(±)-warfarin
2H-1-benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-
 
Notes:
an anticoagulant that acts by inhibiting the synthesis of vitamin k-dependent coagulation factors. warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. it is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. warfarin is also used as a rodenticide. Warfarin is a rodenticide used in the home, outdoors, in food service establishments, near fruit trees, in storage buildings, sewers and other places where rodents may be a problem. This white, odorless, tasteless compound, an anti-coagulant, causes bleeding and blood-thinning. [HMDB]
Synonyms   Articles   Notes   Search
CAS Number: 81-81-2Picture of molecule3D/inchi
Other: 5543-56-6
ECHA EINECS - REACH Pre-Reg: 201-377-6
Nikkaji Web: J3.862H
Beilstein Number: 8868198
MDL: MFCD00006854
XlogP3: 2.70 (est)
Molecular Weight: 308.33332000
Formula: C19 H16 O4
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: herbicides / pesticides
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
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NCBI: Search
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Physical Properties:
Appearance: colorless solid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 161.00 °C. @ 760.00 mm Hg
Boiling Point: 515.15 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 1.160000 mmHg @ 1.16 °C. (est)
Flash Point: 372.00 °F. TCC ( 188.80 °C. ) (est)
logP (o/w): 2.600
Soluble in:
 water, 54.27 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Santa Cruz Biotechnology
For experimental / research use only.
Warfarin ≥99%
Sigma-Aldrich
For experimental / research use only.
Warfarin PESTANAL®, analytical standard
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-cat LD50  6 mg/kg
Defense des Vegetaux. Vol. 32, Pg. 27, 1978.

oral-chicken LD50  942 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BLOOD: HEMORRHAGE
Bulletin of Environmental Contamination and Toxicology. Vol. 37, Pg. 544, 1986.

oral-dog LD50  3 mg/kg
Defense des Vegetaux. Vol. 43(255-256), Pg. 20, 1989.

oral-guinea pig LD50  180 mg/kg
Defense des Vegetaux. Vol. 32, Pg. 27, 1978.

oral-human LDLo  6667 ug/kg
Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.

oral-man TDLo  10200 ug/kg
BLOOD: HEMORRHAGE
"Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956Vol. -, Pg. 1, 1956.

intraperitoneal-mouse LD50  750 mg/kg
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 30, Pg. 531, 1995.

intravenous-mouse LD50  165 mg/kg
"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 274, 1973.

oral-mouse LD50  3 mg/kg
Defense des Vegetaux. Vol. 43(255-256), Pg. 20, 1989.

unreported-mouse LD50  60 mg/kg
Yakkyoku. Pharmacy. Vol. 30, Pg. 397, 1979.

oral-rabbit LD50  800 mg/kg
Defense des Vegetaux. Vol. 32, Pg. 27, 1978.

oral-rat LD50  1600 ug/kg
Toxicology and Applied Pharmacology. Vol. 11, Pg. 327, 1967.

unreported-rat LD50  50 mg/kg
Yakkyoku. Pharmacy. Vol. 30, Pg. 397, 1979.

intraperitoneal-rat LDLo  420 mg/kg
Toxicology and Applied Pharmacology. Vol. 1, Pg. 156, 1959.

Dermal Toxicity:
subcutaneous-mouse LDLo 800 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL)
Trudy, VNIIVS. Transactions of the All-Union Scientific Research Institute of Veterinary Sanitation. Vol. 58, Pg. 122, 1977.

skin-rat LD50 1400 mg/kg
SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE BEHAVIORAL: MUSCLE WEAKNESS KIDNEY, URETER, AND BLADDER: HEMATURIA
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 22(7), Pg. 49, 1978.

Inhalation Toxicity:
inhalation-rat LC50 320 mg/m3
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 22(7), Pg. 49, 1978.

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Safety in Use Information:
Category: herbicides / pesticides
Recommendation for (±)-warfarin usage levels up to:
 not for fragrance use.
 
