Articles:
| Info: | Aspirin |
2-acetyloxybenzoic acid
Notes:
the prototypical analgesic used in the treatment of mild to moderate pain. it has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (from martindale, the extra pharmacopoeia, 30th ed, p5). Constit. of Glycyrrhiza glabra var. typica (licorice) roots
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 50-78-2 Aspirin A salicylate and irreversible COX1 and COX2 inhibitor
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ECSA Chemicals Human Chemistry ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of the largest distributors worldwide. ECSA Chemicals is the largest Swiss-owned company in terms of warehouses for the distribution of chemical products. We have been distributing chemical products for over 100 years and we have a special interest in protecting the environment and in the safety of our facilities and collaborators. Established in 1913 as a small grocery store, in its over 100 years of activity ECSA Chemicals has become one of the most important Swiss-owned distributors of chemical products. The company, which is active in international distribution and trading, is organised into industrial segments that are managed by teams of specialists and experts. They guarantee professional and customised consultancy and services. With our experience, we can rapidly and safely connect you with the best suppliers on the market, providing you with a complete search, consulting and assistance service. The focus of our approach and operations is you, our customers. We strive every day to find the best products that satisfy your needs as quickly as possible. Your satisfaction is our greatest success. WHY CHOOSE ECSA? EXPERIENCE We have been working for 100 years. QUALITY We have obtained many certifications (ISO, SQAS, GDP, Responsible Care, Bio-Inspecta, RSPO, etc.). We guarantee full compliance with the current laws and continuous training for our staff. SAFETY We constantly carry out risk analyses for each infrastructure, defining safety levels and implementing corrective measures promptly wherever they are needed. WIDESPREAD DISTRIBUTION We have warehouses in strategic locations to supply goods to Switzerland and to the rest of the world. STORAGE CAPACITY The 3 ECSA-owned warehouses guarantee considerable storage area and capacity in each warehouse, with full availability of products (base chemicals and speciality chemicals). SPEED Presence all over the country, staff dedicated to sourcing raw materials and considerable storage capacity guarantee that goods are rapidly obtained and supplied. CONSULTANCY Our specialists - in-depth knowledge of the market and products allows us to provide full consulting services, from the purchase to the supply of raw materials. Email: Info Email: Sales Email: Trading Email: Maintenance Email: Energy Voice: +41 91 695 88 00 Fax: +41 91 695 88 01 Linkedin Youtube RSS Feed ECSA Trade ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY Products List: View Product(s): MP-021998 ACETYLSALICYLIC ACID PH. EUR.
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Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GL2912 Acetylsalicylic acid GL0865 Acetylsalicylic acid, USP grade
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 01-10400 ACETYL SALICYLIC ACID
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| CAS Number: | 50-78-2 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 200-064-1 | |
| FDA UNII: | R16CO5Y76E | |
| Nikkaji Web: | J2.300K | |
| Beilstein Number: | 779271 | |
| MDL: | MFCD00002430 | |
| XlogP3: | 1.20 (est) | |
| Molecular Weight: | 180.15956000 | |
| Formula: | C9 H8 O4 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 135.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 321.39 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 0.000025 mmHg @ 25.00 °C. |
| Flash Point: | 268.00 °F. TCC ( 131.20 °C. ) (est) |
| logP (o/w): | 1.190 |
| Soluble in: | |
| water, 5295 mg/L @ 25 °C (est) | |
| water, 4600 mg/L @ 25 °C (exp) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Acetylsalicylic acid 98% |
| BOC Sciences |
| For experimental / research use only. |
| Aspirin
