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Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystals (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 293.00 to 296.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 225.77 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.031000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 195.00 °F. TCC ( 90.30 °C. ) (est)
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| logP (o/w): | 0.799 (est) |
| Soluble in: |
| | water, 1.18E+04 mg/L @ 25 °C (exp) | | | water, 1.538e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
Odor Description:
| odorless |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | information only not used for fragrances or flavors |
| Recommendation for dextro,laevo-leucine usage levels up to: | | | not for fragrance use.
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| Recommendation for dextro,laevo-leucine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | amino-4-methylpentanoic acid | | DL-2- | amino-4-methylpentanoic acid | | 2- | amino-4-methylvaleric acid | | DL-2- | amino-4-methylvaleric acid | | a- | aminoisocaproic acid | | (±)- | leucine | | (RS)- | leucine | | | leucine, DL- | | | pentanoic acid, 2-amino-4-methyl- | | | valeric acid, 2-amino-4-methyl- |
Articles:
| PubMed: | Isolation and characterization of awamori yeast mutants with l-leucine accumulation that overproduce isoamyl alcohol. |
| PubMed: | Thiol-ene click chemistry derived cationic cyclodextrin chiral stationary phase and its enhanced separation performance in liquid chromatography. |
| PubMed: | The treatment and natural course of peripheral and central vertigo. |
| PubMed: | Intermolecular vibrations in hydrophobic amino acid crystals: experiments and calculations. |
| PubMed: | Effects of acetyl-DL-leucine in patients with cerebellar ataxia: a case series. |
| PubMed: | One-step synthesis of silver/dopamine nanoparticles and visual detection of melamine in raw milk. |
| PubMed: | Non-ionic surfactant modified ligand exchange chromatography using copper (II) complex of N,N-dimethyl-L-phenylalanine as the chiral additive for enantioselective amino acids separation. |
| PubMed: | Dual role of hydrophobic racemic thioesters of alpha-amino acids in the generation of isotactic peptides and co-peptides in water; implications for the origin of homochirality. |
| PubMed: | Highly sensitive detection of chiral amino acids by CE based on on-line stacking techniques. |
| PubMed: | Mixed ligand complexes of benzimidazole and pyrimidine hydroxy azo dyes with some transition metals and glycine, dl-alanine or dl-leucine. |
| PubMed: | Effects of acetyl-DL-leucine in vestibular patients: a clinical study following neurotomy and labyrinthectomy. |
| PubMed: | Oligopeptides and copeptides of homochiral sequence, via beta-sheets, from mixtures of racemic alpha-amino acids, in a one-pot reaction in water; relevance to biochirogenesis. |
| PubMed: | Direct lung delivery of a dry powder formulation of DTPA with improved aerosolization properties: effect on lung and systemic decorporation of plutonium. |
| PubMed: | Partial molar volumes of some alpha-amino acids in aqueous sodium acetate solutions at 308.15 K. |
| PubMed: | Isolation of Saccharomyces cerevisiae strains producing higher levels of flavoring compounds for production of "cachaça" the Brazilian sugarcane spirit. |
| PubMed: | Asp578 in LEU4p is one of the key residues for leucine feedback inhibition release in sake yeast. |
| PubMed: | Construction of two new vectors for transformation of laboratory, natural and industrial Saccharomyces cerevisiae strains to trifluoroleucine and G418 resistance. |
| PubMed: | Evaluation of in vitro antimicrobial and in vivo cytotoxic properties of some novel titanium-based coordination complexes. |
| PubMed: | Viscosity behavior of some alpha-amino acids and their groups in water-sodium acetate mixtures. |
| PubMed: | Autoradiography in brain of Macaca fascicularis monkeys after injection of acetyl-DL-leucine [2-14C] (Tanganil). |
| PubMed: | Supported liquid membrane stability in chiral resolution by chemically and physically modified membranes. |
| PubMed: | Cryo-bioorganic chemistry: freezing effect on stereoselection of L- and DL-leucine cooligomerization in aqueous solution. |
