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Category: multiple purpose GRAS food substances, acidity regulators
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
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| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| | FDA/DG SANTE Petitions, Reviews, Notices: |
| 1975 | Sodium phosphate dibasic View - review |
| EU SANCO | Sodium phosphates View - review |
| JECFA Food Additive: | Disodium Hydrogen Phosphate |
| GSFA Codex: | Disodium hydrogen phosphate (339(ii)) |
| FEMA Number: | 2398 disodium phosphate |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 7558-79-4 ; SODIUM PHOSPHATE, DIBASIC |
| FDA Regulation: | FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS Subpart B--Requirements for Specific Standardized Cheese and Related Products Sec. 133.169 Pasteurized process cheese.
FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS Subpart B--Requirements for Specific Standardized Cheese and Related Products Sec. 133.173 Pasteurized process cheese food.
FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS Subpart B--Requirements for Specific Standardized Cheese and Related Products Sec. 133.179 Pasteurized process cheese spread.
FDA PART 135 -- FROZEN DESSERTS Subpart B--Requirements for Specific Standardized Frozen Desserts Sec. 135.110 Ice cream and frozen custard.
FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products Sec. 137.305 Enriched farina.
FDA PART 139 -- MACARONI AND NOODLE PRODUCTS Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products Sec. 139.110 Macaroni products.
FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products Sec. 150.141 Artificially sweetened fruit jelly.
FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products Sec. 150.161 Artificially sweetened fruit preserves and jams.
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Subpart D--Specific Usage Additives Sec. 173.310 Boiler water additives.
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS Subpart C--Substances for Use as Components of Coatings Sec. 175.210 Acrylate ester copolymer coating.
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS Subpart C--Substances for Use as Components of Coatings Sec. 175.300 Resinous and polymeric coatings.
FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS Subpart B--Specific Prior-Sanctioned Food Ingredients Sec. 181.29 Stabilizers.
FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE Subpart B--Multiple Purpose GRAS Food Substances Sec. 182.1778 Sodium phosphate.
FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE Subpart G--Sequestrants1 Sec. 182.6290 Disodium phosphate.
FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE Subpart G--Sequestrants1 Sec. 182.6778 Sodium phosphate.
FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE Subpart I--Nutrients Sec. 182.8778 Sodium phosphate.
FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Subpart A--Foods Sec. 73.85 Caramel.
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Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 240.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 158.00 °C. @ 760.00 mm Hg (est)
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| PH Number: | 8.90
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| Vapor Pressure: | 1.410000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 4.9 ( Air = 1 ) |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| logP (o/w): | -2.148 (est) |
| Shelf Life: | 24.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. store under nitrogen. |
| Storage: | store under nitrogen. |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
| Insoluble in: |
| | alcohol |
Organoleptic Properties:
| Odor Strength: | none |
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Odor Description: at 100.00 %. | odorless Luebke, William tgsc, (2007) |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| Allan Chemical |
| Sodium Phosphate Dibasic
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| American Elements |
| Sodium Phosphate Dibasic 99%
Odor: characteristic Use: Sodium Phosphate Dibasic is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards. |
| American International Chemical, LLC. |
| DISODIUM PHOSPHATE ANHYDROUS FCC GRANULAR
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| BOC Sciences |
| For experimental / research use only. |
| Disodium hydrogenorthophosphate dibasic, 98%
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| Charkit Chemical |
| SODIUM PHOSPHATE DIBASIC ACS/USP
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| Dow Chemical |
| Sodium Phos Dibasic Anhydrous ACS/USP
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| ECSA Chemicals |
| DI-SODIUM HYDROGEN PHOSPHATE ANHYDROUS RPE-A
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| ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
| ECSA Chemicals |
| DISODIUM HYDROGENORTHOPHOSPHATE HEPTAHYDRATE PH.
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| ECSA Chemicals |
| DISODIUM PHOSPHATE E399 (ii)
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| ECSA Chemicals |
| DISODIUM PHOSPHATE
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| Foodchem International |
| Disodium Phosphate
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| Glentham Life Sciences |
| di-Sodium hydrogen phosphate anhydrous, EP, USP grade
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| Glentham Life Sciences |
| di-Sodium hydrogen phosphate, anhydrous
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| Graham Chemical |
| Disodium Phosphate
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| Jost Chemical |
| Sodium Phosphate Dibasic Anhydrous ACS Granular
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| Jost Chemical |
| Sodium Phosphate Dibasic Anhydrous USP Granular
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| Kraft Chemical |
| Disodium Phosphate
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| Penta International |
| SODIUM PHOSPHATE DIBASIC ANHYDROUS POWDER FCC
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| Penta International |
| SODIUM PHOSPHATE DIBASIC DRIED POWDER USP/NF
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| Prinova |
| Disodium Phosphate Anhydrous
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| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Sodium Phosphate, Dibasic ≥99%
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| Sigma-Aldrich |
| Sodium phosphate dibasic, 99%, FG
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| Certified Food Grade Products |
| Tianjin Talent Chemical |
| Disodium Phosphate
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| Wedor Corporation |
| DISODIUM PHOSPHATE
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| Zhong Ya Chemical |
| Sodium Phosphate, Di
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Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 17000 mg/kg Luebke, William tgsc, (2007)
intravenous-rabbit LDLo 1075 mg/kg BEHAVIORAL: TETANY Handbuch der Experimentellen Pharmakologie. Vol. 10, Pg. 361, 1950.
oral-rat LD50 17000 mg/kg "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 16, 1972.
intramuscular-rat LDLo 1000 mg/kg Biochemische Zeitschrift. Vol. 163, Pg. 226, 1925.
intraperitoneal-rat LDLo 1000 mg/kg Biochemische Zeitschrift. Vol. 163, Pg. 226, 1925.
