saponaria officinalis herb
soapwort herb
 
Notes:
None found
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Name: saponaria officinalis l. herb
CAS Number: 84775-97-3 
ECHA EC Number: 283-921-2
Wisconsin Invasive Non-native plant species
Category: information only not used for fragrances or flavors
 
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Bristol Botanicals
Soapwort herb Saponaria officinalis, France
Vege Tech
O.C. Soapwort
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: information only not used for fragrances or flavors
Wisconsin Invasive Non-native plant species
Recommendation for saponaria officinalis herb usage levels up to:
 not for fragrance use.
 
Recommendation for saponaria officinalis herb flavor usage levels up to:
 not for flavor use.
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Safety References:
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 saponaria officinalis l. herb
Chemidplus: 0084775973
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References:
 saponaria officinalis l. herb
Pubchem (sid): 135302364
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Other Information:
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 saponaria officinalis
Search Trop  Picture
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Synonyms:
 bouncing bet herb
 lychnis officinalis herb
 silene saponaria herb
 soap wort herb
 soapwort herb
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Articles:
PubMed: Antiproliferative quillaic acid and gypsogenin saponins from Saponaria officinalis L. roots.
PubMed: Potential of extracts from Saponaria officinalis and Calendula officinalis to modulate in vitro rumen fermentation with respect to their content in saponins.
PubMed: Cytotoxic effects of four Caryophyllaceae species extracts on macrophage cell lines.
PubMed: New pharmacological properties of Medicago sativa and Saponaria officinalis saponin-rich fractions addressed to Candida albicans.
PubMed: Effects of S. officinalis L. radix triterpene glycosides on innate immunity factors.
PubMed: Sexual dimorphism of staminate- and pistillate-phase flowers of Saponaria officinalis (bouncing bet) affects pollinator behavior and seed set.
PubMed: High-speed countercurrent chromatographic recovery and off-line electrospray ionization mass spectrometry profiling of bisdesmodic saponins from Saponaria officinalis possessing synergistic toxicity enhancing properties on targeted antitumor toxins.
PubMed: New triterpenoid saponins from the roots of Saponaria officinalis.
PubMed: Saporin-S6: a useful tool in cancer therapy.
PubMed: Structure-activity relationships of saponins enhancing the cytotoxicity of ribosome-inactivating proteins type I (RIP-I).
PubMed: Macromolecular interactions of triterpenoids and targeted toxins: role of saponins charge.
PubMed: Saponins modulate the intracellular trafficking of protein toxins.
PubMed: Real time monitoring of the cell viability during treatment with tumor-targeted toxins and saponins using impedance measurement.
PubMed: Metal concentrations in the soils and native plants surrounding the old flotation tailings pond of the copper mining and smelting complex Bor (Serbia).
PubMed: Balsamin, a novel ribosome-inactivating protein from the seeds of Balsam apple Momordica balsamina.
PubMed: Immunotoxins and other conjugates containing saporin-s6 for cancer therapy.
PubMed: Liquid-chromatographic profiling of Saponinum album (Merck).
PubMed: Composition of epiphytic bacterial communities differs on petals and leaves.
PubMed: Antioxidant, Antimicrobial Activity and Total Phenolic Content within the Aerial Parts of Artemisia absinthum, Artemisia santonicum and Saponaria officinalis.
PubMed: Differential expression of saporin genes upon wounding, ABA treatment and leaf development.
PubMed: Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein.
PubMed: Saporin suicide gene therapy.
PubMed: Translation Inhibition of Capped and Uncapped Viral RNAs Mediated by Ribosome-Inactivating Proteins.
PubMed: Saponaria officinalis karyology and karyotype by means of image analyzer and atomic force microscopy.
PubMed: Ribosome inactivating protein saporin induces apoptosis through mitochondrial cascade, independent of translation inhibition.
PubMed: [The hypolipidemic action of the complex emulgator-stabilizer on the basis of laminal and a water extract from roots of alien Saponaria officinalis L. in experiment on the rat].
PubMed: Analysis of gypsogenin saponins in homeopathic tinctures.
PubMed: Chimeric toxins inhibit growth of primary oral squamous cell carcinoma cells.
PubMed: Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells.
PubMed: The differential catalytic activity of ribosome-inactivating proteins saporin 5 and 6 is due to a single substitution at position 162.
