centella asiatica
gotu kola
 
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Category: spices, other natural seasonings and flavorings
 
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Mountain Valley Growers
Hydrocotle asiatica Gotu Kola
Vege Tech
O.C. Gotu-Kola
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GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
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None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: spices, other natural seasonings and flavorings
Recommendation for centella asiatica usage levels up to:
 not for fragrance use.
 
Recommendation for centella asiatica flavor usage levels up to:
 not for flavor use.
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Safety References:
None found
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References:
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Other Information:
FDA Listing of Food Additive Status: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 bronchitis 
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Occurrence (nature, food, other): note
 hydrocotyle asiatica
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 pennywort asiatic pennywort
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Synonyms:
 gotu kola
 hydrocotyle asiatica
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Articles:
PubMed: Homology modeling and docking studies on oxidosqualene cyclases associated with primary and secondary metabolism of Centella asiatica.
PubMed: Formulation, standardization and pharmacological studies of Saraswataristam: A polyhedral preparation.
PubMed: Useful ethnophytomedicinal recipes of angiosperms used against diabetes in South East Asian Countries (India, Pakistan & Sri Lanka).
PubMed: The effects of intellan and cytacon on hematological and biochemical parameter in rabbits: A comparative study.
PubMed: Effectiveness of traditional Malaysian vegetables (ulam) in modulating blood glucose levels.
PubMed: Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats.
PubMed: Morphological, chemical and molecular characterization of Centella asiatica germplasms for commercial cultivation in the Indo-Gangetic plains.
PubMed: Effects of Five Ayurvedic Herbs on Locomotor Behaviour in a Drosophila melanogaster Parkinson's Disease Model.
PubMed: Simultaneous interstitial pneumonitis and cardiomyopathy induced by venlafaxine.
PubMed: MicroRNA-1290 promotes asiatic acid‑induced apoptosis by decreasing BCL2 protein level in A549 non‑small cell lung carcinoma cells.
PubMed: Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review.
PubMed: Ethnopharmacological survey of medicinal plants used by traditional health practitioners in Thanchi, Bandarban Hill Tracts, Bangladesh.
PubMed: Anti-quorum sensing activity of flavonoid-rich fraction from Centella asiatica L. against Pseudomonas aeruginosa PAO1.
PubMed: Effect of Centella asiatica on oxidative stress and lipid metabolism in hyperlipidemic animal models.
PubMed: Asiatic acid attenuates cardiac hypertrophy by blocking transforming growth factor-β1-mediated hypertrophic signaling in vitro and in vivo.
PubMed: Formulation, standardization and pharmacological studies of Saraswataristam: a polyhedral preparation.
PubMed: Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma.
PubMed: Comparative study on anti-oxidant and anti-inflammatory activities of Caesalpinia crista and Centella asiatica leaf extracts.
PubMed: Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats.
PubMed: Effects of Medhya Rasayana and Yogic practices in improvement of short-term memory among school-going children.
PubMed: Study of the cytotoxicity of asiaticoside on rats and tumour cells.
PubMed: Asiaticoside attenuates memory impairment induced by transient cerebral ischemia-reperfusion in mice through anti-inflammatory mechanism.
PubMed: Effects of dietary Centella asiatica (L.) Urban on growth performance, nutrient digestibility, blood composition in piglets vaccinated with Mycoplasma hyopneumoniae.
PubMed: Anti-diabetic effect of a combination of andrographolide-enriched extract of Andrographis paniculata (Burm f.) Nees and asiaticoside-enriched extract of Centella asiatica L. in high fructose-fat fed rats.
PubMed: The effect of Centella asiatica, vitamins, glycolic acid and their mixtures preparations in stimulating collagen and fibronectin synthesis in cultured human skin fibroblast.
PubMed: Ethnoveterinary medicinal plants used by the Maale and Ari ethnic communities in southern Ethiopia.
PubMed: Barium Levels in Soils and Centella asiatica.
PubMed: Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice by downregulating collagen deposition.
PubMed: Pycnogenol® and Centella Asiatica for asymptomatic atherosclerosis progression.
PubMed: Caffeoylquinic acids in Centella asiatica protect against amyloid-β toxicity.
PubMed: The centella asiatica juice effects on DNA damage, apoptosis and gene expression in hepatocellular carcinoma (HCC).
PubMed: Asiatic acid alleviates hemodynamic and metabolic alterations via restoring eNOS/iNOS expression, oxidative stress, and inflammation in diet-induced metabolic syndrome rats.
PubMed: Anti-hyperglycemic activity of Centella asiatica is partly mediated by carbohydrase inhibition and glucose-fiber binding.
PubMed: Retention of nutrients in green leafy vegetables on dehydration.
PubMed: [Analysis on preparation and characterization of asiaticoside-loaded flexible nanoliposomes].
PubMed: Centella asiatica in dermatology: an overview.
PubMed: Anti-inflammaging and antiglycation activity of a novel botanical ingredient from African biodiversity (Centevita™).
