nordazepam
2H-1,4-benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-
 
Notes:
an intermediate in the metabolism of diazepam to oxazepam. it may have actions similar to those of diazepam.
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CAS Number: 1088-11-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 214-123-4
FDA UNII: 67220MCM01
Nikkaji Web: J7.250H
Beilstein Number: 0751823
MDL: MFCD00063440
XlogP3: 2.90 (est)
Molecular Weight: 270.71787000
Formula: C15 H11 Cl N2 O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 216.50 °C. @ 760.00 mm Hg
Boiling Point: 462.60 °C. @ 760.00 mm Hg (est)
Flash Point: 452.00 °F. TCC ( 233.60 °C. ) (est)
logP (o/w): 2.930
Soluble in:
 water, 56.95 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Kingchem Laboratories
Nordazepam
Sigma-Aldrich
For experimental / research use only.
Desmethyldiazepam analytical standard
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  290 mg/kg
BEHAVIORAL: ANTICONVULSANT
European Journal of Pharmacology. Vol. 16, Pg. 311, 1971.

oral-mouse LD50  670 mg/kg
BEHAVIORAL: ANTICONVULSANT
European Journal of Pharmacology. Vol. 4, Pg. 467, 1968.

intraperitoneal-rat LD  > 2000 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.

oral-rat LD  > 4000 mg/kg
BEHAVIORAL: ATAXIA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.

Dermal Toxicity:
subcutaneous-mouse LD > 2000 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.

subcutaneous-rat LD > 2000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: pharmaceuticals / chemical synthisis
Recommendation for nordazepam usage levels up to:
 not for fragrance use.
 
Recommendation for nordazepam flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 2997
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Chemidplus: 0001088115
RTECS: DF1750000 for cas# 1088-11-5
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References:
 7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 2997
Pubchem (sid): 134980961
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C07486
HMDB (The Human Metabolome Database): Search
FooDB: FDB007124
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 corn seed
Search Trop  Picture
 not found in nature
 potato tuber
Search Trop  Picture
 wheat seed
Search Trop  Picture
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Synonyms:
2H-1,4-benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-
2H-1,4-benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-
 calmday
7-chlor-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-on
 chlordesmethyldiazepam
7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
 dealkylprazepam
 demadar
1-demethyldiazepam
N-demethyldiazepam
N-deoxydemoxapam
N-deoxydemoxepam
 desalkylprazepam
N-descyclopropylmethylprazepam
 desmethyldiazepam
N-desmethyldiazepam
N1-desmethyldiazepam
 DMDZ
 lomax
 madar
 nordazepamum
 nordiazepam
 norprazepam
 sopax
 stilny
 vegesan
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Quantification of five compounds with heterogeneous physicochemical properties (morphine, 6-monoacetylmorphine, cyamemazine, meprobamate and caffeine) in 11 fluids and tissues, using automated solid-phase extraction and gas chromatography-tandem mass spectrometry.
PubMed: Urinary diazepam metabolite distribution in a chronic pain population.
PubMed: Direct determination of diazepam and its glucuronide metabolites in human whole blood by μElution solid-phase extraction and liquid chromatography-tandem mass spectrometry.
PubMed: Diazepam and its metabolites in the mothers' and newborns' hair as a biomarker of prenatal exposure.
PubMed: An air-tolerant approach to the carbonylative Suzuki-Miyaura coupling: applications in isotope labeling.
PubMed: Concentrations of drugs determined in blood samples collected from suspected drugged drivers in England and Wales.
PubMed: The potential of forensic analysis on human bones found in riverine environment.
PubMed: Evaluation of plasma diazepam and nordiazepam concentrations following administration of diazepam intravenously or via suppository per rectum in dogs.
PubMed: Blood drug concentrations of benzodiazepines correlate poorly with actual driving impairment.
PubMed: Sensitive UPLC-MS-MS assay for 21 benzodiazepine drugs and metabolites, zolpidem and zopiclone in serum or plasma.
PubMed: Concentrations of diazepam and nordiazepam in 1,000 blood samples from apprehended drivers--therapeutic use or abuse of anxiolytics?
PubMed: Muscle relaxants for pain management in rheumatoid arthritis.
PubMed: Combined occlusal and pharmacological therapy in the treatment of temporo-mandibular disorders.
PubMed: Gas chromatography-tandem mass spectrometry assay for the quantification of four benzodiazepines and citalopram in eleven postmortem rabbit fluids and tissues, with application to animal and human samples.
PubMed: Detection and validated quantification of 21 benzodiazepines and 3 "z-drugs" in human hair by LC-MS/MS.
PubMed: Pharmacokinetics of diazepam administered intramuscularly by autoinjector versus rectal gel in healthy subjects: a phase I, randomized, open-label, single-dose, crossover, single-centre study.
PubMed: Comparison by means of bispectral index score, between anxiolysis induced by diazepam and sedation induced by midazolam.
PubMed: Pharmacokinetics of the cytochrome P-450 substrates phenytoin, theophylline, and diazepam in healthy Greyhound dogs.
PubMed: Folie à deux: double case-report of shared delusions with a fatal outcome.
PubMed: Reduction of temazepam to diazepam and lorazepam to delorazepam during enzymatic hydrolysis.
PubMed: Diazepam pharmacokinetics after nasal drop and atomized nasal administration in dogs.
PubMed: Biotransformation of diazepam in a clinically relevant flat membrane bioreactor model using primary porcine hepatocytes.
PubMed: A novel reductive transformation of oxazepam to nordiazepam observed during enzymatic hydrolysis.
PubMed: Electronic properties of neuroleptics: ionization energies of benzodiazepines.
PubMed: Simultaneous determination and quantification of 12 benzodiazepines in serum or whole blood using UPLC/MS/MS.
PubMed: LC-MS/MS analysis of 13 benzodiazepines and metabolites in urine, serum, plasma, and meconium.
PubMed: Quantitation of benzodiazepines in blood and urine using gas chromatography-mass spectrometry (GC-MS).
PubMed: Measurement of benzodiazepines in urine by liquid chromatography-tandem mass spectrometry: confirmation of samples screened by immunoassay.
PubMed: Effects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam.
PubMed: Simultaneous analysis of diazepam and its metabolites in rat plasma and brain tissue by HPLC-UV and SPE.
PubMed: [Mechanisms of opioid-induced overdose: experimental approach to clinical concerns].
PubMed: Quantification of chlordesmethyldiazepam by liquid chromatography-tandem mass spectrometry: application to a cloxazolam bioequivalence study.
PubMed: Cardiac and peripheral blood similarities in the comparison of nordiazepam and bromazepam blood concentrations.
PubMed: Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report.
PubMed: Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes.
