copper orotate
bis(1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylato-N3,O4)copper
 
Notes:
None found
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CAS Number: 61573-60-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 262-855-8
FDA UNII: D0BDL7GZGO
Molecular Weight: 373.72542000
Formula: C10 H6 Cu N4 O8
NMR Predictor: Predict (works with chrome or firefox)
Category: nutrient supplements, EFSA concludes: use is of safety concern.
 
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 12.48 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Global Calcium
Copper Orotate
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: nutrient supplements, EFSA concludes: use is of safety concern.
Recommendation for copper orotate usage levels up to:
 not for fragrance use.
 
Recommendation for copper orotate flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Orotic acid salts as sources of orotic acid and various minerals added for nutritional purposes to food supplements
View page or View pdf
EPI System: View
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EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 44621237
National Institute of Allergy and Infectious Diseases: Data
 copper 2,4-dioxo-1H-pyrimidine-6-carboxylate
Chemidplus: 0061573602
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References:
 copper 2,4-dioxo-1H-pyrimidine-6-carboxylate
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 44621237
Pubchem (sid): 135356685
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
FDA Listing of Food Additive Status: View
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 copper 2,4-dioxo-1H-pyrimidine-6-carboxylate
bis(1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylato-N3,O4)copper
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Articles:
PubMed: Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial.
PubMed: Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial.
PubMed: The orotate transporter encoded by oroP from Lactococcus lactis is required for orotate utilization and has utility as a food-grade selectable marker.
PubMed: Diamine oxidase, a plasma biomarker in rats to GI tract toxicity of oral fluorouracil anti-cancer drugs.
Google Patents: Copper orotate
PubMed: Bis(triphenylphosphine)copper(I) Complexes of Orotate and L-Dihydroorotate.
PubMed: Role of magnesium cations in the yeast orotate phosphoribosyltransferase catalyzed reaction. Mechanism of the inhibition by Cu++ and Ni++ ions.
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