PubMed: Evaluation of Analgesic and Anti-Inflammatory Activity of Chloroform and Methanol Extracts of Centella asiatica Linn.
PubMed: In vitro evidence that an aqueous extract of Centella asiatica modulates α-synuclein aggregation dynamics.
PubMed: Antioxidant activity of herbaceous plant extracts protect against hydrogen peroxide-induced DNA damage in human lymphocytes.
PubMed: Centella asiatica in cosmetology.
PubMed: Asiatic acid, a triterpene, inhibits cell proliferation through regulating the expression of focal adhesion kinase in multiple myeloma cells.
PubMed: Asiatic acid isolated from Centella asiatica inhibits TGF-β1-induced collagen expression in human keloid fibroblasts via PPAR-γ activation.
PubMed: Asiatic acid ameliorates tubulointerstitial fibrosis in mice with ureteral obstruction.
PubMed: In vivo disposition and metabolism of madecassoside, a major bioactive constituent in Centella asiatica (L.) Urb.
PubMed: Production of asiaticoside from centella (Centella asiatica L. Urban) cells in bioreactor.
PubMed: Ecologically relevant UV-B dose combined with high PAR intensity distinctly affect plant growth and accumulation of secondary metabolites in leaves of Centella asiatica L. Urban.
PubMed: Antiproliferative, cell-cycle dysregulation effects of novel asiatic acid derivatives on human non-small cell lung cancer cells.
PubMed: Neuritogenic effect of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells.
PubMed: Neuroprotective effects of madecassoside in early stage of Parkinson's disease induced by MPTP in rats.
PubMed: Effects of asiaticoside on levels of podocyte cytoskeletal proteins and renal slit diaphragm proteins in adriamycin-induced rat nephropathy.
PubMed: Unraveling the binding mechanism of asiatic acid with human serum albumin and its biological implications.
PubMed: Long-term follow-up of oral administration of flavonoids, Centella asiatica and Melilotus, for diabetic cystoid macular edema without macular thickening.
PubMed: Matrix metalloproteinase, hyaluronidase and elastase inhibitory potential of standardized extract of Centella asiatica.
PubMed: Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.
PubMed: De novo sequencing and assembly of Centella asiatica leaf transcriptome for mapping of structural, functional and regulatory genes with special reference to secondary metabolism.
PubMed: Centelloside accumulation in leaves of Centella asiatica is determined by resource partitioning between primary and secondary metabolism while influenced by supply levels of either nitrogen, phosphorus or potassium.
PubMed: [Near-infrared spectroscopy technology for online monitoring of the column separation and purification process of active components of Centella asiatica L. Urban].
PubMed: Metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb Centella asiatica (L.) urban.
PubMed: Statistical Analysis of Metal Chelating Activity of Centella asiatica and Erythroxylum cuneatum Using Response Surface Methodology.
PubMed: A Systematic Review of the Efficacy of Centella asiatica for Improvement of the Signs and Symptoms of Chronic Venous Insufficiency.
PubMed: Field evaluation of in vitro-induced tetraploid and diploid Centella asiatica (L.) Urban.
PubMed: [Simultaneous determination of madecassoside,asiaticoside and their aglycones in Centella asiatica (L.) urban extracts by RP-HPLC].
PubMed: Antioxidant synergism between ethanolic Centella asiatica extracts and α-tocopherol in model systems.
PubMed: Identification of Major Active Ingredients Responsible for Burn Wound Healing of Centella asiatica Herbs.
PubMed: Use of a specific anti-stretch mark cream for preventing or reducing the severity of striae gravidarum. Randomized, double-blind, controlled trial.
PubMed: Microbial transformation of asiatic acid.
PubMed: Mitoprotective effect of Centella asiatica against aluminum-induced neurotoxicity in rats: possible relevance to its anti-oxidant and anti-apoptosis mechanism.
PubMed: Determination of trace and heavy metals in some commonly used medicinal herbs in Ayurveda.
PubMed: Evaluation of amygdaloid neuronal dendritic arborization enhancing effect of Centella asiatica (Linn) fresh leaf extract in adult rats.
PubMed: The pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complications.
PubMed: Efficacy of asiatic acid, a pentacyclic triterpene on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats.
PubMed: Production of polyclonal antibody against madecassoside and development of immunoassay methods for analysis of triterpene glycosides in Centella asiatica.
PubMed: Centella asiatica protects against UVB-induced HaCaT keratinocyte damage through microRNA expression changes.
PubMed: Antipyretic and anti-inflammatory effects of asiaticoside in lipopolysaccharide-treated rat through up-regulation of heme oxygenase-1.
PubMed: Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials.
PubMed: Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts.
PubMed: Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model.
PubMed: Inhibition of cPLA2 and sPLA2 activities in primary cultures of rat cortical neurons by Centella asiatica water extract.