PubMed: Determination of diazepam and its metabolites in human urine by liquid chromatography/tandem mass spectrometry using a hydrophilic polymer column.
PubMed: Fatal intoxication with milnacipran.
PubMed: New high-performance liquid chromatographic method for serum analysis of oxazepam: application to bioequivalence and pharmacokinetic study.
PubMed: Fatal intoxication with labetalol (Trandate).
PubMed: Thiodicarb and methomyl tissue distribution in a fatal multiple compounds poisoning.
PubMed: Bioavailability and dose proportionality of intramuscular diazepam administered by autoinjector.
PubMed: Massive intoxication involving unusual high concentration of amitriptyline.
PubMed: Voriconazole and fluconazole increase the exposure to oral diazepam.
PubMed: Concentrations of scheduled prescription drugs in blood of impaired drivers: considerations for interpreting the results.
PubMed: LC-MS-MS analysis of 2,4-dinitrophenol and its phase I and II metabolites in a case of fatal poisoning.
PubMed: Highlights on new food research.
PubMed: A sensitive and selective method for the detection of diazepam and its main metabolites in urine by gas chromatography-tandem mass spectrometry.
PubMed: Optimized determination of lorazepam in human serum by extraction and high-performance liquid chromatographic analysis.
PubMed: Medicolegal aspects of tetrazepam metabolism.
PubMed: Liquid chromatographic-electrospray ionization mass spectrometric quantitative analysis of buprenorphine, norbuprenorphine, nordiazepam and oxazepam in rat plasma.
PubMed: Fast in vivo microextraction: a new tool for clinical analysis.
PubMed: Date-rape drugs scene in Poland.
PubMed: Quantification of benzodiazepines in whole blood and serum.
PubMed: Papain: a novel urine adulterant.
PubMed: Hair analysis by liquid chromatography-tandem mass spectrometry in toxicological investigation of drug-facilitated crimes: report of 128 cases over the period June 2003-May 2004 in metropolitan Paris.
PubMed: Fast, simple, and validated gas chromatographic-mass spectrometric assay for quantification of drugs relevant to diagnosis of brain death in human blood plasma samples.
PubMed: Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the quantitation of prazepam and its main metabolites in human plasma.
PubMed: High concentrations of diazepam and nordiazepam in blood of impaired drivers: association with age, gender and spectrum of other drugs present.
PubMed: Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.
PubMed: Combined sedation with oral chlordemethyldiazepam and midazolam by nasal route in third molar surgery.
PubMed: Distribution of diazepam and nordiazepam between plasma and whole blood and the influence of hematocrit.
PubMed: Toxicological data and growth characteristics of single post-feeding larvae and puparia of Calliphora vicina (Diptera: Calliphoridae) obtained from a controlled nordiazepam study.
PubMed: Coexistence and concentrations of ethanol and diazepam in postmortem blood specimens: risk for enhanced toxicity?
PubMed: Buprenorphine in drug-facilitated sexual abuse: a fatal case involving a 14-year-old boy.
PubMed: Ximelagatran, an oral direct thrombin inhibitor, has a low potential for cytochrome P450-mediated drug-drug interactions.
PubMed: Effects of diazepam and its metabolites on nocturnal melatonin secretion in the rat pineal and Harderian glands. A comparative in vivo and in vitro study.
PubMed: Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys.
PubMed: Fatal accident caused by isoflurane abuse.
PubMed: Interpretations of the TDxFLx calibration data of the abused drugs.
PubMed: Quantitation using GC-TOF-MS: example of bromazepam.
PubMed: Bio-compatible in-tube solid-phase microextraction capillary for the direct extraction and high-performance liquid chromatographic determination of drugs in human serum.
PubMed: Alcohol and benzodiazepines in fatal poisonings.
PubMed: SPME-LC with UV detection to study delorazepam-serum albumin interactions.
PubMed: Sensitive method for the detection of 22 benzodiazepines by gas chromatography-ion trap tandem mass spectrometry.
PubMed: [Fatal outcome of poisoning with the benzodiazepines flunitrazepam and diazepam].
PubMed: Determination of delorazepam in urine by solid-phase microextraction coupled to high performance liquid chromatography.
PubMed: Direct determination of benzodiazepines in biological fluids by restricted-access solid-phase microextraction.
PubMed: Binding of [3H]CB 34, a selective ligand for peripheral benzodiazepine receptors, to rat brain membranes.
PubMed: Direct LC analysis of five benzodiazepines in human urine and plasma using an ADS restricted access extraction column.
PubMed: A contemporaneous finding of fenproporex in a polydrug suicide.
PubMed: The simultaneous determination of diazepam and its three metabolites in dog plasma by high-performance liquid chromatography with mass spectroscopy detection.
PubMed: Urinary excretion of diazepam metabolites in healthy volunteers and drug users.
PubMed: Diazepam poisoning with one-month monitoring of diazepam and nordiazepam blood levels.
PubMed: Screening, identification and quantitation of benzodiazepines in serum by solid phase extraction on a cyanopropyl phase using high performance liquid chromatography and photodiode array detection.
PubMed: Liquid-phase microextraction as a sample preparation technique prior to capillary gas chromatographic-determination of benzodiazepines in biological matrices.
PubMed: Fatal intoxication with melperone.
PubMed: A modified simple and rapid reversed phase liquid chromatographic method for quantification of diazepam and nordiazepam in plasma.
PubMed: Influence of bleaching on stability of benzodiazepines in hair.
PubMed: Benzodiazepines and postoperative cognitive dysfunction in the elderly. ISPOCD Group. International Study of Postoperative Cognitive Dysfunction.
PubMed: Prolonged sedation requiring mechanical ventilation and continuous flumazenil infusion after routine doses of clorazepam for alcohol withdrawal syndrome.
PubMed: Effect of the gene dosage of CgammaP2C19 on diazepam metabolism in Chinese subjects.
PubMed: Effect of dipotassium clorazepate on amygdaloid-kindling and comparison between amygdaloid- and hippocampal-kindled seizures in rats.
PubMed: Distribution of topiramate in a medical examiner's case.
PubMed: Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives.
PubMed: The urinary elimination profiles of diazepam and its metabolites, nordiazepam, temazepam, and oxazepam, in the equine after a 10-mg intramuscular dose.
PubMed: Determination of benzodiazepines in human urine and plasma with solvent modified solid phase micro extraction and gas chromatography; rationalisation of method development using experimental design strategies.
PubMed: [Possibilities for toxicologic evidence in adipocere formation and postmortem interval of several years].
PubMed: Benzodiazepines: toxic serum concentrations in positive enzyme immunoassay responses.
PubMed: Rapid and simple chromatographic method for the determination of diazepam and its major metabolites in human plasma and urine.
PubMed: Peripheral benzodiazepine receptor messenger RNA is decreased in lymphocytes of generalized anxiety disorder patients.