Recommendation for (±)-warfarin flavor usage levels up to:
 not for flavor use.
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Authority (EFSA) reference(s):
Reasoned opinion on the review of the existing maximum residue levels (MRLs) for warfarin according to Article 12 of Regulation (EC) No 396/2005
View page or View pdf
EPI System: View
EPA-Iris: IRIS
ClinicalTrials.gov: search
Daily Med: search
NIOSH International Chemical Safety Cards: search
NIOSH Pocket Guide: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 81-81-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 54678486
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 4-hydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one
Chemidplus: 0000081812
EPA/NOAA CAMEO: hazardous materials
RTECS: 81-81-2
Synonyms   Articles   Notes   Search   Top
References:
 4-hydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 81-81-2
Pubchem (cid): 54678486
Pubchem (sid): 134972971
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C01541
HMDB (The Human Metabolome Database): HMDB01935
FooDB: FDB022750
Export Tariff Code: 2932.29.4500
MedlinePlusSupp: View
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
•usepaopp pesticide code 086002; trade names: ent-17033, dethmor (warfarin product, cnx 787). •formulation types incl bait & concentrate. mixed formulations incl (warfarin +) pindone; calciferol; sulfaquinoxaline. •rat baits are usually made up by mixing 1 part of commercial prepn containing 0.5 or 0.1% warfarin with 20 parts of oatmeal or other suitable diluent. •a "rodent drink" is made with water containing 0.54% warfarin sodium coated on sugar (dethmor water soluble); a similar "rodent drink" containing 0.54% warfarin coated on sand (silica) is (rax water soluble). ratoxin 1% powder, 1% wtwt coated talc powder. •bait (ready for use); granular bait; bait concentrate; grain bait; tracking powder; gel •trade names for warfarin rodenticide incl co-rax, cov-r-tox, kypfarin, liqua-tox, rax, rodex, rodex blox, tox-hid, warfarin plus (discontinued by velsicol corp), warfarin q. •as therapeutic anticoagulant the drug is avail as racemic mixtures of the 2 optical isomers of the potassium or sodium salt. panwarfin tablets contain amorphous warfarin sodium; coumadin tablets contain the crystalline clathrate. commercially avail warfarin sodium powder for injection (coumadin) contains lyophilized, amorphous warfarin sodium formulated with sodium hydroxide to adjust ph. warfarin potassium & warfarin sodium •therapeutic: warfarin sodium, usp (coumadin, panwarfin) is avail in tablets containing 2, 2.5, 5, 7.5, 10, and 25 mg of drug. warfarin potassium, usp (athrombin-k) is avail in tablets containing 5 & 10 mg of drug. warfarin sodium for injection, usp, containing sodium chloride & thiomerosal, is avail in vials of 50 mg with ampules of sterile water warfarin sodium & warfarin potassium •water soluble, ready-to-use baits, concentrates, powder, liquid concentrate, nylon pouches, coated talc, and dust. •formulations with 2-(dimethylamino)ethanol: warfarin-deanol, md 6134, adoisine
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
None Found
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
None Found
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 not found in nature
Synonyms   Articles   Notes   Search   Top
Synonyms:
3-(a-acetonylbenzyl)-4-hydroxy-coumarin
3-(a-acetonylbenzyl)-4-hydroxycoumarin
DL-3-(a-acetonylbenzyl)-4-hydroxycoumarin
 antrombin K
 arab rat death
 athrombine-K
2H-1-benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-
 brumolin
 co-rax
 coumadin
 coumaphene
 cov-R-tox
 dethmor
 dethnel
 frass-ratron
4-hydroxy-3-(3-oxo-1-phenyl butyl)-2H-1-benzopyran-2-one
4-hydroxy-3-(3-oxo-1-phenyl-butyl)-chromen-2-one
4-hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin
2-hydroxy-3-(3-oxo-1-phenyl-butyl)chromen-4-one
4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
4-hydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one
4-hydroxy-3-(3-oxo-1-phenylbutyl)coumarin
1-(4'-hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
 kumader
 kumadu
 kumatox
 kypfarin
 maveran
 panwarfin
3-(1'-phenyl-2'-acetyl ethyl)-4-hydroxycoumarin
3-(1'-phenyl-2'-acetylethyl)-4-hydroxycoumarin
3-a-phenyl-b-acetylethyl-4-hydroxycoumarin
3-(a-phenyl-β-acetylethyl)-4-hydroxycoumarin
 prothromadin
 rat-o-cide
 ratox
 ratoxin
 ratron G
 rattunal
 rodafarin
 rodafarin C
 rodex
 tedicumar
 temus W
 tintorane
 tox-hid
 vampirinip II
 vampirinip III
 varfine
 warcoumin
 warfant
 warfarat
 warfarin
apo-warfarin
gen-warfarin
rac-warfarin
 warfarin K
 warfarinum
 warfilone
 zoocoumarin
Synonyms   Articles   Notes   Search   Top
Articles:
Info: Warfarin
PubMed: Interaction between warfarin and Korean red ginseng in patients with cardiac valve replacement.
PubMed: Effect of the moderate consumption of olestra in patients receiving long-term warfarin therapy.
PubMed: Long term oral anticoagulant therapy with warfarin: experience with local patient population in kuwait.
PubMed: Edoxaban: a focused review of its clinical pharmacology.
PubMed: Beyond warfarin: A patient-centered approach to selecting novel oral anticoagulants for stroke prevention in atrial fibrillation.
PubMed: Evaluation of the biointeraction of colorant flavazin with human serum albumin: insights from multiple spectroscopic studies, in silico docking and molecular dynamics simulation.
PubMed: Drug-drug interactions between sucroferric oxyhydroxide and losartan, furosemide, omeprazole, digoxin and warfarin in healthy subjects.
PubMed: The Role of Rivaroxaban in Atrial Fibrillation and Acute Coronary Syndromes.
PubMed: [New treatments for stroke and thromboembolism prevention in atrial fibrillation].
PubMed: Dabigatran for stroke prevention in nonvalvular atrial fibrillation: focus in the geriatric population.
PubMed: New oral anticoagulants for stroke prevention in atrial fibrillation: impact of study design, double counting and unexpected findings on interpretation of study results and conclusions.
PubMed: Bioavailability and activity of natural food additive triterpenoids as influenced by protein.
PubMed: Ensuring medication adherence with direct oral anticoagulant drugs: Lessons from adherence with vitamin K antagonists (VKAs).
PubMed: Evaluating warfarin management by pharmacists in a community teaching hospital.
PubMed: Reduced anticoagulation after mechanical aortic valve replacement: interim results from the prospective randomized on-X valve anticoagulation clinical trial randomized Food and Drug Administration investigational device exemption trial.
PubMed: Fondaparinux as alternative anticoagulant to warfarin or low-molecular-weight heparin for recurrent venous thrombosis.
PubMed: Emergency department management of patients on novel oral anticoagulant agents.
PubMed: [Efficacy and safety of apixaban compared with warfarin regarding time within the therapeutic range].
PubMed: Alternative to oral dicoumarin anticoagulants: Considerations in dental care.
PubMed: New Oral Anticoagulants in Practice: Pharmacological and Practical Considerations.
PubMed: Antithrombotic alternatives for stroke prevention in atrial fibrillation: critical differences and remaining questions.
PubMed: The new era of anticoagulation.
PubMed: Competitive interactions of anti-carcinogens with serum albumin: a spectroscopic study of bendamustine and dexamethasone with the aid of chemometrics.
PubMed: Determination of bioequivalence for drugs with narrow therapeutic index: reduction of the regulatory burden.
PubMed: Local verification and assignment of mean normal prothrombin time and International Sensitivity Index values across various instruments: recent experience and outcome from North America.
PubMed: Alogliptin: A new dipeptidyl peptidase-4 inhibitor for the management of type 2 diabetes mellitus.
PubMed: Cost-effectiveness analysis of intracranial stent placement versus contemporary medical management in patients with symptomatic intracranial artery stenosis.