| PubMed: | In vitro effects of acetyl-DL-leucine (tanganil) on central vestibular neurons and vestibulo-ocular networks of the guinea-pig. |
| PubMed: | Racemic dipeptide glycyl-DL-leucine at 120 K. |
| PubMed: | Effect of temperature on viscosity properties of some alpha-amino acids in aqueous urea solutions. |
| PubMed: | Direct thin layer chromatography enantioresolution of some basic DL-amino acids using a pharmaceutical industry waste as chiral impregnating reagent. |
| PubMed: | Trifluoroleucine resistance as a dominant molecular marker in transformation of strains of Saccharomyces cerevisiae isolated from wine. |
| PubMed: | Trifluoroleucine resistance and regulation of alpha-isopropyl malate synthase in Saccharomyces cerevisiae. |
| PubMed: | [Effects of acetyl-DL-leucine on the recovery of the locomotor equilibrium and spontaneous discharge of lateral vestibular nucleus neurons in unilateral vestibular neurectomized cats]. |
| PubMed: | DL-leucine transport in a Saccharomyces cerevisiae mutant resistant to quaternary ammonium salts. |
| PubMed: | Enhanced formation of isoamyl alcohol in Zygosaccharomyces rouxii due to elimination of feedback inhibition of alpha-isopropylmalate synthase. |
| PubMed: | [Drug therapy of vertigo]. |
| PubMed: | On the 13C CP/MAS spectra of leucine. |
| PubMed: | Production and immobilization of D-aminoacylase of Alcaligenes faecalis DA1 for optical resolution of N-acyl-DL-amino acids. |
| PubMed: | Retinamides: hydrolytic conversion of retinoylglycine to retinoic acid in pregnant mice contributes to teratogenicity. |
| PubMed: | Genetic analysis of the Pseudomonas aeruginosa PAO high-affinity branched-chain amino acid transport system by use of plasmids carrying the bra genes. |
| PubMed: | Thiol-based inhibitors of mammalian collagenase. Substituted amide and peptide derivatives of the leucine analogue, 2-[(R,S)-mercaptomethyl]-4-methylpentanoic acid. |
| PubMed: | Inhibition of Moloney murine lymphoma and sarcoma growth in vivo by dietary retinoids. |
| PubMed: | Production of d-Aminoacylase from Alcaligenes denitrificans subsp. xylosoxydans MI-4. |
| PubMed: | Toxicologic and immunologic evaluations of N-(all-trans-retinoyl)-DL-leucine and N-(all-trans-retinoyl)glycine. |
| PubMed: | Production and Purification of d-Aminoacylase from Alcaligenes denitrificans and Taxonomic Study of the Strain. |
| PubMed: | Soft agar colony formation of bladder cells during carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine and application to detection of bladder cancer promoters. |
| PubMed: | Characterization of novel viral polyproteins detected in cells infected by the flavivirus Kunjin and radiolabelled in the presence of the leucine analogue hydroxyleucine. |
| PubMed: | Models of molecular evolution. 2. Stereospecificity of dipeptide syntheses by means of cyanamides and carbodiimides. |
| PubMed: | A comparison of cationic polymerization and esterification for end-point detection in the catalytic thermometric titration of organic bases. |
| PubMed: | [Comparative distribution study of 14C labeled amino acids, glucose-analogue and precursor of nuclei acid, as tumor seeking agents]. |
| PubMed: | On the stereoselective aminoacylation of RNA. |
| PubMed: | Beta-decay, bremsstrahlen, and the origin of molecular chirality. |
| PubMed: | Metabolism of leucine by the isolated perfused goat udder. |
| PubMed: | Evidence that repression mechanisms can exert control over the thr, leu, and ilv operons of Escherichia coli K-12. |
| PubMed: | Rapid enzymatic preparation of [14C]D-leucine from [14C]DL-leucine. |
| PubMed: | The radiolysis and racemization of leucine on proton irradiation. |
| PubMed: | Search for effect of longitudinally polarized protons on optically active amino acid. |
| PubMed: | Liver microsomal drug-metabolizing enzyme activity: enhancement by blockade of degradative processes in promethazine-treated rats. |
| PubMed: | The radiolysis of tryptophan and leucine with 32P beta-radiation. |
| PubMed: | Th activities of perfused livers of control and streptozotocin diabetic rats in the synthesis of some plasma proteins and peptides. |
| PubMed: | [Effect of raised temperatures on the protein and RNA synthesis rate in yeasts]. |
| PubMed: | [Effect of increased temperatures on RNA and protein synthesis in the cells of a synchronous Candida utilis culture]. |