PubMed: The effect of chronic benzodiazepines exposure on body weight in rats.
PubMed: Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam.
PubMed: Pilot investigation of thyrotropin-releasing hormone-induced thyrotropin and prolactin release in anxious patients treated with diazepam.
PubMed: Comparison of single- and repeated-dose pharmacokinetics of diazepam.
PubMed: Benzodiazepine-like compounds in the plasma of patients with fulminant hepatic failure.
PubMed: Naltrexone effects on diazepam intoxication and pharmacokinetics in humans.
PubMed: Diagnostic performance of the EMIT-tox benzodiazepine immunoassay, FPIA serum benzodiazepine immunoassay, and radioreceptor assay in suspected acute poisoning.
PubMed: Application of microdialysis to study the in vitro metabolism of drugs in liver microsomes.
PubMed: A fatality due to moclobemide.
PubMed: Age-related changes in the pharmacokinetic disposition of diazepam in foals.
PubMed: Paroxetine efficacy in the treatment of generalized anxiety disorder.
PubMed: Detection of benzodiazepines and other psychotropic drugs in human hair by GC/MS.
PubMed: Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose.
PubMed: Effect of sertraline on the pharmacokinetics and protein binding of diazepam in healthy volunteers.
PubMed: Benzodiazepine misuse by drug addicts.
PubMed: Evidence against oppositional and pharmacokinetic mechanisms of tolerance to diazepam's sedative effects.
PubMed: Automation of toxicological screenings on a Hewlett Packard Chemstation GC-MS system.
PubMed: Extraction of selected drugs from serum using microwave irradiation.
PubMed: Assessment of diazepam loading dose therapy of delirium tremens.
PubMed: Reduction of oxazepam to desmethyldiazepam by human intestinal bacteria.
PubMed: Hair analysis for nordiazepam and oxazepam by gas chromatography--negative-ion chemical ionization mass spectrometry.
PubMed: [Benzodiazepines in geriatrics--a case report on prolonged action].
PubMed: [Detection of nordiazepam in the hair of drug addicts].
PubMed: Lymphatic bioavailability of diazepam and desmethyldiazepam in the rat.
PubMed: [Determination of diazepam concentration in maternal and fetal serum after intravenous administration during active phase of labor and its effects on neonates].
PubMed: Absorption of diazepam after its rectal administration in dogs.
PubMed: Flumazenil, diazepam, nordiazepam and oxazepam interactions on plasma protein binding.
PubMed: Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation.
PubMed: Interethnic difference in omeprazole's inhibition of diazepam metabolism.
PubMed: Flunitrazepam and nordiazepam slowly released from silastic capsules induce physical dependence in rat.
PubMed: Development and preliminary application of high-performance liquid chromatographic assay of urinary metabolites of diazepam in humans.
PubMed: Acid-base equilibria of 1,4-benzodiazepine 4-oxides by spectrophotometry.
PubMed: Premedication with chlordemethyldiazepam and anxiolytic effect of diazepeam in implantology.
PubMed: [Determination of N-demethyldiazepam and its metabolite oxazepam in plasma by HPLC and their pharmacokinetics in rats].
PubMed: [Comparison of the effectiveness of orally administered clorazepate dipotassium and nordiazepam on preoperative anxiety].
PubMed: Behavioral and metabolic consequences of neonatal exposure to diazepam in rat pups.
PubMed: Effects of liver disease on the pharmacokinetics of intravenous and oral chlordesmethyldiazepam.
PubMed: Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4'-hydroxylation.
PubMed: Inhibition of diazepam metabolism by fluvoxamine: a pharmacokinetic study in normal volunteers.
PubMed: Metabolic and subjective responses to oral diazepam and midazolam.
PubMed: Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms.
PubMed: [Electroencephalographic demonstration of central nervous system effects of different premedication regimens].
PubMed: [Preanesthesia in elderly patients undergoing subarachnoid anesthesia: chlordesmethyldiazepam versus diazepam].
PubMed: Radioiodinated nordiazepam analog for in vivo assessment of benzodiazepine receptors by single photon emission tomography.
PubMed: Relationship between plasma benzodiazepine receptor ligand concentrations and severity of hepatic encephalopathy.
PubMed: Mesolimbic dopamine turnover effects of benzodiazepines do not correlate with sedative and muscle-relaxant potencies.
PubMed: Pharmacokinetic differences of desmethyldiazepam in three outbred Wistar strains related to differences in liver enzyme activities.
PubMed: Immunoassay detection of nordiazepam, triazolam, lorazepam, and alprazolam in blood.
PubMed: Analysis of oxazepam in urine using solid-phase extraction and high-performance liquid chromatography with fluorescence detection by post-column derivatization.
PubMed: Determination of plasma diazepam and desmethyldiazepam by solid-phase extraction and reversed-phase high-performance liquid chromatography.
PubMed: Effects of a 44-day administration of phenobarbital on disposition of clorazepate in dogs.
PubMed: Kinetics of sequential metabolism. II. Formation and metabolism of nordiazepam and oxazepam from diazepam in the perfused murine liver.
PubMed: Kinetics of sequential metabolism. I. Formation and metabolism of oxazepam from nordiazepam and temazepam in the perfused murine liver.
PubMed: Pharmacokinetics of nordiazepam in physical dependence and precipitated abstinence in dogs.
PubMed: Solid-phase extraction of 1,4-benzodiazepines from biological fluids.
PubMed: Inhibitory effect of diltiazem on diazepam metabolism in the mouse hepatic microsomes.
PubMed: Subjective and behavioral effects of diazepam depend on its rate of onset.
PubMed: Studies of "endogenous" benzodiazepine in human hepatic encephalopathy.
PubMed: Studies on the excretion of diazepam and nordazepam into milk for the prediction of milk-to-plasma drug concentration ratios.
PubMed: Quantitation by gas chromatography with selected-ion monitoring mass spectrometry of "natural" diazepam, N-desmethyldiazepam and oxazepam in normal human serum.
PubMed: Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.
PubMed: Determination of nonderivatized para-hydroxylated metabolites of diazepam in biological fluids with a GC Megabore column system.
PubMed: Diazepam metabolism by rat and human liver in vitro: inhibition by mephenytoin.
PubMed: The effects of felodipine on the pharmacokinetics of diazepam.
PubMed: Comparative metabolism of clinically important precursors of N-desmethyldiazepam using phenobarbitone-pretreated rat liver microsomes.
PubMed: Benzodiazepine metabolism in ethanol-treated male rats: use of pair-fed and age-matched controls.
PubMed: Niaprazine vs chlordesmethyldiazepam in sleep disturbances in pediatric outpatients.
PubMed: Effect of benzodiazepines on tryptophan binding to rat hepatic nuclei.
