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Category: acidity regulators, firming agents, sequestrants, nutrient supplements, flavor enhancer
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| | FDA/DG SANTE Petitions, Reviews, Notices: |
| 184.1199 | Calcium gluconate View - review |
| GRN 136 | Calcium gluconate View - notice PDF |
| 582.6219 | Calcium gluconate View - review |
| EU SANCO | Calcium gluconate View - review |
| JECFA Food Additive: | Calcium Gluconate |
| GSFA Codex: | Calcium gluconate (578) |
| DG SANTE Food Additives: | calcium gluconate |
| FDA Mainterm (SATF): | 299-28-5 ; CALCIUM GLUCONATE |
| FDA Regulation: | FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products Sec. 150.141 Artificially sweetened fruit jelly.
FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products Sec. 150.161 Artificially sweetened fruit preserves and jams.
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE Subpart B--Listing of Specific Substances Affirmed as GRAS Sec. 184.1199 Calcium gluconate.
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Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 98.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 195.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 673.00 to 674.00 °C. @ 760.00 mm Hg
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| Flash Point: | 707.00 °F. TCC ( 375.00 °C. )
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| logP (o/w): | -3.175 (est) |
| Soluble in: |
| | water, 3.33E+04 mg/L @ 25 °C (exp) |
| Insoluble in: |
| | alcohol |
Organoleptic Properties:
Odor Description: at 100.00 %. | odorless |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-dog LDLo 1987 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 47, Pg. 183, 1933.
intravenous-guinea pig LDLo 1810 mg/kg GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
CARDIAC: OTHER CHANGES Archives Internationales de Pharmacodynamie et de Therapie. Vol. 191, Pg. 44, 1971.
intraperitoneal-mouse LD50 2200 mg/kg Journal of Drug Research. Vol. 15(1-2), Pg. 121, 1984.
intravenous-mouse LD50 950 mg/kg Toxicology and Applied Pharmacology. Vol. 4, Pg. 492, 1962.
oral-mouse LDLo 10000 mg/kg Farmaco, Edizione Pratica. Vol. 26, Pg. 144, 1971.
intravenous-rat LD50 950 mg/kg Drugs in Japan Vol. 6, Pg. 226, 1982.
oral-rat LDLo 10000 mg/kg Farmaco, Edizione Pratica. Vol. 26, Pg. 144, 1971.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 2890 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 47, 1956.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | acidity regulators, firming agents, sequestrants, nutrient supplements, flavor enhancer |
| Recommendation for calcium gluconate usage levels up to: | | | not for fragrance use.
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Safety References:
References:
| | calcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 299-28-5 |
| Pubchem (cid): | 9290 |
| Pubchem (sid): | 134975115 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C08133 |
| HMDB (The Human Metabolome Database): | Search |
| FooDB: | FDB001981 |
| Export Tariff Code: | 2940.00.6000 |
| FDA Listing of Food Additive Status: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations: •calcium gluconate, usp contains 9% calcium available as calcium gluconate tablets, usp, containing 325, 500, 650, or 1000 mg of the salt for im and iv injection, calcium gluconate injection, usp, admin as 10% soln (0.45 meq ca++ml).
•grades: technical; usp; fcc; special for ampules.
•due to its limited solubility, calcium gluconate must frequently be suspended in liquid mixtures and tragacanth is useful as a suspending agent.
•calcium gluconate injection:a 10% soln; 9.3 mg of ca+2ml 10-ml vial
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | calcicol | | | calciofon | | | calcipur | | | calcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate | | | calcium bis(D-gluconate) | | | calcium bis[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate] | | | calcium di-D-gluconate monohydrate | | | calcium di-dextro-gluconate monohydrate | | | calcium di(D-gluconate) | | | calcium gluconate anhydrous | | | calcium gluconate anhydrous USP FCC powder | | | calcium gluconate monohydrate USP FCC fine granular | | | calcium gluconate monohydrate USP FCC granular | | | calcium gluconate monohydrate USP FCC powder | | | calcium gluconate, anhydrous USP | | | calcium gluconate, monohydrate USP | | | calcium hexagluconate | | | calciumgluconate | | | calglucol | | | dragocal | | | ebucin | | | glucal | | | glucobiogen | | | gluconic acid calcium salt | | D- | gluconic acid calcium salt | | D- | gluconic acid calcium salt (2:1) | | dextro- | gluconic acid calcium salt (2:1) | | D- | gluconic acid, calcium salt (2:1) | | | kalpren | | | novocal |
Articles:
| PubMed: | Aluminum Contamination in Parenteral Nutrition Admixtures for Low-Birth-Weight Preterm Infants in Mexico. |
| J-Stage: | Evaluation of the Suppressive Effect on Bitter Taste of Gluconate |
| PubMed: | Postprandial metabolic responses of serum calcium, parathyroid hormone and C-telopeptide of type I collagen to three doses of calcium delivered in milk. |
| PubMed: | Spontaneous supersaturation of calcium D-gluconate during isothermal dissolution of calcium L-lactate in aqueous sodium D-gluconate. |
| PubMed: | Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo. |
| PubMed: | Aqueous solubility of calcium L-lactate, calcium D-gluconate, and calcium D-lactobionate: importance of complex formation for solubility increase by hydroxycarboxylate mixtures. |
