piperine
piperidine, 1-[5-(3,4-methylenedioxyphenyl)-1-oxo-2, 4-pentadienyl]-
 
Notes:
more potent than vanilloid (capsaicin) at human trpv1; used to increase gastrointestinal assimilation of other agents. Constit. of pepper (Piper nigrum) and many other Piper spp. (Piperaceae). Used to impart pungent taste to brandy. Responsible for the hot taste of pepper. Flavour ingredient
  • BOC Sciences
    • BOC Sciences
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      Product(s):
      7780-20-3 Piperine 95%
       
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CAS Number: 7780-20-3Picture of molecule3D/inchi
Beilstein Number: 0090741
XlogP3: 3.50 (est)
Molecular Weight: 285.34303000
Formula: C17 H19 N O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: white to yellow crystalline powder (est)
Assay: 96.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 498.00 to  499.00 °C. @ 760.00 mm Hg (est)
Flash Point: 492.00 °F. TCC ( 255.30 °C. ) (est)
logP (o/w): 3.365 (est)
Soluble in:
 alcohol
 water, 10.56 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
Piperine 95%
Changsha Organic Herb
Black Pepper Fruit Extract
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50  71 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#05220

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
 
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 4840
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one
Chemidplus: 0007780203
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References:
 5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 4840
Pubchem (sid): 135055675
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
KEGG (GenomeNet): C03882
HMDB (The Human Metabolome Database): Search
FooDB: FDB000449
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 dill seed
Search Trop  Picture
 pepper black pepper
Search Trop  Picture
 pepper black pepper fruit
Search Trop  Picture
 pepper black pepper leaf
Search Trop  Picture
 pepper black pepper leaf oil
Search Trop  Picture
 pepper black pepper root
Search Trop  Picture
 pepper black pepper seed
Search Trop  Picture
 pepper black pepper seed oil
Search Trop  Picture
 pepper black pepper shoot
Search Trop  Picture
 pepper black pepper stem
Search Trop  Picture
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Synonyms:
1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl) piperidine
5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one
1-[5-(3,4-methylenedioxyphenyl)-1-oxo-2, 4-pentadienyl]piperidine
1-(5-(3,4-methylenedioxyphenyl)-1-oxo-2,4-pentadienyl)piperidine
 piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-
 piperidine, 1-(5-(3,4-methylenedioxyphenyl)-1-oxo-2,4-pentadienyl)-
 piperidine, 1-[5- (1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-
 piperidine, 1-[5-(3,4-methylenedioxyphenyl)-1-oxo-2, 4-pentadienyl]-
 piperoyl piperidine
1-piperoyl piperidine
1-piperoyl-piperidine
 piperoylpiperidine
1-piperoylpiperidine
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Articles:
PubMed: Piperine: researchers discover new flavor in an ancient spice.
PubMed: Enhancement of responses to sequential presentation of oral chemical irritants.
PubMed: Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis.
PubMed: Effects of oral chemical irritation on taste.
PubMed: [Studies on the chemical constituents of Piper macropodum C.DC].
PubMed: Spectrophotometric analysis of irradiated spices.
PubMed: Carcinogenicity testing of some constituents of black pepper (Piper nigrum).
PubMed: Anti-inflammatory activity of piperine.
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