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Category: antibrowning agents, antioxidants, preservatives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) | | | alcohol, slightly |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 3560 mg/kg SKIN AND APPENDAGES (SKIN): HAIR: OTHER
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) International Journal of Toxicology. Vol. 19, Pg. 349, 2000.
oral-mouse LD50 820 mg/kg Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 27, Pg. 159, 1976.
intravenous-mouse LD50 175 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 101, 1951.
intravenous-cat LDLo 400 mg/kg Archiv fuer Hygiene. Vol. 57, Pg. 87, 1906.
intravenous-guinea pig LDLo 200 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
intraperitoneal-mouse LD50 950 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1713, 1981.
oral-rabbit LDLo 2825 mg/kg Archiv fuer Hygiene. Vol. 57, Pg. 87, 1906.
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| Dermal Toxicity: |
subcutaneous-cat LDLo 1300 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
subcutaneous-dog LDLo 1300 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
subcutaneous-guinea pig LDLo 600 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
subcutaneous-rabbit LDLo 600 mg/kg Archiv fuer Hygiene. Vol. 57, Pg. 87, 1906.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | antibrowning agents, antioxidants, preservatives |
| Recommendation for sodium sulfite usage levels up to: | | | not for fragrance use.
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| Recommendation for sodium sulfite flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Scientific Opinion on the re-evaluation of sulfur dioxide (E 220), sodium sulfite (E 221), sodium bisulfite (E 222), sodium metabisulfite (E 223), potassium metabisulfite (E 224), calcium sulfite (E 226), calcium bisulfite (E 227) and potassium bisulfite (E 228) as food additives View page or View pdf |
| EPI System: | View |
| Daily Med: | search |
| NIOSH International Chemical Safety Cards: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 7757-83-7 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 24437 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 1 |
| | disodium sulfite |
| Chemidplus: | 0007757837 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 7757-83-7 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | disodium sulfite | | | disodium sulfite (Na2SO3) | | mono | sodium sulfite | | | sodium sulfite anhydrous granular | | | sodium sulphite | | | sodiumsulfite | | | sulftech | | | sulfurous acid disodium salt | | | sulfurous acid sodium salt | | | sulfurous acid sodium salt (1:2) | | | sulfurous acid, disodium salt |
Articles:
| PubMed: | Formation and reduction of furan in a soy sauce model system. |
| PubMed: | Anaerobic digestion of wastewater from the fruit juice industry: experiments and modeling. |
| PubMed: | Fibrous polymer grafted magnetic chitosan beads with strong poly(cation-exchange) groups for single step purification of lysozyme. |
| PubMed: | Dissociation and reduction of covalent β-lactoglobulin-quinone adducts by dithiothreitol, tris(2-carboxyethyl)phosphine, or sodium sulfite. |
| PubMed: | Effects of sulfhydryl compounds, carbohydrates, organic acids, and sodium sulfite on the formation of lysinoalanine in preserved egg. |
| PubMed: | Oral drug delivery of therapeutic gases - carbon monoxide release for gastrointestinal diseases. |
| PubMed: | Reduction of carcinogenic 4(5)-methylimidazole in a caramel model system: influence of food additives. |
| PubMed: | Decreased immunoglobulin E (IgE) binding to cashew allergens following sodium sulfite treatment and heating. |
| PubMed: | Development of crayfish bio-based plastic materials processed by small-scale injection moulding. |
| PubMed: | Quantum dots as a possible oxygen sensor. |
| PubMed: | Determination of free sulfites (SO3-2) in dried fruits processed with sulfur dioxide by ion chromatography through anion exchange column and conductivity detection. |
| PubMed: | On-line redox derivatization liquid chromatography for selective separation of Fe(II) and Fe(III) cyanide complexes using porous graphitic carbon. |
| PubMed: | Formation of 4(5)-methylimidazole and its precursors, α-dicarbonyl compounds, in Maillard model systems. |
| PubMed: | Improvement and validation of the method to determine neutral detergent fiber in feed. |
| PubMed: | FdhTU-modulated formate dehydrogenase expression and electron donor availability enhance recovery of Campylobacter jejuni following host cell infection. |
| PubMed: | Optimal production of L-threo-2,3-dihydroxyphenylserine (L-threo-DOPS) on a large scale by diastereoselectivity-enhanced variant of L-threonine aldolase expressed in Escherichia coli. |
| PubMed: | Purification and characterization of polyphenol oxidase from rape flower. |
| PubMed: | Comparison of common lignin methods and modifications on forage and lignocellulosic biomass materials. |
| PubMed: | Bioplastics from feather quill. |
| PubMed: | Food additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitro. |
| PubMed: | Effect of antibrowning agents on browning and intermediate formation in the glucose-glutamic acid model. |
| PubMed: | A multipathogen selective enrichment broth for simultaneous growth of Salmonella spp., Vibrio parahaemolyticus, and Vibrio cholerae. |
| PubMed: | Rapid microplate high-throughput methodology for assessment of Folin-Ciocalteu reducing capacity. |