PubMed: Betrixaban (PRT054021): pharmacology, dose selection and clinical studies.
PubMed: Deep vein thrombosis and novel oral anticoagulants: a clinical review.
PubMed: Pharmacogenetics and coumarin dosing--recalibrating expectations.
PubMed: Bleeding events following concurrent use of warfarin and oseltamivir by Medicare beneficiaries.
PubMed: A comparison of results of the US food and drug administration's mini-sentinel program with randomized clinical trials: the case of gastrointestinal tract bleeding with dabigatran.
PubMed: Novel oral anticoagulants for stroke prevention in the geriatric population.
PubMed: Inadvertent exaggerated anticoagulation following use of bismuth subsalicylate in an enterally fed patient receiving warfarin therapy.
PubMed: Cost implications of formulary decisions on oral anticoagulants in nonvalvular atrial fibrillation.
PubMed: Adverse events in patients initiated on dabigatran etexilate therapy in a pharmacist-managed anticoagulation clinic.
PubMed: Dabigatran etexilate for thromboembolic prophylaxis in non-valvular atrial fibrillation: the RE-LY study and substudies with commentary.
PubMed: Practical considerations in the use of novel oral anticoagulants for stroke prevention in nonvalvular atrial fibrillation.
PubMed: Advantages and limitations of the new anticoagulants.
PubMed: Genetics-based pediatric warfarin dosage regimen derived using pharmacometric bridging.
PubMed: Drug adherence in patients taking oral anticoagulation therapy.
PubMed: Balancing efficacy and bleeding risk in the prevention of stroke due to atrial fibrillation with newer oral anticoagulants.
PubMed: Antithrombotic therapy for pregnant women.
PubMed: Cranberry juice ingestion and clinical drug-drug interaction potentials; review of case studies and perspectives.
PubMed: Novel oral anticoagulants for thromboprophylaxis after orthopaedic surgery.
PubMed: The promise of pharmacoepidemiology in helping clinicians assess drug risk.
PubMed: Novel oral anticoagulants: a review of new agents.
PubMed: Patients satisfaction with warfarin and willingness to switch to dabigatran: a patient survey.
PubMed: Apixaban in the prevention of stroke and systemic embolism in nonvalvular atrial fibrillation.
PubMed: New alternative anticoagulants in atrial fibrillation: the move beyond warfarin.
PubMed: Clinical strategies for selecting oral anticoagulants in patients with atrial fibrillation.
PubMed: The changing face of oral anticoagulants.
PubMed: Kcentra: a 4-factor prothrombin complex concentrate for reversal of warfarin anticoagulation.
PubMed: Data mining of the public version of the FDA Adverse Event Reporting System.
PubMed: Balancing the benefits and risks of 2 doses of dabigatran compared with warfarin in atrial fibrillation.
PubMed: [Anticoagulation in atrial fibrillation: new therapeutic alternatives].
PubMed: Supratherapeutic international normalized ratio due to reduced vitamin K intake secondary to prolonged vomiting in a patient on warfarin.
PubMed: European cardiac nurses' current practice and knowledge on anticoagulation therapy.
PubMed: Novel oral anticoagulants for stroke prevention in atrial fibrillation: a focus on the older patient.
PubMed: Updated guidelines on outpatient anticoagulation.
PubMed: The safety and efficacy of apixaban : where do we stand in 2013?
PubMed: [The change of paradigm in stroke prevention in atrial fibrillation. Challenges and emerging opportunities for the family physician].
PubMed: [Direct oral thrombin inhibitor, "dabigatran"].
PubMed: One-year adherence to warfarin treatment for venous thromboembolism in high-risk patients and its association with long-term risk of recurrent events.
PubMed: Anticoagulation for non-valvular atrial fibrillation: new anticoagulant agents.
PubMed: [ANMCO statement on prevention of thromboembolism in atrial fibrillation and role of the new oral anticoagulants].
PubMed: Rivaroxaban for the treatment of acute coronary syndromes.
PubMed: Characteristics and essences upon conjugation of imidacloprid with two model proteins.
PubMed: Tutorial in oral antithrombotic therapy: biology and dental implications.
PubMed: Stroke prevention in atrial fibrillation--an Asian stroke perspective.
PubMed: Left atrial appendage closure devices. Their role in 2013.
PubMed: Dabigatran and postmarketing reports of bleeding.
PubMed: A new era of oral anticoagulation in atrial fibrillation: implications in clinical practice.
PubMed: Recent advances in antithrombotic therapy for stroke prevention in patients with atrial fibrillation.
PubMed: Novel oral anticoagulants for stroke prevention in patients with atrial fibrillation.
PubMed: Direct thrombin and factor Xa inhibition for stroke prevention in patients with atrial fibrillation.
PubMed: Novel oral anticoagulants: a review of the literature and considerations in special clinical situations.
PubMed: The discovery of dabigatran etexilate.
PubMed: Antithrombotics for stroke prevention in non-valvular atrial fibrillation: an update.
PubMed: Rash associated with dabigatran etexilate.
PubMed: The pharmacology and therapeutic use of dabigatran etexilate.
PubMed: Novel oral anticoagulants for stroke prevention in patients with atrial fibrillation: dawn of a new era.
PubMed: Medication dyes as a source of drug allergy.
PubMed: Review of recently approved alternatives to anticoagulation with warfarin for emergency clinicians.
PubMed: New oral anticoagulants in elderly patients with atrial fibrillation.
PubMed: [Dabigatran as an alternative to warfarin for the prevention of thromboembolism in atrial fibrillation].
PubMed: Deficiencies of the FDA in evaluating generic formulations: addressing narrow therapeutic index drugs.
PubMed: Anticoagulant prevention in patients with atrial fibrillation: alternatives to vitamin K antagonists.
PubMed: Role of new drugs for management of atrial fibrillation.
PubMed: Management of atrial fibrillation: direct factor IIa and Xa inhibitors or "warfarin shotgun"?
PubMed: Transitions of care in patients receiving oral anticoagulants: general principles, procedures, and impact of new oral anticoagulants.
PubMed: Dabigatran: a cause of hematologic emergency.
PubMed: Comparing new anticoagulants.
PubMed: An update on antithrombotic therapy in atrial fibrillation: the role of newer and emergent drugs.
PubMed: [Dabigatran etexilate in clinical practice for prevention of thromboembolic events in patients with atrial fibrillation].
PubMed: Dabigatran compared with warfarin for stroke prevention with atrial fibrillation: experience in Hong Kong.
PubMed: Underreporting of hemorrhagic and thrombotic complications of pharmaceuticals to the U.S. Food and Drug Administration: empirical findings for warfarin, clopidogrel, ticlopidine, and thalidomide from the Southern Network on Adverse Reactions (SONAR).
PubMed: The new oral anticoagulants: a challenge for hospital formularies.
PubMed: Target-specific oral anticoagulants for stroke prevention in patients with atrial fibrillation: real-world considerations.
PubMed: Stroke prevention in atrial fibrillation: impact of novel oral anticoagulants.
PubMed: New oral anticoagulants: a review of the literature with particular emphasis on patients with impaired renal function.
PubMed: Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: a systematic review.
PubMed: Management of oral anticoagulation in patients undergoing minor dental procedures.
PubMed: Systematic review and adjusted indirect comparison meta-analysis of oral anticoagulants in atrial fibrillation.
PubMed: Enantioselective binding interaction of the metolachlor pesticide enatiomers with bovine serum albumin--a spectroscopic analysis study.
PubMed: Botanical-drug interactions: a scientific perspective.
PubMed: Aspirin- and clopidogrel-associated bleeding complications: data mining of the public version of the FDA adverse event reporting system, AERS.
PubMed: Safety and efficacy of apixaban in the treatment of atrial fibrillation.
