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Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | pale yellow to brown needles (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 177.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 495.00 to 496.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 489.00 °F. TCC ( 253.70 °C. ) (est)
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| logP (o/w): | 3.440 |
| Soluble in: |
| | alcohol | | | water, 500 mg/L @ 25 °C (exp) |
| Insoluble in: |
| | water |
Organoleptic Properties:
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| Odor Type: odorless |
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| | odorless |
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| Flavor Type: bitter |
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| | bitter |
Taste Description:
| bitter |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-cat LDLo 100 mg/kg Rivista di Malariologia. Vol. 11, Pg. 3, 1932.
intramuscular-frog LDLo 400 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
oral-frog LDLo 1500 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
oral-guinea pig LD50 1800 mg/kg Schweizerische Medizinische Wochenschrift. Vol. 84, Pg. 351, 1954.
unreported-man LDLo 294 mg/kg "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
intraperitoneal-mouse LD50 115 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1760, 1985.
intravenous-mouse LD50 68 mg/kg Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991.
intravenous-rabbit LDLo 70 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
oral-rabbit LDLo 500 mg/kg Rivista di Malariologia. Vol. 11, Pg. 3, 1932.
intraperitoneal-rat LD > 100 mg/kg Cancer Research. Vol. 52, Pg. 2797, 1992.
oral-rat LDLo 800 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 408, 1950.
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| Dermal Toxicity: |
subcutaneous-cat LDLo 100 mg/kg Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 205, Pg. 129, 1948.
subcutaneous-dog LDLo 180 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
subcutaneous-frog LDLo 200 mg/kg BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 205, Pg. 129, 1948.
subcutaneous-mouse LDLo 200 mg/kg BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA
BLOOD: OTHER CHANGES
CARDIAC: OTHER CHANGES Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 205, Pg. 129, 1948.
subcutaneous-rabbit LDLo 231 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
subcutaneous-rat LDLo 200 mg/kg CARDIAC: OTHER CHANGES
BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA
BLOOD: OTHER CHANGES Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 205, Pg. 129, 1948.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | cosmetic agents |
| Recommendation for quinine usage levels up to: | | | not for fragrance use.
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| Recommendation for quinine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 130-95-0 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 3034034 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol |
| Chemidplus: | 0000130950 |
| RTECS: | VA6020000 for cas# 130-95-0 |
References:
| | (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 130-95-0 |
| Pubchem (cid): | 3034034 |
| Pubchem (sid): | 134973208 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | chinin | | | cinchonan-9-ol, 6'-methoxy-, (3a,8a,9R)- | | | cinchonan-9-ol, 6'-methoxy-, (8a,9R)- | | (R)-[(2S,4S,5R)-5- | ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol | | (R)-(6- | methoxy-4-chinolinyl)[(2S,4S,5R)-5-vinyl-1-azabicyclo[2.2.2]oct-2-yl]methanol | | (R)-(6- | methoxy-4-quinolinyl)[(2S,4S,5R)-5-vinyl-1-azabicyclo[2.2.2]oct-2-yl]methanol | | (3a,8a,9R)-6'- | methoxycinchonan-9-ol | | (8a,9R)-6'- | methoxycinchonan-9-ol | | 6'- | methoxycinchonan-9-ol | | (8S,9R)- | quinine | | (R)-(-)- | quinine |
Articles:
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