L-citrulline malate 1;1;2:1
(1)-malic acid, compound with L-arginine (1:1)
 
Notes:
None found
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CAS Number: 16856-16-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 240-881-0
Molecular Weight: 308.29180000
Formula: C10 H20 N4 O7
NMR Predictor: Predict (works with chrome or firefox)
Category: special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: special dietary and nutritional additives
Recommendation for L-citrulline malate 1;1;2:1 usage levels up to:
 not for fragrance use.
 
Recommendation for L-citrulline malate 1;1;2:1 flavor usage levels up to:
 not for flavor use.
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Safety References:
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 170599
National Institute of Allergy and Infectious Diseases: Data
 (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;2-hydroxybutanedioic acid
Chemidplus: 0016856169
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References:
 (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;2-hydroxybutanedioic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 170599
Pubchem (sid): 135261623
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
FDA Listing of Food Additive Status: View
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
(2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;2-hydroxybutanedioic acid
L-arginine, compd. with 2-hydroxybutanedioic acid (1:1)
laevo-citrulline malate 1;1;2:1
(1)-malic acid, compound with L-arginine (1:1)
(1)-malic acid, compound with laevo-arginine (1:1)
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Articles:
PubMed: Acute citrulline-malate supplementation improves maximal strength and anaerobic power in female, masters athletes tennis players.
PubMed: Acute Citrulline-Malate supplementation and high-intensity cycling performance.
PubMed: Acute citrulline malate supplementation improves upper- and lower-body submaximal weightlifting exercise performance in resistance-trained females.
PubMed: Effects of Supplemental Citrulline-Malate Ingestion on Blood Lactate, Cardiovascular Dynamics, and Resistance Exercise Performance in Trained Males.
PubMed: Treating sarcopenia in older and oldest old.
PubMed: Effects of supplemental citrulline malate ingestion during repeated bouts of lower-body exercise in advanced weightlifters.
PubMed: Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.
PubMed: Beneficial effects of citrulline malate on skeletal muscle function in endotoxemic rat.
PubMed: [Use of citrulline malate (stimol) in patients with autonomic dystonia associated with arterial hypotension].
PubMed: Effects of citrulline malate on bacterial lipopolysaccharide induced endotoxemia in rats.
PubMed: Use of a microbial model for the determination of drug effects on cell metabolism and energetics: study of citrulline-malate.
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