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Category: special dietary and nutritional additives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
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| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| | FDA/DG SANTE Petitions, Reviews, Notices: |
| FR DOC # 2012-14263 | Gruma Corporation, Spina Bifida Association, March of Dimes Foundation, American Academy of Pediatrics, Royal DSM N.V., and National Council of La Raza; Filing of Food Additive Petition View - petition PDF |
| FR DOC # 2012-17432 | Gruma Corporation, Spina Bifida Association, March of Dimes Foundation, American Academy of Pediatrics, Royal DSM N.V., and National Council of La Raza; Filing of Food Additive Petition; Correction View - petition PDF |
| FDA Mainterm (SATF): | 59-30-3 ; FOLIC ACID |
| FDA Regulation: | FDA PART 101 -- FOOD LABELING Subpart E--Specific Requirements for Health Claims Sec. 101.79 Health claims: Folate and neural tube defects.
FDA PART 101 -- FOOD LABELING Subpart A--General Provisions Sec. 101.9 Nutrition labeling of food.
FDA PART 107 -- INFANT FORMULA Subpart D--Nutrient Requirements Sec. 107.100 Nutrient specifications.
FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products Sec. 137.165 Enriched flour.
FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products Sec. 137.185 Enriched self-rising flour.
FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products Sec. 137.260 Enriched corn meals.
FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products Sec. 137.305 Enriched farina.
FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products Sec. 137.350 Enriched rice.
FDA PART 139 -- MACARONI AND NOODLE PRODUCTS Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products Sec. 139.115 Enriched macaroni products.
FDA PART 139 -- MACARONI AND NOODLE PRODUCTS Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products Sec. 139.122 Enriched nonfat milk macaroni products.
FDA PART 139 -- MACARONI AND NOODLE PRODUCTS Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products Sec. 139.155 Enriched noodle products.
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart D--Special Dietary and Nutritional Additives Sec. 172.345 Folic acid (folacin).
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart I--Multipurpose Additives Sec. 172.896 Dried yeasts.
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Physical Properties:
| Appearance: | yellow to yellowish orange crystals (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 250.00 °C. @ 760.00 mm Hg
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| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| logP (o/w): | -0.990 (est) |
| Soluble in: |
| | water, 1.6 mg/L @ 25 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-rat LD50 500 mg/kg Drugs in Japan Vol. -, Pg. 1409, 1995.
intravenous-rabbit LD50 410 mg/kg Drugs in Japan Vol. -, Pg. 1409, 1995.
oral-mouse LD50 10000 mg/kg Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.
intravenous-mouse LD50 282 mg/kg Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.
intraperitoneal-mouse LD50 85 mg/kg BEHAVIORAL: COMA
BEHAVIORAL: MUSCLE WEAKNESS
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Experientia. Vol. 41, Pg. 72, 1985.
intravenous-guinea pig LD50 120 mg/kg Drugs in Japan Vol. -, Pg. 1409, 1995.
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| Dermal Toxicity: |
subcutaneous-mouse LDLo 200 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES
BLOOD: CHANGES IN SPLEEN Proceedings of the Society for Experimental Biology and Medicine. Vol. 71, Pg. 544, 1949.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | special dietary and nutritional additives |
| Recommendation for folic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for folic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Scientific Opinion on the safety and efficacy of folic acid as a feed additive for all animal species View page or View pdf |
Scientific Opinion on the substantiation of a health claim related to increasing maternal folate status by supplemental folate intake and reduced risk of neural tube defects pursuant to Article 14 of Regulation (EC) No 1924/2006 View page or View pdf |
Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for folate View page or View pdf |
Scientific Opinion on Dietary Reference Values for folate View page or View pdf |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 59-30-3 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6037 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 1 |
| | (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid |
| Chemidplus: | 0000059303 |
| EPA/NOAA CAMEO: | hazardous materials |
References:
| | (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 59-30-3 |
| Pubchem (cid): | 6037 |
| Pubchem (sid): | 134972291 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C00504 |
| HMDB (The Human Metabolome Database): | HMDB00121 |
| FooDB: | FDB014504 |
| FDA Listing of Food Additive Status: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations: •5 mg (base) per ml (rx) [folvite (benzyl alcohol 1.5 %)]; 10 mg per ml (rx)
•folic acid (folvite) is marketed as oral tablets containing 0.4, 0.8, and 1 mg and as an aqueous solution for injection. tablets of folic acid contain either 0.1, 0.4, 0.8, or 1 mg of pteroylglutamic acid, as an aqueous solution for injection, and in combination with other vitamins and minerals
•injectable solutions are prepared by dissolving folic acid in normal sodium bicarbonate solution (which should be sterilized by filtration) or by preparing solutions of the sodium or methylglucamine salt.
•lexpec folic acid. syrup containing folic acid 2.5 mg in each 5 ml (recommended diluent, sorbitol solution or sorbitol solution and water, equal parts).
•10% feed grade, usp
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| N-(4-(((2- | amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid | | N-(4-((2- | amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid | | N-(4-((2- | amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-laevo-glutamic acid | | N-(p-(((2- | amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid | | N-(4-{[(2- | amino-4-hydroxypteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid | | N-(4-{[(2- | amino-4-oxo-1,4-dihydro-6-pteridinyl)methyl]amino}benzoyl)-L-glutamic acid | | (2S)-2-[(4-{[(2- | amino-4-oxo-1,4-dihydro-6-pteridinyl)methyl]amino}benzoyl)amino]pentanedioic acid | | N-[(4-{[(2- | amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid | | (2S)-2-{[(4-{[(2- | amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]amino}pentanedioic acid | | (2S)-2-[[4-[(2- | amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid | | | apo-folic | | | dosfolat B activ | | | folacin | | | folate | | L- | glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)- | | L- | glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)- | | L- | glutamic acid, N-(4-((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)- | | | glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, L- | | | glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L | | L- | glutamic acid, N-[4-[[(1,2-dihydro-4-hydroxy-2-imino-6-pteridinyl)methyl]amino]benzoyl]- | | L- | glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- | | L- | glutamic acid, N-[4-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]- | | L- | glutamic acid, N-[4-[[(2-amino-4,8-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- | | | glutamic acid, N-[p-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, l- | | | glutamic acid, pteroyl-, L- | | | novo-folacid | | | pteroyl glutamic acid | | | pteroyl-L-glutamic acid | | N- | pteroyl-L-glutamic acid | | | pteroyl-L-monoglutamic acid | | L- | pteroylglutamic acid | | | vitamin M |
Articles:
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