PubMed: Serum disposition of oral clorazepate from regular-release and sustained-delivery tablets in dogs.
PubMed: [Monitoring of diazepam treatment: comparison of the results of gas chromatography and radioreceptor methods].
PubMed: Pharmacokinetics of diazepam intramuscularly administered to rhesus monkeys.
PubMed: Chronic administration of and dependence on halazepam, diazepam, and nordiazepam in the dog.
PubMed: Elevated brain concentrations of 1,4-benzodiazepines in fulminant hepatic failure.
PubMed: Effect of orally administered misoprostol and cimetidine on the steady state pharmacokinetics of diazepam and nordiazepam in human volunteers.
PubMed: Amnestic effects of intravenous diazepam in healthy young men.
PubMed: Differences in the duration of sedative and anxiolytic effects of desmethyldiazepam in two outbred Wistar strains.
PubMed: Determination of diazepam and nordazepam in milk and plasma in the presence of oxazepam and temazepam.
PubMed: Characterization by saturation studies of the in vivo binding of [3H]flunitrazepam in mouse brain.
PubMed: Pharmacokinetic profiles of prazepam and 14C-prazepam in rat.
PubMed: Pharmacokinetics of intravenous and oral chlordesmethyldiazepam in patients on regular haemodialysis.
PubMed: Distribution of diazepam, nordiazepam, and oxazepam between brain extraneuronal space, brain tissue, plasma, and cerebrospinal fluid in diazepam and nordiazepam dependent dogs.
PubMed: Disposition of clorazepate in dogs after single- and multiple-dose oral administration.
PubMed: A death due to self-administered fentanyl.
PubMed: Benzodiazepine-induced antagonism of opioid antinociception may be abolished by spinalization or blockade of the benzodiazepine receptor.
PubMed: Ciprofloxacin does not impair the elimination of diazepam in humans.
PubMed: Depressive stupor and chlordesmethyldiazepam.
PubMed: [Antagonism with flumazenil of sedation by benzodiazepine during loco-regional anesthesia].
PubMed: Liquid chromatographic assay and pharmacokinetics of halazepam and its metabolite in humans.
PubMed: Diazepam loading in alcohol withdrawal: clinical pharmacokinetics.
PubMed: Cytochrome P450IIIA enzymes in rat liver microsomes: involvement in C3-hydroxylation of diazepam and nordazepam but not N-dealkylation of diazepam and temazepam.
PubMed: Depressive stupor treated with intramuscular chlordesmethyldiazepam.
PubMed: Effect of omeprazole and cimetidine on plasma diazepam levels.
PubMed: Effects of single doses of alprazolam and diazepam, alone and in combination with ethanol, on psychomotor and cognitive performance and on autonomic nervous system reactivity in healthy volunteers.
PubMed: Effect of chronic oral delorazepam on in vitro and in vivo hepatic drug-metabolizing enzyme activities in the rat.
PubMed: Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.
PubMed: Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole.
PubMed: Determination of pharmacodynamics of diazepam by quantitative pharmaco-EEG.
PubMed: Bioinequivalence of a generic brand of diazepam.
PubMed: A large-sample study of diazepam pharmacokinetics.
PubMed: [Control of the side effects of ketamine: chlordemethyldiazepam vs diazepam in pre-anesthesia].
PubMed: In vitro drug metabolism and pharmacokinetics of diazepam in cynomolgus monkey hepatocytes during culture for six days.
PubMed: Effect of the benzodiazepines diazepam, des-N-methyldiazepam and midazolam on corticosteroid biosynthesis in bovine adrenocortical cells in vitro; location of site of action.
PubMed: Detection of desmethyldiazepam and diazepam in brain of different species and plants.
PubMed: Physical dependence on diazepam in the dog: precipitation of different abstinence syndromes by the benzodiazepine receptor antagonists Ro 15-1788 and ZK 93426.
PubMed: Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.
PubMed: A rapid HPLC procedure for the simultaneous determination of chloroquine, monodesethylchloroquine, diazepam, and nordiazepam in blood.
PubMed: Efficacy of flumazenil in COPD patient with therapeutic diazepam levels.
PubMed: [Chlordesmethyldiazepam and prolactinemia during surgical stress].
PubMed: Placental transfer and distribution of pinazepam and its metabolite N-desmethyldiazepam in the maternal and fetal rabbit: effect of the stage of gestation.
PubMed: Double-blind placebo cross-over study of long-acting (chlordesmethyldiazepam) versus short-acting (lorazepam) benzodiazepines in generalized anxiety disorders.
PubMed: Toxicity in a case of acute and massive overdose of chlordiazepoxide and its correlation to blood concentration.
PubMed: Radioreceptor assay of clonazepam and diazepam in blood for therapeutic drug monitoring.
PubMed: Benzodiazepines: are they of natural origin?
PubMed: Clorazepate, correlation between metabolism and anticonvulsant activity.
PubMed: [A ketamine-chlordemethyldiazepam combination in celioscopy].
PubMed: Studies of cyclodextrin inclusion complexes: II--Inclusion complexes between alpha-cyclodextrin and N-desmethyldiazepam and chlordiazepoxide.
PubMed: Sensitive determination of diazepam and N-desmethyldiazepam in human material using capillary gas chromatography-mass spectrometry.
PubMed: [Screening of the new benzodiazepine derivative, pinazepan, and its major metabolites].
PubMed: Comparative single-dose kinetics and dynamics of lorazepam, alprazolam, prazepam, and placebo.
PubMed: [Use of a chlordemethyldiazepam-fentanyl combination in invasive neuroradiologic examinations].
PubMed: Desmethyldiazepam pharmacokinetics: studies following intravenous and oral desmethyldiazepam, oral clorazepate, and intravenous diazepam.
PubMed: Metabolism of diazepam in vitro by human liver. Independent variability of N-demethylation and C3-hydroxylation.
PubMed: Kinetics of drug action in disease states. XXV. Effect of experimental hypovolemia on the pharmacodynamics and pharmacokinetics of desmethyldiazepam.
PubMed: Effects of HOE 760 (histamine H2-receptor antagonist) on diazepam pharmacokinetics.
PubMed: [Potentiating drugs in postoperative pain control with opiates for patient controlled analgesia].
PubMed: Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs.
PubMed: The effect of fluoxetine on the pharmacokinetics and psychomotor responses of diazepam.
PubMed: Effect of food on absorption of chlordemethyldiazepam.
PubMed: Kinetics of drug action in disease states. XXIV. Pharmacodynamics of diazepam and its active metabolites in rats.
PubMed: Endogenous benzodiazepines in brain: right or wrong?
PubMed: Improved method for the determination of diazepam and N-desmethyldiazepam in plasma using capillary gas chromatography and nitrogen-phosphorus detection.
