calcium gluconate
calcium di-D-gluconate monohydrate
 
Notes:
the calcium salt of gluconic acid. the compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states. Food additive: firming agent, sequestrant, stabiliser, texturiser. Anticaking agent in powdered coffee Calcium gluconate is a mineral supplement. It is the form of calcium most widely used in the treatment of hypocalcemia. Calcium gluconate contains 9.3% calcium. It is also used to counteract an overdose of magnesium sulfate, often administered to pregnant women experiencing premature labor to slow or stop contractions. Excess magnesium sulfate can cause respiratory depression, for which calcium gluconate would be the antidote.
  • American International Chemical, LLC.
    • American International Chemical, Inc.
      Consistent sources
      North American supplier for globally sourced ingredients.
      AIC is a Westborough, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of Sales Representatives, along with our network of strategically located warehouses are ready to supply product when and where you need it.
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      Product(s):
      CGAGIP Calcium Gluconate
       
  • BOC Sciences
    • BOC Sciences
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      Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
      BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
      BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
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      Product(s):
      299-28-5 Gluconate Calcium
       
  • Charkit Chemical
    • Charkit Chemical Corporation
      The Specialty Chemical Specialists
      Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.
      about: Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals.
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      CALCIUM GLUCONATE
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
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      Product(s):
      03-01900 CALCIUM GLUCONATE MONOHYDRATE USP
      03-01905 CALCIUM GLUCONATE ANHYDROUS USP
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping!
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
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      Product(s):
      G0037 Calcium Gluconate Monohydrate >98.0%(T)
       
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CAS Number: 299-28-5Picture of molecule3D/inchi
Other(deleted CASRN): 18016-24-5
ECHA EINECS - REACH Pre-Reg: 206-075-8
FDA UNII: SQE6VB453K
Nikkaji Web: J2.984J
MDL: MFCD00064209
Molecular Weight: 430.37414000
Formula: C12 H22 Ca O14
NMR Predictor: Predict (works with chrome or firefox)
Category: acidity regulators, firming agents, sequestrants, nutrient supplements, flavor enhancer
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1199 Calcium gluconate View - review
GRN 136 Calcium gluconate View - notice PDF
582.6219 Calcium gluconate View - review
EU SANCO Calcium gluconate View - review
JECFA Food Additive: Calcium Gluconate
GSFA Codex: Calcium gluconate (578)
DG SANTE Food Additives: calcium gluconate
FDA Mainterm (SATF):299-28-5 ; CALCIUM GLUCONATE
FDA Regulation:
FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.141 Artificially sweetened fruit jelly.


FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.161 Artificially sweetened fruit preserves and jams.


FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1199 Calcium gluconate.
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Physical Properties:
Appearance: white crystalline powder (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 195.00 °C. @ 760.00 mm Hg
Boiling Point: 673.00 to  674.00 °C. @ 760.00 mm Hg
Flash Point: 707.00 °F. TCC ( 375.00 °C. )
logP (o/w): -3.175 (est)
Soluble in:
 water, 3.33E+04 mg/L @ 25 °C (exp)
Insoluble in:
 alcohol
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Organoleptic Properties:
Odor Description:
at 100.00 %. 
odorless
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: humectants
oral care agents
skin conditioning
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Suppliers:
American Elements
Calcium D-gluconate 99%
Odor: characteristic
Use: Calcium D-Gluconate is one of numerous organo-metallic compounds sold by American Elements under the tradename AE Organo-Metallics™ for uses requiring non-aqueous solubility such as recent solar energy and water treatment applications. Calcium D-Gluconate is generally immediately available in most volumes, including bulk quantities. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
Calcium Gluconate
BOC Sciences
For experimental / research use only.
Gluconate Calcium
Carbosynth
For experimental / research use only.
D-Gluconic acid calcium salt
Charkit Chemical
CALCIUM GLUCONATE
Global Calcium
Calcium Gluconate EP
Global Calcium
Calcium Gluconate for Injection EP
Global Calcium
Calcium Gluconate Hydrate JP
Global Calcium
Calcium Gluconate IP
Global Calcium
Calcium Gluconate USP ( Monohydrate )
Penta International
CALCIUM GLUCONATE ANHYDROUS USP
Penta International
CALCIUM GLUCONATE MONOHYDRATE USP
Qingdao Dacon Trading
Calcium Gluconate
Sigma-Aldrich: Sigma
For experimental / research use only.
Calcium D-gluconate monohydrate ≥98%
TCI AMERICA
For experimental / research use only.
Calcium Gluconate Monohydrate >98.0%(T)
Viachem
Calcium Lactate Gluconate
Flavor: bland
Calcium lactate gluconate (C3H5O3)2Ca + (C6H11O7)2Ca, is a white crystalline salt made by the action of lactic acid on calcium carbonate. It is used in foods (as a baking powder) and given medicinally.Calcium lactate is often found in aged cheeses. Small crystals of it precipitate out when lactic acid is converted into a less soluble form by the bacteria active during the ripening process.
Wedor Corporation
CALCIUM GLUCONATE
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LDLo  1987 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 47, Pg. 183, 1933.