| PubMed: | [A multipathogen selective enrichment broth (SVV) for simultaneous growth of Salmonella, Vibrio parahaemolyticus, and Vibrio cholerae]. |
| PubMed: | Effects of sulfur dioxide derivatives on expression of oncogenes and tumor suppressor genes in human bronchial epithelial cells. |
| PubMed: | Effects of chemical composition variation on the dynamics of ruminal fermentation and biological value of corn milling (co)products. |
| PubMed: | Application of multivariate analysis to the effects of additives on chemical and sensory quality of stored coffee brew. |
| PubMed: | Determination of free and reversibly-bound sulfite in selected foods by high-performance liquid chromatography with fluorometric detection. |
| PubMed: | Kinetics of growth and leukotoxin production by Mannheimia haemolytica in continuous culture. |
| PubMed: | Texture of cooked rice prepared from aged rice and its improvement by reducing agents. |
| PubMed: | Fed-batch cultivation of the marine bacterium Sulfitobacter pontiacus using immobilized substrate and purification of sulfite oxidase by application of membrane adsorber technology. |
| PubMed: | Food preservatives sodium sulfite and sorbic acid suppress mitogen-stimulated peripheral blood mononuclear cells. |
| PubMed: | Stability of barley and malt lipid transfer protein 1 (LTP1) toward heating and reducing agents: relationships with the brewing process. |
| PubMed: | An optimized enumeration method for sorbitol-fermenting Bifidobacteria in water samples. |
| PubMed: | Comparative study on the use of ortho-phthalaldehyde, naphthalene-2,3-dicarboxaldehyde and anthracene-2,3-dicarboxaldehyde reagents for alpha-amino acids followed by the enantiomer separation of the formed isoindolin-1-one derivatives using quinine-type chiral stationary phases. |
| PubMed: | Determination of carbofuran by flow-injection with chemiluminescent detection. |
| PubMed: | Identification of factors involved in recovery of heat-injured Salmonella Enteritidis. |
| PubMed: | Evaluation of a simple membrane-based nucleic acid preparation protocol for RT-PCR detection of potato viruses from aphid and plant tissues. |
| PubMed: | [Study on extraction and stability of pigment from flowers of Leucosceptrum canum]. |
| PubMed: | Fast kinetic determination of 1-naphthylacetic acid in commercial formulations, soils, and fruit samples using stopped-flow phosphorimetry. |
| PubMed: | The effect of vitamin E supplementation on discoloration of injection-site lesions in retail cuts and the greening reaction observed in injection-site lesions in muscles of the chuck. |
| PubMed: | Determination of the amino acid tryptophan and the biogenic amine tryptamine in foods by the heavy atom induced-room temperature phosphorescence methodology. |
| PubMed: | Controlled release of oxytetracycline in sheep. |
| PubMed: | [Colorimetric determination of sulfite in "kanpyo" (dried gourd shavings) and "konnyakuseiko" (devil's-tongue fine powder) using sulfite oxidase and catalase]. |
| PubMed: | [Spore rec-assay by dry sheet medium culture plate for bacterial counts]. |
| PubMed: | Determination of the pesticide napropamide in soil, pepper, and tomato by micelle-stabilized room-temperature phosphorescence. |
| PubMed: | Sodium sulphite inhibition of potato and cherry polyphenolics in nucleic acid extraction for virus detection by RT-PCR. |
| PubMed: | [Microbiological stability study of minimally processed cantaloupe (Cucumis melo L) by vacuum]. |
| PubMed: | Analysis and stability of carotenoids in the flowers of daylily (Hemerocallis disticha) as affected by various treatments. |
| PubMed: | Method for the Quantitative Determination of 1-Naphthaleneacetic Acid in Spiked Canned Pineapple Samples by Micelle-Stabilized Room Temperature Phosphorescence. |
| PubMed: | [In vitro study of the interference of certain food components with the metabolism of aflatoxin B1]. |
| PubMed: | Protein insolubilization and thiol oxidation in sulfite-treated wheat gluten films during aging at various temperatures and relative humidities. |
| PubMed: | Chemistry, biochemistry, nutrition, and microbiology of lysinoalanine, lanthionine, and histidinoalanine in food and other proteins. |
| PubMed: | Activation of the superoxide-generating NADPH oxidase of intestinal lymphocytes produces highly reactive free radicals from sulfite. |
| PubMed: | Lysinoalanine in food and in antimicrobial proteins. |
| PubMed: | Growth and toxin production by Clostridium botulinum on sliced raw potatoes in a modified atmosphere with and without sulfite. |
| PubMed: | Effects of sodium sulfite on recovery and composition of detergent fiber and lignin. |
| PubMed: | Enhancement of ethylenethiourea recoveries in food analyses by addition of cysteine hydrochloride. |
| PubMed: | Evaluation of phototoxic properties of some food additives: sulfites exhibit prominent phototoxicity. |
| PubMed: | Evaluation of teratogenic potential of sodium sulfite in rats. |
| PubMed: | [Inhibition of methanogenesis in the rumen of sheep. II. Methanogenesis after administration of inhibitors]. |
| PubMed: | Sulfite suppresses the mutagenic property of coffee. |
| PubMed: | Cytogenetic effects of the food preservatives--sodium benzoate and sodium sulphite on Vicia faba root meristems. |
| PubMed: | DNA and its precursors might interact with the food preservatives, sodium sulphite and sodium benzoate. |
| PubMed: | Rapid screening procedure for the determination of preservatives in ground beef: sulfites, benzoates, sorbates, and ascorbates. |
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