PubMed: [Effects of chlordemethyldiazepam on blood cortisol during surgical stress].
PubMed: Pharmacokinetics and bioavailability of intravenous and oral chlordesmethyldiazepam in humans.
PubMed: Comparison of sublingual and oral prazepam in normal subjects. II. Pharmacokinetic and pharmacodynamic data.
PubMed: Imipramine treatment alters the pharmacokinetics and pharmacodynamics of diazepam.
PubMed: Identification and differentiation of benzodiazepines and their metabolites in urine by computerized gas chromatography-mass spectrometry.
PubMed: Simultaneous determination of diazepam and its active metabolites in rat serum, brain and cerebrospinal fluid by high-performance liquid chromatography.
PubMed: Analysis of chlorodesmethyldiazepam and its metabolites in plasma and urine.
PubMed: The effect of diazepam on nociception in mice.
PubMed: Placental and blood-CSF transfer of orally administered diazepam in the same person.
PubMed: Validation of a radioreceptor assay technique for monitoring pharmacological active material during intensive diazepam tetanus therapy.
PubMed: Effects of propranolol, atenolol, and chlordesmethyldiazepam on response to mental stress in patients with recent myocardial infarction.
PubMed: Diazepam and desmethyldiazepam differ in their affinities and efficacies at 'central' and 'peripheral' benzodiazepine receptors.
PubMed: Microsample determination of diazepam and its three metabolites in serum by reversed-phase high-performance liquid chromatography.
PubMed: [Premedication for endoscopic examinations with intravenous administration of chlordesmethyldiazepam. A controlled double-blind study with diazepam and placebo].
PubMed: Nocturnal doses of ranitidine and nizatidine do not affect the disposition of diazepam.
PubMed: Apparent lesser physical dependence potential of nor-diazepam compared to diazepam in the rat.
PubMed: Differences in diazepam pharmacokinetics in Chinese and white Caucasians--relation to body lipid stores.
PubMed: Diazepam and N-desmethyldiazepam are found in rat brain and adrenal and may be of plant origin.
PubMed: [Chlordesmethyldiazepam as an anesthesia-inducing agent: time of loss of consciousness. Statistical analysis in man].
PubMed: Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in human brain.
PubMed: Influence of propranolol coadministration or cigarette smoking on the kinetics of desmethyldiazepam following intravenous clorazepate.
PubMed: Diazepam and methadone blood levels following concurrent administration of diazepam and methadone.
PubMed: [Determination of diazepam and its metabolites in the blood by microcolumn high-performance liquid chromatography].
PubMed: Serum concentrations of diazepam and its metabolite desmethyldiazepam in epileptic patients after chronic diazepam treatment.
PubMed: Potencies of diazepam metabolites in rats trained to discriminate diazepam.
PubMed: Pharmacokinetics of chlordesmethyldiazepam after single-dose oral administration in humans.
PubMed: P-450 activity in monolayer cultures of hepatocytes seeded in polystyrene tissue culture dishes.
PubMed: [Epilepsy induced by penicillin in rabbits: comparative study of the anticonvulsant effects of diazepam and chlordesmethyldiazepam].
PubMed: The effect of diazepam on indices of 5-HT function in man.
PubMed: Aging: changes in distribution of diazepam and metabolites in the rat.
PubMed: Interaction of diazepam with famotidine and cimetidine, two H2-receptor antagonists.
PubMed: The pharmacological profile of chlordesmethyldiazepam and other benzodiazepines.
PubMed: Acute tolerance to diazepam in mice: pharmacokinetic considerations.
PubMed: Premedication with oral and rectal diazepam.
PubMed: Screening and quantification of hypnotic sedatives in serum by capillary gas chromatography with a nitrogen-phosphorus detector, and confirmation by capillary gas chromatography-mass spectrometry.
PubMed: Diazepam metabolism in the guinea pig materno-fetal model: effects of cigarette smoke.
PubMed: The pharmacokinetics of diazepam and desmethyldiazepam in rat brain and plasma.
PubMed: Preliminary study of the pharmacokinetics of desmethyldiazepam administered as drops or tablets.
PubMed: Age-related multiple-dose pharmacokinetics and anxiolytic effects of delorazepam (chlordesmethyldiazepam).
PubMed: Disruption of schedule-controlled behavior by Ro 15-1788 one day after acute treatment with benzodiazepines.
PubMed: Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro.
PubMed: [Effects of intravenous administration of chlordesmethyldiazepam on paroxysmal intercritical activity in various electroclinical forms of infantile epilepsy].
PubMed: Tissue distribution of diazepam and its metabolite desmethyldiazepam: a human autopsy study.
PubMed: N-desmethyldiazepam physical dependence in dogs.
PubMed: Development of tolerance to the anticonvulsant effect of diazepam in amygdala-kindled rats.
PubMed: Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788.
PubMed: Severe withdrawal syndrome after substitution of a short-acting benzodiazepine for a long-acting benzodiazepine.
PubMed: Liquid-chromatographic assay of diazepam and its major metabolites in serum, and application to pharmacokinetic study of high doses of diazepam in schizophrenics.
PubMed: [Efficacy and kinetics of chlorazepate administered to anxious patients in a single daily dose].
PubMed: Responsiveness to oral diazepam in the elderly: relationship to total and free plasma concentrations.
PubMed: Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines.
PubMed: [Effect of sodium valproate on brain levels of diazepam and N-desmethyldiazepam in the rat].
PubMed: Effect of clorazepate in spasticity and rigidity: a quantitative study of reflexes and plasma concentrations.
PubMed: Plasma concentrations of diazepam and N-desmethyldiazepam in Asian children after an intravenous or rectal dose of diazepam.
PubMed: Long-lasting anticonvulsant effects of diazepam in different mouse strains: correlations with brain concentrations and receptor occupancy.
PubMed: Diazepam and desmethyldiazepam in breast milk.
PubMed: Inhibition of diazepam metabolism in microsomal- and perfused liver preparations of the rat by desmethyldiazepam, N-methyloxazepam and oxazepam.
PubMed: Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics.
PubMed: Withdrawal responses to abrupt discontinuation of desmethyldiazepam.
PubMed: Diazepam tapering in detoxification for high-dose benzodiazepine abuse.
PubMed: Propranolol interactions with diazepam, lorazepam, and alprazolam.
PubMed: In vitro interaction of diazepam and oxazepam with pancuronium and suxamethonium.
PubMed: Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepam.
PubMed: Plasma concentrations and clinical effects after single oral doses of prazepam, clorazepate, and diazepam.
PubMed: Development of tolerance to the anticonvulsant effect of diazepam in dogs.
PubMed: Value of serum diazepam and nordiazepam measurements in anxious patients.
PubMed: Clinical importance of the interaction of diazepam and cimetidine.