PubMed: Emerging anticoagulant therapies for atrial fibrillation: new options, new challenges.
PubMed: An evidence-based review of apixaban and its potential in the prevention of stroke in patients with atrial fibrillation.
PubMed: Complications of anticoagulation.
PubMed: Emergency management of bleeding associated with old and new oral anticoagulants.
PubMed: Antithrombotic therapy for secondary stroke prevention.
PubMed: Fatal gastrointestinal hemorrhage after a single dose of dabigatran.
PubMed: Hemopericardium and cardiac tamponade associated with dabigatran use.
PubMed: [Apixaban].
PubMed: Bioevaluation of human serum albumin-hesperidin bioconjugate: insight into protein vector function and conformation.
PubMed: Dabigatran for the prevention of thromboembolic complications in the elderly: a RE-LY-able alternative to warfarin?
PubMed: Rapid LC-MS/MS determination and pharmacokinetic application of linarin in rat plasma.
PubMed: New oral anticoagulants: will they replace warfarin?
PubMed: Jonathan E. Rhoads lecture 2012: improving patient care with practice-based research.
PubMed: Multispectroscopic and molecular modeling approach to investigate the interaction of flavokawain B with human serum albumin.
PubMed: Development and validation of LC-MS/MS method for the estimation of β-hydroxy-β-methylbutyrate in rat plasma and its application to pharmacokinetic studies.
PubMed: A guidance pathway for the selection of novel anticoagulants in the treatment of atrial fibrillation.
PubMed: Clinical pharmacokinetics and pharmacodynamics of linagliptin.
PubMed: Evaluation of food-drug interaction of guava leaf tea.
PubMed: Oral IIa and Xa inhibitors for prevention of stroke in atrial fibrillation: clinical studies and regulatory considerations.
PubMed: [Old and new oral anticoagulants. Pharmacological perspective].
PubMed: [Possible interaction between pomegranate juice and warfarin].
PubMed: New anticoagulants in ischemic heart disease.
PubMed: Vitamin K nutrition, metabolism, and requirements: current concepts and future research.
PubMed: Implementing the new oral anticoagulants into the hospital formulary.
PubMed: The Efficacy of Rivaroxaban in Patients With Atrial Fibrillation.
PubMed: Dabigatran: a new chapter in anticoagulation.
PubMed: Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors.
PubMed: Use of direct thrombin inhibitor for treatment of cerebral venous thrombosis.
PubMed: Novel drugs for oral anticoagulation pharmacotherapy.
PubMed: Biophysical influence of isocarbophos on bovine serum albumin: spectroscopic probing.
PubMed: Dabigatran etexilate: an oral direct thrombin inhibitor for the management of thromboembolic disorders.
PubMed: Dabigatran or warfarin for the prevention of stroke in atrial fibrillation? A closer look at the RE-LY trial.
PubMed: Successful management of anticoagulation therapy during international travel.
PubMed: Dabigatran: comparison to warfarin, pathway to approval, and practical guidelines for use.
PubMed: Newer anticoagulants in cardiovascular disease: a systematic review of the literature.
PubMed: Identification of cytochrome P450 2D6 and 2C9 substrates and inhibitors by QSAR analysis.
PubMed: Epidural hematoma and intraoperative hemorrhage in a spine trauma patient on Pradaxa (dabigatran).
PubMed: Effects of subacute oral warfarin administration on peripheral blood granulocytes in rats.
PubMed: Clinical pharmacokinetics and pharmacodynamics of vildagliptin.
PubMed: I recently heard that there are alternative medications to the blood thinner warfarin. What are they, and how are they different?
PubMed: Apixaban for the prevention of stroke in atrial fibrillation.
PubMed: Old and new oral anticoagulants for venous thromboembolism and atrial fibrillation: a review of the literature.
PubMed: New frontiers for stroke prevention in atrial fibrillation.
PubMed: Heparin-induced thrombocytopenia.
PubMed: Cranberry and warfarin interaction: a case report and review of the literature.
PubMed: Newer anticoagulants for non-valvular atrial fibrillation.
PubMed: Dabigatran use in a postoperative coronary artery bypass surgery patient with nonvalvular atrial fibrillation and heparin-PF4 antibodies.
PubMed: Spontaneous splenic hemorrhage after initiation of dabigatran (Pradaxa) for atrial fibrillation.
PubMed: Rivaroxaban (Xarelto) for acute coronary syndrome.
PubMed: Dabigatran etexilate: what do hospitalists need to know?
PubMed: Role of pharmacogenomics in the management of traditional and novel oral anticoagulants.
PubMed: FDA advisory decision highlights some problems inherent in pragmatic trials.
PubMed: Single-walled carbon nanotubes based quenching of free FAM-aptamer for selective determination of ochratoxin A.
PubMed: Dietary interactions and INR variability: retrospective evaluation of patients couples on oral anticoagulant therapy.
PubMed: Competitive binding of small molecules with biopolymers: a fluorescence spectroscopy and chemometrics study of the interaction of aspirin and ibuprofen with BSA.
PubMed: What risk do consumers face when seeking medical advice from health food stores?
PubMed: Multivariate analysis of the relation between diet and warfarin dose.
PubMed: Dabigatran: review of pharmacology and management of bleeding complications of this novel oral anticoagulant.
PubMed: New anticoagulants for the prevention of stroke in atrial fibrillation.
PubMed: Hospital-based clinical implications of the novel oral anticoagulant, dabigatran etexilate, in daily practice.
PubMed: Warfarin resistance and caffeine containing beverages.
PubMed: Mechanism and conformational studies of farrerol binding to bovine serum albumin by spectroscopic methods.
PubMed: Anticoagulant management in the cardiovascular setting.
PubMed: Recurrent venous thrombosis despite 'optimal anticoagulation therapy' for antiphospholipid syndrome--could new oral anticoagulants solve the problem?
PubMed: Buyer beware? Does the information provided with herbal products available over the counter enable safe use?
PubMed: Old versus new oral anticoagulants: focus on pharmacology.
PubMed: Update on anti-coagulation in atrial fibrillation.
PubMed: Recent progress in anticoagulant therapy: oral direct inhibitors of thrombin and factor Xa.
PubMed: Role of emerging antithrombotic therapy in the prevention of cardioembolic complications in patients with atrial fibrillation.
PubMed: Dabigatran in atrial fibrillation: pharmacology and clinical trials.
PubMed: The quality of information on websites selling St. John's wort.
PubMed: New oral anticoagulants for venous thromboembolism prophylaxis in orthopaedic surgery.
PubMed: What is the state of the art in orthopaedic thromboprophylaxis in lower extremity reconstruction?
PubMed: Spotlight on dabigatran etexilate in the prevention of stroke and systemic embolism in patients with atrial fibrillation.
PubMed: Dabigatran etexilate: a novel oral thrombin inhibitor for thromboembolic disease.
PubMed: New oral anticoagulants and outpatient prophylaxis of venous thromboembolism.
PubMed: New options for stroke prevention in atrial fibrillation.
PubMed: Anticoagulant options--why the FDA approved a higher but not a lower dose of dabigatran.
PubMed: Incidental atrial fibrillation and its management.
PubMed: Dabigatran etexilate: the first oral anticoagulant available in the United States since warfarin.
PubMed: New drug offers warfarin alternative for atrial fibrillation. An immediate switch is right for some people, but not necessary for all.
PubMed: Evaluation of warfarin drug interaction listings in US product information for warfarin and interacting drugs.
PubMed: Thromboembolism.
PubMed: Warfarin-cranberry juice interaction.
PubMed: Drug and dietary interactions of warfarin and novel oral anticoagulants: an update.
PubMed: New oral anticoagulants.
PubMed: Case report: Cranberry juice and warfarin.
PubMed: Genetic warfarin dosing: tables versus algorithms.
