piper methysticum extract
extract of the leaves, roots and stems of the kawa-kawa, piper methysticum, piperaceae
 
Notes:
Skin soothing agent.
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Name: piper methysticum extract
CAS Number: 84696-40-2 
ECHA EC Number: 283-648-9
Category: cosmetic agents
 
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
Carrubba
kava kava extract
Vege Tech
kawa extract
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for piper methysticum extract usage levels up to:
 not for fragrance use.
 
Recommendation for piper methysticum extract flavor usage levels up to:
 not for flavor use.
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Safety References:
AIDS Citations: Search
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EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 piper methysticum extract
Chemidplus: 0084696402
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References:
 piper methysticum extract
Pubchem (sid): 135283770
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Other Information:
Export Tariff Code: 1302.19.0000
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 skin conditioning 
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Occurrence (nature, food, other): note
 kava
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Synonyms:
 extract of the leaves, roots and stems of the kawa-kawa, piper methysticum, piperaceae
 kava-kava extract
 kawa extract
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Articles:
PubMed: Fatal kavalactone intoxication by suicidal intravenous injection.
PubMed: Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs.
PubMed: Measuring the chemical and cytotoxic variability of commercially available kava (Piper methysticum G. Forster).
PubMed: Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.
PubMed: Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study.
PubMed: Does a medicinal dose of kava impair driving? A randomized, placebo-controlled, double-blind study.
PubMed: Toxicology and carcinogenesis studies of kava kava extract (CAS No. 9000-38-8) in F344/N rats and B6C3F1 mice (Gavage Studies).
PubMed: [Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies].
PubMed: Regulatory causality evaluation methods applied in kava hepatotoxicity: are they appropriate?
PubMed: Re-introduction of kava (Piper methysticum) to the EU: is there a way forward?
PubMed: Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways.
PubMed: Kava hepatotoxicity: pathogenetic aspects and prospective considerations.
PubMed: Cyclodextrins as carriers for kavalactones in aqueous media: spectroscopic characterization of (S)-7,8-dihydrokavain and beta-cyclodextrin inclusion complex.
PubMed: Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract.
PubMed: The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum.
PubMed: Kava Anxiety Depression Spectrum Study (KADSS): a mixed methods RCT using an aqueous extract of Piper methysticum.
PubMed: Discriminative-stimulus and time-course effects of kava-kava (Piper methysticum) in rats.
PubMed: Efficacy of extracting solvents to chemical components of kava (Piper methysticum) roots.
PubMed: Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea.
PubMed: Identification of C-glycoside flavonoids as potential mutagenic compounds in kava.
PubMed: Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract.
PubMed: Safety of ethanolic kava extract: Results of a study of chronic toxicity in rats.
PubMed: Melanogenesis stimulation in murine B16 melanoma cells by Kava (Piper methysticum) rhizome extract and kavalactones.
PubMed: Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum).
PubMed: HPLC analysis of flavokavins and kavapyrones from Piper methysticum Forst.
PubMed: Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro.
PubMed: Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard.
PubMed: Pharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. f.).
PubMed: Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes.
PubMed: Enhanced cognitive performance and cheerful mood by standardized extracts of Piper methysticum (Kava-kava).
PubMed: Kava does not display metabolic toxicity in a homogeneous cellular assay.
PubMed: Saccade and cognitive impairment associated with kava intoxication.
PubMed: Quantitative elimination of Flavokavines A and B from Kava Kava (Piper methysticum G. Forst) by isoelectric focused adsorptive bubble separation.
PubMed: Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice.
PubMed: Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum).
PubMed: Identification of novel electrophilic metabolites of piper methysticum Forst (Kava).
PubMed: Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure.
PubMed: Kava-Kava administration reduces anxiety in perimenopausal women.
PubMed: Saccade and cognitive function in chronic kava users.
PubMed: Kava extract for treating anxiety.
PubMed: Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).
PubMed: Anxiolytic-like effects of kava-kava in the elevated plus maze test--a comparison with diazepam.
PubMed: Densitometric analysis of kawain in kava-kava root extracts.
PubMed: Kava extract for treating anxiety.
PubMed: A systematic review of the safety of kava extract in the treatment of anxiety.
PubMed: Cyclooxygenase enzyme inhibitory compounds with antioxidant activities from Piper methysticum (kava kava) roots.
PubMed: Novel compounds from Piper methysticum Forst (Kava Kava) roots and their effect on cyclooxygenase enzyme.
PubMed: Synergy and other interactions in phytomedicines.
PubMed: Kava extract for treating anxiety.
PubMed: Kava pyrones exert effects on neuronal transmission and transmembraneous cation currents similar to established mood stabilizers--a review.
PubMed: Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm.
PubMed: Efficacy of kava extract for treating anxiety: systematic review and meta-analysis.
PubMed: Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava).
PubMed: [Kava-kava preparations--alternative anxiolytics].
PubMed: Electrospray high performance liquid chromatography-mass spectrometry in phytochemical analysis of kava (Piper methysticum) extract.
PubMed: Efficacy of a special Kava extract (Piper methysticum) in patients with states of anxiety, tension and excitedness of non-mental origin - A double-blind placebo-controlled study of four weeks treatment.
PubMed: Kavapyrone enriched extract from Piper methysticum as modulator of the GABA binding site in different regions of rat brain.
PubMed: Effects of oxazepam and an extract of kava roots (Piper methysticum) on event-related potentials in a word recognition task.
PubMed: Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents.
PubMed: Effect of aqueous and lipid-soluble extracts of kava on the conditioned avoidance response in rats.
PubMed: Comparison of the central nervous system activity of the aqueous and lipid extract of kava (Piper methysticum).
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