PubMed: Multiple-dose halazepam kinetics.
PubMed: Diazepam and desmethyldiazepam plasma concentrations in chronic anxious outpatients.
PubMed: Pharmacokinetics of diazepam and nordiazepam in the cat.
PubMed: Cimetidine interaction with dipotassium clorazepate disposition in the anesthetized dog.
PubMed: The contribution of the active metabolites to the tolerance developing to diazepam in man: relationship to bioassayed serum benzodiazepine levels.
PubMed: Elimination kinetics and symptomatology of diazepam withdrawal in abusers.
PubMed: Subcellular distribution of pinazepam and its metabolite N-desmethyldiazepam in rat liver.
PubMed: Dose-response analysis of the behavioral effects of diazepam: II. Psychomotor performance, cognition and mood.
PubMed: Drowsiness sedation levels in anxious neurotic outpatients.
PubMed: Decreased serum protein binding of diazepam and its major metabolite in the neonate during the first postnatal week relate to increased free fatty acid levels.
PubMed: Antiepileptic effect and serum levels of clorazepate on children with refractory seizures.
PubMed: Placental transfer of pinazepam and its metabolite N-desmethyldiazepam in women at term.
PubMed: [Pharmacokinetics and metabolite pattern of tetrazepam and chlordesmethyldiazepam].
PubMed: Diazepam/beta-adrenoceptor antagonist interactions.
PubMed: Clorazepate dipotassium and diazepam in renal insufficiency: serum concentrations and protein binding of diazepam and desmethyldiazepam.
PubMed: Pharmacokinetics of benzodiazepines: metabolic pathways and plasma level profiles.
PubMed: Diazepam: prediction of pharmacodynamics from pharmacokinetics.
PubMed: Pharmacokinetic model for diazepam and its major metabolite desmethyldiazepam following diazepam administration.
PubMed: Radioimmunoassay for determination of prazepam and its metabolites.
PubMed: Prolonged accumulation of diazepam in obesity.
PubMed: Differences in in vitro binding of diazepam and N-desmethyldiazepam to maternal and fetal plasma proteins at birth: relation to free fatty acid concentration and other parameters.
PubMed: Pharmacokinetics of benzodiazepines and psychostimulants in children.
PubMed: Disposition, distribution, plasma protein binding and biliary excretion of pinazepam after i.p. administration to rat.
PubMed: [Use of chlordemethyldiazepam in pediatric preanesthesia].
PubMed: Identification of some interferences in the analysis of clorazepate.
PubMed: High-performance liquid chromatography determination of dipotassium clorazepate and its major metabolite nordiazepam in plasma.
PubMed: Psychomotor effects of diazepam in anxious patients and healthy volunteers.
PubMed: Steady state plasma concentration profiles and therapeutic response in anxious-depressed outpatients after administration of a chlordiazepoxide-amitriptyline combination.
PubMed: Repeated diazepam dosing in cirrhotic patients: cumulation and sedation.
PubMed: [Benzodiazepines: significance of kinetics for therapy].
PubMed: Diazepam kinetics in patients with severe burns.
PubMed: Serum protein binding of diazepam, desmethyldiazepam, furosemide, indomethacin, warfarin, and phenobarbital in human fetus, mother, and newborn infant.
PubMed: Multiple-dose pharmacokinetics of diazepam following once-daily administration of a controlled-release capsule.
PubMed: Metabolic and pharmacological studies with N-methyl-N'-methyl-2'-allyl-2-benzoyl-4-chloro-glycinanilide (F 1797).
PubMed: Halazepam as a precursor of desmethyldiazepam: quantitation by electron-capture gas-liquid chromatography.
PubMed: [Intraerythrocyte penetration of diazepam and its 2 principal metabolites].
PubMed: The role of buffer composition during equilibrium dialysis in determining concentrations of free diazepam in serum.
PubMed: Benzodiazepine kinetics: implications for therapeutics and pharmacogeriatrics.
PubMed: Blood concentrations of diazepam and its metabolites in children and neonates with tetanus.
PubMed: Pharmacokinetics of chlorazepate after intravenous and intramuscular administration.
PubMed: Correlation of the bioavailability of diazepam from uncoated tablets in beagle dogs with its dissolution rate and bioavailability in humans.
PubMed: Determination of peptidoaminobenzophenone (2-o-chlorobenzoyl-4-chloro-N-methyl-N'-glycylglycinanilide) and its metabolites in human plasma by glass capillary gas chromatography negative ion chemical ionization mass spectrometry--1.
PubMed: Chronic diazepam treatment in psychiatric outpatients.
PubMed: Cimetidine impairs clearance of antipyrine and desmethyldiazepam in the elderly.
PubMed: [Prevention and therapy of delirium tremens with tiapride and chlordesmethyldiazepam].
PubMed: New anxiolytics: are they really new?
PubMed: Value of a single night-time dose of potassium clorazepate in anxiety: a controlled trial comparison with diazepam.
PubMed: Prolongation of drug half-life due to obesity: studies of desmethyldiazepam (clorazepate).
PubMed: Kinetics of high-dose i.v. diazepam.
PubMed: Does ethyl-beta-carboline-3-carboxylate interact with mouse brain benzodiazepine receptors in vivo?
PubMed: Desmethyldiazepam kinetics after intravenous, intramuscular, and oral administration of clorazepate dipotassium.
PubMed: Relationship of diazepam serum level to antianxiety effects.
PubMed: Valproic acid and diazepam interaction in vivo.
PubMed: A radioreceptor assay to study the affinity of benzodiazepines and their receptor binding activity in human plasma including their active metabolites.
PubMed: Effect of ethanol ingestion on outcome of drug overdose.
PubMed: Disposition, distribution, and liver first-pass effect of pinazepam in the rat.
PubMed: Steady-state plasma desmethyldiazepam during long-term clorazepate use: effects of antacids.
PubMed: [The distribution of drugs between plasma, brain and cerebrospinal fluid in the human].
PubMed: Effects of oral chlordemethyldiazepam on plasma adrenaline and noradrenaline and cardiovascular reactivity in preoperative patients.
PubMed: Anticonvulsant potency of unmetabolized diazepam.
PubMed: Sensitivity of auditory lateralization and temporal order tests to benzodiazepines.
PubMed: Pinazepam: a precursor of N-desmethyldiazepam.
PubMed: Radioimmunoassay of benzodiazepines.
PubMed: Elimination kinetics of desmethyldiazepam in two young and two elderly subjects.
PubMed: Does chlordesmethyldiazepam have a specific anti-erotic effect? Report on five observations.
PubMed: [Bioavailibility of dipotassium chlorazepate].
PubMed: Rapid gas chromatographic measurement of diazepam and its metabolites desmethyldiazepam, oxazepam, and 3-hydroxydiazepam (temazepam) in small samples of plasma.
