Articles:
vitamin B12 coenzyme
Notes:
Adenosylcobalamin is one of two metabolically active forms synthesized upon ingestion of vitamin B12 and is the predominant form in the liver; it acts as a coenzyme in the reaction catalyzed by methylmalonyl-CoA mutase. A cobalamin (cbl) derivative in which the substituent is deoxyadenosyl. It is one of two metabolically active forms synthesized upon ingestion of vitamin B12 and is the predominant form in the liver; it acts as a coenzyme in the reaction catalyzed by methylmalonyl-CoA mutase (MCM; E.C. 5.4.99.2).
Inborn errors of vitamin B12 metabolism are autosomal recessive disorders and have been classified into nine distinct complementation classes. Disorders affecting adenosylcobalamin cause methylmalonic acidemia and metabolic acidosis. Methylmalonyl-CoA mutase catalyzes the conversion of L-methylmalonyl-CoA to succinyl-CoA and uses adenosylcobalamin (AdoCbl) as a cofactor. Cbl must be transported into mitochondria, reduced and adenosylated before it can be utilized by MCM. (PMID: 17011224) [HMDB]
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| CAS Number: | 13870-90-1 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 237-627-6 | |
| FDA UNII: | F0R1QK73KB | |
| Beilstein Number: | 4122932 | |
| MDL: | MFCD00135609 | |
| Molecular Weight: | 1579.60835700 | |
| Formula: | C72 H100 Co N18 O17 P | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: nutrient supplements
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
antioxidants skin conditioning skin protecting agents |
Suppliers:
| AuNutra® Industries |
| Cobamamide ( VB12) |
| BOC Sciences |
| For experimental / research use only. |
| Cobamamide > 95%
Odor: characteristic Use: Cobamamide is an emulsifying agent. |
| Charkit Chemical |
| ADENOSYLCOBALAMIN |
| George Uhe Company |
| Cobamamide |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Coenzyme B12 ≥98% |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Coenzyme B12 ≥97.0% |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-mouse LD50 1000 mg/kg Drugs in Japan Vol. -, Pg. 405, 1990. intraperitoneal-mouse LD50 2000 mg/kg Drugs in Japan Vol. -, Pg. 405, 1990. oral-guinea pig LD50 5000 mg/kg Drugs in Japan Vol. -, Pg. 405, 1990. intravenous-guinea pig LD50 1000 mg/kg Drugs in Japan Vol. -, Pg. 405, 1990. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 2000 mg/kg Drugs in Japan Vol. -, Pg. 405, 1990. subcutaneous-guinea pig LD50 2000 mg/kg Drugs in Japan Vol. -, Pg. 405, 1990. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | nutrient supplements | ||
| Recommendation for cobamamide usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for cobamamide flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| European Food Safety Authority (EFSA) reference(s): | |
| 5’-deoxyadenosylcobalamin and methylcobalamin as sources for Vitamin B12 added as a nutritional substance in food supplements[1] - Scientific opinion of the Scientific Panel on Food Additives and Nutrient Sources added to food View page or View pdf | |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6436143 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| (2S,3S,4R)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]1-[3- | |
| Chemidplus: | 0013870901 |
| RTECS: | GG3800000 for cas# 13870-90-1 |
References:
| (2S,3S,4R)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]1-[3- | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 6436143 |
| Pubchem (sid): | 135030335 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| KEGG (GenomeNet): | C00194 |
| HMDB (The Human Metabolome Database): | HMDB02086 |
| FooDB: | FDB022837 |
| FDA Listing of Food Additive Status: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| Wikipedia: | View |
| EFSA Update of results on the monitoring of furan levels in food: | Read Report |
| EFSA Previous report: Results on the monitoring of furan levels in food: | Read Report |
| EFSA Report of the CONTAM Panel on provisional findings on furan in food: | Read Report |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| found in nature |
Synonyms:
| adenosyl cobalamin | |
| adenosylcobalamin | |
| calomide | |
| cobalamine coenzyme | |
| cobamamidum | |
| cobamide | |
| cobinamide, O-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazol | |
| coenzyme B12 | |
| DBC coenzyme | |
| 5- | deoxyadenosyl cobalamin |
| 5'- | deoxyadenosyl vitamin B12 |
| deoxyadenosylcobalamin | |
| 5- | deoxyadenosylcobalamin |
| desoxy-5'-adenosine-5'alpha-(dimethyl-5,6-benzimidazolyl)cobamide | |
| dibencozide | |
| 5,6- | dimethylbenzimidazolylcobamid coenzym |
| funacomide | |
| vitamin B12 coenzyme |