Articles:
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senecionan-11,16-dione, 12,18-dihydroxy-, 4-oxide (9CI)
Notes:
None found
| CAS Number: | 15503-86-3 |  3D/inchi
|
| Other: | 547-04-6 | |
| FDA UNII: | 51819GRV4U | |
| Beilstein Number: | 0058804 | |
| MDL: | MFCD00150878 | |
| Molecular Weight: | 367.39865000 | |
| Formula: | C18 H25 N O7 | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Soluble in: | |
| water, 3.56e+004 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Retrorsine N-oxide dihydrate |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-mouse LD50 835 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 75, Pg. 83, 1942. intraperitoneal-rat LD50 250 mg/kg LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: OTHER CHANGES Chemico-Biological Interactions. Vol. 5, Pg. 227, 1972. oral-rat LD50 48 mg/kg LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: OTHER CHANGES Chemico-Biological Interactions. Vol. 5, Pg. 227, 1972. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | natural substances and extractives | ||
| Recommendation for isatidine usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for isatidine flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| European Food Safety Authority (EFSA) reference(s): | |
| Dietary exposure assessment to pyrrolizidine alkaloids in the European population View page or View pdf | |
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 76972338 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| Chemidplus: | 0015503863 |
| RTECS: | VH7700000 for cas# 15503-86-3 |
References:
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 76972338 |
| Pubchem (sid): | 134992843 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| HMDB (The Human Metabolome Database): | Search |
| VCF-Online: | VCF Volatile Compounds in Food |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| senecio vulgaris Search Trop Picture |
Synonyms:
| 12,18- | dihydroxysenecionan-11,16-dione-4-oxide |
| trans-15- | ethylidene-12beta-hydroxy-12alpha-hydroxymethyl-13beta-methylsenec-1-enine-4-oxide |
| cis- | retronecic acid ester of retronecine-n-oxide |
| retrorsine N-oxide | |
| retrorsine-N-oxide | |
| senecionan-11,16-dione, 12,18-dihydroxy-, 4-oxide (9CI) |