| PubMed: | Effect of calcium on the kinetics of free fatty acid release during in vitro lipid digestion in model emulsions. |
| PubMed: | Safety and efficacy of polycalcium for improving biomarkers of bone metabolism: a 4-week open-label clinical study. |
| PubMed: | A single-dose study of denosumab in patients with various degrees of renal impairment. |
| PubMed: | Amlodipine fatality in an infant with postmortem blood levels. |
| PubMed: | Feasibility of using dialysis for determining calcium ion concentration and pH in calcium-fortified soymilk at high temperature. |
| PubMed: | Drug shortage. |
| PubMed: | Aluminium exposure from parenteral nutrition in preterm infants and later health outcomes during childhood and adolescence. |
| PubMed: | Hormone replacement after thyroid and parathyroid surgery. |
| PubMed: | Calcium and phosphate compatibility in low-osmolarity parenteral nutrition admixtures intended for peripheral vein administration. |
| PubMed: | Intravenous ceftriaxone and calcium in the neonate: assessing the risk for cardiopulmonary adverse events. |
| PubMed: | High altitude induced anorexia: effect of changes in leptin and oxidative stress levels. |
| PubMed: | Silicate release from glass for pharmaceutical preparations. |
| PubMed: | Primary periodic paralyses. |
| PubMed: | [Zinc and copper content in individual components used to prepare pediatric total nutrition mixtures]. |
| PubMed: | Calcium supplementation in clinical practice: a review of forms, doses, and indications. |
| PubMed: | The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats. |
| PubMed: | Reaction on D-glucal by an inverting phosphorylase to synthesize derivatives of 2-deoxy-beta-D-arabino-hexopyranosyl-(1-->4)-D-glucose (2II-deoxycellobiose). |
| PubMed: | Arsenic species in solutions for parenteral nutrition. |
| PubMed: | [A case of intraoperative hyperkalemia induced with administration of an angiotensin II receptor antagonist (AIIA) and intake of dried persimmons]. |
| PubMed: | Incorporation of a high concentration of mineral or vitamin into chitosan-based films. |
| PubMed: | Fluid and electrolyte therapy in ruminants. |
| PubMed: | A fortifier comprising protein, vitamins, and calcium-glycerophosphate for preterm human milk. |
| PubMed: | [The evaluation of the efficiency of biological prophylaxis of lead poisoning (experimental study)]. |
| PubMed: | Acute effects of calcium sodium citrate supplementation of a test meal on mineral homeostasis, oxalate, and calcium oxalate crystallization in the urine of healthy humans--preliminary results in patients with idiopathic calcium urolithiasis. |
| PubMed: | Anything else to add? |
| PubMed: | Parenteral calcium gluconate supplementation: efficacious or potentially disastrous? |
| PubMed: | The study of a physiological significance of prolactin in the regulation of calcium metabolism during pregnancy and lactation in rats. |
| PubMed: | Chromium and zinc contamination of parenteral nutrient solution components commonly used in infants and children. |
| PubMed: | Calcium and phosphate solubility curves for parenteral nutrient solutions containing Vaminolact. |
| PubMed: | Evaluation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty acids on calcification. |
| PubMed: | Effects of meal on the pharmacokinetics of fluoride from oral monofluorophosphate. |
| PubMed: | Influence of dietary calcium and vitamin D on colon epithelial cell proliferation and 1,2-dimethylhydrazine-induced colon carcinogenesis in rats fed high fat diets. |
| PubMed: | Hypocalcemia and pregnancy-induced hypertension produced by maternal fasting. |
| PubMed: | Glycero- vs glucose-phosphate in parenteral nutrition of premature infants: a comparative in vitro evaluation of calcium/phosphorus compatibility. |
| PubMed: | Effect of dietary calcium on colon carcinogenesis induced by a single injection of 1,2-dimethylhydrazine in rats. |
| PubMed: | Secondary copper deficiency in cattle caused by molybdenum contamination of fodder: a case history. |
| PubMed: | Parturient paresis and hypocalcemia in ruminant livestock. |
| PubMed: | Gastrointestinal absorption of calcium from milk and calcium salts. |
| PubMed: | The effect of long-term enrichment of diet with selenium, vitamin E and B15 on the activity of certain enzymes in rat brain. |
| PubMed: | Calcium and phosphate solubility in neonatal parenteral nutrient solutions containing Aminosyn PF. |
| PubMed: | Calcium and phosphate solubility in neonatal parenteral nutrient solutions containing TrophAmine. |
| PubMed: | The effect of vitamin and mineral supplements and health foods on physical endurance and performance. |
| PubMed: | Hydrofluoric acid skin treatment not approved by FDA. |
| PubMed: | Effect of long-term diet enrichment with selenium, vitamin E and vitamin B15 on the degree of fatty infiltration of the liver. |
| PubMed: | Calcium and phosphorus in neonatal parenteral nutrition solutions. |
| PubMed: | The early diagnosis of gastrinoma. |
| PubMed: | Nutritional rickets due to food fadism. |
| PubMed: | [Effect of methionine and vitamins B12 and B15 on the content and distribution of proteins, glycogen and lipids in the hepatic lobules of chickens]. |
| PubMed: | FDA's hands loosely tied. |
| PubMed: | Vitamin B15--whatever it is, it won't help. |
| PubMed: | From those wonderful people who brought you laetrile. |
| PubMed: | [Dynamic aspects of blood gastrin after antral stimulation]. |
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