butenafine hydrochloride
N-4-tert-butylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride
 
Notes:
studied on experimental dermatophytosis.
  • BOC Sciences
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      Product(s):
      101827-46-7 Butenafine HCl >98%
      Butenafine HCl is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.
       
       
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      Product(s):
      B3293 Butenafine Hydrochloride >98.0%(HPLC)(T)
       
Synonyms   Articles   Notes   Search
CAS Number: 101827-46-7Picture of molecule3D/inchi
FDA UNII: R8XA2029ZI
MDL: MFCD00917064
Molecular Weight: 353.93516000
Formula: C23 H28 Cl N
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
Butenafine HCl >98%
Odor: characteristic
Use: Butenafine HCl is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.
Carbosynth
For experimental / research use only.
Butenafine Hydrochloride
Kingchem Laboratories
Butenafine Hydrochloride
Santa Cruz Biotechnology
For experimental / research use only.
Butenafine Hydrochloride ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Butenafine Hydrochloride ≥98% (HPLC)
TCI AMERICA
For experimental / research use only.
Butenafine Hydrochloride >98.0%(HPLC)(T)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-dog LD50  > 5000 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ATAXIA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1551, 1990.

intravenous-mouse LD50  > 140 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.

oral-mouse LD50  > 5000 mg/kg
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1539, 1990.

intravenous-rat LD50  > 100 mg/kg
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1539, 1990.

oral-rat LD50  > 4000 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.

intraperitoneal-rat LDLo  1000 mg/kg
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 2589, 1990.

Dermal Toxicity:
skin-dog LD50 > 100 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.

skin-mouse LD50 > 800 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.

subcutaneous-mouse LD50 > 200 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.

skin-rat LD50 > 1000 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.

subcutaneous-rat LD50 > 150 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: pharmaceuticals / chemical synthisis
Recommendation for butenafine hydrochloride usage levels up to:
 not for fragrance use.
 
Recommendation for butenafine hydrochloride flavor usage levels up to:
 not for flavor use.
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Safety References:
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 443867
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: nwg
 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride
Chemidplus: 0101827467
RTECS: QJ8585000 for cas# 101827-46-7
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References:
 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 443867
Pubchem (sid): 135041927
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C12490
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2921.49.5000
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 butenafine HCl
N-4-tert-butylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride
N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine hydrochloride
1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride
N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-1-naphthalenemethanamine hydrochloride
 KP-363
 mentax
 mentax-TC
1-naphthalenemethanamine, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-, hydrochloride
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Articles:
PubMed: Tinea nigra presenting speckled or "salt and pepper" pattern.
PubMed: Influence of penetration enhancers and molecular weight in antifungals permeation through bovine hoof membranes and prediction of efficacy in human nails.
PubMed: Efficacy of topical antifungals in the treatment of dermatophytosis: a mixed-treatment comparison meta-analysis involving 14 treatments.
PubMed: Determination of butenafine hydrochloride in human plasma by liquid chromatography electrospray ionization-mass spectrometry following its topical administration in human subjects.
PubMed: Stability-indicating LC assay for butenafine hydrochloride in creams using an experimental design for robustness evaluation and photodegradation kinetics study.
PubMed: RP-HPLC method for simultaneous determination of butenafine hydrochloride and betamethasone dipropionate in a cream formulation.
PubMed: A simple and rapid method to assess butenafine hydrochloride in skin samples and a comparative cutaneous retention study of two marketed formulations.
PubMed: Simultaneous HPLC determination of butenafine hydrochloride and betamethasone in a cream formulation.
PubMed: Butenafine and superficial mycoses: current status.
PubMed: A Japanese case of tinea corporis caused by Arthroderma benhamiae.
PubMed: Butenafine hydrochloride (Mentax) cream for the treatment of hyperkeratotic type tinea pedis and its transfer into the horny layer, with or without concomitant application of 20% urea ointment (Keratinamin).
PubMed: Comparison of in vitro antifungal activities of topical antimycotics launched in 1990s in Japan.
PubMed: Butenafine hydrochloride: for the treatment of interdigital tinea pedis.
PubMed: Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream.
PubMed: Management of toenail onychomycosis with 2% butenafine and 20% urea cream: a placebo-controlled, double-blind study.
PubMed: A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine, a new antifungal agent.
PubMed: Butenafine 1% cream in the treatment of tinea cruris: a multicenter, vehicle-controlled, double-blind trial.
PubMed: One-week therapy with twice-daily butenafine 1% cream versus vehicle in the treatment of tinea pedis: a multicenter, double-blind trial.
PubMed: Treatment of interdigital tinea pedis with a 4-week once-daily regimen of butenafine hydrochloride 1% cream.
PubMed: Two mechanisms of butenafine action in Candida albicans.
PubMed: [Synthesis and antifungal activity of butenafine hydrochloride (KP-363), a new benzylamine antifungal agent].
PubMed: Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental tinea pedis in guinea pigs.
PubMed: Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs.
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