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Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 1.395e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | information only not used for fragrances or flavors |
| Recommendation for N-methyl alanine usage levels up to: | | | not for fragrance use.
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| Recommendation for N-methyl alanine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| DL- | alanine, N-methyl- | | N- | methyl-DL-alanine | | N- | methylalanine | | 2-( | methylamino)propanoic acid |
Articles:
| PubMed: | Profiling ephedrine prepared from N-methylalanine via the Akabori-Momotani reaction. |
| PubMed: | Metabolomics Analysis Revealed Distinct Cyclic Changes of Metabolites Altered by Chronic Ethanol-Plus-Binge and Shp Deficiency. |
| PubMed: | Selective quantitation of the neurotoxin BMAA by use of hydrophilic-interaction liquid chromatography-differential mobility spectrometry-tandem mass spectrometry (HILIC-DMS-MS/MS). |
| PubMed: | Application of design of experiments (DoE) optimization to the one-pot synthesis of 4,6-dihydropteridinones. |
| PubMed: | Hydrogen-deuterium exchange of α-carbon protons and fragmentation pathways in N-methylated glycine and alanine-containing peptides derivatized by quaternary ammonium salts. |
| PubMed: | Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin. |
| PubMed: | Scalable solution-phase synthesis of the biologically active cyclodepsipeptide destruxin E, a potent negative regulator of osteoclast morphology. |
| PubMed: | Dissociation of antimicrobial and hemolytic activities of gramicidin S through N-methylation modification. |
| PubMed: | In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. |
| PubMed: | Design, synthesis and pharmacological characterization of endomorphin analogues with non-cyclic amino acid residues in position 2. |
| PubMed: | Effect of a carboxyl group on the chemiluminescent reaction of tris(2,2'-bipyridine)ruthenium(III) with aliphatic amines. |
| PubMed: | Actinomycins with altered threonine units in the beta-peptidolactone. |
| PubMed: | Kinetic and crystallographic analysis of mutant Escherichia coli aminopeptidase P: insights into substrate recognition and the mechanism of catalysis. |
| PubMed: | Exploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1. |
| PubMed: | Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. |
| PubMed: | Probing host-selective phytotoxicity: synthesis of destruxin B and several natural analogues. |
| PubMed: | Synthesis and immunological activity of water-soluble thalidomide prodrugs. |
| PubMed: | Analogue-resistant mutants of Azotobacter chroococcum derepressed for nitrogenase activity and early ammonia excretion having potential as inoculants for cereal crops. |
| PubMed: | Monomeric sarcosine oxidase: 2. Kinetic studies with sarcosine, alternate substrates, and a substrate analogue. |
| PubMed: | Role of the pyrrolidine ring of proline in determining the substrate specificity of cdc2 kinase or cdk5. |
| PubMed: | Structural modifications of the N-terminal tetrapeptide segment of [D-Ala2]deltorphin I: effects on opioid receptor affinities and activities in vitro and on antinociceptive potency. |
| PubMed: | Fluorescence study of neurohypophyseal hormones and their analogues. Distance distributions in a series of arginine-vasopressin analogues. |
| PubMed: | 1H-NMR and 13C-NMR investigation of complexes of Mn2+ with ocytocin analogues in (2H6)dimethylsulfoxide. |
| PubMed: | Structure-activity relationships of dermorphin analogues containing N-substituted amino acids in the 2-position of the peptide sequence. |
| PubMed: | Uptake and receptor sites for glycine in isolated bovine adrenal medulla chromaffin cells. |
| PubMed: | Chemical characterization and toxicity of dihydro derivatives of nodularin and microcystin-LR, potent cyanobacterial cyclic peptide hepatotoxins. |
| PubMed: | Isolation and Characterization of Two Novel Nematicidal Depsipeptides from an Imperfect Fungus, Strain D1084. |
| PubMed: | Enzymatic synthesis of actinomycin D and analogues containing N-methylalanine from synthetic pentapeptide lactone precursors. |
| PubMed: | Inhibition of sodium-dependent L-leucine uptake in rat brain synaptosomes. |
| PubMed: | Circular dichroism studies of some arginine-vasopressin analogues. |
| PubMed: | Identification of a myometrial oxytocin-receptor protein. |
| PubMed: | The importance of residues 2 (arginine) and 6 (histidine) in high-affinity angiotensin II antagonists. |
| PubMed: | Iodinated photoreactive vasopressin antagonists: labelling of hepatic vasopressin receptor subunits. |
| PubMed: | Vasopressin antagonist analogs modified at position 7. |
| PubMed: | A resonance Raman study on the structures of complexes of flavoprotein D-amino acid oxidase. |
| PubMed: | [Synthesis and analysis of conformationally restricted analogs of peptide inhibitors of the angiotensin-converting enzyme]. |
| PubMed: | Arginine-vasopressin analogues with high antidiuretic/vasopressor selectivity. Synthesis, biological activity, and receptor binding affinity of arginine-vasopressin analogues with substitutions in positions 1, 2, 4, 7, and 8. |
| PubMed: | Conformational preferences and binding to neurophysins of oxytocin analogs with sarcosine or N-methylalanine in position 7. |
| PubMed: | Interactions of vasopressin agonists and antagonists with membrane receptors. |
| PubMed: | Influence of sarcosine or N-methylalanine in position 7 on the antagonistic properties of [1-deaminopenicillamine]- and [1-(beta-mercapto-beta, beta-cyclopentylmethylene-propionic acid)]-vasopressin. |
| PubMed: | Synthesis and some pharmacological properties of [4-threonine,7-sarcosine]oxytocin, a peptide with high oxytocic potency, and of [4-threonine,7-N-methylalanine]oxytocin. |
| PubMed: | Synthesis and some pharmacological properties of oxytocin and vasopressin analogues with sarcosine or N-methyl-L-alanine in position 7. |
| PubMed: | Configuration assignments of the amino acid residues and the presence of N-methyldehydroalanine in toxins from the blue-green alga, Microcystis aeruginosa. |
| PubMed: | Transport of L-alanine in cultured human fibroblasts: evidence for two kinetically distinguishable systems. |
| PubMed: | Molecular specificity of tubular reabsorption of L-proline. A microperfusion study in rat kidney. |
| PubMed: | Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs. |
| PubMed: | Colchicine-induced resistance to antibiotic and amino-acid analogue in plant cell cultures. |
| PubMed: | Formation of amino acids on heating glycine with alumina. |
| PubMed: | Solubilization, partial purification and properties of N-methylglutamate dehydrogenase from Pseudomonas aminovorans. |
| PubMed: | Placental amino acid uptake. III. Transport systems for neutral amino acids. |
| PubMed: | Purification and characterization of N-methylalanine dehydrogenase. |
| PubMed: | Quantitative determination of secondary amines: measurement of N-methylalanine. |
| PubMed: | Polymerization of optical isomers of phenylalanine N-carboxyanhydride by poly(N-methylalanine) diethylamide. |
| PubMed: | Nonprotein amino acids from spark discharges and their comparison with the murchison meteorite amino acids. |
| PubMed: | Synthesis of (5-valine,7-N-methylalanine)-angiotensin II, a hypertensive peptide. |
| PubMed: | Nonprotein amino acids in the murchison meteorite. |
| PubMed: | The enzymatic synthesis of N-methylalanine. |
| PubMed: | The synthesis of dl-3:4-dihydroxyphenyl-N-methylalanine. |
| PubMed: | A study of the oxidation of 3:4-dihydroxyphenyl-N-methylalanine with reference to its possible function as a precursor of adrenaline. |
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