PubMed: Study in vitro of the impact of endophytic bacteria isolated from Centella asiatica on the disease incidence caused by the hemibiotrophic fungus Colletotrichum higginsianum.
PubMed: Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats.
PubMed: A liquid chromatography/electrospray ionization tandem mass spectrometric method for quantification of asiatic acid from plasma: application to pharmacokinetic study in rats.
PubMed: Anxiolytic effects of standardized extract of Centella asiatica (ECa 233) after chronic immobilization stress in mice.
PubMed: Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress.
PubMed: An investigation of arsenic contamination in Peninsular Malaysia based on Centella asiatica and soil samples.
PubMed: Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study.
PubMed: First Report of Septoria centellae Associated with Leaf Spot of Centella asiatica in Korea.
PubMed: Effect of Agrobacterium rhizogenes and elicitation on the asiaticoside production in cell cultures of Centella asiatica.
PubMed: Scientific basis of botanical medicine as alternative remedies for rheumatoid arthritis.
PubMed: Improved in vitro and in vivo collagen biosynthesis by asiaticoside-loaded ultradeformable vesicles.
PubMed: Plectranthus amboinicus and Centella asiatica Cream for the Treatment of Diabetic Foot Ulcers.
PubMed: Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential.
PubMed: Asiaticoside induces type I collagen synthesis and osteogenic differentiation in human periodontal ligament cells.
PubMed: Development of photochemoprotective herbs containing cosmetic formulations for improving skin properties.
PubMed: Interesting asian plants: their compounds and effects on electrophysiology and behaviour.
PubMed: A new method for preparing pentacyclic triterpene rich Centella asiatica extracts.
PubMed: Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action.
PubMed: Effect of an herbal mouth rinse in preventing periodontal inflammation in an experimental gingivitis model: a pilot study.
PubMed: Microsatellite markers isolated from the wild medicinal plant Centella asiatica (Apiaceae) from an enriched genomic library.
PubMed: Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells.
PubMed: A β-cyclodextrin, polyethyleneimine and silk fibroin hydrogel containing Centella asiatica extract and hydrocortisone acetate: releasing properties and in vivo efficacy for healing of pressure sores.
PubMed: Evaluation of comparative free-radical quenching potential of Brahmi (Bacopa monnieri) and Mandookparni (Centella asiatica).
PubMed: Madecassoside suppresses migration of fibroblasts from keloids: involvement of p38 kinase and PI3K signaling pathways.
PubMed: Evaluation of antioxidant activity of two important memory enhancing medicinal plants Baccopa monnieri and Centella asiatica.
PubMed: The influence of certain taxonomic and environmental parameters on biomass production and triterpenoid content in the leaves of Centella asiatica (L.) Urb. from Madagascar.
PubMed: Ethnobotanical treatment strategies against Alzheimer's disease.
PubMed: Aqueous extract of Centella asiatica promotes corneal epithelium wound healing in vitro.
PubMed: Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis.
PubMed: TECA (Titrated Extract of Centella Asiatica): new microcirculatory, biomolecular, and vascular application in preventive and clinical medicine. A status paper.
PubMed: Sri Lankan rice mixed meals: effect on glycaemic index and contribution to daily dietary fibre requirement.
PubMed: In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension.
PubMed: Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity.
PubMed: Centella asiatica extracts modulate hydrogen peroxide-induced senescence in human dermal fibroblasts.
PubMed: Discrimination of three Pegaga (Centella) varieties and determination of growth-lighting effects on metabolites content based on the chemometry of 1H nuclear magnetic resonance spectroscopy.
PubMed: Exploring the role of "Brahmi" (Bocopa monnieri and Centella asiatica) in brain function and therapy.
PubMed: Flavonoid and leaf gas exchange responses of Centella asiatica to acute gamma irradiation and carbon dioxide enrichment under controlled environment conditions.
PubMed: Asiaticoside: attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax.
PubMed: Regeneration of Centella asiatica plants from non-embryogenic cell lines and evaluation of antibacterial and antifungal properties of regenerated calli and plants.
PubMed: Antioxidant capacity and phenolic composition of fermented Centella asiatica herbal teas.
PubMed: Growth and asiaticoside production in multiple shoot cultures of a medicinal herb, Centella asiatica (L.) Urban, under the influence of nutrient manipulations.
PubMed: Enhancement of the skin-protective activities of Centella asiatica L. Urban by a nano-encapsulation process.
PubMed: A rapid one-step immunochromatographic assay for the detection of asiaticoside.
PubMed: The inductive effects of Centella asiatica on rat spermatogenic cell apoptosis in vivo.
PubMed: Genetic diversity of Centella asiatica in China analyzed by inter-simple sequence repeat (ISSR) markers: combination analysis with chemical diversity.
PubMed: Protective role of Centella asiatica on lead-induced oxidative stress and suppressed reproductive health in male rats.
PubMed: [Studies on fingerprints of Centella asiatica by HPLC].
PubMed: Wound repair and anti-inflammatory potential of essential oils from cones of Pinaceae: preclinical experimental research in animal models.
