laudanosine, 1699-51-0

Articles:

PubMed:	[Determination of atracurium and laudanosine in dog plasma during cardiopulmonary bypass by high performance liquid chromatography with fluorometric detection].
PubMed:	Synthesis of 1-substituted tetrahydroisoquinolines by lithiation and electrophilic quenching guided by in situ IR and NMR spectroscopy and application to the synthesis of salsolidine, carnegine and laudanosine.
PubMed:	Synthesis of alkaloids by Stevens rearrangement of nitrile-stabilized ammonium ylides: (±)-laudanosine, (±)-laudanidine, (±)-armepavine, (±)-7-methoxycryptopleurine, and (±)-xylopinine.
PubMed:	Laudanosine has no effects on respiratory activity but induces non-respiratory excitement activity in isolated brainstem-spinal cord preparation of neonatal rats.
PubMed:	Methyl-laudanosine: a new pharmacological tool to investigate the function of small-conductance Ca(2+)-activated K(+) channels.
PubMed:	Modulation of rat brain synaptosomal plasma membrane achieved by atracurium and its metabolite laudanosine.
PubMed:	Laudanosine and atracurium concentrations in a patient receiving long-term atracurium infusion.
PubMed:	Mechanism of the cardiovascular activity of laudanosine: comparison with papaverine and other benzylisoquinolines.
PubMed:	Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity.
PubMed:	Convulsive effects and pharmacokinetics of laudanosine in the rat.
PubMed:	Pharmacology of laudanosine in dogs.
PubMed:	Laudanosine (a metabolite of atracurium) increases the minimum alveolar concentration of halothane in rabbits.
PubMed:	Suicide with cisatracurium and thiopental: forensic and analytical aspects.
PubMed:	Pharmacokinetic modelling of a parent drug and its metabolite. Atracurium and laudanosine.
PubMed:	Atracurium decay and the formation of laudanosine in humans.
PubMed:	Cardiovascular and neurological effects of laudanosine. Studies in mice and rats, and in conscious and anaesthetized dogs.
PubMed:	Electrophysiological characterization of the SK channel blockers methyl-laudanosine and methyl-noscapine in cell lines and rat brain slices.
PubMed:	Effect of atracurium and laudanosine on the release of 3H-noradrenaline.
PubMed:	[Effect of laudanosine on catecholamine release in dogs].
PubMed:	Cardiovascular and electroencephalographic effects of laudanosine in "nephrectomized" cats.
PubMed:	Cerebrospinal fluid concentrations of atracurium, laudanosine and vecuronium following clinical subarachnoid hemorrhage.
PubMed:	Pharmacodynamics and atracurium and laudanosine concentrations during a fixed continuous infusion of atracurium in mechanically ventilated patients with acute respiratory distress syndrome.
PubMed:	Laudanosine, an atracurium and cisatracurium metabolite.
PubMed:	Cerebrospinal fluid concentrations of laudanosine after administration of atracurium.
PubMed:	Electroencephalographic effects of laudanosine in an animal model of epilepsy.
PubMed:	Modification by drugs used in anaesthesia of CNS stimulation induced in mice by laudanosine and strychnine.
PubMed:	Clearance of atracurium and laudanosine in the urine and by continuous venovenous haemofiltration.
PubMed:	Concentrations of atracurium and laudanosine in cerebrospinal fluid and plasma during intracranial surgery.
PubMed:	Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors.
PubMed:	Blockade and activation of the human neuronal nicotinic acetylcholine receptors by atracurium and laudanosine.
PubMed:	Plasma laudanosine levels in patients given atracurium during liver transplantation.
PubMed:	Concentrations of atracurium and laudanosine in cerebrospinal fluid and plasma in three intensive care patients.
PubMed:	Pharmacokinetics of atracurium and laudanosine in the elderly.
PubMed:	Disposition of infusions of atracurium and its metabolite, laudanosine, in patients in renal and respiratory failure in an ITU.
PubMed:	Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers.
PubMed:	Plasma concentrations of laudanosine, but not of atracurium, are increased during the anhepatic phase of orthotopic liver transplantation in pigs.
PubMed:	The distribution of laudanosine in tissues after death from atracurium injection.
PubMed:	High-performance liquid chromatographic method for the determination of atracurium and laudanosine in human plasma. Application to pharmacokinetics.
PubMed:	Transplacental distribution of atracurium, laudanosine and monoquaternary alcohol during elective caesarean section.
PubMed:	High-performance liquid chromatographic assay for laudanosine in biological fluids and tissue for neurotoxic studies in rats.
PubMed:	Modification of central nervous system effects of laudanosine by inhalation anaesthetics.
PubMed:	Pharmacokinetics of atracurium and laudanosine in patients with hepatic cirrhosis.
PubMed:	The metabolic disposition of laudanosine in dog, rabbit, and man.
PubMed:	[Absorption of papaverine, laudanosine and cepharanthine across human intestine by using human Caco-2 cells monolayers model].
PubMed:	Nitrous oxide antagonizes CNS stimulation by laudanosine in mice.
PubMed:	Production of laudanosine following infusion of atracurium in man and its effects on awakening.
PubMed:	Effect of renal failure on laudanosine excretion in man.
PubMed:	Pharmacokinetics of 1R-cis 1'R-cis atracurium besylate (51W89) and plasma laudanosine concentrations in health and chronic renal failure.
PubMed:	Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine.
PubMed:	Clinical experience and plasma laudanosine concentrations during the infusion of atracurium in the intensive therapy unit.
PubMed:	Simultaneous determination of atracurium and its metabolite laudanosine in post-mortem fluids by liquid chromatography/multiple-stage mass spectrometry on an ion trap.
PubMed:	Chiral separation of norlaudanosoline, laudanosoline, laudanosine, chlorthalidone, and three benzoin derivatives using amino acid based molecular micelles.
PubMed:	Identification of laudanosine, an atracurium metabolite, following a fatal drug-related shooting.
PubMed:	Hepatotoxicity testing of atracurium and laudanosine in the isolated, perfused rat liver.
PubMed:	Determination of atracurium and laudanosine in human plasma by high-performance liquid chromatography.
PubMed:	The microbial oxygenation of the benzylisoquinoline alkaloid laudanosine.
PubMed:	Atracurium and laudanosine pharmacokinetics in acute renal failure.
PubMed:	Simplified method for the determination of atracurium and laudanosine in pig plasma by high-performance liquid chromatography and fluorimetric detection.
PubMed:	The possible neuroprotective effect of laudanosine, an atracurium and cisatracurium metabolite.
PubMed:	High-dose laudanosine enhances liver cell activity and bile flow during reperfusion of the liver.
PubMed:	Determination of atracurium, laudanosine and related compounds in plasma by high-performance liquid chromatography.
PubMed:	The use of cisatracurium in critical care: A review of the literature.
PubMed:	Investigation of chondroitin sulfate D and chondroitin sulfate E as novel chiral selectors in capillary electrophoresis.
PubMed:	[DEHYDRATION OF TERTIARY AMINES WITH HG(II)-EDTA. 8. ON THE CONFIGURATION OF 1-BENZYL-N-TERT-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLINE AND LAUDANOSINE].
PubMed:	[Dehydration of tertiary amines by mercuric acetate in the presence of ethylenediaminetetraacetic acid. 1. The configuration of laudanosine].
PubMed:	Microbial transformations of natural antitumor agents. 2. Studies with d-tetrandrine and laudanosine.
PubMed:	[DEHYDROGENATION OF TERTIARY AMINES WITH HG(II)-EDTA. 6. FURTHER STUDIES ON THE PROCESS OF AROMATIZATION OF LAUDANOSINE WITH HG(III)-EDTA].
PubMed:	[Dehydration of tertiary amines with Hg(II)-EDTA. 4. On the course of aromatization of laudanosine with Hg(II)-EDTA].
PubMed:	Characterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy.
PubMed:	Synthesis and radioligand binding studies of bis-(8-isopropyl-isoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels.
PubMed:	Atracurium infusions in patients with fulminant hepatic failure awaiting liver transplantation.
PubMed:	Anesthesiologist suicide with atracurium.
PubMed:	The in vitro degradation of cisatracurium, the R, cis-R'-isomer of atracurium, in human and rat plasma.
PubMed:	The biosynthesis of papaverine proceeds via (S)-reticuline.
PubMed:	Enantioselective synthesis of tetrahydroprotoberberines and bisbenzylisoquinoline alkaloids from a deprotonated α-aminonitrile.
PubMed:	Identification and quantitation of six non-depolarizing neuromuscular blocking agents by LC-MS in biological fluids.
PubMed:	Pharmacokinetics and dynamics of atracurium infusions after paediatric orthotopic liver transplantation.
PubMed:	Determination of atracurium, cisatracurium and mivacurium with their impurities in pharmaceutical preparations by liquid chromatography with charged aerosol detection.
PubMed:	Perinatal neuroprotection by muscle relaxants against hypoxic-ischemic lesions: is it a possible hypothesis?