intravenous-guinea pig LDLo  1810 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA CARDIAC: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 191, Pg. 44, 1971.

intraperitoneal-mouse LD50  2200 mg/kg
Journal of Drug Research. Vol. 15(1-2), Pg. 121, 1984.

intravenous-mouse LD50  950 mg/kg
Toxicology and Applied Pharmacology. Vol. 4, Pg. 492, 1962.

oral-mouse LDLo  10000 mg/kg
Farmaco, Edizione Pratica. Vol. 26, Pg. 144, 1971.

intravenous-rat LD50  950 mg/kg
Drugs in Japan Vol. 6, Pg. 226, 1982.

oral-rat LDLo  10000 mg/kg
Farmaco, Edizione Pratica. Vol. 26, Pg. 144, 1971.

Dermal Toxicity:
subcutaneous-mouse LD50 2890 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 47, 1956.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: acidity regulators, firming agents, sequestrants, nutrient supplements, flavor enhancer
Recommendation for calcium gluconate usage levels up to:
 not for fragrance use.
 
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 299-28-5
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 9290
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 calcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
Chemidplus: 0000299285
RTECS: EW2100000 for cas# 299-28-5
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References:
 calcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 299-28-5
Pubchem (cid): 9290
Pubchem (sid): 134975115
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C08133
HMDB (The Human Metabolome Database): Search
FooDB: FDB001981
Export Tariff Code: 2940.00.6000
FDA Listing of Food Additive Status: View
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
•calcium gluconate, usp contains 9% calcium available as calcium gluconate tablets, usp, containing 325, 500, 650, or 1000 mg of the salt for im and iv injection, calcium gluconate injection, usp, admin as 10% soln (0.45 meq ca++ml). •grades: technical; usp; fcc; special for ampules. •due to its limited solubility, calcium gluconate must frequently be suspended in liquid mixtures and tragacanth is useful as a suspending agent. •calcium gluconate injection:a 10% soln; 9.3 mg of ca+2ml 10-ml vial
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 additives 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 calcicol
 calciofon
 calcipur
 calcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
 calcium bis(D-gluconate)
 calcium bis[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate]
 calcium di-D-gluconate monohydrate
 calcium di-dextro-gluconate monohydrate
 calcium di(D-gluconate)
 calcium gluconate anhydrous
 calcium gluconate anhydrous USP FCC powder
 calcium gluconate monohydrate USP FCC fine granular
 calcium gluconate monohydrate USP FCC granular
 calcium gluconate monohydrate USP FCC powder
 calcium gluconate, anhydrous USP
 calcium gluconate, monohydrate USP
 calcium hexagluconate
 calciumgluconate
 calglucol
 dragocal
 ebucin
 glucal
 glucobiogen
 gluconic acid calcium salt
D-gluconic acid calcium salt
D-gluconic acid calcium salt (2:1)
dextro-gluconic acid calcium salt (2:1)
D-gluconic acid, calcium salt (2:1)
 kalpren
 novocal
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Articles:
PubMed: Aluminum Contamination in Parenteral Nutrition Admixtures for Low-Birth-Weight Preterm Infants in Mexico.
J-Stage: Evaluation of the Suppressive Effect on Bitter Taste of Gluconate
PubMed: Postprandial metabolic responses of serum calcium, parathyroid hormone and C-telopeptide of type I collagen to three doses of calcium delivered in milk.
PubMed: Spontaneous supersaturation of calcium D-gluconate during isothermal dissolution of calcium L-lactate in aqueous sodium D-gluconate.
PubMed: Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo.
PubMed: Aqueous solubility of calcium L-lactate, calcium D-gluconate, and calcium D-lactobionate: importance of complex formation for solubility increase by hydroxycarboxylate mixtures.
PubMed: Effect of calcium on the kinetics of free fatty acid release during in vitro lipid digestion in model emulsions.
PubMed: Safety and efficacy of polycalcium for improving biomarkers of bone metabolism: a 4-week open-label clinical study.
PubMed: A single-dose study of denosumab in patients with various degrees of renal impairment.
PubMed: Amlodipine fatality in an infant with postmortem blood levels.
PubMed: Feasibility of using dialysis for determining calcium ion concentration and pH in calcium-fortified soymilk at high temperature.
PubMed: Drug shortage.
PubMed: Aluminium exposure from parenteral nutrition in preterm infants and later health outcomes during childhood and adolescence.