PubMed: A new cyclodextrin-grafted viscose loaded with aescin formulations for a cosmeto-textile approach to chronic venous insufficiency.
PubMed: Two new dammarane monodesmosides from Centella asiatica.
PubMed: Arsenic accumulation in native plants of West Bengal, India: prospects for phytoremediation but concerns with the use of medicinal plants.
PubMed: Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all.
PubMed: Effects of acute gamma irradiation on physiological traits and flavonoid accumulation of Centella asiatica.
PubMed: Induction of root colonization by Piriformospora indica leads to enhanced asiaticoside production in Centella asiatica.
PubMed: Irbic acid, a dicaffeoylquinic acid derivative from Centella asiatica cell cultures.
PubMed: Centella asiatica Attenuates D-Galactose-Induced Cognitive Impairment, Oxidative and Mitochondrial Dysfunction in Mice.
PubMed: Estimation of proximate composition, micronutrients and phytochemical compounds in traditional vegetables from Andaman and Nicobar Islands.
PubMed: Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice.
PubMed: Development and validation of high-performance liquid chromatography/electrospray ionization mass spectrometry for assay of madecassoside in rat plasma and its application to pharmacokinetic study.
PubMed: Carotenoid and mineral content of different morphotypes of Centella asiatica L. (Gotukola).
PubMed: Wound healing acceleration effect of endemic Ononis species growing in Turkey.
PubMed: A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells.
PubMed: Combination of flavonoids with Centella asiatica and Melilotus for diabetic cystoid macular edema without macular thickening.
PubMed: The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients.
PubMed: Triterpene composition and bioactivities of Centella asiatica.
PubMed: Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts.
PubMed: Optimization of an efficient semi-solid culture protocol for sterilization and plant regeneration of Centella asiatica (L.) as a medicinal herb.
PubMed: Preparation of a specific monoclonal antibody to asiaticoside for the development of an enzyme-linked immunosorbent assay.
PubMed: Effects of asiatic acid on passive and active avoidance task in male Spraque-Dawley rats.
PubMed: In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19).
PubMed: The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzheimer's disease.
PubMed: [Effects of compound Centella asiatica enema on kidneys coefficient, electrolytes and blood in chronic renal failure rats].
PubMed: Microbial transformation of asiatic acid by Alternaria longipes.
PubMed: Characterisation and immuno-stimulating activity of polysaccharides from Thai medicinal plants.
PubMed: The antiepileptic effect of Centella asiatica on the activities of Na/K, Mg and Ca-ATPases in rat brain during pentylenetetrazol-induced epilepsy.
PubMed: An ethnopharmacological study on Verbascum species: from conventional wound healing use to scientific verification.
PubMed: In vitro biological evaluation of electrospun cellulose acetate fiber mats containing asiaticoside or curcumin.
PubMed: A clinical study on the management of generalized anxiety disorder with Centella asiatica.
PubMed: Carotenoid content and in vitro bioaccessibility of lutein in some leafy vegetables popular in Sri Lanka.
PubMed: Evaluation of the wound healing potentials of two subspecies of Hypericum perforatum on cultured NIH3T3 fibroblasts.
PubMed: Antispermatogenic and antifertility effect of Pegaga (Centella asiatica L) on the testis of male Sprague-Dawley rats.
PubMed: Use of asiatic pennywort Centella asiatica aqueous extract as a bath treatment to control columnaris in Nile tilapia.
PubMed: Evaluation of an onion extract, Centella asiatica, and hyaluronic acid cream in the appearance of striae rubra.
PubMed: Antidiabetic screening of commercial botanical products in 3T3-L1 adipocytes and db/db mice.
PubMed: Total phenolic compounds, flavonoids, and radical scavenging activity of 21 selected tropical plants.
PubMed: Flavor characterization of sugar-added pennywort (Centella asiatica L.) juices treated with ultra-high pressure and thermal processes.
PubMed: Protective effects of asiaticoside on septic lung injury in mice.
PubMed: In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica.
PubMed: Madecassoside suppresses LPS-induced TNF-alpha production in cardiomyocytes through inhibition of ERK, p38, and NF-kappaB activity.
PubMed: Trends in aging and skin care: Ayurvedic concepts.
PubMed: Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase.
PubMed: Phytotherapeutics: an evaluation of the potential of 1000 plants.
PubMed: Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice.
PubMed: Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission.
PubMed: Two new triterpene glycosides from Centella asiatica.
PubMed: Contact dermatitis due to Centella asiatica.
PubMed: Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats.
PubMed: [Multicentric study on a topical compound with lymph-draining action in the treatment of the phlebostatic ulcer of the inferior limbs].
PubMed: Clinical Evaluation of Shilajatu Rasayana in patients with HIV Infection.
PubMed: Study and description of hydrogels and organogels as vehicles for cosmetic active ingredients.