| PubMed: | [Synthesis of amino acid antipyrine-4-amides. II. 4-antipyrinamides of DL-leucine, phenylalanine, tyrosine, glutaminic acid and epsilon-aminocaproic acid]. |
| PubMed: | Asymmetric degradation of DL-leucine with longitudinally polarised electrons. |
| PubMed: | Asymmetric degradation of DL-leucine with longitudinally polarised electrons. |
| PubMed: | Raman spectra of D and L amino acid copolymers. Poly-DL-alanine, poly-DL-leucine, and poly-DL-lysine. |
| PubMed: | Distribution of lactic dehydrogenase in X-irradiated tissues. |
| PubMed: | Differences in the incorporation of L- and DL-Amino acids into renal tubular cells. An autoradiographic study. |
| PubMed: | Regulation of leucine catabolism in Pseudomonas putida. |
| PubMed: | New amino acid regulatory locus having unusual properties in heterozygous merodiploids. |
| PubMed: | Oxidation of DL-3-phenylalanine-1- 14 C, DL-leucine-1- 14 C, and D-glucose-1- 14 C-6-phosphate to 14 CO 2 in human placenta. |
| PubMed: | [Incorporation in vitro of DL-leucine-1-C14 into proteins of the rat liver, kidney and diaphragm in presence of various concentrations of albumin]. |
| PubMed: | [Incorporation in vitro of DL-leucine-1-C14 into the proteins of the cells of Yoshida's ascites hepatoma and of ascitic sarcoma 180 in presence of various concentrations of albumin]. |
| PubMed: | Regulation of branched-chain amino acid biosynthesis in Salmonella typhimurium: isolation of regulatory mutants. |
| PubMed: | Effect of steroid hormones on dl-leucine-1-14C uptake by the uterus of pregnant rats maintained on a protein-free diet. |
| PubMed: | Uptake of 3-H-DL-leucine and 3-H-uridine by the caudal neurosecretory system of the loach (Misgurnus anguillicaudatus) maintained in vitro. |
| PubMed: | [Studies on the dependency upon radiation dose of microwaves saturation in electron spin resonance radiation-induced free radicals of DL-valine and DL-leucine]. |
| PubMed: | Liver adenine nucleotides: fructose-induced depletion and its effect on protein synthesis. |
| PubMed: | [Quantitative study by radioautography and electron microscopy of the utilization of DL-leucine-H3 by duck hypophyseal cells in organ culture]. |
| PubMed: | Protein biosynthesis in trypanosomidae. II. The metabolic fate of DL-leucine-1-C14 in Trypanosoma cruzi. |
| PubMed: | PROTEIN SYNTHESIS, STORAGE, AND DISCHARGE IN THE PANCREATIC EXOCRINE CELL. AN AUTORADIOGRAPHIC STUDY. |
| PubMed: | IN VIVO AND IN VITRO EFFECT OF GLUCAGON DL-LEUCINE-1-C14 INCORPORATION INTO PROTEIN OF RAT PANCREAS. |
| PubMed: | STUDIES ON THE METABOLISM OF THE RETINA AND LATERAL GENICULATE NUCLEUS. IN VIVO INCORPORATION OF H-3-DL-LEUCINE IN ALBINO RATS. |
| PubMed: | Biosynthesis of chloramphenicol. IV. Incorporation of carbon 14-labled precursors. |
| PubMed: | Studies on the metabolic function of branched-chain volatile fatty acids, growth factors for ruminococci. I. Incorporation of isovalerate into leucine. |
| PubMed: | Physiological studies of the rumen protozoan Ophryoscolex caudatus Eberlein. |
| PubMed: | [Experimental research on the behavior of vestibular function after the administration of certain drugs. II. Acetyl-DL-leucine]. |
| PubMed: | A cytochemical study on the pancreas of the guinea pig. 5. In vivo incorporation of leucine-1-C14 into the chymotrypsinogen of various cell fractions. |
| PubMed: | [Incorporation of tritium-labeled DL-leucine into the blood cells in acute leukosis and in chronic myeloid leukemia]. |
| PubMed: | [Data on protein metabolism in normal bone marrow. Incorporation of tritium-labeled DL-leucine and tritium-labeled DL-beta-phenylalanine]. |
| PubMed: | Effects of thyroxin on amino acid incorporation into protein. |
| PubMed: | A cyto-chemical study on the pancreas of the guinea pig. III. In vivo incorporation of leucine-1-C14 into the proteins of cell fractions. |
| PubMed: | [Trial therapy of labyrinthine vertigo by acetyl-DL-leucine]. |
| PubMed: | In vitro incorporation of C14-DL-leucine into normal and leukemic white cells. |
| PubMed: | Acylchlorides of amino acids and peptides as monomers for the preparation of polymeric polypeptides. I. Syntheses of poly-beta-alanine, poly-DL-alanine, poly-L-leucine and poly-glycyl-DL-leucine. |
| PubMed: | PLASMA PROTEIN PRODUCTION INFLUENCED BY AMINO ACID MIXTURES AND LACK OF ESSENTIAL AMINO ACIDS : A DEFICIENCY STATE RELATED TO UNKNOWN FACTORS. |
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