PubMed: Dabigatran etexilate: a review of its use in the prevention of stroke and systemic embolism in patients with atrial fibrillation.
PubMed: Novel oral factor Xa and thrombin inhibitors in the management of thromboembolism.
PubMed: New alternative to warfarin may help reduce stroke risk in patients with AF.
PubMed: Eicosapentaenoic acid reduces warfarin-induced arterial calcification in rats.
PubMed: Role of cytochrome P450 genotype in the steps toward personalized drug therapy.
PubMed: Dabigatran emerges as safe and effective warfarin alternative. The recently approved drug is more expensive, but appears to be more predictable.
PubMed: A potential interaction between warfarin and atovaquone.
PubMed: The potential role of new oral anticoagulants in the prevention and treatment of thromboembolism.
PubMed: Spectrophotometric study of the interaction between chlorotetracycline and bovine serum albumin using Eosin Y as site marker with the aid of chemometrics.
PubMed: Learning from product labels and label changes: how to build pharmacogenomics into drug-development programs.
PubMed: Is it OK to drink cranberry juice if I take Coumadin?
PubMed: A review of the clinical pharmacokinetics and pharmacodynamics of varenicline for smoking cessation.
PubMed: Effect of intrinsic and extrinsic factors on the clinical pharmacokinetics and pharmacodynamics of prasugrel.
PubMed: Evaluation of the effect of lime fruit juice on the anticoagulant effect of warfarin.
PubMed: My wife and I both take warfarin because we have atrial fibrillation. We've been told to stay away from green vegetables, because they are high in vitamin K. Is there a guideline for a "safe" amount to eat?
PubMed: Personalized approaches to clopidogrel therapy: are we there yet?
PubMed: Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the Effective aNticoaGulation with factor xA next GEneration in Atrial Fibrillation-Thrombolysis In Myocardial Infarction study 48 (ENGAGE AF-TIMI 48).
PubMed: [Fifty years of clinical use of warfarin].
PubMed: Stroke in atrial fibrillation--hope on the horizon?
PubMed: New oral antithrombotic agents for the prevention of deep venous thrombosis and pulmonary embolism in orthopedic surgery.
PubMed: Warfarin genotyping using three different platforms.
PubMed: Cutting through the statistical fog: understanding and evaluating non-inferiority trials.
PubMed: Dabigatran: an oral novel potent reversible nonpeptide inhibitor of thrombin.
PubMed: Relationship between dietary vitamin K intake and the stability of anticoagulation effect in patients taking long-term warfarin.
PubMed: Effect of high-dose cranberry juice on the pharmacodynamics of warfarin in patients.
PubMed: Sprouting a warfarin interaction.
PubMed: Alternatives to warfarin--the next generation of anticoagulants.
PubMed: Oral direct factor Xa inhibitors, with special emphasis on rivaroxaban.
PubMed: Drug and dietary interactions of the new and emerging oral anticoagulants.
PubMed: Pharmacogenetics testing: implications for cardiovascular therapeutics with clopidogrel and warfarin.
PubMed: Analysis of the interactions of mixtures of two beta-agonists steroids with bovine serum albumin: a fluorescence spectroscopy and chemometrics investigation.
PubMed: Discharge teaching about warfarin: patient retention of knowledge.
PubMed: Achievement of therapeutic international normalized ratio following adjustment of tube feeds.
PubMed: Important drug-nutrient interactions.
PubMed: Warfarin knowledge in patients with atrial fibrillation: implications for safety, efficacy, and education strategies.
PubMed: Warfarin bioavailability with feeding tubes and enteral formula.
PubMed: Dabigatran etexilate, a new oral direct thrombin inhibitor, for stroke prevention in patients with atrial fibrillation.
PubMed: [Possible interaction between probiotics and warfarin].
PubMed: Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation?
PubMed: Pharmacogenomics: bridging the gap between science and practice.
PubMed: New approaches to atrial fibrillation management: treat the patient, not the ECG.
PubMed: Venous thromboembolism: a clinical review.
PubMed: [Marked PT-INR prolongation associated with appetite loss due to urinary tract infection in a late elderly case with chronic atrial fibrillation].
PubMed: Potential interaction between MonaVie Active and Warfarin.
PubMed: Non ST-elevation acute coronary syndrome.
PubMed: Probable warfarin interaction with menthol cough drops.
PubMed: Possible interaction between pomegranate juice and warfarin.
PubMed: Vitamin K in parenteral nutrition.
PubMed: Interactions between quercetin and warfarin for albumin binding: A new eye on food/drug interference.
PubMed: Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity.
PubMed: Comment: fatal intracranial bleed potentially due to a warfarin and influenza vaccine interaction.
PubMed: Anticoagulant rodenticides in three owl species from Western Canada, 1988-2003.
PubMed: Patient time requirements for anticoagulation therapy with warfarin.
PubMed: The first evaluation of a novel vitamin K antagonist, tecarfarin (ATI-5923), in patients with atrial fibrillation.
PubMed: Should we be applying warfarin pharmacogenetics to clinical practice? No, not now.
PubMed: Potential interaction between pomegranate juice and warfarin.
PubMed: Warfarin interactions with substances listed in drug information compendia and in the FDA-approved label for warfarin sodium.
PubMed: Potential clinical and economic outcomes of CYP2C9 and VKORC1 genotype-guided dosing in patients starting warfarin therapy.
PubMed: The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial.
PubMed: Oral anticoagulation with factor Xa and thrombin inhibitors: on the threshold of change.
PubMed: Comparison of performance of three commercial platforms for warfarin sensitivity genotyping.
PubMed: Acute coronary syndrome (unstable angina and non-ST elevation MI).
PubMed: Thromboembolism.
PubMed: Chiral toxicology: it's the same thing...only different.
PubMed: Erythrocyte folate and 5-methyltetrahydrofolate levels decline during 6 months of oral anticoagulation with warfarin.
PubMed: Will a once-weekly anticoagulant for the treatment and secondary prevention of thromboembolism improve adherence?
PubMed: Simultaneous determination of nonnutritive sweeteners in foods by HPLC/ESI-MS.
PubMed: Cardiology patient pages. A patient's guide to taking coumadin/warfarin.
PubMed: Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization.
PubMed: Novel oral anticoagulants.
PubMed: A regulatory science perspective on warfarin therapy: a pharmacogenetic opportunity.
PubMed: Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fibrillation.
PubMed: Interaction between warfarin and black tea.
PubMed: [Nonoclusive thrombosis of mechanical mitral valve prosthesis caused by inadequate treatment of anticoagulant therapy resistance].
PubMed: [Warfarin resistance and related pharmacogenetic information].
PubMed: Pharmacogenetic testing for warfarin sensitivity.
PubMed: Overview of pharmacogenetics in anticoagulation therapy.
PubMed: Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin.
PubMed: Medication administration through enteral feeding tubes.
PubMed: Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin.
PubMed: Determination of ochratoxin a with a DNA aptamer.
PubMed: Interaction between capecitabine and gemcitabine with warfarin in a patient with pancreatic cancer.
PubMed: Role of ambrisentan in the management of pulmonary hypertension.
PubMed: Dabigatran etexilate: an oral direct thrombin inhibitor for prophylaxis and treatment of thromboembolic diseases.
PubMed: Warfarin resistance.
PubMed: Spectrometric and voltammetric studies of the interaction between quercetin and bovine serum albumin using warfarin as site marker with the aid of chemometrics.
PubMed: The critical path of warfarin dosing: finding an optimal dosing strategy using pharmacogenetics.
PubMed: Clinically relevant safety issues associated with St. John's wort product labels.