PubMed: [Anxiolytics in man: studies on sleep and performance (author's transl)].
PubMed: Interaction of caffeine with benzodiazepines: behavioral effects in mice.
PubMed: Clinical bioavailability evaluation of a controlled release formulation of diazepam.
PubMed: Pharmacokinetics of diazepam in epileptic patients and normal volunteers following intravenous administration.
PubMed: [Pharmacokinetic of benzodiazepines in old age].
PubMed: Long-term use of diazepam.
PubMed: The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration.
PubMed: Clorazepate and phenobarbital as antiepileptic drugs: a double-blind study.
PubMed: Aspects of the interaction of thyroxine and its binding serum proteins with 1,4-benzodiazepine tranquillizers.
PubMed: A rapid procedure for the screening and quantitation of barbiturates, diazepam, desmethyldiazepam and methaqualone.
PubMed: [Pharmacokinetics of oral prazepam].
PubMed: [Plasma levels following high diazepam doses in intensive-care medicine (author's transl)].
PubMed: Effects of desmethyldiazepam on diazepam kinetics: a study of effects of a metabolite on parent drug disposition.
PubMed: Comparative protein binding of diazepam and desmethyldiazepam.
PubMed: Pharmacological requirements of patients during alcohol withdrawal.
PubMed: The effect of diazepam on rates of fertilization in the CF-1 mouse.
PubMed: Clearance of diazepam can be impaired by its major metabolite desmethyldiazepam.
PubMed: Binding of diazepam and desmethyldiazepam to plasma protein: concentration-dependence and interactions.
PubMed: Effects of two dosages of chlordesmethyldiazepam on mnestic-information processes in normal subjects.
PubMed: Metabolism of pinazepam by rat liver microsomes.
PubMed: Benzodiazepine overdosage: plasma concentrations and clinical outcome.
PubMed: Effect of chloro-N-desmethyldiazepam on serum and brain tryptophan and serotonin in relation to the activity of central serotonergic neurons.
PubMed: Concentrations of N-descyclopropylmethylprazepam in whole-blood, plasma, and milk after administration of prazepam to humans.
PubMed: Plasma diazepam and desmethyldiazepam concentrations during long-term diazepam therapy.
PubMed: Some behavioral effects of chlorodesmethyldiazepam and lorazepam.
PubMed: Effect of age and sex on disposition of desmethyldiazepam formed from its precursor clorazepate.
PubMed: Pharmacokinetics of N-desmethyldiazepam after a single oral dose of clorazepate: the effect of smoking.
PubMed: Studies on some pharmacological activities of 7-nitro-2-amino-5-phenyl-3H-1,5-benzodiazepine (CP 1414 S) in the rat. A comparison with diazepam.
PubMed: Evaluation of an enzyme immunoassay for determining diazepam and nordiazepam in serum and urine.
PubMed: Comparative protein binding of diazepam and desmethyldiazepam.
PubMed: Influence of cimetidine on the pharmacokinetics of desmethyldiazepam and oxazepam.
PubMed: High-performance liquid chromatographic and gas-liquid chromatographic determination of diazepam and nordiazepam in plasma.
PubMed: [Current intravenous anesthetics].
PubMed: Desmethyldiazepam kinetics in the elderly after oral prazepam.
PubMed: Methane negative chemical ionization analysis of 1,3-dihydro-5-phenyl-1,4-benzodiazepin-2-ones.
PubMed: Simultaneous assay of diazepam, chlordiazepoxide, N-desmethyldiazepam, N-desmethylchloridazepoxide, and demoxepam in serum by high performance, liquid chromatography.
PubMed: Effect of diazepam and desmethyldiazepam in spasticity and rigidity. A quantitative study of reflexes and plasma concentrations.
PubMed: Delayed clearance of diazepam due to cimetidine.
PubMed: Diazepam and N-desmethyldiazepam concentrations in saliva, plasma and CSF.
PubMed: Diazepam and N-desmethyldiazepam redistribution after heparin.
PubMed: [Drug catabolism and its significance for pharmacotherapy].
PubMed: Diurnal variations in plasma diazepam concentrations associated with reciprocal changes in free fraction.
PubMed: Determination of some benzodiazepines and metabolites in serum, urine and saliva by high-performance liquid chromatography.
PubMed: Diazepam and N-desmethyldiazepam in saliva of hospital inpatients.
PubMed: Comparative effects of two commercially available blood collection tubes on plasma concentrations of drugs.
PubMed: Withdrawal reaction from long-term, low-dosage administration of diazepam. A double-blind, placebo-controlled case study.
PubMed: Plasma levels of chlorodesmethyldiazepam in humans.
PubMed: Kinetics and neuropsychologic effects of IV diazepam in the presence and absence of its active N-desmethyl metabolite in humans.
PubMed: Anxiety and sedation during a stressful situation after single dose of diazepam versus N-desmethyldiazepam--a controlled trial.
PubMed: Entry of diazepam and its major matabolite into cerebrospinal fluid.
PubMed: Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics.
PubMed: The psychosedative effect of chlordesmethyldiazepam on anxiety states in neurotic and psychotic inpatients.
PubMed: Pharmacokinetics of dipotassium chlorazepate in patients after repeated 50 mg oral doses.
PubMed: Monitoring clorazepate dipotassium as desmethyldiazepam in plasma by electron-capture gas--liquid chromatography.
PubMed: Intravascular factors affecting diazepam binding to human serum albumin.
PubMed: Desmethyldiazepam: a specific radioimmunoassay.
PubMed: Single case study. Diazepam (Valium) detoxification.
PubMed: Effect of age and Billroth gastrectomy on absorption of desmethyldiazepam from clorazepate.
PubMed: Pharmacokinetics of prazepam in man.
PubMed: In vitro effects of diazepam, desmethyldiazepam & nitrazepam on ATPase activity of human fetal brain.
PubMed: Acute and chronic effects of three benzodiazepines in the social interaction anxiety test in mice.
PubMed: [A screening radioimmunoassay for 1,4-benzodiazepines in human blood, serum, and urine using anti-oxazepam-hemisuccinate-antibodies (author's transl)].
PubMed: Single-dose kinetics of prazepam, a precursor of desmethyldiazepam.
PubMed: Effect of age on the pharmacokinetics of diazepam given in conjunction with spinal anesthesia.
PubMed: Sensitive gas chromatographic method for the determination of diazepam and N-desmethyldiazepam in plasma.
PubMed: Analysis for diazepam and nordiazepam by electron-capture gas chromatography and by liquid chromatography.
PubMed: Elimination half-life of nordiazepam.
PubMed: Liquid-chromatographic assay of diazepam and its major metabolites in plasma.
