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Category: herbicides / pesticides
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 111.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 429.90 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 1.180000 mmHg @ 1.18 °C. (est) |
| Flash Point: | 417.00 °F. TCC ( 213.80 °C. ) (est)
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| logP (o/w): | 6.370 |
| Soluble in: |
| | water, 0.012 mg/L @ 20 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 205 mg/kg SKIN AND APPENDAGES (SKIN): HAIR: OTHER
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 19, Pg. S243, 1994.
intraperitoneal-rat LD50 58100 ug/kg SKIN AND APPENDAGES (SKIN): HAIR: OTHER
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: MUSCLE WEAKNESS Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 19, Pg. S243, 1994.
oral-rat LD50 570 mg/kg BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 19, Pg. S243, 1994.
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| Dermal Toxicity: |
skin-rabbit LD50 > 2000 mg/kg Agrochemcicals Japan. Vol. (63), Pg. 12, 1993.
skin-rat LD50 > 2000 mg/kg Farm Chemicals Handbook. Vol. -, Pg. C269, 1991.
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| Inhalation Toxicity: |
inhalation-rat LC50 620 mg/m3 Agrochemcicals Japan. Vol. (63), Pg. 12, 1993.
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Safety in Use Information:
| Category: | herbicides / pesticides |
| Recommendation for pyridaben usage levels up to: | | | not for fragrance use.
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| Recommendation for pyridaben flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Reasoned opinion on the modification of the existing maximum residue level maximum residue level (MRL) for pyridaben in cucurbits – edible peel View page or View pdf |
Retrospective analysis of the immunotoxic effects of plant protection products as reported in the Draft Assessment Reports for their peer review at EU level View page or View pdf |
Peer review of the pesticide risk assessment for the active substance pyridaben in light of confirmatory data submitted View page or View pdf |
Review of the existing maximum residue levels for pyridaben according to Article 12 of Regulation (EC) No 396/2005 View page or View pdf |
Modification of the existing maximum residue levels for pyridaben in tomatoes and aubergines View page or View pdf |
Modification of the existing maximum residue level for pyridaben in sweet pepper/bell pepper and setting of an import tolerance in tree nuts View page or View pdf |
| EPI System: | View |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 91754 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | 2-tert-butyl-5-[(4-tert-butylphenyl)methylsulfanyl]-4-chloropyridazin-3-one |
| Chemidplus: | 0096489713 |
| RTECS: | UR6149000 for cas# 96489-71-3 |
References:
| | 2-tert-butyl-5-[(4-tert-butylphenyl)methylsulfanyl]-4-chloropyridazin-3-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 91754 |
| Pubchem (sid): | 135049310 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2-tert- | butyl-5-(4-tert-butyl-benzylthio)-4-chloropyridazin-3(2H)-one | | 2-tert- | butyl-5-[(4-tert-butylphenyl)methylsulfanyl]-4-chloropyridazin-3-one | | 3(2H)- | pyridazinone, 4-chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylethyl)phenyl)methyl)thio)- | | | sanmite |
Articles:
| PubMed: | Worker illness related to newly marketed pesticides--Douglas County, Washington, 2014. |
| PubMed: | Transfer rates of 19 typical pesticides and the relationship with their physicochemical property. |
| PubMed: | Synthesis and Bio-Evaluation of New (18) F-Labeled Pyridaben Analogs with Improved Stability for Myocardial Perfusion Imaging in Mice. |
| PubMed: | Detection of pyridaben residue levels in hot pepper fruit and leaves by liquid chromatography-tandem mass spectrometry: effect of household processes. |
| PubMed: | Effect of Chinese traditional cooking on eight pesticides residue during cowpea processing. |
| PubMed: | Determination of 28 pesticides applied on two tomato cultivars with a different surface/weight ratio of the berries, using a multiresidue GC-MS/MS method. |
| PubMed: | sHsp22.6, an intronless small heat shock protein gene, is involved in stress defence and development in Apis cerana cerana. |
| PubMed: | Part I: temporal and spatial distribution of multiclass pesticide residues in lake waters of Northern Greece: application of an optimized SPE-UPLC-MS/MS pretreatment and analytical method. |
| PubMed: | Part II: temporal and spatial distribution of multiclass pesticide residues in lake sediments of northern Greece: application of an optimized MAE-LC-MS/MS pretreatment and analytical method. |
| PubMed: | Inhibitory effects of respiration inhibitors on aflatoxin production. |
| PubMed: | The effects of pyridaben pesticide on the DNA integrity of sperms and early in vitro embryonic development in mice. |
| PubMed: | The effects of pyridaben pesticide on the histomorphometric, hormonal alternations and reproductive functions of BALB/c mice. |
| PubMed: | Identification and characterization of seven glutathione S-transferase genes from citrus red mite, Panonychus citri (McGregor). |
| PubMed: | Assessment of pesticide residues in strawberries grown under various treatment regimes. |
| PubMed: | Residue and risk assessment of pyridaben in cabbage. |
| PubMed: | