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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 426.10 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 370.00 °F. TCC ( 187.70 °C. ) (est)
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| logP (o/w): | 6.770 (est) |
| Soluble in: |
| | water, 0.2568 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for butenafine usage levels up to: | | | not for fragrance use.
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| Recommendation for butenafine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 2484 |
| Pubchem (sid): | 135023666 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | butenafinum | | N-(p-tert- | butylbenzyl)-n-methyl-1-naphthalenemethylamine | | 1-(4-tert- | butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine |
Articles:
| PubMed: | Diagnosis and management of tinea infections. |
| PubMed: | Ruthenium-catalyzed reductive methylation of imines using carbon dioxide and molecular hydrogen. |
| PubMed: | Tinea nigra presenting speckled or "salt and pepper" pattern. |
| PubMed: | HPLC-DAD for the determination of three different classes of antifungals: method characterization, statistical approach, and application to a permeation study. |
| PubMed: | A case of Tinea nigra associated to a bite from a European rabbit (Oryctolagus cuniculus, Leporidae): the role of dermoscopy in diagnosis. |
| PubMed: | Fungal toenail infections. |
| PubMed: | Antimycotics suppress the Malassezia extract-induced production of CXC chemokine ligand 10 in human keratinocytes. |
| PubMed: | A comparative study to evaluate efficacy, safety and cost-effectiveness between Whitfield's ointment + oral fluconazole versus topical 1% butenafine in tinea infections of skin. |
| PubMed: | A comparative randomized open label study to evaluate efficacy, safety and cost effectiveness between topical 2% sertaconazole and topical 1% butenafine in tinea infections of skin. |
| PubMed: | In vitro susceptibility of dermatomycoses agents to six antifungal drugs and evaluation by fractional inhibitory concentration index of combined effects of amorolfine and itraconazole in dermatophytes. |
| PubMed: | Optimizing topical antifungal therapy for superficial cutaneous fungal infections: focus on topical naftifine for cutaneous dermatophytosis. |
| PubMed: | Chiral N-benzyl-N-methyl-1-(naphthalen-1-yl)ethanamines and their in vitro antifungal activity against Cryptococcus neoformans, Trichophyton mentagrophytes and Trichophyton rubrum. |
| PubMed: | Influence of penetration enhancers and molecular weight in antifungals permeation through bovine hoof membranes and prediction of efficacy in human nails. |
| PubMed: | Suppressive effects of antimycotics on thymic stromal lymphopoietin production in human keratinocytes. |
| PubMed: | Efficacy of topical antifungals in the treatment of dermatophytosis: a mixed-treatment comparison meta-analysis involving 14 treatments. |
| PubMed: | Comparison of superficial mycosis treatment using Butenafine and Bifonazole nitrate clinical efficacy. |
| PubMed: | Tinea nigra: successful treatment with topical butenafine. |
| PubMed: | Squalene monooxygenase - a target for hypercholesterolemic therapy. |
| PubMed: | Determination of butenafine hydrochloride in human plasma by liquid chromatography electrospray ionization-mass spectrometry following its topical administration in human subjects. |
| PubMed: | Fungal toenail infections. |
| PubMed: | Stability-indicating LC assay for butenafine hydrochloride in creams using an experimental design for robustness evaluation and photodegradation kinetics study. |
| PubMed: | RP-HPLC method for simultaneous determination of butenafine hydrochloride and betamethasone dipropionate in a cream formulation. |
| PubMed: | A simple and rapid method to assess butenafine hydrochloride in skin samples and a comparative cutaneous retention study of two marketed formulations. |
| PubMed: | Studies on comparison of the efficacy of terbinafine 1% cream and butenafine 1% cream for the treatment of Tinea cruris. |
| PubMed: | Simultaneous HPLC determination of butenafine hydrochloride and betamethasone in a cream formulation. |
| PubMed: | [Activity of butenafine against ocular pathogenic filamentous fungi in vitro]. |
| PubMed: | In vitro antifungal activities of luliconazole, a new topical imidazole. |
| PubMed: | Are placebo-controlled trials of creams for athlete's foot still justified? |
| PubMed: | Butenafine and superficial mycoses: current status. |
| PubMed: | Fungal toenail infections. |
| PubMed: | Randomised controlled trial of topical butenafine in tinea cruris and tinea corporis. |
| PubMed: | Topical treatments for fungal infections of the skin and nails of the foot. |