PubMed:	Evaluation of the enantioselectivity of glycogen-based dual chiral selector systems towards basic drugs in capillary electrophoresis.
PubMed:	Comparison of the pharmacodynamics and pharmacokinetics of an infusion of cis-atracurium (51W89) or atracurium in critically ill patients undergoing mechanical ventilation in an intensive therapy unit.
PubMed:	In vitro degradation of atracurium in human plasma.
PubMed:	The pharmacokinetics of cisatracurium in patients with acute respiratory distress syndrome.
PubMed:	Effects of neuromuscular blocking agents on excitatory transmission and gamma-aminobutyric acidA-mediated inhibition in the rat hippocampal slice.
PubMed:	Pharmacokinetics of cisatracurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia.
PubMed:	The prolonged use of atracurium in a patient with tetanus.
PubMed:	Pharmacokinetics of atracurium and its metabolites in patients with normal renal function, and in patients in renal failure.
PubMed:	Pharmacophore modelling of structurally unusual diltiazem mimics at L-type calcium channels.
PubMed:	A comparison of the infusion pharmacokinetics and pharmacodynamics of cisatracurium, the 1R-cis 1'R-cis isomer of atracurium, with atracurium besylate in healthy patients.
PubMed:	A pharmacokinetic-pharmacodynamic model for a muscle relaxant: atracurium.
PubMed:	Pharmacokinetics of 51W89: preliminary data.
PubMed:	Atracurium-induced neuromuscular block in the isolated arm.
PubMed:	Pharmacokinetics and neuromuscular blocking effects of atracurium besylate and two of its metabolites in patients with normal and impaired renal function.
PubMed:	The pharmacokinetics and pharmacodynamics of atracurium in patients with and without renal failure.
PubMed:	Synthesis of carbon-11 labeled 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium derivatives as new potential PET SKCa channel imaging agents.
PubMed:	Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca(2+)-activated K(+) channel blockers.
PubMed:	Risk-based approach for the transfer of quantitative methods: bioanalytical applications.
PubMed:	SK channels control the firing pattern of midbrain dopaminergic neurons in vivo.
PubMed:	Studies of polymerized sodium N-undecylenyl-L-valinate in chiral micellar electrokinetic capillary chromatography of neutral, acidic, and basic compounds.
PubMed:	Pharmacokinetics and pharmacodynamics of cisatracurium in patients with end-stage liver disease undergoing liver transplantation.
PubMed:	Lambda-carrageenan: a novel chiral selector for capillary electrophoresis.
PubMed:	Influence of extreme obesity on the body disposition and neuromuscular blocking effect of atracurium.
PubMed:	Prolonged infusion of atracurium in an infant.
PubMed:	Atracurium overdose in a small infant.
PubMed:	Generation of reactive metabolites during spontaneous degradation of atracurium in vitro.
PubMed:	Pharmacokinetics of atracurium in anaesthetized infants and children.
PubMed:	Relationships between structure and vascular activity in a series of benzylisoquinolines.
PubMed:	Activation of brain acetylcholine receptors by neuromuscular blocking drugs. A possible mechanism of neurotoxicity.
PubMed:	Influence of incubated atracurium on rat liver function.
PubMed:	Residual curarization in the neonate after caesarean section.
PubMed:	Pharmacokinetics and pharmacodynamics of atracurium obtained with arterial and venous blood samples.
PubMed:	Anaesthesia for the treatment of a giant cerebral aneurysm under hypothermic circulatory arrest.
PubMed:	Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+-activated K+ channels.
PubMed:	The efficient synthesis of morphinandienone alkaloids by using a combination of hypervalent iodine(III) reagent and heteropoly acid.
PubMed:	Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain.
PubMed:	Effect of dopamine, dimethoxyphenylethylamine, papaverine, and related compounds on mitochondrial respiration and complex I activity.
PubMed:	Identification of urinary and biliary conjugated metabolites of the neuromuscular blocker 51W89 by liquid chromatography/mass spectrometry.
PubMed:	Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle.
PubMed:	The cardiovascular effects of atracurium and it's metabolite.
PubMed:	Pharmacological action of breakdown products of atracurium and related substances.
PubMed:	Cisatracurium infusion for neuromuscular blockade in the pediatric intensive care unit: A dose-finding study.
PubMed:	Applicability of ultra-performance liquid chromatography-tandem mass spectrometry for heroin profiling.
PubMed:	Bioactive constituents of the roots of Polyalthia cerasoides.
PubMed:	Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors.
