metam
carbamodithioic acid, N-methyl-
 
Notes:
None found
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CAS Number: 144-54-7Picture of molecule3D/inchi
FDA UNII: OA1I97689K
Nikkaji Web: J9.912K
XlogP3-AA: 0.70 (est)
Molecular Weight: 107.19885000
Formula: C2 H5 N S2
NMR Predictor: Predict (works with chrome or firefox)
Category: herbicides / pesticides
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Appearance: white crystalline solid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Soluble in:
 water, 4.404e+005 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: herbicides / pesticides
Recommendation for metam usage levels up to:
 not for fragrance use.
 
Recommendation for metam flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment for metam in light of confirmatory data
View page or View pdf
Review of the existing maximum residue levels for metam according to Article 12 of Regulation (EC) No 396/2005
View page or View pdf
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 3001858
National Institute of Allergy and Infectious Diseases: Data
 methylcarbamodithioic acid
Chemidplus: 0000144547
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References:
 methylcarbamodithioic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 3001858
Pubchem (sid): 135023924
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
HMDB (The Human Metabolome Database): Search
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 carbamodithioic acid, N-methyl-
 metam [ISO]
 methan
 methylcarbamodithioic acid
 methylcarbamodithioic acid (8CI)
 methyldithiocarbamate
 methyldithiocarbamic acid
 methyldithiocarbanic acid (8CI)
 nethan [BSI]
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Articles:
PubMed: Different modes of synergistic toxicities between metam/copper (II) and metam/zinc (II) in HepG2 cells: apoptosis vs. necrosis.
PubMed: Determination of methyl isocyanate in outdoor residential air near metam-sodium soil fumigations.
PubMed: Determination of methylisothiocyanate in soil and water by HS-SPME followed by GC-MS-MS with a triple quadrupole.
PubMed: The thiocarbamate disulphide drug, disulfiram induces osteopenia in rats by inhibition of osteoblast function due to suppression of acetaldehyde dehydrogenase activity.
PubMed: Gas-phase reaction of methyl isothiocyanate and methyl isocyanate with hydroxyl radicals under static relative rate conditions.
PubMed: Water and methyl isothiocyanate distribution in soil after drip fumigation.
PubMed: Reduction of methyl isothiocyanate atmospheric emissions after application of metam sodium by shank injection.
PubMed: Toxicity of pesticides associated with potato production, including soil fumigants, to snapping turtle eggs (Chelydra serpentina).
PubMed: Pesticides that inhibit the ubiquitin-proteasome system: effect measure modification by genetic variation in SKP1 in Parkinson׳s disease.
PubMed: Hazard-ranking of agricultural pesticides for chronic health effects in Yuma County, Arizona.
PubMed: Dissipation of soil fumigants from soil following repeated applications.
PubMed: Comparison of field methyl isothiocyanate flux following Pacific Northwest surface-applied and ground-incorporated fumigation practices.
PubMed: Effects of surface treatments and application shanks on nematode, pathogen and weed control with 1,3-dichloropropene.
PubMed: Metam sodium intoxication: the specific role of degradation products--methyl isothiocyanate and carbon disulphide--as a function of exposure.
PubMed: Uranyl sequestration: synthesis and structural characterization of uranyl complexes with a tetradentate methylterephthalamide ligand.
PubMed: Drip application of methyl bromide alternative chemicals for control of soilborne pathogens and weeds.
PubMed: Review of metastasizing (malignant) ameloblastoma (METAM): pattern of metastasis and treatment.
PubMed: Changes in microorganisms populations in the soil after fumigation.
PubMed: Metam sodium reduces viability and infectivity of Eimeria oocysts.
PubMed: Dithiocarbamates induce craniofacial abnormalities and downregulate sox9a during zebrafish development.
PubMed: Testing of a new disinfectant process for poultry viruses.
PubMed: Dose response assessment for effects of acute exposure to methyl isothiocyanate (MITC).
PubMed: Surface water seal application to minimize volatilization loss of methyl isothiocyanate from soil columns.
PubMed: Microbial aspects of accelerated degradation of metam sodium in soil.
PubMed: Titanium(IV) complexes with N,N'-dialkyl-2,3-dihydroxyterephthalamides and 1-hydroxy-2(1H)-pyridinone as siderophore and tunichrome analogues.
PubMed: Illnesses associated with chloropicrin use in California agriculture, 1992-2003.
PubMed: Accelerated degradation of metam-sodium in soil and consequences for root-disease management.
PubMed: Evaluation of alternatives to methyl bromide in melon crops in Guatemala.
PubMed: Biological Suppression and Natural Population Decline of Heterodera schachtii in a California Field.
PubMed: Status of chemical alternatives to methyl bromide for pre-plant fumigation of soil.
PubMed: Sulfhydryl systems are a critical factor in the zebrafish developmental toxicity of the dithiocarbamate sodium metam (NaM).
PubMed: Determination of methyl isothiocyanate in air downwind of fields treated with metam-sodium by subsurface drip irrigation.
PubMed: Mixed-mode reversed-phase and ion-exchange monolithic columns for micro-HPLC.
PubMed: Exposure to sodium metam during zebrafish somitogenesis results in early transcriptional indicators of the ensuing neuronal and muscular dysfunction.
PubMed: [Italian Program for Surveillance of Acute Pesticide-Related Illnesses: cases identified in 2005].
PubMed: Optimization of metam sodium application by rotary spading injection.
PubMed: Effect of application timing and method on efficacy and phytotoxicity of 1,3-D, chloropicrin and metam-sodium combinations in squash plasticulture.
PubMed: Control of Paratrichodorus allius and Corky Ringspot Disease in Potato with Shank-injected Metam Sodium.
