endo-1,3-beta-glucanase
glucanase, endo-1,3-beta-
 
Notes:
a family of glycosidases that hydrolyse crystalline cellulose into soluble sugar molecules. within this family there are a variety of enzyme subtypes with differing substrate specificities that must work together to bring about complete cellulose hydrolysis. they are found in structures called cellulosomes.
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CAS Number: 9025-37-0 
Category: food additive
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 535 Beta-glucanase from Streptomyces violaceoruber View - notice PDF
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50  > 5000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2619, 1989.

oral-rat LD50  > 5000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2619, 1989.

Dermal Toxicity:
skin-rat LD50 > 2000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2619, 1989.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: food additive
Recommendation for endo-1,3-beta-glucanase usage levels up to:
 not for fragrance use.
 
Recommendation for endo-1,3-beta-glucanase flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Assessment of the application for renewal of authorisation of endo-1,4-ß-xylanase produced by Aspergillus nigerCBS 109.713 and endo-1,4-ß-glucanase produced by Aspergillus nigerDSM 18404 for poultry species, ornamental birds and weaned piglets, from BASF…
View page or View pdf
Safety evaluation of the food enzyme endo-1,3(4)-ß-glucanase from the genetically modified Bacillus subtilis strain DP-Ezm28
View page or View pdf
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0009025370
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References:
Pubchem (sid): 135333840
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Other Information:
HMDB (The Human Metabolome Database): Search
FDA Listing of Food Additive Status: View
VCF-Online: VCF Volatile Compounds in Food
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 endo-1,3-beta-glucanase
Search  PMC Picture
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Synonyms:
 glucanase, endo-1,3-beta-
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Articles:
PubMed: Identification and enzymatic characterization of an endo-1,3-β-glucanase from Euglena gracilis.
PubMed: Scientifically advanced solutions for chestnut ink disease.
PubMed: Structures of an active-site mutant of a plant 1,3-β-glucanase in complex with oligosaccharide products of hydrolysis.
PubMed: Effects of cereal β-glucans and enzyme inclusion on the porcine gastrointestinal tract microbiota.
PubMed: Two high-resolution structures of potato endo-1,3-β-glucanase reveal subdomain flexibility with implications for substrate binding.
PubMed: Critical roles of Asp270 and Trp273 in the α-repeat of the carbohydrate-binding module of endo-1,3-β-glucanase for laminarin-binding avidity.
PubMed: Molecular characterization of endo-1,3-β-glucanase from Cellulosimicrobium cellulans: effects of carbohydrate-binding module on enzymatic function and stability.
PubMed: Biochemical characterization of Magnaporthe oryzae β-glucosidases for efficient β-glucan hydrolysis.
PubMed: A cryoprotective and cold-adapted 1,3-β-endoglucanase from cherimoya (Annona cherimola) fruit.
PubMed: Influence of pre-press solvent-extracted cottonseed meal supplemented with exogenous enzyme and digestible lysine on performance, digestibility, carcass and immunity responses of broiler chickens.
PubMed: Elicitor-induced transcription factors for metabolic reprogramming of secondary metabolism in Medicago truncatula.
PubMed: The 1.5 A structure of endo-1,3-beta-glucanase from Streptomyces sioyaensis: evolution of the active-site structure for 1,3-beta-glucan-binding specificity and hydrolysis.
PubMed: The Schizosaccharomyces pombe endo-1,3-beta-glucanase Eng1 contains a novel carbohydrate binding module required for septum localization.
PubMed: Influence of canola meal-based diets supplemented with exogenous enzyme and digestible lysine on performance, digestibility, carcass, and immunity responses of broiler chickens.
PubMed: Cloning and characterization of six highly similar endo-1,3-beta-glucanase genes in hexaploid wheat.
PubMed: Crystallization and preliminary crystallographic analysis of endo-1,3-beta-glucanase from alkaliphilic Nocardiopsis sp. strain F96.
PubMed: Crystallization and preliminary crystallographic analysis of endo-1,3-beta-glucanase from Arthrobacter sp.
PubMed: Characterization of the CaENG1 gene encoding an endo-1,3-beta-glucanase involved in cell separation in Candida albicans.
PubMed: Hydrolase and glycosynthase activity of endo-1,3-beta-glucanase from the thermophile Pyrococcus furiosus.
PubMed: Structure of beta-glucan oligomer from laminarin and its effect on human monocytes to inhibit the proliferation of U937 cells.
PubMed: Cloning, characterization and expression of OsGLN2, a rice endo-1,3-beta-glucanase gene regulated developmentally in flowers and hormonally in germinating seeds.
PubMed: Role of the alpha-glucanase Agn1p in fission-yeast cell separation.
PubMed: An ancient enzyme domain hidden in the putative beta-glucan elicitor receptor of soybean may play an active part in the perception of pathogen-associated molecular patterns during broad host resistance.
PubMed: Biochemical characterization and antifungal activity of an endo-1,3-beta-glucanase of Paenibacillus sp. isolated from garden soil.
PubMed: Characterization of 1,3-beta-glucanase and 1,3;1,4-beta-glucanase genes from Phytophthora infestans.
PubMed: Eng1p, an endo-1,3-beta-glucanase localized at the daughter side of the septum, is involved in cell separation in Saccharomyces cerevisiae.
PubMed: Dietary-fiber-degrading enzymes from a human intestinal Clostridium and their application to oligosaccharide production from nonstarchy polysaccharides using immobilized cells.
PubMed: Isolation and biochemical characterization of an endo-1,3-beta-glucanase from Streptomyces sioyaensis containing a C-terminal family 6 carbohydrate-binding module that binds to 1,3-beta-glucan.
PubMed: Characterization of an endo-1,3-beta-D-glucanase produced during the interaction between the mycoparasite Stachybotrys elegans and its host Rhizoctonia solani.
PubMed: News & notes: production, purification, and properties of an endo-1, 3-beta-glucanase from the basidiomycete Agaricus bisporus.
PubMed: Highly thermostable endo-1,3-beta-glucanase (laminarinase) LamA from Thermotoga neapolitana: nucleotide sequence of the gene and characterization of the recombinant gene product.
PubMed: Changes in levels of mRNAs for cell wall-related enzymes in growing cotton fiber cells.
PubMed: Purification and characterization of an endo-1,3-beta-glucanase from Aspergillus fumigatus.
PubMed: Purification and properties of a basic endo-1,3-beta-glucanase from rice (Oryza sativa L.).
PubMed: Lytic activity of enzyme preparation from Aspergillus carbonarius.
PubMed: Photoaffinity labeling of soluble auxin-binding proteins.
PubMed: Effect of beta-glucanases on Penicillium oxalicum cell wall fractions.
PubMed: [1,3-beta-Glucanases of actinomycetes].
PubMed: [Endo-1,3-beta-glucanase from Actinomyces cellulosae].
PubMed: Synthesis of 1,3-beta-glucanases in Saccharomyces cerevisiae during the mitotic cycle, mating, and sporulation.
PubMed: Saccharomyces cerevisiae mutant defective in exo-1,3-beta-glucanase production.
PubMed: Occurrence of an endo-1,3-beta-glucanase in culture fluids of the yeast Candida utilis. Purification and characterization of the enzyme activity.
PubMed: Production of 1, 3-beta-glucanase by Bacillus No. 221. An alkalophilic microorganism.
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