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Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 61.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 136.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 134.00 to 135.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 3.120000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 113.00 °F. TCC ( 45.20 °C. ) (est)
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| logP (o/w): | 0.120 |
| Soluble in: |
| | water, 1.06e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 4000 mg/kg BEHAVIORAL: COMA Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 522, 1957.
oral-rat LD > 500 mg/kg National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 26, 1953.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | information only not used for fragrances or flavors |
| Recommendation for acetone oxime usage levels up to: | | | not for fragrance use.
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| Recommendation for acetone oxime flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA Substance Registry Services (TSCA): | 127-06-0 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 67180 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | N-propan-2-ylidenehydroxylamine |
| Chemidplus: | 0000127060 |
| RTECS: | AL6825000 for cas# 127-06-0 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acetone, oxime | | | acetoneoxime | | | acetonoxime | | | acetoxime | | N- | hydroxy-2-propanimine
| | N- | hydroxypropan-2-imine | | b-iso | nitrosopropane | | beta-iso | nitrosopropane | | | propan-2-one oxime | | N- | propan-2-ylidene hydroxyl amine | | N- | propan-2-ylidenehydroxylamine | | 2- | propanone oxime | | 2- | propanoneoxime | | | servon XACT 100 |
Articles:
| PubMed: | GSK-3? activation is required for ZIP-induced disruption of learned fear |
| PubMed: | Antiherpetic potential of 6-bromoindirubin-3'-acetoxime (BIO-acetoxime) in human oral epithelial cells |
| PubMed: | Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy |
| PubMed: | Amination of tyrosine in liver cytosol protein of male F344 rats treated with 2-nitropropane, 2-nitrobutane, 3-nitropentane, or acetoxime |
| PubMed: | Palladium(II)-Catalyzed Acetoxime Directed ortho-Arylation of Aromatic Alcohols |
| PubMed: | Oxidation of the ketoxime acetoxime to nitric oxide by oxygen radical-generating systems |
| PubMed: | Palladium-catalyzed direct mono-aroylation of O-arylmethyl and aryl-substituted acetoxime ethers |
| PubMed: | Reversion of structure-activity relationships of antitumor platinum complexes by acetoxime but not hydroxylamine ligands |
| PubMed: | Sex and organ differences in oxidative DNA and RNA damage due to treatment of Sprague-Dawley rats with acetoxime or 2-nitropropane |
| PubMed: | Slow oxidation of acetoxime and methylethyl ketoxime to the corresponding nitronates and hydroxy nitronates by liver microsomes from rats, mice, and humans |
| PubMed: | Mixed unsymmetric oxadiazoline and/or imine platinum(II) complexes |
| PubMed: | An evaluation of indirubin analogues as phosphorylase kinase inhibitors |
| PubMed: | Vasorelaxant activity of some oxime derivatives |
| PubMed: | Rapid analysis of acetone in human plasma by derivatization desorption electrospray ionization |
| PubMed: | Synthesis and anti-inflammatory activity of novel (substituted)benzylidene acetone oxime ether derivatives: molecular modeling study |
| PubMed: | Induction of hyperplastic liver nodules in Wistar and MRC-Wistar rats by phenobarbital and the liver carcinogens acetoxime, 1-nitroso-5,6-dihydrouracil and 3-nitroso-2-oxazolidinone |
| PubMed: | Direct ortho-C-H functionalization of aromatic alcohols masked by acetone oxime ether via exo-palladacycle |
| PubMed: | Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis |
| PubMed: | Acetoxime is metabolized by human and rodent hepatic cytochrome P450 enzymes to the genotoxicant and carcinogen propane 2-nitronate |
| PubMed: | Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/?-Catenin Pathway |
| PubMed: | Relaxant effect of oxime derivatives in isolated rat aorta: role of nitric oxide (NO) formation in smooth muscle |
| PubMed: | Determination of acetone in human breath by gas chromatography-mass spectrometry and solid-phase microextraction with on-fiber derivatization |
| PubMed: | Oxidative DNA and RNA damage in rat liver due to acetoxime: similarity to effects of 2-nitropropane |
| PubMed: | H/D isotopic and temperature effects in the polarized IR spectra of hydrogen-bond cyclic trimers in the crystal lattices of acetone oxime and 3,5-dimethylpyrazole |
| PubMed: | Photodissociation dynamics of acetoxime in gas phase |
| PubMed: | Synthesis of 3,5-isoxazolidinediones and 1H-2,3-benzoxazine-1,4(3H)-diones from aliphatic oximes and dicarboxylic acid chlorides |
| PubMed: | 6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for tre |
| PubMed: | Synthesis, Structures, and Photocurrent Responses of Polyoxo-Titanium Clusters with Oxime Ligands: From Ti(4) to Ti(18) |
| PubMed: | Activation of n-3 polyunsaturated fatty acids as oxime esters: a novel approach for their exclusive incorporation into the primary alcoholic positions of the glycerol moiety by lipase |
