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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | -45.00 °C. @ 760.00 mm Hg (est)
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| Boiling Point: | 81.60 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 88.800000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 1.42 ( Air = 1 ) |
| Flash Point: | 42.00 °F. TCC ( 5.60 °C. ) (est)
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| logP (o/w): | -0.340 |
| Soluble in: |
| | water, 1.00E+06 mg/L @ 25 °C (exp) | | | water, 1.367e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| American International Chemical, LLC. |
| Acetonitrile LC Mass Spec Grade
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| Charkit Chemical |
| ACETONITRILE HPLC GRADE
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| Charkit Chemical |
| ACETONITRILE
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| Connect Chemicals |
| Acetonitrile
Odor: characteristic Use: Acetonitrile is a clear, colourless liquid with ethereal odour. The primary industrial utility of Acetonitrile is as a solvent. It is an excellent polar aprotic solvent, with a high dipole moment and dielectric constant.
As solvent Acetonitrile is used in organic and biochemical reactions, as well as extraction solvent for purification. Acetonitrile can be used as starting material in the synthesis of amines, amides, amidines, ketones, carboxylic acids and esters, aldehydes and other compounds. |
| Covalent Chemical |
| Acetonitrile
|
| ECSA Chemicals |
| ACETONITRILE PURE
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| ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
| ECSA Chemicals |
| ACETONITRILE RPE-ACS-FOR ANALYSIS-REAG. PH.E
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| ECSA Chemicals |
| ACETONITRILE RS PLUS HPLC GRADIENT GRADE ML
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| ECSA Chemicals |
| ACETONITRILE RS-ACS-REAG.PH.EUR.-FOR HPLC ML
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| ECSA Chemicals |
| ACETONITRILE RS-FOR HPLC-LC/MS, ML 2500
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| ECSA Chemicals |
| ACETONITRILE RS-PLUS-FOR UHPLC - MS 1 L
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| EMD Millipore |
| For experimental / research use only. |
| Acetonitrile
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| Glentham Life Sciences |
| Acetonitrile
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| OQEMA |
| Acetonitrile
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| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Acetonitrile ≥99.9%
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| Sigma-Aldrich |
| For experimental / research use only. |
| Acetonitrile anhydrous, 99.8%
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| Silver Fern Chemical |
| Acetonitrile
Odor: characteristic Use: Acetonitrile is used mainly as a solvent for batteries, laboratory testing, pharmaceuticals, and in photography. |
| TCI AMERICA |
| For experimental / research use only. |
| Acetonitrile [for Spectrophotometry] >99.5%(GC)
|
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-cat LD50 200 mg/kg Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. Vol. 19, Pg. 225, 1969.
oral-child TDLo 800 mg/kg BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
GASTROINTESTINAL: NAUSEA OR VOMITING American Journal of Emergency Medicine. Vol. 9, Pg. 268, 1991.
oral-guinea pig LD50 177 mg/kg Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
oral-mammal (species unspecified) LD50 1670 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
oral-man TDLo 64 mg/kg BEHAVIORAL: EXCITEMENT Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 447, 1991.
oral-man TDLo 571 mg/kg GASTROINTESTINAL: NAUSEA OR VOMITING
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Acta Pharmacologica et Toxicologica, Supplementun. Vol. 41, Pg. 340, 1977.
intraperitoneal-mouse LD50 175 mg/kg SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA Toxicology and Applied Pharmacology. Vol. 59, Pg. 589, 1981.
intravenous-mouse LD50 612 mg/kg "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 16, 1982.
oral-mouse LD50 269 mg/kg Archives of Toxicology. Vol. 55, Pg. 47, 1984.
oral-rabbit LD50 50 mg/kg Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. Vol. 19, Pg. 225, 1969.
intraperitoneal-rat LD50 850 mg/kg Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
intravenous-rat LD50 1680 mg/kg Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
oral-rat LD50 2460 mg/kg Union Carbide Data Sheet. Vol. 3/18/1965
parenteral-rat LD50 1100 mg/kg "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 16, 1982.
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| Dermal Toxicity: |
subcutaneous-frog LDLo 9100 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA
PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE Archives Internationales de Pharmacodynamie et de Therapie. Vol. 5, Pg. 161, 1899.
subcutaneous-mouse LD50 4480 mg/kg "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 16, 1982.
skin-rabbit LD50 > 2000 mg/kg International Journal of Toxicology. Vol. 19, Pg. 363, 2000.
subcutaneous-rabbit LDLo 105 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 36, Pg. 455, 1929.
subcutaneous-rat LD50 3500 mg/kg "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 16, 1982.
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| Inhalation Toxicity: |
inhalation-cat LC50 18000 mg/m3 "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 16, 1982.
inhalation-dog LCLo 16000 ppm/4H Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
inhalation-guinea pig LC50 5655 ppm/4H BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BLOOD: HEMORRHAGE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
inhalation-human TCLo 160 ppm/4H LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 65, 1969.
inhalation-mouse LC50 2693 ppm/1H LIVER: OTHER CHANGES Clinical Toxicology. Vol. 18, Pg. 991, 1981.
inhalation-rabbit LC50 2828 ppm/4H BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BLOOD: HEMORRHAGE
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
inhalation-rat LC50 7551 ppm/8H BLOOD: HEMORRHAGE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for acetonitrile usage levels up to: | | | not for fragrance use.
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| Recommendation for acetonitrile flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cyanomethane | | | ethane nitrile | | | ethanenitrile | | | ethanonitrile | | | ethyl nitrile | | | methane, cyano- | | | methanecarbonitrile | | | methyl cyanide | | | methylidyne, cyano- |
Articles:
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