logP (o/w): | 1.054 (est) |
| Soluble in: | |
| water, 2.50E+05 mg/L @ 25 °C (exp) | |
| water, 1e+006 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| (-)-Ephedrine hydrochloride 97 % (TLC).
Odor: characteristic Use: alpha and beta Adrenoreceptors subtypes agonist; MAO inhibitor. Alkaloid derivative of l-Ephedrine from plants of the Ephedra genus, Ephedraceae.
ADCs Cytotoxin |
| Penta International |
| EPHEDRINE HYDROCHLORIDE |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| (1R,2S)-(-)-Ephedrine hydrochloride 99% |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-cat LDLo 60 mg/kg CARDIAC: OTHER CHANGES Medecine Vol. 9, Pg. 59, 1930. intravenous-dog LDLo 70 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Medecine Vol. 9, Pg. 59, 1930. parenteral-frog LDLo 440 mg/kg Manshu Igaku Zasshi. Manchuria Medical Journal. Vol. 3, Pg. 1, 1925. intravenous-guinea pig LD50 98 mg/kg PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: EXCITEMENT Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963. intraperitoneal-hamster LDLo 350 mg/kg CARDIAC: OTHER CHANGES Medecine Vol. 9, Pg. 59, 1930. intraperitoneal-mouse LD50 242 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 158, Pg. 135, 1967. intravenous-mouse LD50 95 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949. oral-mouse LD50 400 mg/kg Journal of Medicinal Chemistry. Vol. 9, Pg. 966, 1966. parenteral-mouse LDLo 500 mg/kg Manshu Igaku Zasshi. Manchuria Medical Journal. Vol. 3, Pg. 1, 1925. intramuscular-rabbit LD50 175 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946. intravenous-rabbit LD50 65 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949. intraperitoneal-rat LD50 165 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946. intravenous-rat LD50 69 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 33, Pg. 80, 1944. | |
| Dermal Toxicity: | |
|
subcutaneous-dog LDLo 220 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Medecine Vol. 9, Pg. 59, 1930. subcutaneous-frog LDLo 400 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE Medecine Vol. 9, Pg. 59, 1930. subcutaneous-guinea pig LD50 192 mg/kg PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: EXCITEMENT Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963. subcutaneous-mouse LD50 40870 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 214, 1946. subcutaneous-rabbit LD50 165 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946. subcutaneous-rat LD50 1150 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for (1R,2S)-(-)-ephedrine hydrochloride usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for (1R,2S)-(-)-ephedrine hydrochloride flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 50-98-6 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 65326 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 1 |
| (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride | |
| Chemidplus: | 0000050986 |
| RTECS: | KB1750000 for cas# 50-98-6 |
References:
| (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 50-98-6 |
| Pubchem (cid): | 65326 |
| Pubchem (sid): | 135022311 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEMBL: | View |
| KEGG (GenomeNet): | D01386 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2939.40.5000 |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| altusin | |
| benzenemethanol, a-[(1S)-1-(methylamino)ethyl]-, (aR)-, hydrochloride (1:1) | |
| bronkotabs | |
| (-)- | ephedrine hydrochloride |
| (1R,2S)- | ephedrine hydrochloride |
| L-erythro- | ephedrine hydrochloride |
| ephedroguent | |
| ephedronguent | |
| L- | erythro-2-(Methylamino)-1-phenylpropan-1-ol hydrochloride |
| (1R,2S)-(-)-2- | methylamino-1-phenyl-1-propanol hydrochloride |
| (1R,2S)-2-( | methylamino)-1-phenyl-1-propanol hydrochloride (1:1) |
| (1R,2S)-2-( | methylamino)-1-phenylpropan-1-ol hydrochloride (1:1) |
| (1R,2S)-2-( | methylamino)-1-phenylpropan-1-ol;hydrochloride |
| [R-(R*,S*)]-a-[1-( | methylamino)ethyl]benzenemethanol hydrochloride |
| (1R,2S)-a-[1-( | methylamino)ethyl]benzyl alcohol hydrochloride |
| primatene tablets | |
| quadrinal | |
| sanedrine | |
| tedral |