PubMed: [Factors influencing activity of oral anticoagulants. Interactions with drugs and food].
PubMed: Proton pump inhibitors may increase the risk of delayed bleeding complications after open heart surgery if used concomitantly with warfarin.
PubMed: Patient knowledge on oral anticoagulants: results of a questionnaire survey in Germany and comparison with the literature.
PubMed: Changing trends in anti-coagulant therapies. Are heparins and oral anti-coagulants challenged?
PubMed: Pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 polymorphisms: are we there yet?
PubMed: Advancement in antithrombotics for stroke prevention in atrial fibrillation.
PubMed: Survival of heparins, oral anticoagulants, and aspirin after the year 2010.
PubMed: Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database.
PubMed: Potential interaction between warfarin and high dietary protein intake.
PubMed: Practical aspects of treatment with drotrecogin alfa (activated).
PubMed: Vitamin K-independent warfarin resistance after concurrent administration of warfarin and continuous enteral nutrition.
PubMed: Warfarin overdose due to the possible effects of Lycium barbarum L.
PubMed: Cranberry juice and warfarin: okay together?
PubMed: Recent developments in antithrombotic therapy: will sodium warfarin be a drug of the past?
PubMed: Potential interaction of Ginkgo biloba leaf with antiplatelet or anticoagulant drugs: what is the evidence?
PubMed: The FDA announces new drug labeling for pharmacogenetic testing: is personalized medicine becoming a reality?
PubMed: Factors influencing warfarin dose requirements in African-Americans.
PubMed: Vitamin K: what are the current dietary recommendations for patients taking coumadin?
PubMed: Anticoagulant effect of sodium dehydroacetate (DHA-S) in rats.
PubMed: Interaction between warfarin and cranberry juice.
PubMed: Garlic (Allium sativum L.): adverse effects and drug interactions in humans.
PubMed: Pharmacogenomics and warfarin therapy.
PubMed: The new anticoagulants.
PubMed: Dietary supplements, herbs and oral anticoagulants: the nature of the evidence.
PubMed: Outpatient-based primary and secondary thromboprophylaxis with low-molecular-weight heparin.
PubMed: FDA encourages genetics-aided warfarin dosing.
PubMed: Changing times: DNA resequencing and the "nearly normal autopsy".
PubMed: [Advice for patients taking oral anticoagulants (coumadin or Previscan)].
PubMed: Bleeding complications with warfarin use: a prevalent adverse effect resulting in regulatory action.
PubMed: Varenicline: the newest agent for smoking cessation.
PubMed: Comparison of LionHeart LVAD-implanted calves based on renal infarctions.
PubMed: Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam--probes of CYP2C9, CYP1A2, and CYP3A4.
PubMed: Rivaroxaban.
PubMed: Evaluation and management of atrial fibrillation.
PubMed: Not only green tea but also green leafy vegetables inhibit warfarin.
PubMed: Safety considerations with omega-3 fatty acid therapy.
PubMed: Relationship between diet and anticoagulant response to warfarin: a factor analysis.
PubMed: Interaction potential between cranberry juice and warfarin.
PubMed: Multiresidue analysis of seven anticoagulant rodenticides by high-performance liquid chromatography/electrospray/mass spectrometry.
PubMed: New antithrombotic agents.
PubMed: Oral varenicline for smoking cessation.
PubMed: Dietary vitamin K intake and anticoagulation in elderly patients.
PubMed: Cranberry does not affect prothrombin time in male subjects on warfarin.
PubMed: Warfarin interaction with herbal drugs and food.
PubMed: Potential applicability and utilization of left atrial appendage occlusion devices in patients with atrial fibrillation.
PubMed: Cranberry and urinary tract infections: slightly fewer episodes in young women, but watch out for interactions.
PubMed: Interaction between warfarin and cranberry juice.
PubMed: Dietary vitamin K variability affects International Normalized Ratio (INR) coagulation indices.
PubMed: Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure.
PubMed: Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding.
PubMed: The challenges of new drugs benefits and risks analysis: lessons from the ximelagatran FDA Cardiovascular Advisory Committee.
PubMed: Warfarin resistance: interaction between warfarin and Eruca sativa L.
PubMed: [Determination of vitamin K in aojiru (green juice) products by HPLC].
PubMed: Plasma leptin: associations with metabolic, inflammatory and haemostatic risk factors for cardiovascular disease.
PubMed: Factors influencing patient knowledge of warfarin therapy after mechanical heart valve replacement.
PubMed: Treatment of cancer-associated thrombosis: distinguishing among antithrombotic agents.
PubMed: [Pharmacogenetics of warfarin].
PubMed: Dietary supplement and selected food interactions with warfarin.
PubMed: [Interaction between Waran and cranberry juice].
PubMed: Warfarin and its interactions with foods, herbs and other dietary supplements.
PubMed: Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans.
PubMed: Development of a cell culture/ELISA assay to detect anticoagulant rodenticides and its application to analysis of rodenticide treated grain.
PubMed: Treatment of heparin-induced thrombocytopenia: is there a role for bivalirudin?
PubMed: A spectroscopic study of the interaction of isoflavones with human serum albumin.
PubMed: Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies.
PubMed: Trials and tribulations of non-inferiority: the ximelagatran experience.
PubMed: Considerations and challenges with existing treatments for thrombosis in cancer patients.
PubMed: Quality assessment of internet pharmaceutical products using traditional and non-traditional analytical techniques.
PubMed: Pharmacokinetics of telithromycin: application to dosing in the treatment of community-acquired respiratory tract infections.
PubMed: Atrial fibrillation and stroke: four treatment controversies.
PubMed: An adverse interaction between warfarin and fluoropyrimidines revisited.
PubMed: Possible interaction between warfarin and cranberry juice.
PubMed: Low potential for interactions between melagatran/ximelagatran and other drugs, food, or alcohol.
PubMed: Evolving management strategies for heparin-induced thrombocytopenia.
PubMed: Anticoagulation: new challenges, old drugs.
PubMed: The approach to massive pulmonary embolism.
PubMed: Pharmacology and pharmacogenetics of warfarin and other coumarins when used with supplements.
PubMed: Clinical pharmacokinetics of losartan.
PubMed: Uncertain times for oral anticoagulation therapy.
PubMed: Comment: Decreased warfarin effect after initiation of high-protein, low-carbohydrate diets.
PubMed: Systematic overview of warfarin and its drug and food interactions.
PubMed: Efficacy and safety of rosuvastatin in treatment of dyslipidemia.
PubMed: A better way to prevent blood clots? A drug derived from cobra venom offers an alternative to warfarin, although liver problems temper its benefits.
PubMed: Efficacy and tolerability of the switch from a branded to a generic warfarin sodium product: an observer-blinded, randomized, crossover study.
PubMed: Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions.
PubMed: A phase I clinical trial of thoracic radiotherapy and concurrent celecoxib for patients with unfavorable performance status inoperable/unresectable non-small cell lung cancer.
PubMed: Influence of CYP2C9 polymorphisms, demographic factors and concomitant drug therapy on warfarin metabolism and maintenance dose.
PubMed: Preventing stroke in atrial fibrillation: the SPORTIF programme.
PubMed: Capecitabine: a review.
PubMed: Decreased warfarin effect after initiation of high-protein, low-carbohydrate diets.
PubMed: Oral anticoagulation: challenges in the case-management setting.
PubMed: What's the scoop with grapefruit?
PubMed: Interaction of warfarin with drugs, natural substances, and foods.