PubMed: Prophylaxis with Centella asiatica confers protection to prepubertal mice against 3-nitropropionic-acid-induced oxidative stress in brain.
PubMed: Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) Urban.
PubMed: 3,5-Dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease.
PubMed: Centella asiatica Improves Physical Performance and Health-Related Quality of Life in Healthy Elderly Volunteer.
PubMed: Antioxidant and cytotoxic activities of Centella asiatica (L) Urb.
PubMed: Conversion of alpha-amyrin into centellosides by plant cell cultures of Centella asiatica.
PubMed: Adulticidal and larvicidal efficacy of some medicinal plant extracts against tick, fluke and mosquitoes.
PubMed: Characterization of a dammarenediol synthase in Centella asiatica (L.) Urban.
PubMed: Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells.
PubMed: Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade.
PubMed: Protection of DNA and membranes from gamma-radiation induced damages by Centella asiatica.
PubMed: A new herbal combination, Etana, for enhancing erectile function: an efficacy and safety study in animals.
PubMed: Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia.
PubMed: An improved HPLC-UV method for the simultaneous quantification of triterpenic glycosides and aglycones in leaves of Centella asiatica (L.) Urb (APIACEAE).
PubMed: Modulation of lipid metabolism by Centella asiatica in oxidative stress rats.
PubMed: In vitro and in vivo modulation of cartilage degradation by a standardized Centella asiatica fraction.
PubMed: Determination of asiatic acid in beagle dog plasma after oral administration of Centella asiatica extract by precolumn derivatization RP-HPLC.
PubMed: Madecassoside attenuates inflammatory response on collagen-induced arthritis in DBA/1 mice.
PubMed: Comparison of the effects of collagenase and extract of Centella asiatica in an experimental model of wound healing: an immunohistochemical and histopathological study.
PubMed: Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress.
PubMed: Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts.
PubMed: Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer's disease animal model.
PubMed: Protective antioxidant effect of Centella asiatica bioflavonoids on lead acetate induced neurotoxicity.
PubMed: Studies on Indian green leafy vegetables for their antioxidant activity.
PubMed: [Molecular characters of Centella asiatica found with RAPD technology].
PubMed: Enhancement of Amygdaloid Neuronal Dendritic Arborization by Fresh Leaf Juice of Centella asiatica (Linn) During Growth Spurt Period in Rats.
PubMed: Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging.
PubMed: Prophylactic neuroprotective property of Centella asiatica against 3-nitropropionic acid induced oxidative stress and mitochondrial dysfunctions in brain regions of prepubertal mice.
PubMed: An in vitro investigation of herbs traditionally used for kidney and urinary system disorders: potential therapeutic and toxic effects.
PubMed: Larvicidal and adulticidal activities of some medicinal plants against the malarial vector, Anopheles stephensi (Liston).
PubMed: [Preparation of asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb using preparative high performance liquid chromatography].
PubMed: Mosquito larvicidal activity of oleic and linoleic acids isolated from Citrullus colocynthis (Linn.) Schrad.
PubMed: Anti-rheumatoid arthritic effect of madecassoside on type II collagen-induced arthritis in mice.
PubMed: Triterpenoid saponin content and the expression level of some related genes in calli of Centella asiatica.
PubMed: Effect of Centella asiatica leaf powder on oxidative markers in brain regions of prepubertal mice in vivo and its in vitro efficacy to ameliorate 3-NPA-induced oxidative stress in mitochondria.
PubMed: Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin.
PubMed: Topical formulation of a new plant extract complex with refirming properties. Clinical and non-invasive evaluation in a double-blind trial.
PubMed: Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice.
PubMed: Enrichment and purification of madecassoside and asiaticoside from Centella asiatica extracts with macroporous resins.
PubMed: Centella asiatica water extract inhibits iPLA2 and cPLA2 activities in rat cerebellum.
PubMed: Preparation and characterization of herbal creams for improvement of skin viscoelastic properties.
PubMed: Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide.
PubMed: Two new flavonoids from Centella asiatica (Linn.).
PubMed: Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism.
PubMed: Hepatotoxic slimming aids and other herbal hepatotoxins.
PubMed: Madecassoside reduces ischemia-reperfusion injury on regional ischemia induced heart infarction in rat.
PubMed: Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways.
PubMed: Enhancement of hippocampal CA3 neuronal dendritic arborization by Centella asiatica (Linn) fresh leaf extract treatment in adult rats.
PubMed: Repellent activity of selected plant essential oils against the malarial fever mosquito Anopheles stephensi.
PubMed: Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica.
PubMed: Radioprotective Potential of Plants and Herbs against the Effects of Ionizing Radiation.
PubMed: Electrospun gelatin fiber mats containing a herbal-Centella asiatica-extract and release characteristic of asiaticoside.
PubMed: Apoptosis induction of Centella asiatica on human breast cancer cells.
PubMed: A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatitis.
PubMed: Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system.
PubMed: A novel triterpene from Centella asiatica.
PubMed: [Studies on chemical constituents in herb of Centella asiatica].
PubMed: Antigenotoxic role of Centella asiatica L. extract against cyproterone acetate induced genotoxic damage in cultured human lymphocytes.
PubMed: Simultaneous quantitation of three major triterpenoid glycosides in Centella asiatica extracts by high performance liquid chromatography with evaporative light scattering detection.
PubMed: [Separation and determination of madecassic acid in triterpenic genins of Centella asiatica by high performance liquid chromatography using beta-cyclodextrin as mobile phase additive].
PubMed: A rapid RP-HPTLC densitometry method for simultaneous determination of major flavonoids in important medicinal plants.
PubMed: Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity.
PubMed: Enhanced production of asiaticoside from hairy root cultures of Centella asiatica (L.) Urban elicited by methyl jasmonate.
PubMed: Chemical constituents of Centella asiatica.
PubMed: Endophytic fungi from leaves of Centella asiatica: occurrence and potential interactions within leaves.
PubMed: Treatment with Centalla asiatica (Linn) fresh leaf extract enhances learning ability and memory retention power in rats.
PubMed: Beneficial effects of Centella asiatica aqueous extract against arsenic-induced oxidative stress and essential metal status in rats.
PubMed: Comparative analysis of active constituents in Centella asiatica samples from Madagascar: application for ex situ conservation and clonal propagation.
PubMed: [Determination of aisaticoside in Centella asiatica extract by HPLC-ELSD].
PubMed: A bioactive polyacetylene compound isolated from Centella asiatica.
PubMed: Chemical components of Centella asiatica and their bioactivities.
PubMed: The anti-thrombotic active constituents from Centella asiatica.
PubMed: Centella asiatica.
PubMed: Chromatographic behaviour of steroidal saponins studied by high-performance liquid chromatography-mass spectrometry.
PubMed: Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts.
PubMed: [Plant metabolites as nootropics and cognitives].
PubMed: Centella asiatica (L.) leaf extract treatment during the growth spurt period enhances hippocampal CA3 neuronal dendritic arborization in rats.
PubMed: A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic options.
PubMed: Effect of Centella asiatica L (Umbelliferae) on normal and dexamethasone-suppressed wound healing in Wistar Albino rats.
PubMed: In vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method.
PubMed: The effect of methyl jasmonate on triterpene and sterol metabolisms of Centella asiatica, Ruscus aculeatus and Galphimia glauca cultured plants.
PubMed: Isobolographically additive anticonvulsant activity between Centella asiatica's ethyl acetate fraction and some antiepileptic drugs.
PubMed: Adriamycin induced myocardial failure in rats: protective role of Centella asiatica.
PubMed: Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats.
PubMed: Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling.
PubMed: Evaluation of anxiolytic properties of Gotukola--(Centella asiatica) extracts and asiaticoside in rat behavioral models.
PubMed: Effect of Centella asiatica on arsenic induced oxidative stress and metal distribution in rats.
PubMed: [Healing activity of methanolic extract of the barks of Spathodea campanulata Beauv (Bignoniaceae) in rat experimental burn model].
PubMed: Immunomodulatory activities of Centella asiatica and Rhinacanthus nasutus extracts.
PubMed: Centella asiatica treatment during postnatal period enhances learning and memory in mice.
PubMed: [Effects of total triterpenes of Centella asiatica on the corticosterone levels in serum and contents of monoamine in depression rat brain].
PubMed: Identification of triterpenoid compounds of Centella asiatica by thin-layer chromatography and mass spectrometry.
PubMed: Modification of gamma ray induced changes in the mouse hepatocytes by Centella asiatica extract: in vivo studies.
PubMed: Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro.
PubMed: Phenolic contents and antioxidant activity of some food and medicinal plants.
PubMed: Phlebotonics for venous insufficiency.
PubMed: Emerging role of Centella asiatica in improving age-related neurological antioxidant status.
PubMed: Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts in supportive periodontal therapy.
PubMed: [Topical chemotherapy for the treatment of burns].
PubMed: Advanced formulation and pharmacological activity of hydrogel of the titrated extract of C. asiatica.
PubMed: Cloning and expression of a farnesyl diphosphate synthase in Centella asiatica (L.) Urban.
PubMed: Plant medicines of Indian origin for wound healing activity: a review.
PubMed: Cloning of a cDNA probably encoding oxidosqualene cyclase associated with asiaticoside biosynthesis from Centella asiatica (L.) Urban.
PubMed: Hepatotoxicity associated with the ingestion of Centella asiatica.
PubMed: Precision improvement for the analysis of flavonoids in selected Thai plants by capillary zone electrophoresis.
PubMed: Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats.
PubMed: Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells.
PubMed: Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica.
PubMed: [Asiaticoside inducing apoptosis of tumor cells and enhancing anti-tumor activity of vincristine].
PubMed: Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats.
PubMed: Asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblasts.