PubMed: Hormone replacement after thyroid and parathyroid surgery.
PubMed: Calcium and phosphate compatibility in low-osmolarity parenteral nutrition admixtures intended for peripheral vein administration.
PubMed: Intravenous ceftriaxone and calcium in the neonate: assessing the risk for cardiopulmonary adverse events.
PubMed: High altitude induced anorexia: effect of changes in leptin and oxidative stress levels.
PubMed: Silicate release from glass for pharmaceutical preparations.
PubMed: Primary periodic paralyses.
PubMed: [Zinc and copper content in individual components used to prepare pediatric total nutrition mixtures].
PubMed: Calcium supplementation in clinical practice: a review of forms, doses, and indications.
PubMed: The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats.
PubMed: Reaction on D-glucal by an inverting phosphorylase to synthesize derivatives of 2-deoxy-beta-D-arabino-hexopyranosyl-(1-->4)-D-glucose (2II-deoxycellobiose).
PubMed: Arsenic species in solutions for parenteral nutrition.
PubMed: [A case of intraoperative hyperkalemia induced with administration of an angiotensin II receptor antagonist (AIIA) and intake of dried persimmons].
PubMed: Incorporation of a high concentration of mineral or vitamin into chitosan-based films.
PubMed: Fluid and electrolyte therapy in ruminants.
PubMed: A fortifier comprising protein, vitamins, and calcium-glycerophosphate for preterm human milk.
PubMed: [The evaluation of the efficiency of biological prophylaxis of lead poisoning (experimental study)].
PubMed: Acute effects of calcium sodium citrate supplementation of a test meal on mineral homeostasis, oxalate, and calcium oxalate crystallization in the urine of healthy humans--preliminary results in patients with idiopathic calcium urolithiasis.
PubMed: Anything else to add?
PubMed: Parenteral calcium gluconate supplementation: efficacious or potentially disastrous?
PubMed: The study of a physiological significance of prolactin in the regulation of calcium metabolism during pregnancy and lactation in rats.
PubMed: Chromium and zinc contamination of parenteral nutrient solution components commonly used in infants and children.
PubMed: Calcium and phosphate solubility curves for parenteral nutrient solutions containing Vaminolact.
PubMed: Evaluation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty acids on calcification.
PubMed: Effects of meal on the pharmacokinetics of fluoride from oral monofluorophosphate.
PubMed: Influence of dietary calcium and vitamin D on colon epithelial cell proliferation and 1,2-dimethylhydrazine-induced colon carcinogenesis in rats fed high fat diets.
PubMed: Hypocalcemia and pregnancy-induced hypertension produced by maternal fasting.
PubMed: Glycero- vs glucose-phosphate in parenteral nutrition of premature infants: a comparative in vitro evaluation of calcium/phosphorus compatibility.
PubMed: Effect of dietary calcium on colon carcinogenesis induced by a single injection of 1,2-dimethylhydrazine in rats.
PubMed: Secondary copper deficiency in cattle caused by molybdenum contamination of fodder: a case history.
PubMed: Parturient paresis and hypocalcemia in ruminant livestock.
PubMed: Gastrointestinal absorption of calcium from milk and calcium salts.
PubMed: The effect of long-term enrichment of diet with selenium, vitamin E and B15 on the activity of certain enzymes in rat brain.
PubMed: Calcium and phosphate solubility in neonatal parenteral nutrient solutions containing Aminosyn PF.
PubMed: Calcium and phosphate solubility in neonatal parenteral nutrient solutions containing TrophAmine.
PubMed: The effect of vitamin and mineral supplements and health foods on physical endurance and performance.
PubMed: Hydrofluoric acid skin treatment not approved by FDA.
PubMed: Effect of long-term diet enrichment with selenium, vitamin E and vitamin B15 on the degree of fatty infiltration of the liver.
PubMed: Calcium and phosphorus in neonatal parenteral nutrition solutions.
PubMed: The early diagnosis of gastrinoma.
PubMed: Nutritional rickets due to food fadism.
PubMed: [Effect of methionine and vitamins B12 and B15 on the content and distribution of proteins, glycogen and lipids in the hepatic lobules of chickens].
PubMed: FDA's hands loosely tied.
PubMed: Vitamin B15--whatever it is, it won't help.
PubMed: From those wonderful people who brought you laetrile.
PubMed: [Dynamic aspects of blood gastrin after antral stimulation].
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