Articles:
7,14-methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))-
Notes:
a quinolizidine alkaloid isolated from several fabaceae including lupinus; spartium; and cytisus. it has been used as an oxytocic and an anti-arrhythmia agent. it has also been of interest as an indicator of cyp2d6 genotype.
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| CAS Number: | 90-39-1 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 201-988-8 | |
| FDA UNII: | 298897D62S | |
| Nikkaji Web: | J69.077E | |
| MDL: | MFCD00069653 | |
| XlogP3-AA: | 2.50 (est) | |
| Molecular Weight: | 234.38622000 | |
| Formula: | C15 H26 N2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.02000 @ 25.00 °C. |
| Refractive Index: | 1.52600 to 1.53000 @ 20.00 °C. |
| Melting Point: | 30.50 °C. @ 760.00 mm Hg |
| Boiling Point: | 325.00 °C. @ 760.00 mm Hg |
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. ) |
| logP (o/w): | 3.210 (est) |
| Soluble in: | |
| water, 3040 mg/L @ 22 °C (exp) | |
| water, 1374 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| ExtraSynthese |
| For experimental / research use only. |
| Sparteine |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| (-)-Sparteine 99% |
| TCI AMERICA |
| For experimental / research use only. |
| (-)-Sparteine >98.0%(GC) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-dog LD50 15 mg/kg Veterinary and Human Toxicology. Vol. 41, Pg. 33, 1999. intramuscular-frog LDLo 1665 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1398, 1935. intraperitoneal-guinea pig LDLo 23 mg/kg Journal of Agricultural Research Vol. 32, Pg. 51, 1926. intravenous-guinea pig LDLo 27 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: TREMOR Planta Medica. Vol. 50, Pg. 420, 1984. intraperitoneal-mouse LD50 36 mg/kg BEHAVIORAL: TREMOR BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Planta Medica. Vol. 50, Pg. 420, 1984. oral-mouse LD50 220 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: TREMOR Planta Medica. Vol. 50, Pg. 420, 1984. intravenous-rabbit LDLo 30 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1398, 1935. intraperitoneal-rat LD50 42 mg/kg Compilation of LD50 Values of New Drugs. oral-rat LD50 960 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 210, Pg. 27, 1974. | |
| Dermal Toxicity: | |
|
subcutaneous-frog LDLo 3330 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1398, 1935. subcutaneous-mouse LD50 105 mg/kg Pharmacology and Toxicology. English translation of FATOAO. Vol. 21, Pg. 468, 1958. subcutaneous-rabbit LDLo 100 mg/kg "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 589, 1948. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | natural substances and extractives | ||
| Recommendation for (-)-sparteine usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for (-)-sparteine flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 7014 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| Chemidplus: | 0000090391 |
| RTECS: | WG5950000 for cas# 90-39-1 |
References:
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 7014 |
| Pubchem (sid): | 134970944 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2921.30.3000 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| found in nature |
Synonyms:
| esparteina | |
| genisteine alkaloid | |
| lupinidine | |
| 7,14- | methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro- |
| 7,14- | methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))- |
| 6-beta,7-alpha,9-alpha,11-alpha- | pachycarpine |
| sparteina | |
| L- | sparteine |
| sparteinum |