PubMed: Thai medicinal plants modulate nitric oxide and tumor necrosis factor-alpha in J774.2 mouse macrophages.
PubMed: Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats.
PubMed: Dermal fibroblast-associated gene induction by asiaticoside shown in vitro by DNA microarray analysis.
PubMed: [Effect of total glucosides of Centella asiatica on antagonizing liver fibrosis induced by dimethylnitrosamine in rats].
PubMed: Stimulation of asiaticoside accumulation in the whole plant cultures of Centella asiatica (L.) urban by elicitors.
PubMed: Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica.
PubMed: [Effect of total triterpenes from Centella asiatica on the depression behavior and concentration of amino acid in forced swimming mice].
PubMed: The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats.
PubMed: Nutritional support for wound healing.
PubMed: Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. A preliminary study.
PubMed: Structure and potential immunological activity of a pectin from Centella asiatica (L.) Urban.
PubMed: Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids.
PubMed: Effect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer's disease in rats.
PubMed: An improved HPLC method for quantitative determination of six triterpenes in Centella asiatica extracts and commercial products.
PubMed: Anti-oxidant activity of Centella asiatica on lymphoma-bearing mice.
PubMed: Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats.
PubMed: [Resources distribution and pharamacognostic identification of Centella asiatica (L.) urban produced in China].
PubMed: Radioprotection of Swiss albino mouse by Centella asiatica extract.
PubMed: Immunomodulating effects of rasayana drugs in diabetics - a clinical study.
PubMed: An in vitro, ex vivo, and in vivo demonstration of the lipolytic effect of slimming liposomes: An unexpected alpha(2)-adrenergic antagonism.
PubMed: In vitro anti-hepatoma activity of fifteen natural medicines from Canada.
PubMed: Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats.
PubMed: Asiatic acid derivatives protect cultured cortical neurons from glutamate-induced excitotoxicity.
PubMed: Total triterpenic fraction of Centella asiatica in chronic venous insufficiency and in high-perfusion microangiopathy.
PubMed: Modification of the echogenicity of femoral plaques after treatment with total triterpenic fraction of Centella asiatica: a prospective, randomized, placebo-controlled trial.
PubMed: Total triterpenic fraction of Centella asiatica in the treatment of venous hypertension: a clinical, prospective, randomized trial using a combined microcirculatory model.
PubMed: Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: a clinical, prospective, placebo-controlled, randomized, dose-ranging trial.
PubMed: Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model.
PubMed: Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry.
PubMed: Flight microangiopathy in medium- to long-distance flights: prevention of edema and microcirculation alterations with total triterpenic fraction of Centella asiatica.
PubMed: Treatment of diabetic microangiopathy and edema with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled randomized study.
PubMed: Increase in echogenicity of echolucent carotid plaques after treatment with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled, randomized trial.
PubMed: Effects of the total triterpenic fraction of Centella asiatica in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial.
PubMed: Medicinal foodstuffs. XXVII. Saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, from Centella asiatica cultivated in Sri Lanka.
PubMed: Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of emerging edible plants.
PubMed: Effect of Centella asiatica Linn on physical and chemical factors induced gastric ulceration and secretion in rats.
PubMed: In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins.
PubMed: Protection against radiation-induced conditioned taste aversion by Centella asiatica.
PubMed: Development of a novel dosage form for intramuscular injection of titrated extract of Centella asiatica in a mixed micellar system.
PubMed: Hemorrhoids and varicose veins: a review of treatment options.
PubMed: [Effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency].
PubMed: Standardisation and Quality Evaluation of Centella asiatica Linn.
PubMed: A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects.
PubMed: Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats.
PubMed: Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica.
PubMed: Electrospray characterization of selected medicinal plant extracts.
PubMed: New innovations in scar management.
PubMed: Individuals at Risk of Coronary Heart Disease (CHD), its Prevention and Management by an Indigenous Compound.
PubMed: Creams for preventing stretch marks in pregnancy.
PubMed: Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants.
PubMed: Characterization of an ursane triterpenoid from centella asiatica with growth inhibitory activity against spilarctia obliqua.
PubMed: Effect of different drying methods on concentrations of several phytochemicals in herbal preparation of 8 medicinal plants leaves.
PubMed: Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds.
PubMed: The effect of tetrandrine and extracts of Centella asiatica on acute radiation dermatitis in rats.
PubMed: In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica.
PubMed: Asiaticoside-induced elevation of antioxidant levels in healing wounds.
PubMed: Extraction and analysis of cosmetic active ingredients from an anti-cellulitis transdermal delivery system by high-performance liquid chromatography.
PubMed: Evaluation of topical formulations of aqueous extract of Centella asiatica on open wounds in rats.
PubMed: In vitro evaluation of inhibitory nature of extracts of 18-plant species of Chhindwara against 3-keratinophilic fungi.
PubMed: Effects of Centella asiatica extract on dermal wound healing in rats.
PubMed: Quantitative determination of triterpenes in extracts and phytopreparations of Centella asiatica (L.) urban.