PubMed: The effect of AZT and chloroquine on the activities of ricin and a saporin-transferrin chimeric toxin.
PubMed: Expression and characterisation in E. coli of mutant forms of saporin.
PubMed: Mitochondrial DNA D-loop as a new target of Saporin 6 nuclease activity.
PubMed: Construction of tumor-specific toxins using ubiquitin fusion technique.
PubMed: Interactions between saporin, a ribosome-inactivating protein, and DNA: a study by atomic force microscopy.
PubMed: Differences in X-ray absorption due to cadmium treatment in Saponaria officinalis leaves.
PubMed: Cytotoxicity of ribosome-inactivating protein saporin is not mediated through alpha2-macroglobulin receptor.
PubMed: The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities.
PubMed: Enzymatic specificity of three ribosome-inactivating proteins against fungal ribosomes, and correlation with antifungal activity.
PubMed: Selective lesions of rabbit extraocular muscles injected with the anti-AChR immunotoxin saporin-mAb 73.
PubMed: HER/erbB receptors as therapeutic targets of immunotoxins in human rhabdomyosarcoma cells.
PubMed: Reliable sequence determination of ribosome- inactivating proteins by combining electrospray mass spectrometry and Edman degradation.
PubMed: Polynucleotide:adenosine glycosidase activity of saporin-L1: effect on various forms of mammalian DNA.
PubMed: Preferential destruction of cerebellar Purkinje cells by OX7-saporin.
PubMed: The crystal structure of saporin SO6 from Saponaria officinalis and its interaction with the ribosome.
PubMed: New triterpenoid saponins and sapogenins from Saponaria officinalis.
PubMed: [Immunostimulating activity of a saponin-containing extract of Saponaria officinalis].
PubMed: Saponarioside C, the first alpha-D-galactose containing triterpenoid saponin, and five related compounds from Saponaria officinalis.
PubMed: The plant ribosome inactivating protein saporin induces micronucleus formation in peripheral human lymphocytes in vitro.
PubMed: Major triterpenoid saponins from saponaria officinalis
PubMed: Crystallization and preliminary X-ray study of saporin, a ribosome-inactivating protein from Saponaria officinalis.
PubMed: The unusual stability of saporin, a candidate for the synthesis of immunotoxins.
PubMed: Characterization of a saporin isoform with lower ribosome-inhibiting activity.
PubMed: Polynucleotide:adenosine glycosidase activity of ribosome-inactivating proteins: effect on DNA, RNA and poly(A).
PubMed: Fluorescence spectroscopic study of the interaction of saporin with phospholipid vesicles.
PubMed: Polynucleotide: adenosine glycosidase activity of saporin-L1: effect on DNA, RNA and poly(A).
PubMed: A saporin-insulin conjugate: synthesis and biochemical characterization.
PubMed: A chimeric saporin-transferrin conjugate compared to ricin toxin: role of the carrier in intracellular transport and toxicity.
PubMed: Anti-B16-F10 melanoma activity of a basic fibroblast growth factor-saporin mitotoxin.
PubMed: Selection and characterization of early hematopoietic progenitors using an anti-CD71/S06 immunotoxin.
PubMed: A conjugate between human urokinase and saporin, a type-1 ribosome-inactivating protein, is selectively cytotoxic to urokinase receptor-expressing cells.
PubMed: Distribution and properties of major ribosome-inactivating proteins (28 S rRNA N-glycosidases) of the plant Saponaria officinalis L. (Caryophyllaceae).
PubMed: Diverse activity of sc-RIP saporin 6 on primary and metastatic melanoma cells in vitro.
PubMed: Exploration of the frontiers of tradomedical practices: basis for development of alternative medical healthcare services in developing countries.
PubMed: Molecular action of the type 1 ribosome-inactivating protein saporin 5 on Vicia sativa ribosomes.
PubMed: The expression of saporin, a ribosome-inactivating protein from the plant Saponaria officinalis, in Escherichia coli.
PubMed: Recognition and killing of tumour cells expressing heat shock protein 65 kD with immunotoxins containing saporin.
PubMed: Some ribosome-inactivating proteins depurinate ribosomal RNA at multiple sites.
PubMed: Thermo-stability and antitumor activity on colon cancer cell lines of monoclonal anti-CEA antibody-saporin immunotoxin.