PubMed:	Transformation of opium poppy (Papaver somniferum L.) with antisense berberine bridge enzyme gene (anti-bbe) via somatic embryogenesis results in an altered ratio of alkaloids in latex but not in roots.
PubMed:	The GC-MS detection and characterization of reticuline as a marker of opium use.
PubMed:	Instability of pancuronium in postmortem blood and liver taken after a fatal intramuscular Pavulon injection.
PubMed:	The GC-MS detection and characterization of reticuline as a marker of opium use.
PubMed:	Aporphine alkaloids from Guatteria spp. with leishmanicidal activity.
PubMed:	Modulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry.
PubMed:	Colominic acid: a novel chiral selector for capillary electrophoresis of basic drugs.
PubMed:	Pharmacokinetic-pharmacodynamic modeling of atracurium in intensive care patients.
PubMed:	Approaching a million-fold sensitivity increase in capillary electrophoresis with direct ultraviolet detection: cation-selective exhaustive injection and sweeping
PubMed:	Comparative evaluation of capillary electrophoresis and high-performance liquid chromatography for the separation of cis-cis, cis-trans, and trans-trans isomers of atracurium besylate.
PubMed:	[Cisatracurium].
PubMed:	[The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium].
PubMed:	[New muscle relaxants].
PubMed:	Approaches to short-acting neuromuscular blocking agents: nonsymmetrical bis-tetrahydroisoquinolinium mono- and diesters.
PubMed:	Simple high-performance liquid chromatographic method for the analysis of the non-depolarizing neuromuscular blocking drugs in clinical anaesthesia.
PubMed:	Pharmacokinetics of atracurium metabolites.
PubMed:	Review of atracurium by continuous i.v. infusion.
PubMed:	High pressure liquid chromatographic determination of the five major alkaloids in Papaver somniferum L. and thebaine in Papaver bracteatum Lindl. capsular tissue.
PubMed:	Hofmann elimination with diazomethane on curare bases and selected quaternary tetrahydroisoquinoline alkaloids.
PubMed:	A relatively simple differential screening test for GABA or glycine antagonists using rat electroretinography.
PubMed:	Alkaloids of Hernandia voyronii: chloroquine-potentiating activity and structure elucidation of herveline D.
PubMed:	Neutral heroin impurities from tetrahydrobenzylisoquinoline alkaloids.
PubMed:	The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum.
PubMed:	The insulin pump as murder weapon: a case report.
PubMed:	Does ester hydrolysis change the in vitro degradation rate of cisatracurium and atracurium?
PubMed:	Concentration-effect relationship of cisatracurium at three different dose levels in the anesthetized patient.
PubMed:	[Effects of priming technique on onset profile of cisatracurium].
PubMed:	In vitro degradation of atracurium and cisatracurium at pH 7.4 and 37 degrees C depends on the composition of the incubating solutions.
PubMed:	Importance of the organ-independent elimination of cisatracurium.
PubMed:	Simultaneous determination of dextrorphan and guaifenesin in human plasma by liquid chromatography with fluorescence detection.
PubMed:	Is 51W89 an improvement compared with atracurium?
PubMed:	Inhibition of purine nucleobase transport in human erythrocytes and cell lines by papaverine. Investigation of structure-activity relationship.
PubMed:	Simple and rapid high-performance liquid chromatography method for the determination of alcuronium in human plasma and urine.
PubMed:	Inhibition of hepatic microsomal drug metabolism by atracurium administration in the rat.
PubMed:	Separation of eight alkaloids and meconic acid and quantitation of five principal alkaloids in gum opium by gradient reversed-phase high-performance liquid chromatography.
PubMed:	Effects of atracurium, vecuronium or pancuronium pretreatment on lignocaine seizure thresholds in cats.
PubMed:	Preponderance of hydrolysis in inactivation of atracurium: questions remain.
PubMed:	Status epilepticus following enflurane anaesthesia.
PubMed:	Atracurium infusions in patients with renal failure on an ITU.
PubMed:	Pharmacokinetics of atracurium and its metabolites.
PubMed:	Atracurium: an overview.
PubMed:	The cerebral effects of pancuronium and atracurium in halothane-anesthetized dogs.
PubMed:	Magic bullets, science, and medicine.
PubMed:	[Metabolism and pharmacokinetics of atracurium].
PubMed:	Stereochemical preferences for curarimimetic neuromuscular junction blockade IV: Monoquaternary ammonium probes possessing carbon and nitrogen asymmetry.
PubMed:	Stereochemical preferences for curarimimetic neuromuscular junction blockade I: enantiomeric monoquaternary amines as probes.