PubMed: Generic warfarin: implications for clinical practice and perceptions of anticoagulation providers.
PubMed: Interaction between Gemcitabine and Warfarin Causing Gastrointestinal Bleeding in a Patient with Pancreatic Cancer.
PubMed: The role of oral direct thrombin inhibitors in atrial fibrillation.
PubMed: Ximelagatran: pharmacology, pharmacokinetics, and pharmacodynamics.
PubMed: New possibilities in anticoagulant management of atrial fibrillation.
PubMed: Changing the guard in long-term anticoagulation: clinical and economic implications.
PubMed: The potential for changing prescribing patterns from warfarin to oral direct thrombin inhibitors: clinical scenarios.
PubMed: Treatment of venous thromboembolism and long-term prevention of recurrence: present treatment options and ximelagatran.
PubMed: Clinical pharmacology of bosentan, a dual endothelin receptor antagonist.
PubMed: [New perspectives for anticoagulation in non-rheumatic atrial fibrillation: oral antithrombins].
PubMed: Observations on possible effects of daily vitamin K replacement, especially upon warfarin therapy.
PubMed: Ximelagatran in prevention of cardiovascular events.
PubMed: New blood thinner offers first potential alternative in 50 years: ximelagatran.
PubMed: Potential interaction between soy milk and warfarin.
PubMed: Ximelagatran: an oral direct thrombin inhibitor.
PubMed: Consistent vitamin K helps warfarin do its job. Food can throw off warfarin's ability to prevent blood clots. Keeping your vitamin K intake relatively constant can help you avoid problems with this medication.
PubMed: Clinical pharmacokinetics of levetiracetam.
PubMed: D-003 and warfarin interaction on the bleeding time and venous thrombosis experimentally induced in rats.
PubMed: [Biological effects of vitamin K and concentration of vitamin K in Norwegian food].
PubMed: The scoop on green tea.
PubMed: Vitamin K and oral anticoagulation: thought for food.
PubMed: Role of dietary vitamin K intake in chronic oral anticoagulation: prospective evidence from observational and randomized protocols.
PubMed: Clinical pharmacokinetics of thalidomide.
PubMed: Of blood, bones, and broccoli: warfarin-vitamin K interactions.
PubMed: Regulatory considerations of pharmaceutical solid polymorphism in Abbreviated New Drug Applications (ANDAs).
PubMed: Warfarin and cranberry juice: an interaction?
PubMed: Racial and ethnic differences in warfarin response.
PubMed: Will direct thrombin inhibitors replace warfarin for preventing embolic events in atrial fibrillation?
PubMed: Possible interaction between warfarin and cranberry juice.
PubMed: Hyperhomocysteinemia and B-vitamin status after discontinuation of oral anticoagulation therapy in patients with a history of venous thromboembolism.
PubMed: Vitamin K content of nuts and fruits in the US diet.
PubMed: Overview of heparin-induced thrombocytopenia.
PubMed: Clinical pharmacokinetics of linezolid, a novel oxazolidinone antibacterial.
PubMed: Oral direct thrombin inhibitors in clinical development.
PubMed: [Vitamin K in food and the effect of warfarin].
PubMed: The pharmacodynamics and pharmacokinetics of the oral direct thrombin inhibitor ximelagatran and its active metabolite melagatran: a mini-review.
PubMed: Current anticoagulant therapy--unmet clinical needs.
PubMed: Mixing medicines, herbs, food, and surgery.
PubMed: The coagulation system contributes to synergistic liver injury from exposure to monocrotaline and bacterial lipopolysaccharide.
PubMed: New Food and Drug Administration requirements for inclusion of vitamin K in adult parenteral multivitamins.
PubMed: Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. SPORTIF II: a dose-guiding, tolerability, and safety study.
PubMed: Lopinavir/ritonavir: a review of its use in the management of HIV infection.
PubMed: Pharmacokinetics of selective estrogen receptor modulators.
PubMed: Anticoagulation of pregnant women with mechanical heart valves.
PubMed: Venous thromboembolism prevention with LMWHs in medical and orthopedic surgery patients.
PubMed: Genetic and environmental risk factors for oral anticoagulant overdose.
PubMed: Literacy, readability and cultural barriers: critical factors to consider when educating older African Americans about anticoagulation therapy.
PubMed: [Oral anticoagulant treatment: practical aspects and significance of anticoagulant clinics].
PubMed: Effect of soy milk on warfarin efficacy.
PubMed: Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions.
PubMed: Interactions of warfarin.
PubMed: Clinical pharmacokinetics of tegaserod, a serotonin 5-HT(4) receptor partial agonist with promotile activity.
PubMed: Enhancement of allyl alcohol hepatotoxicity by endotoxin requires extrahepatic factors.
PubMed: Melatonin for the prevention and treatment of jet lag.
PubMed: Optimizing prophylaxis of venous thromboembolism.
PubMed: Interaction between warfarin and mango fruit.
PubMed: Is low-intensity anticoagulant therapy possible with an open pivot valve?: analysis of its development.
PubMed: Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update.
PubMed: Use of alternative pharmacotherapy in management of cardiovascular diseases.
PubMed: Pharmacokinetic profile of zafirlukast.
PubMed: FDA adverse event reports on statin-associated rhabdomyolysis.
PubMed: Adverse events and deaths associated with laboratory errors at a hospital--Pennsylvania, 2001.
PubMed: Seaweed, vitamin K, and warfarin.
PubMed: Use of recombinant hirudin in heparin-induced thrombocytopenia and thrombosis (HITT) and renal failure--a case report.
PubMed: FDA warns Merck over its promotion of rofecoxib.
PubMed: Warfarin resistance and enteral feedings: 2 case reports and a supporting in vitro study.
PubMed: [The safety of herbal medicines in the psychiatric practice].
PubMed: Drug interactions with irbesartan.
PubMed: Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates.
PubMed: Practitioner report involving intravenous use of vitamin K1 prompts label review and revision.
PubMed: Melatonin for preventing and treating jet lag.
PubMed: Clinical pharmacokinetics of capecitabine.
PubMed: Profile of moxifloxacin drug interactions.
PubMed: Subtherapeutic INR values associated with a switch to generic warfarin.
PubMed: Generic substitution: issues for problematic drugs.
PubMed: Development of a self-assessment instrument to determine daily intake and variability of dietary vitamin K.
PubMed: Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range.
PubMed: Tests of potential functional barriers for laminated multilayer food packages. Part II: Medium molecular weight permeants.
PubMed: Herbs and the brain: friend or foe? The effects of ginkgo and garlic on warfarin use.
PubMed: The interaction between vitamin K nutriture and warfarin administration in patients with bacterial overgrowth due to atrophic gastritis.
PubMed: Dose selection and dosing interval determination for LTRA use in asthma.
PubMed: Assessment of healthcare professionals' knowledge about warfarin-vitamin K drug-nutrient interactions.
PubMed: Who needs individual bioequivalence studies for narrow therapeutic index drugs? A case for warfarin.
PubMed: Warfarin and celecoxib interaction.
PubMed: [Oral anticoagulants and medicinal plants. An emerging interaction].
PubMed: Response to warfarin and other oral anticoagulants: effects of disease states.
PubMed: Management of deep venous thrombosis and pulmonary embolism.
PubMed: Workshop: Patient Self-Management: Update of Ongoing Studies in Sweden.
PubMed: Characteristics of rat platelets and relative contributions of platelets and blood coagulation to haemostasis.
PubMed: Outpatient management of patients on warfarin.
PubMed: Ciprofloxacin-warfarin coagulopathy: a case series.
PubMed: Cyclodextrin-based optosensor for the determination of warfarin in waters.
PubMed: Candidates for thrombolytic treatment in acute ischaemic stroke--where are our patients in Hong Kong?
PubMed: Selective estrogen receptor modulators: a new category of compounds to extend postmenopausal women's health.