PubMed: Allergic contact dermatitis due to Centella asiatica: a new case.
PubMed: Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract.
PubMed: Cytotoxic and anti-tumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban.
PubMed: Allergic contact dermatitis due to Centella asiatica extract.
PubMed: Amino Acid analysis of intellan, a herbal product used in enhancing brain function.
PubMed: [The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study].
PubMed: In vitro experiments with Centella asiatica: investigation to elucidate the effect of an indigenously prepared powder of this plant on the acid-fastness and viability of M. tuberculosis.
PubMed: Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer.
PubMed: Pharmacognostic studies on centella asiatica (L) urban.
PubMed: Enhancement of the attachment on microcarriers and tPA production by fibroblast cells in a serum-free medium by the addition of the extracts of Centella asiatica.
PubMed: Effects of plant extract Centella asiatica (Linn.) on cold restraint stress ulcer in rats.
PubMed: [Activity of Centella asiatica in venous insufficiency].
PubMed: Allergic contact dermatitis from a cream containing Centella asiatica extract.
PubMed: Triterpenoids and their glycosides from the bark of Schefflera octophylla.
PubMed: Centella Asiatica Triterpenic Fraction (CATTF) reduces the number of circulating endothelial cells in subjects with post phlebitic syndrome.
PubMed: Prophylaxis of Striae gravidarum with a topical formulation. A double blind trial.
PubMed: Improvement of capillary permeability in patients with venous hypertension after treatment with TTFCA.
PubMed: Pharmacokinetics of the total triterpenic fraction of Centella asiatica after single and multiple administrations to healthy volunteers. A new assay for asiatic acid.
PubMed: Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica.
PubMed: Capillary filtration and ankle edema in patients with venous hypertension treated with TTFCA.
PubMed: Effects of Centella asiatica extract on mucopolysaccharide metabolism in subjects with varicose veins.
PubMed: An experimental study of the anti-HSV-II action of 500 herbal drugs.
PubMed: [Medical and surgical therapies. Their respective indications in lymphedema].
PubMed: Effect of the triterpenoid fraction of Centella asiatica on macromolecules of the connective matrix in human skin fibroblast cultures.
PubMed: Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs.
PubMed: Contact dermatitis due to madecassol.
PubMed: [Effect of Centella asiatica on the biosynthetic activity of fibroblasts in culture].
PubMed: [Comparative capillaroscopic study of certain bioflavonoids and total triterpenic fractions of Centella asiatica in venous insufficiency].
PubMed: [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside].
PubMed: [Centella asiatica extract in venous disorders of the lower limbs. Comparative clinico-instrumental studies with a placebo].
PubMed: [Use of a titrated extract of Centella asiatica in chronic hepatic disorders (author's transl)].
PubMed: [Modification of the kinetics of healing after iterative exeresis in the rat. Action of a triterpenoid and its derivatives on the duration of healing].
PubMed: [Animal study of the transcutaneous movement of the tritium-labelled active principles of Centella asiatica L. extract after administration in impregnated gauze or unguent].
PubMed: [Results of a controlled experiment of the titrated extract of Centella asiatica in a leper population with perforative foot lesions].
PubMed: [Action of a pentacyclic triterpenoid, asiaticoside, isolated from Hydrocotyle masagascariensis or Centella asiatica, against gastric ulceration in the Wistar rat exposed to cold at 2 degrees C].
PubMed: Use of titrated extract of Centella asiatica (TECA) in bilharzial bladder lesions.
PubMed: [Action of the titrated extract of Centella Asiatica in the cicatrization of leg ulcers (10 mg. tablets). Apropos of 50 cases].
PubMed: Crude extract of Centella asiatica and products derived from its glycosides as oral antifertility agents.
PubMed: [Isolation of a new triterpenic acid from Centella asiatica (L.) Urb. of Madagascar: madecassic acid].
PubMed: [ANTHRONE DETERMINATION OF THE ASIATICOSIDE ISOLATED FROM CENTELLA ASIATICA BY QUANTITATIVE CHROMATOGRAPHY ON THIN LAYERS OF GLASS POWDER].
PubMed: [Anthrone determination of asiaticoside, ester-oside of Centella asiatica].
PubMed: Pharmacognostic study of Merremia emarginata Hallier & comparison with Centella asiatica Linn.
PubMed: [Treatment of stubborn ulcers of the lower extremities with Asiaticoside (Centella asiatica)].
PubMed: [On the treatment of cutaneous lesions with extract of "Centella asiatica"].
PubMed: [Asiaticoside; active constituent of Centella asiatica, initiating agent of the new growth in the early stage of cicatrization of skin ulcers].
PubMed: [Asiaticoside extracted from Centella asiatica and its therapeutic uses in cicatrization of experimental and refractory wounds (leprosy, cutaneous tuberculosis and lupus)].
PubMed: Derivatives of Centella asiatica used against leprosy.
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