Odor: characteristic Use: A salicylate and irreversible COX1 and COX2 inhibitor |
| ECSA Chemicals |
| ACETYLSALICYLIC ACID PH. EUR. |
| ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
| Glentham Life Sciences |
| Acetylsalicylic acid, USP grade |
| Glentham Life Sciences |
| Acetylsalicylic acid |
| Penta International |
| ACETYL SALICYLIC ACID |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Acetylsalicylic acid ≥99.0%, crystalline |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-child LDLo 104 mg/kg LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: HEMORRHAGE GASTROINTESTINAL: NAUSEA OR VOMITING Lancet. Vol. 2, Pg. 809, 1952. oral-child TDLo 10 mg/kg/1D-I LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED Clinical Toxicology. Vol. 18, Pg. 247, 1981. oral-child TDLo 39 mg/kg/13D-I LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" American Journal of Diseases of Children. Vol. 139, Pg. 453, 1985. intravenous-dog LD50 681 mg/kg BEHAVIORAL: ANALGESIA Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964. oral-dog LD50 700 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971. oral-guinea pig LD50 1075 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958. oral-hamster LD50 3500 mg/kg Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984. oral-human TDLo 480 mg/kg/7D-I BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 281, 1975. oral-human TDLo 669 mg/kg/11D LIVER: LIVER FUNCTION TESTS IMPAIRED American Journal of Hospital Pharmacy. Vol. 35, Pg. 330, 1978. oral-human TDLo 1050 mg/kg/14D VASCULAR: OTHER CHANGES Clinical Pharmacology and Therapeutics Vol. 67, Pg. 530, 2000. oral-human TDLo 2880 mg/kg/8W SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 631, 1983. oral-mammal (species unspecified) LD50 1750 mg/kg Indian Journal of Medical Research. Vol. 81, Pg. 621, 1985. unreported-man LDLo 294 mg/kg "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. oral-man TDLo 857 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: COMA Human Toxicology. Vol. 7, Pg. 161, 1988. oral-man TDLo 1625 mg/kg BEHAVIORAL: COMA Clinical Pediatrics Vol. 24, Pg. 678, 1985. oral-man TDLo 13036 mg/kg/5Y SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" GASTROINTESTINAL: OTHER CHANGES MUSCULOSKELETAL: JOINTS Annals of Internal Medicine. Vol. 126, Pg. 665, 1997. intraperitoneal-mouse LD50 167 mg/kg United States Patent Document. Vol. #4376771 oral-mouse LD50 250 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. unreported-mouse LD50 1350 mg/kg United States Patent Document. Vol. #5240918 oral-rabbit LD50 1010 mg/kg BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(3), Pg. 43, 1980. intraperitoneal-rat LD50 340 mg/kg Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62, Pg. 11, 1966. oral-rat LD50 200 mg/kg "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 67, 1969. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 1020 mg/kg Chemical and Pharmaceutical Bulletin. Vol. 28, Pg. 1237, 1980. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for acetyl salicylic acid usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for acetyl salicylic acid flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| NIOSH International Chemical Safety Cards: | search |
| NIOSH Pocket Guide: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 50-78-2 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 2244 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 1 |
| 2-acetyloxybenzoic acid | |
| Chemidplus: | 0000050782 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 50-78-2 |
References:
| 2-acetyloxybenzoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 50-78-2 |
| Pubchem (cid): | 2244 |
| Pubchem (sid): | 134971785 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| KEGG (GenomeNet): | C01405 |
| HMDB (The Human Metabolome Database): | HMDB01879 |
| FooDB: | FDB000894 |
