Articles:
O-2,2'-cyclocytidine monohydrochloride
Notes:
congener of cytarabine that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action.
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| CAS Number: | 10212-25-6 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 233-515-6 | |
| FDA UNII: | 3T6920M469 | |
| MDL: | MFCD00012636 | |
| Molecular Weight: | 261.66444000 | |
| Formula: | C9 H12 Cl N3 O4 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 422.20 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 0.000000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 408.00 °F. TCC ( 209.10 °C. ) (est) |
| logP (o/w): | -2.301 (est) |
| Soluble in: | |
| water, 3.943e+004 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Cyclocytidine HCl ≥98% by HPLC
Odor: characteristic Use: 2,2'-Anhydro-cytidine-HCl is a DNA synthesis inhibitor commonly used as an antineoplastic agent to treat leukemias. |
| Changzhou Longo Chemical |
| Cyclocytidine Hydrochloride |
| George Uhe Company |
| Ancitabine Hydrochloride |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Ancitabine hydrochloride |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Ancitabine hydrochloride |
| TCI AMERICA |
| For experimental / research use only. |
| 2,2'-O-Cyclocytidine Hydrochloride >98.0%(HPLC)(N) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-dog LD50 344 mg/kg GASTROINTESTINAL: NAUSEA OR VOMITING Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 353, 1974. intraperitoneal-mouse LD50 2528 mg/kg National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986 intravenous-mouse LD50 800 mg/kg Drugs in Japan Vol. 6, Pg. 55, 1982. oral-mouse LD50 > 7000 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979. intraperitoneal-rat LD50 3800 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979. intravenous-rat LD50 820 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979. oral-rat LD50 > 7000 mg/kg Drugs in Japan Vol. -, Pg. 86, 1990. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 4050 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979. subcutaneous-rat LD50 > 5500 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for (-)-cyclocytidine hydrochloride usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for (-)-cyclocytidine hydrochloride flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 25050 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| (2R,3R,3aS,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydrofuro[1,2][1,3]oxazolo[3,4-a]pyrimidin-3-ol;hydrochloride | |
| Chemidplus: | 0010212256 |
| RTECS: | LV2615000 for cas# 10212-25-6 |
References:
| (2R,3R,3aS,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydrofuro[1,2][1,3]oxazolo[3,4-a]pyrimidin-3-ol;hydrochloride | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 25050 |
| Pubchem (sid): | 134990804 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C13112 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2934.99.4400 |
| ChemSpider: | View |
| Wikipedia: | View |
| EFSA Update of results on the monitoring of furan levels in food: | Read Report |
| EFSA Previous report: Results on the monitoring of furan levels in food: | Read Report |
| EFSA Report of the CONTAM Panel on provisional findings on furan in food: | Read Report |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| ancitabin hydrochlorid | |
| ancitabin hydrochloride | |
| ancitabine hydrochloride | |
| 2,2'- | anhydro-1-beta-dextro-arabinofuranosyl cytosine hydrochloride |
| 2,2'- | anhydroarabinosylcytosine hydrochloride |
| 2,2'- | anhydroaracytidine hydrochloride |
| 2,2'- | anhydrocytarabine hydrochloride |
| 2,2'- | anhydrocytidine hydrochloride |
| cyclocytidine hydrochloride | |
| 2,2'-O- | cyclocytidine Hydrochloride |
| O-2,2'- | cyclocytidine monohydrochloride |
| (2R,3R,3aS,9aR)-2-( | hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydrofuro[1,2][1,3]oxazolo[3,4-a]pyrimidin-3-ol;hydrochloride |
| OCTD hydrochloride |