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Category: chelating agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 614.00 to 615.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 617.00 °F. TCC ( 325.20 °C. ) (est)
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| logP (o/w): | -0.434 (est) |
| Soluble in: |
| | water, 1000000 mg/L @ 25 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 330 mg/kg KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Revue d'Epidemiologie, Medecine Sociale et Sante Publique. Vol. 10, Pg. 391, 1962.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | chelating agents |
| Recommendation for tetrasodium EDTA usage levels up to: | | | not for fragrance use.
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| Recommendation for tetrasodium EDTA flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| NIOSH International Chemical Safety Cards: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| EPA Substance Registry Services (TSCA): | 64-02-8 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6144 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| | tetrasodium 2-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl-(2-oxido-2-oxoethyl)amino] acetate |
| Chemidplus: | 0000064028 |
| RTECS: | 64-02-8 |
References:
| | tetrasodium 2-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl-(2-oxido-2-oxoethyl)amino] acetate |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 64-02-8 |
| Pubchem (cid): | 6144 |
| Pubchem (sid): | 134971962 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | edetate tetrasodium | | | ethylenediaminetetraacetic acid tetrasodium salt | | ( | ethylenedinitrilo)tetraacetic acid tetrasodium salt | | | glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, tetrasodium salt | | | sodium edetate | | | tetrasodium 2-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl-(2-oxido-2-oxoethyl)amino] acetate | | | tetrasodium 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetraacetate | | | tetrasodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate | | | tetrasodium edetate | | | tetrasodium EDTA | | | tetrasodium ethylene diamine tetraacetate | | | tetrasodium ethylenediamine-N,N,N',N'-tetraacetate | | | tetrasodium ethylenediaminetetraacetate |
Articles:
| PubMed: | EDTA: An Antimicrobial and Antibiofilm Agent for Use in Wound Care. |
| PubMed: | Full and broad-spectrum in vivo eradication of catheter-associated biofilms using gentamicin-EDTA antibiotic lock therapy. |
| PubMed: | Occupational rhinitis and asthma due to EDTA-containing detergents or disinfectants. |
| PubMed: | Contact allergy to tetrasodium EDTA in a sunscreen. |
| PubMed: | Inhibition of biofilms associated with dentures and toothbrushes by tetrasodium EDTA. |
| PubMed: | Toluidine blue-mediated photodynamic effects on staphylococcal biofilms. |
| PubMed: | A subpopulation of Candida albicans and Candida tropicalis biofilm cells are highly tolerant to chelating agents. |
| PubMed: | Tetrasodium EDTA as a novel central venous catheter lock solution against biofilm. |
| PubMed: | Bone matrix insulin-like growth factor (IGF)-I, IGF-II and transforming growth factor (TGF)-beta1 levels in men and postmenopausal women with osteoporosis: lack of association with circulating growth factors and bone mineral density. |
| PubMed: | Use of in vivo-generated biofilms from hemodialysis catheters to test the efficacy of a novel antimicrobial catheter lock for biofilm eradication in vitro. |
| PubMed: | Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. |
| PubMed: | Removal efficiency of calcium hydroxide dressing from the root canal. |
| PubMed: | Preparation of an optimum mobile phase for the simultaneous determination of neurochemicals in mouse brain tissues by high-performance liquid chromatography with electrochemical detection. |
| PubMed: | Effect of tetrasodium EDTA on enzymatic determinations of urinary oxalate. |
| PubMed: | A rapid method for the isolation of peroxisomes from rat liver. |
| PubMed: | Characterization of a parasporal inclusion body from sporulating, enterotoxin-positive Clostridium perfringens type A. |
| PubMed: | Extraction of light filth from ground allspice: collaborative study. |
| PubMed: | Influence of manganese ions on the contraction of the guinea-pig isolated vas deferens. |
| PubMed: | Influence of sodium and potassium ions on the contraction induced by calcium ions in guinea-pig isolated vas deferens. |
| PubMed: | The effect of EDTA on the histochemical myofibrillar ATPase reaction. |
| PubMed: | DECALCIFICATION OF TEMPORAL BONES WITH TETRASODIUM EDETATE. |
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