PubMed: Plasma concentrations of medazepam and its metabolites after oral administration.
PubMed: Simultaneous determination of diazepam and its metabolies N-desmethyldiazepam, oxydiazepam and oxazepam in plasma and urine of man and dog by means of high-performance liquid chromatography.
PubMed: Gas chromatographic determination of chlorodesmethyldiazepam and lorazepam in rats and mice.
PubMed: Monitoring diazepam and desmethyldiazepam concentrations in plasma by gas-liquid chromatography, with use of a nitrogen-sensitive detector.
PubMed: Altered elimination of desmethyldiazepam in the elderly.
PubMed: Self-rated sedation and plasma concentrations of desmethyldiazepam following single doses of clorazepate.
PubMed: Effects on learning and memory of 2-week treatments with chlordiazepoxide lactam, N-desmethyldiazepam, oxazepam and methyloxazepam, alone or in combination with alcohol.
PubMed: Plasma concentration of diazepam and N-desmethyldiazepam in children after a single rectal or intramuscular dose of diazepam.
PubMed: Dose-dependent pharmacokinetics of 7-chloro-1,3-dihydro-5-(2'-chlorophenyl)-2H-1,4-benzodiazepin-2-one in dogs.
PubMed: Quantitation of chlordiazepoxide and its metabolites in biological fluids by thin-layer chromatography.
PubMed: Plasma concentrations of diazepam and N-desmethyldiazepam in newborn infants after intravenous, intramuscular, rectal and oral administration.
PubMed: Rapid recovery from massive diazepam overdose.
PubMed: A micromethod for simultaneous estimation of blood levels of some commonly used antiepileptic drugs.
PubMed: Fluorescence--TLC densitometric determination of diazepam and other 1,4-benzodiazepines in serum.
PubMed: Simultaneous gas-chromatographic analysis for diazepam and its major metabolite, desmethyldiazepam, with use of double internal standardization.
PubMed: Immediate and residual effects in man of the metabolites of diazepam.
PubMed: [Clinical pharmacokinetics of diazepam and its biologically active metabolites (author's transl)].
PubMed: Impaired absorption of desmethyldiazepam from clorazepate by magnesium aluminum hydroxide.
PubMed: Pharmacokinetic understanding of antianxiety drug therapy.
PubMed: Plasma concentrations of diazepam and desmethyldiazepam during chronic diazepam therapy.
PubMed: Clorazepate kinetics in treated epileptics.
PubMed: [Studies on metabolism of prazepam. II. Metabolism of prazepam, diazepam and desalkylprazepam by rat liver microsomes (author's transl)].
PubMed: [Binding of prazepam, desalkylprazepam and diazepam to human serum albumin (author's transl)].
PubMed: Plasma and urine concentrations of diazepam and its metabolites in children, adults and in diazepam-intoxicated patients.
PubMed: Effect of a cocktail on diazepam absorption.
PubMed: Diazepam, alcohol and drivers.
PubMed: Determination of benzodiazepine anticonvulsants in plasma by high-performance liquid chromatography.
PubMed: Prazepam, a precursor of desmethyldiazepam.
PubMed: High-performance liquid chromatographic determination of benzodiazepines in human plasma.
PubMed: High-pressure liquid chromatographic analysis of diazepam, oxazepam and N-desmethyldiazepam in human blood.
PubMed: Determination of desmethyldiazepam in plasma by electron-capture GLC: application to pharmacokinetic studies of clorazepate.
PubMed: Thin-layer chromatographic method for determination of diazepam and its major metabolite, N-desmethyldiazepam, in human serum.
PubMed: Determination of N-desmethyldiazepam in plasma by gas chromatography with an internal standard.
PubMed: Conflict behavior in the squirrel monkey: effects of chlordiazepoxide, diazepam and N-desmethyldiazepam.
PubMed: Influence of the 2'-chloro substitution on central activity of desmethyldiazepam.
PubMed: [Determination of dipotassium clorazepate in the plasma by gas chromatography (author's transl)].
PubMed: Rapid determination of diazepam and nordiazepam in plasma by electron capture gas--liquid chromatography. Application in clinical pharmacokinetic studies.
PubMed: Rapid gas chromatographic assay of serum diazepam, N-desmethyldiazepam, and N-desalkylflurazepam.
PubMed: Hydroxylation of three benzodiazepines in vitro.
PubMed: Activity of N-desmethyldiazepam (nordiazepam) [proceedings].
PubMed: Serum medazepam, diazepam, and N-desmethyldiazepam levels after single and multiple oral doses of medazepam.
PubMed: [Important factors determining human distribution and elimination of diazepam].
PubMed: On the hypnogenic and anticonvulsant activities of demethyldiazepam and chlordemethyldiazepam: time-effect relations.
PubMed: Rapid micro-method for the measurement of diazepam and desmethyldiazepam in blood plasma by gas-liquid chromatography.
PubMed: Pharmacokinetics of N-desmethyldiazepam in healthy volunteers after single daily doses of dipotassium chlorazepate.
PubMed: Analysis of medazepam, diazepam, and metabolites in plasma by gas-liquid chromatography with electrolytic conductivity detection.
PubMed: Allergy to diazepam.
PubMed: Disposition of diazepam and its major metabolite desmethyldiazepam in patients with liver disease.
PubMed: Unchanged protein binding and the increase of serum diazepam levels after food intake.
PubMed: Double-blind cross-over clinical comparison of two 2'-chloro benzodiazepines: 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (chlordesmethyldiazepam) versus 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam) in neurotic anxiety.
PubMed: Single-blind evaluation of hypnotic activity of chlordesmethyldiazepam in No-placebo-reactor medical patients.
PubMed: [Treatment of epileptic crisis with chlorazepate dipotassium. Clinical study of 48 patients with the determination of serum levels of nordiazepam].
PubMed: Steady-state bioavailability of two clorazepate dipotassium dosage forms.
PubMed: Effect of desmethyldiazepam and chlordesmethyldiazepam on 3',5'-cyclic guanosine monophosphate levels in rat cerebellum.
PubMed: A simplified quantitative method for the simultaneous determination of diazepam and its metabolites in serum by thin-layer chromatography.
PubMed: Quantitative high-performance liquid chromatography of diazepam and N-desmethyldiazepam in blood.
PubMed: Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat.
PubMed: N-desmethyldiazepam: a new metabolite of chlordiazepoxide in man.
PubMed: [Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice].
PubMed: Effect of N-desmethyldiazepam (nordiazepam) and a precursor, potassium clorazepate, on sleep in man.
PubMed: Feto-maternal concentrations of diazepam and W-demethyldiazepam after intra-amniotic diazepam injection.
PubMed: Pharmacokinetics of N-demethyldiazepam in patients suffering from insomnia and treated with nortriptyline.
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