| Export Tariff Code: | 2918.22.1000 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: aspirin formulations: aspirin formulations: preparations dose (mg) product manufacturer pieces, chewing gum aspergum heritage, schering plough tablets aspirin adult low strength geri-care,mango-humphries aspirin low dose basic viatamins norwich aspirin chattem 325 with buffers magnaprin, improved rugby 325 with buffers magnaprin arthritis strength rugby norwich aspirin maximum strength chattem norwich aspirin maximum strength chattem tablets, chewable bayer children's chewable aspirin bayer aspirin childrens amerisourcebergen, cardinal health, chain drug marketing, eckerd, ivax, major, pdk, prime marketing, qualitest, rugby, url aspirin for children geri-care st. joseph aspirin low strength chewable mcneil tablets, delayed-release (enteric-coated) aspirin adult low strength amerisourcebergen aspirin adult low strength aspirin enteric coated advance aspirin low dose qualitest aspirin regimen aspirin regimen low strength cardinal health bayer aspirin regimen adult low strength bayer ecotrin adult low strength (with propylene glycol) glaxosmithkline ecotrin adult low strength (with propylene glycol) glaxosmithkline st. joseph adult low strength enteric coated tablets mcneil 81 with buffers ascriptin enteric regular strength novartis halfprin kramer aspirin for arthritis cardinal health bayer aspirin regimen regular strength caplets (with propylene glycol bayer ecotrin regular strength (with propylene glycol) glaxosmithkline genacote 325 with buffers ascriptin enteric regular strength novartis aspirin extra strength medicine shoppe aspirin maximum strength chain drug marketing ecotrin maximum strength (with propylene glycol) glaxosmithkline aspirin delayed release tablets time-cap, united research easprin harvest tablets, extended-release zorprin tablets, film-coated 81 with buffers women's aspirin plus calcium caplets (with calcium carbonate and crospovidone) bayer aspirin lite coated amerisourcebergen aspirin microthin coating cardinal health bayer aspirin caplets bayer genuine bayer aspirin tablets bayer 325 with buffers ascriptin regular strength novartis 325 with buffers ascriptin arthritis pain caplets novartis 325 with buffers bufferin tablets (with povidone and propylene glycol), novartis consumer health bayer aspirin extra strength caplets (with propylene glycol) bayer bayer aspirin extra strength gelcaplets (with parabens) bayer bayer aspirin extra strength tablets bayer 500 with buffers ascriptin maximum strength caplets novartis 500 with buffers bayer aspirin plus buffered extra strength caplets (with calcium carbonate and propylene glycol) bayer 500 with buffers bufferin arthritis strength caplets (with povidone and propylene glycol) bristol-myers 500 with buffers bufferin extra strength (with povidone and propylene glycol) novartis consumer health tablets, for solution alka-seltzer effervescent pain reliever and antacid (with citric acid 1 g and sodium bicarbonate 1.916 g) bayer alka-seltzer lemon-lime effervescent pain reliever and antacid (with aspartame citric acid 1 g and sodium bicarbonate 1.7 g) bayer alka-seltzer extra strength effervescent pain reliever and antacid (with citric acid 1 g and sodium bicarbonate 1.985 g) bayer rectal suppositories aspirin suppositories consolidated midland aspirin suppositories consolidated midland aspirin suppositories consolidated midland aspirin suppositories consolidated midland, paddock aspirin suppositories consolidated midland, paddock | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| glycyrrhiza glabra var. typica root Search Trop Picture |
Synonyms:
| acesal | |
| acesan | |
| acetard | |
| 2- | acetoxybenzenecarboxylic acid |
| 2- | acetoxybenzoic acid |
| ortho- | acetyl salicylic acid |
| acetyl salicylic acid USP | |
| 2-( | acetyloxy)benzoic acid |
| o-( | acetyloxy)benzoic acid |
| 2- | acetyloxybenzoic acid |
| o- | acetylsalicylic acid |
| ortho- | acetylsalicylic acid |
| acimetten | |
| asagran | |
| ascriptin | |
| aspirdrops | |
| aspirin | |
| aspirin 20-60 mesh USP | |
| aspirin 40-80 mesh USP | |
| aspirin USP | |
| aspropharm | |
| benaspir | |
| benzoic acid, 2-(acetyloxy)- | |
| cardioaspirina | |
| claradin | |
| clariprin | |
| decaten | |
| doril | |
| easprin | |
| globentyl | |
| kapsazal | |
| melhoral | |
| micristin | |
| miniasal | |
| pharmacin | |
| polopiryna | |
| premaspin | |
| rhodine NC RP | |
| salcetogen | |
| salospir | |
| solprin | |
| tasprin | |
| toldex | |
| triaminicin |