PubMed: Isolation and partial characterization of a new ribosome-inactivating protein from Petrocoptis glaucifolia (Lag.) Boiss.
PubMed: A ribosomal protein is specifically recognized by saporin, a plant toxin which inhibits protein synthesis.
PubMed: Studies on ribosome-inactivating proteins from Saponaria officinalis.
PubMed: A Saporin-6 cDNA containing a precursor sequence coding for a carboxyl-terminal extension.
PubMed: Production and characterization of two immunotoxins specific for M5b ANLL leukaemia.
PubMed: Saporin 6 conjugated to monoclonal antibody selectively kills human melanoma cells.
PubMed: Inhibition of growth of breast cancer cells in vitro by the ribosome-inactivating protein saporin 6.
PubMed: Cytotoxic activity of an anti-transferrin receptor immunotoxin on normal and leukemic human hematopoietic progenitors.
PubMed: The amino acid sequence of a ribosome-inactivating protein from Saponaria officinalis seeds.
PubMed: Immunotoxins, ligand-toxin conjugates and molecular targeting.
PubMed: Selective killing of CD4+ and CD8+ cells with immunotoxins containing saporin.
PubMed: Differential activity of saporin 6 on normal and leukemic hemopoietic cells.
PubMed: Nucleotide sequence of cDNA coding for saporin-6, a type-1 ribosome-inactivating protein from Saponaria officinalis.
PubMed: Immunotoxin-mediated inhibition of chronic lymphocytic leukemia cell proliferation in humans.
PubMed: In vivo effects in mice of an anti-T cell immunotoxin.
PubMed: N-terminal sequence of some ribosome-inactivating proteins.
PubMed: B-cell restricted saporin immunotoxins: activity against B-cell lines and chronic lymphocytic leukemia cells.
PubMed: Ribosome-inactivating proteins from plant cells in culture.
PubMed: Synthesis and characterization of an antihuman T-lymphocyte saporin immunotoxin (OKT1-SAP) with in vivo stability into nonhuman primates.
PubMed: Activity of a monoclonal antibody-saporin-6 conjugate against B-lymphoma cells.
PubMed: A DNA sequence from Saponaria officinalis is similar to various RNA polymerase genes.
PubMed: Killing of K562 cells with conjugates between human transferrin and a ribosome-inactivating protein (SO-6).
PubMed: An immunotoxin containing a rat IgM monoclonal antibody (Campath 1) and saporin 6: effect on T lymphocytes and hemopoietic cells.
PubMed: Hepatotoxicity of immunotoxins made with saporin, a ribosome-inactivating protein from Saponaria officinalis.
PubMed: A mechanism for the hypocholesterolaemic activity of saponins.
PubMed: Isolation of Spinasterol and its Glucoside from Cell Suspension Cultures of Saponaria officinalis: 13C-NMR Spectral Data and Batch Culture Production.
PubMed: In vitro determination of the spermicidal activity of plant saponins.
PubMed: An immunotoxin composed of monoclonal anti-Thy 1.1 antibody and a ribosome-inactivating protein from Saponaria officinalis: potent antitumor effects in vitro and in vivo.
PubMed: Characterization of a Saponaria officinalis seed ribosome-inactivating protein: immunoreactivity and sequence homologies.
PubMed: Cytoxicity of erythrocyte ghosts loaded with ribosome-inactivating proteins following fusion with CHO cells.
PubMed: Ribosome-inactivating proteins from the seeds of Saponaria officinalis L. (soapwort), of Agrostemma githago L. (corn cockle) and of Asparagus officinalis L. (asparagus), and from the latex of Hura crepitans L. (sandbox tree).
PubMed: Effects of soy protein and saponins on serum, tissue and feces steroids in rat.
PubMed: [FLUCTUATION IN THE SAPONIN CONTENT AND THE HEMOLYTIC ACTIVITY OF SAPONARIA OFFICINALIS L., PRIMULA OFFICINALIS (L.) HILL., POLEMONIUM COERULEUM L., AND GLYCYRRHIZA GLABRA L].
PubMed: [Effect of beta-indolacetic acid and sodium 2,4-dichlorophenoxyacetate on the saponin content in Saponaria officinalis L. and Digitalis purpurea L].
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