Articles:
5-bromo-2'-deoxyuridine
Notes:
a nucleoside that substitutes for thymidine in dna and thus acts as an antimetabolite. it causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. it has been given orphan drug status for use in the treatment of primary brain tumors.
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 59-14-3 Bromodeoxyuridine (BrdU) > 98% by HPLC 5-Bromo-2'-deoxyuridine (5-BrdU) is a thymidine analog that can be incorporated into newly synthesized DNA to label it.
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Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GE3595 5-Bromo-2'-deoxyuridine
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TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): B1575 5-Bromo-2'-deoxyuridine >98.0%(HPLC)(T)
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| CAS Number: | 59-14-3 |  3D/inchi
|
| Other(deleted CASRN): | 1236362-78-9 | |
| ECHA EINECS - REACH Pre-Reg: | 200-415-9 | |
| FDA UNII: | G34N38R2N1 | |
| Nikkaji Web: | J2.335C | |
| Beilstein Number: | 0030395 | |
| MDL: | MFCD00006529 | |
| XlogP3: | -0.30 (est) | |
| Molecular Weight: | 307.10067000 | |
| Formula: | C9 H11 Br N2 O5 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 192.50 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 1.700000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w): | -0.290 |
| Soluble in: | |
| water, 966.6 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Bromodeoxyuridine (BrdU) > 98% by HPLC
Odor: characteristic Use: 5-Bromo-2'-deoxyuridine (5-BrdU) is a thymidine analog that can be incorporated into newly synthesized DNA to label it. |
| Carbosynth |
| For experimental / research use only. |
| 5-Bromo-2'-deoxyuridine |
| EMD Millipore |
| For experimental / research use only. |
| 5-Bromo-2'-deoxyuridine |
| George Uhe Company |
| 5-Bromo-2'-deoxyuridine |
| Glentham Life Sciences |
| 5-Bromo-2'-deoxyuridine |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 5-Bromo-2'-deoxyuridine ≥98% |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| 5-Bromo-2'-deoxyuridine BioUltra, ≥99% |
| TCI AMERICA |
| For experimental / research use only. |
| 5-Bromo-2'-deoxyuridine >98.0%(HPLC)(T) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-mouse LD50 3050 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION CARDIAC: PULSE RATE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 530, 1971. intravenous-mouse LD50 2500 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION CARDIAC: PULSE RATE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 530, 1971. oral-mouse LD50 9100 mg/kg BLOOD: CHANGES IN SPLEEN BEHAVIORAL: MUSCLE WEAKNESS Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 530, 1971. oral-quail LD50 > 100 mg/kg Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982. intraperitoneal-rat LD50 1500 mg/kg Advances in Teratology. Vol. 3, Pg. 181, 1968. intravenous-rat LD50 2320 mg/kg VASCULAR: OTHER CHANGES Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 735, 1971. oral-rat LD50 8400 mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 467, 1973. unreported-rat LD50 2300 mg/kg Drugs in Japan Vol. 6, Pg. 721, 1982. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 3500 mg/kg CARDIAC: PULSE RATE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 530, 1971. subcutaneous-rat LD50 3900 mg/kg CARDIAC: PULSE RATE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 530, 1971. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for broxuridine usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for broxuridine flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 59-14-3 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6035 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| 5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione | |
| Chemidplus: | 0000059143 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | YU7350000 for cas# 59-14-3 |
References:
| 5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 59-14-3 |
| Pubchem (cid): | 6035 |
| Pubchem (sid): | 134972288 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | D01763 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2934.20.8000 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
| EFSA Update of results on the monitoring of furan levels in food: | Read Report |
| EFSA Previous report: Results on the monitoring of furan levels in food: | Read Report |
| EFSA Report of the CONTAM Panel on provisional findings on furan in food: | Read Report |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| brdurd | |
| 5- | bromo-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| 5- | bromo-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione |
| 5- | bromo-1-(2-deoxy-b-D-ribofuranosyl)uracil |
| 5- | bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| (+)-5- | bromo-2-deoxyuridine |
| (+)-5- | bromo-2'-deoxyuridine |
| 5- | bromo-2'-deoxyuridine |
| bromodeoxyuridine | |
| 5- | bromodeoxyuridine |
| 5- | bromodesoxyuridine |
| bromoouridine | |
| bromouracil deoxyriboside | |
| 5- | bromouracil deoxyriboside |
| 5- | bromouracil-2-deoxyriboside |
| 1-[(4S,2R,5R)-4- | hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-bromo-1,3-dihydropyrimidine-2,4-dione |
| radibud | |
| uridine, 5-bromo-2'-deoxy- |