conessine
N,N-dimethylcon-5-enin-3-amine
 
Notes:
None found
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      546-06-5 CONESSINE 95%
       
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CAS Number: 546-06-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 208-897-2
FDA UNII: EZ38J9BBDF
Nikkaji Web: J6.427K
Beilstein Number: 4702160
MDL: MFCD00016752
XlogP3-AA: 4.90 (est)
Molecular Weight: 356.59680000
Formula: C24 H40 N2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 125.50 °C. @ 760.00 mm Hg
Boiling Point: 450.43 °C. @ 760.00 mm Hg (est)
Flash Point: 391.00 °F. TCC ( 199.60 °C. ) (est)
logP (o/w): 6.060 (est)
Soluble in:
 water, 2.352 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
CONESSINE 95%
ExtraSynthese
For experimental / research use only.
Conessine
Penta International
CONESSINE
Santa Cruz Biotechnology
For experimental / research use only.
Conessine
Sigma-Aldrich: Sigma
For experimental / research use only.
Conessine ≥97% (HPLC)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LDLo  208 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 373, 1936.

Dermal Toxicity:
subcutaneous-guinea pig LDLo 138 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 373, 1936.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for conessine usage levels up to:
 not for fragrance use.
 
Recommendation for conessine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 441082
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0000546065
RTECS: GK7621000 for cas# 546-06-5
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References:
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 441082
Pubchem (sid): 135030592
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C06545
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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Synonyms:
 conessin
 connessine
N,N-dimethylcon-5-enin-3-amine
 konessin
 neriine
 roquessine
 wrightine
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Articles:
PubMed: Holarrhena antidysenterica Extract and Its Steroidal Alkaloid, Conessine, as Resistance-Modifying Agents Against Extensively Drug-Resistant Acinetobacter baumannii.
PubMed: Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica.
PubMed: Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships.
PubMed: Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani.
PubMed: Antimicrobial activity of the methanolic bark extract of Holarrhena pubescens (Buch. Ham), its fractions and the pure compound conessine.
PubMed: Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships.
PubMed: The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.
PubMed: Novel H3 receptor antagonists with improved pharmacokinetic profiles.
PubMed: Development and validation of a visible absorption densitometry method for quantitation of conessine in Holarrhena antidysenterica (Kurchi).
PubMed: Chromatographic analysis of Kutajarista--an ayurvedic polyherbal formulation.
PubMed: A new family of H3 receptor antagonists based on the natural product Conessine.
PubMed: High-performance thin layer chromatography method for estimation of conessine in herbal extract and pharmaceutical dosage formulations.
PubMed: A new family of histamine H3 receptor antagonists based on a natural product: discovery, SAR, and properties of the series.
PubMed: Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL.
PubMed: Antibacterial activities of the extracts and conessine from Holarrhena floribunda G. Don. (Apocynaceae).
PubMed: Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.
PubMed: Highly enantioselective construction of fused pyrrolidine systems that contain a quaternary stereocenter: concise formal synthesis of (+)-conessine.
PubMed: Alkaloid production by plant cell cultures of Holarrhena antidysenterica: II. Effect of precursor feeding and cultivation in stirred tank bioreactor.
PubMed: Alkaloid production by plant cell suspension cultures of Holarrhena antidysenterica: I. Effect of major nutrients.
PubMed: Alkaloids in the tissue culture of Holarrhena antidysenterica.
PubMed: [Changes in conessine in stem bark of Holarrhena floribunda in Burkina Faso].
PubMed: Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models.
PubMed: [Steroidal alkaloids 98. Chemical constitution of the seeds of Holarrhena floribunda (G. Don) Dur. and Schiz: cycloartenol, nor-31 lanosterol, dehydro-24 lophenol, desmosterol and steroidal alkaloids: conessine, isoconessimine, conamine and conarrhimine].
PubMed: [Steroid alkaloids. LXXXIV. (25). Synthesis of 18-hydroxyprogesterone and 18-nor-13 beta hydroxyprogesterone from conessine].
PubMed: [On biosynthesis of steroid derivatives in the plant kingdom. 9. Biosynthesis of conessine from pregnenolone].
PubMed: [Steroidal alkaloids. LXX. Acid rearrangements of conessine: neoconessine and novoconessine].
PubMed: [Steroidal alkaloids. 58. Westphalen rearrangement of conessine derivatives. Alloconessine].
PubMed: [Steroidal alkaloids. LXIX. Acid catalyzed rearrangements of conessine. Structure of isoconessine].
PubMed: Microbiological transformation of conessine. II.
PubMed: [Steroid alkaloids. 53. Synthesis of dihydro-4,5 hydroxy-18 progesterone and nor-18 hydroxy-13 dihydro-4,5 progesterone starting with conessine].
PubMed: The microbiological oxidation of conessine.
PubMed: [Effects of isoconessine and neoconessine on Endamoeba histolytica in vitro, as compared with conessine and emetine].
PubMed: [Two recent cases of psychic manifestation caused by conessine].
PubMed: [Conessine (hydrobromide) conessini hydrobromidum: bibromhydrate of conessine].
PubMed: [Aminohydroxyconessine dihydrobromide in therapy of intestinal or hepatic amebiasis; results obtained].
PubMed: [New orientation and new therapeutic weapons in the therapy of intestinal amebiasis].
PubMed: [Dibromhydr Amino-oxyconessine dibromhydrate in the treatment of intestinal or hepatic amebiasis; results].
PubMed: [New therapy of intestinal amebiasis].
PubMed: [On a new acquisition in phytotherapy: Holarrhena floribunda and its principal alkaloid: conessine].
PubMed: [Emetine resistant amebiasis, a major indication for conessine].
PubMed: [Further notes on the Congress of Amebiasis].
PubMed: [Conessine in therapy of intestinal amebiasis].
PubMed: [Considerations of the slowness of urinary elimination of conessine].
PubMed: [Conessine in the treatment of vaginitis due to Trichomonas].
PubMed: [Experimental studies on conessine. VI. Comparison of experimental and clinical results of emetine and conessine].
PubMed: [Experimental studies on conessine. V. Action of hydrochlorides of conessine or emetine on cultures of Entamoeba dysenteriae].
PubMed: [Experimental studies of conessine. Cultures of dysenteric amoeba in mediums to which chlorhydrates of conessine or emetine were previously added].
PubMed: [Experimental studies of conessine. Comparative study of the culture medium of dysenteric amoeba after addition of chlorhydrates of conessine or emetine].
PubMed: [Distribution and fixation time of conessine in the organs of the monkey].
PubMed: [Experimental studies on conessine. II. Elimination of conessine in man during treatment of amebic dysentery].
PubMed: [Two cases of amebic hepatitis treated by conessine chlorhydrate].
PubMed: [Practical therapeutic experiments with conessine].
PubMed: [Psychic disturbances observed during treatment with conessine].
PubMed: [Conessine bromohydrate].
PubMed: [Treatment of amebiasis with conessine].
PubMed: [Not Available].
PubMed: [Not Available].
PubMed: [Not Available].
PubMed: [Not Available].
PubMed: [Not Available].
PubMed: [Not Available].
PubMed: [Not Available].
PubMed: [Not Available].
PubMed: [Not Available].
PubMed: A comparison of the irritant action of conessine, isoconessine, and neoconessine.
PubMed: The pharmacological properties of conessine, isoconessine and neoconessine.
PubMed: Constitution of conessine.
PubMed: [Not Available].
PubMed: [Not Available].
PubMed: [Not Available].
PubMed: Observations on the Amoebicidal Action of Conessine.
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