PubMed: Potential effects of environmental contamination on Yuma Myotis demography and population growth.
PubMed: Control of Meloidogyne chitwoodi in Potato with Shank-injected Metam Sodium and other Nematicides.
PubMed: Linkage of the California Pesticide Use Reporting Database with spatial land use data for exposure assessment.
PubMed: Distribution and efficacy of drip-applied metam-sodium against the survival of Rhizoctonia solani and yellow nutsedge in plastic-mulched sandy soil beds.
PubMed: Weed control in rice with metham-sodium.
PubMed: Soil treatment with hot air (Cultivit) as alternative to methyl bromide.
PubMed: Reproductive functions and hypothalamic catecholamines in response to the soil fumigant metam sodium: adaptations to extended exposures.
PubMed: Dithiocarbamates have a common toxic effect on zebrafish body axis formation.
PubMed: Illnesses related to shank application of metam-sodium, Arvin, California, July 2002.
PubMed: Modeling methyl isothiocyanate soil flux and emission ratio from a field following a chemigation of metam-sodium.
PubMed: Effects of application methods of metam sodium and plastic covers on horizontal and vertical distributions of methyl isothiocyanate in bedded field plots.
PubMed: Root-knot nematode management in double-cropped plasticulture vegetables.
PubMed: Fumigant distribution in forest nursery soils under water seal and plastic film after application of dazomet, metam-sodium and chloropicrin.
PubMed: Physical, chemical and environmental properties of selected chemical alternatives for the pre-plant use of methyl bromide as soil fumigant.
PubMed: Study of the voltammetric behaviour of metam and its application to an amperometric flow system.
PubMed: The crucial role of calcium interacting with soil pH in enhanced biodegradation of metam-sodium.
PubMed: Biofumigation: environmental impacts on the biological activity of diverse pure and plant-derived isothiocyanates.
PubMed: Sodium methyldithiocarbamate inhibits MAP kinase activation through toll-like receptor 4, alters cytokine production by mouse peritoneal macrophages, and suppresses innate immunity.
PubMed: Incompatibility of metam sodium with halogenated fumigants.
PubMed: Chronic dietary risk for pesticide residues in food in Brazil: an update.
PubMed: Agricultural pesticide use and childhood cancer in California.
PubMed: Effect of combined application of methyl isothiocyanate and chloropicrin on their transformation.
PubMed: Enrichment and molecular characterization of chloropicrin- and metam-sodium-degrading microbial communities.
PubMed: Modeling of methyl isothiocyanate air concentrations associated with community illnesses following a metam-sodium sprinkler application.
PubMed: Developmental toxicity of the dithiocarbamate pesticide sodium metam in zebrafish.
PubMed: Transformation of chloropicrin and 1,3-dichloropropene by metam sodium in a combined application of fumigants.
PubMed: Fumigant combinations for Cyperus esculentum L control.
PubMed: Management Options for Pratylenchus penetrans in Easter Lily.
PubMed: Behavior of methyl isothiocyanate in soils under field conditions in Morocco.
PubMed: Behavior of 1,3-dichloropropene and methyl isothiocyanate in undisturbed soil columns.
PubMed: Efficacy of the liquid formulation of some nematicides.
PubMed: Community exposures to airborne agricultural pesticides in California: ranking of inhalation risks.
PubMed: Soil solarization reduces arbuscular mycorrhizal fungi as a consequence of weed suppression.
PubMed: Toxicology of metam sodium.
PubMed: Control of Paratrichodorus allius and Corky Ringspot Disease of Potato in the Columbia Basin of Oregon.
PubMed: Control of Meloidogyne chitwoodi in Potato with Fumigant and Nonfumigant Nematicides.
PubMed: Influence of metam sodium on the dissipation and residual biological activity of the herbicides EPTC and pebulate in surface soil under black plastic mulch.
PubMed: The influence of metam sodium on soil respiration.
PubMed: Selective trace determination of dithiocarbamate fungicides in fruits and vegetables by reversed-phase ion-pair liquid chromatography with ultraviolet and electrochemical detection.
PubMed: Chelating agents for uranium(VI): 2. Efficacy and toxicity of tetradentate catecholate and hydroxypyridinonate ligands in mice.
PubMed: Fumigant-related illnesses: Washington State's five-year experience.
PubMed: Symptom base rates after chemical exposure for white, Hispanic and African-Americans.
PubMed: Octadentate catecholamide ligands for Pu(IV) based on linear or preorganized molecular backbones.
PubMed: A community-based epidemiologic study of acute health effects from a metam-sodium spill on California's Sacramento River.
PubMed: S-methylation as a bioactivation mechanism for mono- and dithiocarbamate pesticides as aldehyde dehydrogenase inhibitors.
PubMed: Irritant dermatitis among workers cleaning up a pesticide spill: California 1991.
PubMed: Psychological, psychosocial, and psychophysiological sequelae in a community affected by a railroad chemical disaster.
PubMed: Persistent respiratory health effects after a metam sodium pesticide spill.
PubMed: Blockade of ovulation in the rat by the fungicide sodium N-methyldithiocarbamate: relationship between effects on the luteinizing hormone surge and alterations in hypothalamic catecholamines.
PubMed: Dose-response assessment of airborne methyl isothiocyanate (MITC) following a metam sodium spill.
PubMed: Aftermath of a chemical spill: psychological and physiological sequelae.
PubMed: The emergency medical response to the Cantara hazardous materials incident.
PubMed: Dermatitis among workers cleaning the Sacramento River after a chemical spill--California, 1991.
PubMed: Control of Pratylenchus penetrans on Potato with Metam-sodium Applied in Irrigation Water.
PubMed: Interaction of plastic, hay and grass mulches, and metam-sodium on control of Pratylenchus penetrans in tomatoes.
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