PubMed: Vitamin K: a practical guide to the dietary management of patients on warfarin.
PubMed: Optimizing anticoagulant therapy in the management of pulmonary embolism.
PubMed: Assessment of the quality and quantity of drug-drug interaction studies in recent NDA submissions: study design and data analysis issues.
PubMed: Vitamin K-supplemented snacks containing olestra: implication for patients taking warfarin.
PubMed: Clinical pharmacokinetics of troglitazone.
PubMed: Hypersensitivity myocarditis associated with ephedra use.
PubMed: Medtronic Freestyle aortic root bioprosthesis: Implant techniques.
PubMed: Clinical aspects of the use of clopidogrel, a new antiplatelet agent.
PubMed: Grapefruit juice might still be factor in warfarin response.
PubMed: Management of narrow therapeutic index drugs.
PubMed: Deep venous thrombosis: early discharge strategies and outpatient management.
PubMed: Isoniazid drug and food interactions.
PubMed: Herbal remedies: adverse effects and drug interactions.
PubMed: Successful percutaneous balloon mitral valvuloplasty in a patient with left atrial thrombus--a case report.
PubMed: Protein-calorie malnutrition does not predict subtle vitamin K depletion in hospitalized patients.
PubMed: Abbreviated hospitalization for deep venous thrombosis with the use of ardeparin.
PubMed: Clinical pharmacokinetics of nimesulide.
PubMed: Rational assessment of the interaction profile of cerivastatin supports its low propensity for drug interactions.
PubMed: The antiplatelet effects of ticlopidine and clopidogrel.
PubMed: Grapefruit juice and the response to warfarin.
PubMed: Modern management of prosthetic valve anticoagulation.
PubMed: Azimilide dihydrochloride, a novel antiarrhythmic agent.
PubMed: Pharmacokinetics of grepafloxacin.
PubMed: Clinical pharmacokinetics of nefazodone.
PubMed: Probable interaction between warfarin and ginseng.
PubMed: Dietary vitamin K1 and stability of oral anticoagulation: proposal of a diet with constant vitamin K1 content.
PubMed: The clinical pharmacokinetics of levofloxacin.
PubMed: Interventional cardiology and intracoronary stents--a changing practice: approved vs. nonapproved indications.
PubMed: Comparison of two methods for INR determination in a pharmacist-based oral anticoagulation clinic.
PubMed: Warfarin resistance: diagnosis and therapeutic alternatives.
PubMed: Vitamin K status influences brain sulfatide metabolism in young mice and rats.
PubMed: Hail stentors! How the hail do I stop the warfarin?
PubMed: Olestra and the FDA.
PubMed: When discharging patients on coumadin, heed this advice.
PubMed: A review of the clinical pharmacokinetics of meloxicam.
PubMed: HPLC determination of anticoagulant rodenticide residues in animal livers.
PubMed: Development and pharmacology of fluvastatin.
PubMed: Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency.
PubMed: [Warfarin therapy and chlorella].
PubMed: Clinical pharmacokinetics of lansoprazole.
PubMed: Pharmacokinetic development of quinolone antibiotics.
PubMed: Drug-food interactions in clinical practice.
PubMed: Protease inhibitors: where are they now?
PubMed: Overview of the pharmacokinetics of fluvoxamine.
PubMed: Development and pharmacology of fluvastatin.
PubMed: Interactions of warfarin with drugs and food.
PubMed: Clinical pharmacokinetics of pravastatin.
PubMed: Pharmacokinetics of oxicam nonsteroidal anti-inflammatory agents.
PubMed: Outpatient use of a portable international normalized ratio/prothrombin time monitor.
PubMed: An outbreak of vampire bat bite in a Brazilian village.
PubMed: Accidental poisoning by warfarin-contaminated herbal tea.
PubMed: Benazepril: a new ACE inhibitor.
PubMed: Low molecular weight heparins. An objective overview.
PubMed: Factors that influence therapeutic anticoagulation control.
PubMed: Development of a diet low in vitamin K-1 (phylloquinone).
PubMed: The Carpentier-Edwards pericardial aortic valve: intermediate results.
PubMed: Vancomycin, metronidazole, and tetracyclines.
PubMed: Interactions of fluoroquinolones with other drugs: mechanisms, variability, clinical significance, and management.
PubMed: Clinical toleration and safety of azithromycin.
PubMed: [Oral anticoagulant therapy with special reference to the influence of food and drug interactions].
PubMed: Adverse reaction reporting of interaction between warfarin and fluoroquinolones.
PubMed: Some properties of rat platelet aggregation and effects of butylated hydroxytoluene, warfarin and aspirin.
PubMed: Anticoagulation instability with life-threatening complication after dietary modification.
PubMed: Reversal of osmolite-warfarin interaction by changing warfarin administration time.
PubMed: Warfarin antagonism of natto and increase in serum vitamin K by intake of natto.
PubMed: Recovery of warfarin from an enteral nutrient formula.
PubMed: Unsuspected source of vitamin K in patients treated with anticoagulants: a case report.
PubMed: Pharmacokinetic characteristics of roxatidine.
PubMed: Propafenone: a new antiarrhythmic agent.
PubMed: Biology, ecology, and control of the vampire bat.
PubMed: An attempted homicide using d-CON rat poison.
PubMed: Clinical pharmacokinetics of ketoconazole.
PubMed: Liquid chromatographic determination of coumarin anticoagulants in tablets: collaborative study.
PubMed: Is the dose of warfarin prescribed by American physicians unnecessarily high?
PubMed: Drug interactions in surgical patients.
PubMed: Maternal toxicity in humans and animals: effects on fetal development and criteria for detection.
PubMed: Drug-food interaction information: a file card for patient education.
PubMed: Warfarin and enteral nutrition products.
PubMed: Metabolism and disposition of buspirone.
PubMed: The metabolic disposition of acifran, a new antihyperlipidemic agent, in rats and dogs.
PubMed: [Resistance to vitamin K antagonists. 6 cases].
PubMed: On the influence of vitamin K-rich vegetables and wine on the effectiveness of warfarin treatment.
PubMed: [Diagnostic aspects and results of drug therapy in pulmonary thromboembolism].
PubMed: [Thrombolytic therapy with urokinase in 8 patients with massive pulmonary thromboembolism].
PubMed: Warfarin resistance linked to enteral nutrition products.
PubMed: Enalapril: a review of human pharmacology.
PubMed: Interactions of analgesics with other drugs.
PubMed: Laboratory tests of seven rodenticides for the control of Meriones shawi.
PubMed: A comparative assessment of efficacy of three anticoagulant rodenticides.
PubMed: Liquid nutrition as a cause of warfarin resistance.
PubMed: Clinical Pharmacokinetics of indomethacin.
PubMed: Acquired warfarin resistance and weight-reducing diet.
PubMed: Warfarin resistance and vitamin K.
PubMed: Institutional pharmacists' guide to complying with PPI regulations.
PubMed: Warfarin dosage and vitamin K in Osmolite.
PubMed: "Resistance" to warfarin due to unrecognized vitamin K supplementation.
PubMed: Problems encountered in protecting stored grain from damage by rodents, birds, insects and mites in England and Wales.
PubMed: Inhibition of the hypoprothrombinemic effect of warfarin (Coumadin) by Ensure Plus, a dietary supplement.
PubMed: The influence of fasting on the disposition of warfarin in rats.
PubMed: Trials of the anticoagulants rodenticide WBA 8119 against confined colonies of warfarin-resistant house mice (Mus musculus L.).
PubMed: Trials of the anticoagulant rodenticide WBA 8119 against confined colonies of warfarin-resistant house mice (Mus musculus L.).
PubMed: Laboratory evaluation of WBA 8119 as a rodenticide for use against warfarin-resistant and non-resistant rats and mice.
PubMed: Some properties of calciferol as a rodenticide.
PubMed: MR-100: an anticoagulant rodenticide.
PubMed: Japanese-restaurant syndrome.
PubMed: Effect of silicones on the absorption of anticoagulant drugs.
PubMed: New rodenticide, 'MR-100', containing a taste enhancer.
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