| PubMed: | In vitro activities of miltefosine and two novel antifungal biscationic salts against a panel of 77 dermatophytes. |
| PubMed: | An unprecedented rearrangement in collision-induced mass spectrometric fragmentation of protonated benzylamines. |
| PubMed: | [The effect of propyl gallate on the activity of various antifungal drugs against filamentous fungi in vitro]. |
| PubMed: | What is the best way to treat tinea cruris? |
| PubMed: | Comparative efficacy of topical 1% butenafine and 1% clotrimazole in tinea cruris and tinea corporis: a randomized, double-blind trial. |
| PubMed: | In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenafine, against clinically important fungi in comparison with fluconazole and butenafine. |
| PubMed: | Topical therapy for fungal infections. |
| PubMed: | Role of antifungal agents in the treatment of seborrheic dermatitis. |
| PubMed: | Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria. |
| PubMed: | Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine. |
| PubMed: | Butenafine: an update of its use in superficial mycoses. |
| PubMed: | KP-103, a novel triazole derivative, is effective in preventing relapse and successfully treating experimental interdigital tinea pedis and tinea corporis in guinea pigs. |
| PubMed: | A Japanese case of tinea corporis caused by Arthroderma benhamiae. |
| PubMed: | Six novel antimycotics. |
| PubMed: | Butenafine hydrochloride (Mentax) cream for the treatment of hyperkeratotic type tinea pedis and its transfer into the horny layer, with or without concomitant application of 20% urea ointment (Keratinamin). |
| PubMed: | Experimental and conformational analyses of interactions between butenafine and lipids. |
| PubMed: | Efficacy and safety of butenafine in superficial dermatophytoses (tinea pedis, tinea cruris, tinea corporis). |
| PubMed: | Comparison of in vitro antifungal activities of topical antimycotics launched in 1990s in Japan. |
| PubMed: | In vitro antifungal activity of KP-103, a novel triazole derivative, and its therapeutic efficacy against experimental plantar tinea pedis and cutaneous candidiasis in guinea pigs. |
| PubMed: | Butenafine hydrochloride: for the treatment of interdigital tinea pedis. |
| PubMed: | Azole antifungal agents related to naftifine and butenafine. |
| PubMed: | Contact dermatitis due to tea tree oil. |
| PubMed: | The antifungal agent butenafine manifests anti-inflammatory activity in vivo. |
| PubMed: | Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream. |
| PubMed: | Management of toenail onychomycosis with 2% butenafine and 20% urea cream: a placebo-controlled, double-blind study. |
| PubMed: | Allylamine type xanthone antimycotics. |
| PubMed: | Butenafine, a fungicidal benzylamine derivative, used once daily for the treatment of interdigital tinea pedis. |
| PubMed: | An overview of topical antifungal therapy in dermatomycoses. A North American perspective. |
| PubMed: | Butenafine. |
| PubMed: | A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine, a new antifungal agent. |
| PubMed: | Topical butenafine for tinea pedis. |
| PubMed: | Butenafine 1% cream in the treatment of tinea cruris: a multicenter, vehicle-controlled, double-blind trial. |
| PubMed: | One-week therapy with twice-daily butenafine 1% cream versus vehicle in the treatment of tinea pedis: a multicenter, double-blind trial. |
| PubMed: | Treatment of interdigital tinea pedis with a 4-week once-daily regimen of butenafine hydrochloride 1% cream. |
| PubMed: | Update on topical therapy for superficial fungal infections: focus on butenafine. |
| PubMed: | Neutral red assay in minimum fungicidal concentrations of antifungal agents. |
| PubMed: | Thiophene congeners of morpholine and allylamine type antifungals--syntheses and biological activities. |
| PubMed: | [A study on effectiveness of treatment and prevention of relapse using topical administration of terbinafine in a guinea pig model for tinea pedis]. |
| PubMed: | Two mechanisms of butenafine action in Candida albicans. |
| PubMed: | Anti-Trichophyton mentagrophytes activity and percutaneous permeation of butenafine in guinea pigs. |
| PubMed: | Topical treatment with butenafine significantly lowers relapse rate in an interdigital tinea pedis model in guinea pigs. |
| PubMed: | [Antifungal agents--recent trends in development and progress in research of action mechanism]. |
| PubMed: | [Synthesis and antifungal activity of butenafine hydrochloride (KP-363), a new benzylamine antifungal agent]. |
| PubMed: | Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental tinea pedis in guinea pigs. |
| PubMed: | Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs. |
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