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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 125.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 450.43 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 391.00 °F. TCC ( 199.60 °C. ) (est)
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| logP (o/w): | 6.060 (est) |
| Soluble in: |
| | water, 2.352 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LDLo 208 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 373, 1936.
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| Dermal Toxicity: |
subcutaneous-guinea pig LDLo 138 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 373, 1936.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for conessine usage levels up to: | | | not for fragrance use.
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| Recommendation for conessine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | conessin | | | connessine | | N,N- | dimethylcon-5-enin-3-amine | | | konessin | | | neriine | | | roquessine | | | wrightine |
Articles:
| PubMed: | Holarrhena antidysenterica Extract and Its Steroidal Alkaloid, Conessine, as Resistance-Modifying Agents Against Extensively Drug-Resistant Acinetobacter baumannii. |
| PubMed: | Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica. |
| PubMed: | Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships. |
| PubMed: | Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani. |
| PubMed: | Antimicrobial activity of the methanolic bark extract of Holarrhena pubescens (Buch. Ham), its fractions and the pure compound conessine. |
| PubMed: | Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships. |
| PubMed: | The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. |
| PubMed: | Novel H3 receptor antagonists with improved pharmacokinetic profiles. |
| PubMed: | Development and validation of a visible absorption densitometry method for quantitation of conessine in Holarrhena antidysenterica (Kurchi). |
| PubMed: | Chromatographic analysis of Kutajarista--an ayurvedic polyherbal formulation. |
| PubMed: | A new family of H3 receptor antagonists based on the natural product Conessine. |
| PubMed: | High-performance thin layer chromatography method for estimation of conessine in herbal extract and pharmaceutical dosage formulations. |
| PubMed: | A new family of histamine H3 receptor antagonists based on a natural product: discovery, SAR, and properties of the series. |
| PubMed: | Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL. |
| PubMed: | Antibacterial activities of the extracts and conessine from Holarrhena floribunda G. Don. (Apocynaceae). |
| PubMed: | Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. |
| PubMed: | Highly enantioselective construction of fused pyrrolidine systems that contain a quaternary stereocenter: concise formal synthesis of (+)-conessine. |
| PubMed: | Alkaloid production by plant cell cultures of Holarrhena antidysenterica: II. Effect of precursor feeding and cultivation in stirred tank bioreactor. |
| PubMed: | Alkaloid production by plant cell suspension cultures of Holarrhena antidysenterica: I. Effect of major nutrients. |
| PubMed: | Alkaloids in the tissue culture of Holarrhena antidysenterica. |
| PubMed: | [Changes in conessine in stem bark of Holarrhena floribunda in Burkina Faso]. |
| PubMed: | Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. |
| PubMed: | [Steroidal alkaloids 98. Chemical constitution of the seeds of Holarrhena floribunda (G. Don) Dur. and Schiz: cycloartenol, nor-31 lanosterol, dehydro-24 lophenol, desmosterol and steroidal alkaloids: conessine, isoconessimine, conamine and conarrhimine]. |
| PubMed: | [Steroid alkaloids. LXXXIV. (25). Synthesis of 18-hydroxyprogesterone and 18-nor-13 beta hydroxyprogesterone from conessine]. |
| PubMed: | [On biosynthesis of steroid derivatives in the plant kingdom. 9. Biosynthesis of conessine from pregnenolone]. |
| PubMed: | [Steroidal alkaloids. LXX. Acid rearrangements of conessine: neoconessine and novoconessine]. |
| PubMed: | [Steroidal alkaloids. 58. Westphalen rearrangement of conessine derivatives. Alloconessine]. |
| PubMed: | [Steroidal alkaloids. LXIX. Acid catalyzed rearrangements of conessine. Structure of isoconessine]. |
| PubMed: | Microbiological transformation of conessine. II. |
| PubMed: | [Steroid alkaloids. 53. Synthesis of dihydro-4,5 hydroxy-18 progesterone and nor-18 hydroxy-13 dihydro-4,5 progesterone starting with conessine]. |
| PubMed: | The microbiological oxidation of conessine. |
| PubMed: | [Effects of isoconessine and neoconessine on Endamoeba histolytica in vitro, as compared with conessine and emetine]. |
| PubMed: | [Two recent cases of psychic manifestation caused by conessine]. |
| PubMed: | [Conessine (hydrobromide) conessini hydrobromidum: bibromhydrate of conessine]. |
| PubMed: | [Aminohydroxyconessine dihydrobromide in therapy of intestinal or hepatic amebiasis; results obtained]. |
| PubMed: | [New orientation and new therapeutic weapons in the therapy of intestinal amebiasis]. |
| PubMed: | [Dibromhydr Amino-oxyconessine dibromhydrate in the treatment of intestinal or hepatic amebiasis; results]. |
| PubMed: | [New therapy of intestinal amebiasis]. |
| PubMed: | [On a new acquisition in phytotherapy: Holarrhena floribunda and its principal alkaloid: conessine]. |
| PubMed: | [Emetine resistant amebiasis, a major indication for conessine]. |
| PubMed: | [Further notes on the Congress of Amebiasis]. |
| PubMed: | [Conessine in therapy of intestinal amebiasis]. |
| PubMed: | [Considerations of the slowness of urinary elimination of conessine]. |
| PubMed: | [Conessine in the treatment of vaginitis due to Trichomonas]. |
| PubMed: | [Experimental studies on conessine. VI. Comparison of experimental and clinical results of emetine and conessine]. |
| PubMed: | [Experimental studies on conessine. V. Action of hydrochlorides of conessine or emetine on cultures of Entamoeba dysenteriae]. |
| PubMed: | [Experimental studies of conessine. Cultures of dysenteric amoeba in mediums to which chlorhydrates of conessine or emetine were previously added]. |
| PubMed: | [Experimental studies of conessine. Comparative study of the culture medium of dysenteric amoeba after addition of chlorhydrates of conessine or emetine]. |
| PubMed: | [Distribution and fixation time of conessine in the organs of the monkey]. |
| PubMed: | [Experimental studies on conessine. II. Elimination of conessine in man during treatment of amebic dysentery]. |
| PubMed: | [Two cases of amebic hepatitis treated by conessine chlorhydrate]. |
| PubMed: | [Practical therapeutic experiments with conessine]. |
| PubMed: | [Psychic disturbances observed during treatment with conessine]. |
| PubMed: | [Conessine bromohydrate]. |
| PubMed: | [Treatment of amebiasis with conessine]. |
| PubMed: | [Not Available]. |
| PubMed: | [Not Available]. |
| PubMed: | [Not Available]. |
| PubMed: | [Not Available]. |
| PubMed: | [Not Available]. |
| PubMed: | [Not Available]. |
| PubMed: | [Not Available]. |
| PubMed: | [Not Available]. |
| PubMed: | [Not Available]. |
| PubMed: | A comparison of the irritant action of conessine, isoconessine, and neoconessine. |
| PubMed: | The pharmacological properties of conessine, isoconessine and neoconessine. |
| PubMed: | Constitution of conessine. |
| PubMed: | [Not Available]. |
| PubMed: | [Not Available]. |
| PubMed: | [Not Available]. |
| PubMed: | Observations on the Amoebicidal Action of Conessine. |
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