| PubMed: | Nitrate formation during ozonation as a surrogate parameter for abatement of micropollutants and the N-nitrosodimethylamine (NDMA) formation potential |
| PubMed: | GSK3 inhibitors regulate MYCN mRNA levels and reduce neuroblastoma cell viability through multiple mechanisms, including p53 and Wnt signaling |
| PubMed: | Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds |
| PubMed: | Chimeric 5/35 adenovirus-mediated Dickkopf-1 overexpression suppressed tumorigenicity of CD44? gastric cancer cells via attenuating Wnt signaling |
| PubMed: | Oximate-substituted zirconium alkoxides |
| PubMed: | Nitroreduction is not involved in the genotoxicity of 2-nitropropane in cultured mammalian cells |
| PubMed: | Lipoamide dehydrogenase and diaphorase catalyzed conversion of some NO donors to NO and reduction of NO scavenger 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (PTIO) |
| PubMed: | Fast and low-temperature sintering of silver complex using oximes as a potential reducing agent for solution-processible, highly conductive electrodes |
| PubMed: | Selective C(sp(3) )-H and C(sp(2) )-H Fluorination of Alcohols Using Practical Auxiliaries |
| PubMed: | Studies on the acetylation and NMR reassignment of indirubin derivatives |
| PubMed: | Inhibition of copper amine oxidases by pyridine-derived aldoximes and ketoximes |
| PubMed: | Vapor-phase Beckmann rearrangement of oxime molecules over H-Faujasite zeolite |
| PubMed: | Apposition of silica lamellae during growth of spicules in the demosponge Suberites domuncula: biological/biochemical studies and chemical/biomimetical confirmation |
| PubMed: | Rapid determination of acetone in human plasma by gas chromatography-mass spectrometry and solid-phase microextraction with on-fiber derivatization |
| PubMed: | Investigation of the chemical basis of nitroalkane toxicity: tautomerism and decomposition of propane 1- and 2-nitronate under physiological conditions |
| PubMed: | Synthesis, antifungal activities, and potential detoxification of N-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)thiocarbamates |
| PubMed: | Rapid determination of acetone in human blood by derivatization with pentafluorobenzyl hydroxylamine followed by headspace liquid-phase microextraction and gas chromatography/mass spectrometry |
| PubMed: | E/Z Energetics for Molecular Modeling and Design |
| PubMed: | Carcinogenicity test of acetoxime in MRC-Wistar rats |
| PubMed: | Genotoxicity of N-nitroso-N-methylurea and acetone oxime in the transgenic Drosophila carrying the human gene encoding a subunit of glutathione S-transferase |
| PubMed: | Nitrite formation from hydroxylamine and oximes by Pseudomonas aeruginosa |
| PubMed: | Novel quantum mechanical/molecular mechanical method combined with the theory of energy representation: free energy calculation for the Beckmann rearrangement promoted by proton transfers in the supercritical |
| PubMed: | Reaction mechanism of an intramolecular oxime transfer reaction: a computational study |
| PubMed: | Is the Beckmann rearrangement a concerted or stepwise reaction? A computational study |
| PubMed: | Sulfotransferase-mediated genotoxicity of propane 2-nitronate in cultured ovine seminal vesicle cells |
| PubMed: | Theoretical and experimental study of 15N NMR protonation shifts |
| PubMed: | Activation of propane 2-nitronate to a genotoxicant in V79-derived cell lines engineered for the expression of rat hepatic sulfotransferases |
| PubMed: | Comparison of kinetic properties of amine oxidases from sainfoin and lentil and immunochemical characterization of copper/quinoprotein amine oxidases |
| PubMed: | The formation of silkworm virus by acetoxime feeding |
| PubMed: | Ab initio molecular electrostatic potentials of perillartine analogues: implications for sweet-taste receptor recognition |
| PubMed: | Human phenol sulfotransferases hP-PST and hM-PST activate propane 2-nitronate to a genotoxicant |
| PubMed: | Aluminum compounds containing eta1- and/or eta5-bidentate dianionic pyrrolyl-methylamide ligands |
| PubMed: | An Intramolecular Nitrone-Olefin Dipolar Cycloaddition-Based Approach to Total Synthesis of the Cylindricine and Lepadiformine Marine Alkaloids |
| PubMed: | Pt(II)-mediated imine-nitrile coupling leading to symmetrical (1,3,5,7,9-pentaazanona-1,3,6,8-tetraenato)Pt(II) complexes containing the incorporated 1,3-diiminoisoindoline moiety |
| PubMed: | Synthesis and beta-adrenergic blocking activity of new aliphatic oxime ethers |
| PubMed: | Preparation of beta- and gamma-lactams from carbamoyl radicals derived from oxime oxalate amides |
| PubMed: | Regulation of endothelin-1 expression in normal and transfected endothelial cells |
| PubMed: | Prophage induction in lysogenic Escherichia coli with simple hydroxylamine and hydrazine compounds |
| PubMed: | Gas chromatographic-mass spectrometric analysis of hydroxylamine for monitoring the metabolic hydrolysis of metalloprotease inhibitors in rat and human liver microsomes |
| PubMed: | [Electrochemical reduction of (R)-1- hydroxyl-1-(m-hydroxylphenyl)-acetone oxime--a new method of preparing metaraminol (author's transl)] |
| PubMed: | [Structure of adducts prepared from nicotinamide adenine dinucleotide and their oximes] |
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