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| Dermal Toxicity: |
subcutaneous-rat LDLo 1000 mg/kg Biochemische Zeitschrift. Vol. 163, Pg. 226, 1925.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | multiple purpose GRAS food substances, acidity regulators |
| Recommendation for disodium phosphate usage levels up to: | | | not for fragrance use.
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| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3 |
| Click here to view publication 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 2300.00000 |
| beverages(nonalcoholic): | - | 350.00000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 350.00000 |
| fruit ices: | - | 350.00000 |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | 50.00000 | 250.00000 |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Scientific Opinion on the safety evaluation of the active substances, iron, polyethyleneglycol, disodium pyrophosphate, monosodium phosphate and sodium chloride for use in food contact materials View page or View pdf |
Assessment of one published review on health risks associated with phosphate additives in food View page or View pdf |
Re-evaluation of phosphoric acid–phosphates – di-, tri- and polyphosphates (E 338–341, E 343, E 450–452) as food additives and the safety of proposed extension of use View page or View pdf |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| NIOSH International Chemical Safety Cards: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 7558-79-4 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 24203 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WISER: | UN 3077 |
| WGK Germany: | 1 |
| | disodium hydrogen phosphate |
| Chemidplus: | 0007558794 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 7558-79-4 |
References:
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C13558 |
| HMDB (The Human Metabolome Database): | Search |
| FooDB: | FDB013359 |
| Export Tariff Code: | 2835.22.0000 |
| FDA Listing of Food Additive Status: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations: •sodium phosphates injection, usp, 3 mm pml (millimolesml)each ml contains 276 mg of monobasic sodium phosphate, monohydrate and 142 mg of dibasic sodium phosphate, anhydrous (equivalent to 268 mg of dibasic sodium phosphate, heptahydrate). it contains no bacteriostat, antimicrobial agent or added buffer.
•sodium phosphate preparations: (ahfs, 2009)
sodium phosphate preparations: (ahfs, 2009)
route
dosage form
strength
brand or generic name (manufacturer)
tablet
dibasic sodium phosphate (anhydrous) 0.398 g with monobasic sodium phosphate (monohydrate) 1.102 g
osmoprep (salix)
tablet
dibasic sodium phosphate (anhydrous) 0.398 g with monobasic sodium phosphate (monohydrate) 1.102 g
visicol (salix)
rectal
solution
dibasic sodium phosphate 60 mgml with monobasic sodium phosphate 160 mgml
fleet enema (fleet)
rectal
solution
dibasic sodium phosphate 60 mgml with monobasic sodium phosphate 160 mgml
fleet pediatric enema (fleet)
•visicol (sodium phosphate monobasic monohydrate, usp, and sodium phosphate dibasic anhydrous, usp)each tablet contains 1.102 grams of sodium phosphate monobasic monohydrate, usp and 0.398 grams of sodium phosphate dibasic anhydrous, usp for a total of 1.5 grams of sodium phosphate per tablet. inert ingredients include microcrystalline cellulose (mcc), nf; magnesium stearate, nf; and colloidal silicon dioxide, nf. visicol is gluten-free.
•sodium phosphate and sodium biphosphate enema usp dosage forms-- enema usp: 6% sodium phosphate and 16% sodium biphosphate; sodium phosphate and sodium biphosphate oral solution usp dosage forms-- solution usp: 18% sodium phosphate and 48% sodium biphosphate.
•sorensen's phosphate, sorensen's sodium phosphate. disodium phosphate dihydrate
•fleet's enema: solution (sodium phosphate 6 g and sodium biphosphate 16 g). fleet's phospho-soda: (sodium phosphate 18 g and sodium biphosphate 48 g).
•an oral soln (fleet phospho-soda) contains 1.8 g of dibasic sodium phosphate and 4.8 g of monobasic sodium phosphate in 10 ml saline laxatives
•grade: commercial, nf national formulary grade of chemical (sodium phosphate, dibasic anhydrous and heptahydrate), fcc food chemicals codex (sodium phosphate, dibasic anhydrous or dihydrate)
•available as anhydrous or dihydric salts.
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Potential Blenders and core components note
Potential Uses:
| | anticorrosive agents | |
| | buffering agents | |
Occurrence (nature, food, other): note
Synonyms:
| | disodium hydrogen phosphate | | | disodium phosphate (food grade) | | | disodium phosphate anhydrous | | | disodium phosphate anhydrous FCC granular | | | phosphoric acid disodium salt | | | sodium monohydrogen phosphate (2:1:1) | | | sodium phosphate (NaHPO4) | | | sodium phosphate dibasic | | | sodium phosphate dibasic anhydrous ACS | | | sodium phosphate dibasic anhydrous powder FCC | | | sodium phosphate dibasic anhydrous ultra pure | | | sodium phosphate dibasic anhydrous USP | | | sodium phosphate dibasic dried powder USP/NF | | | sodium phosphate, di |
Articles:
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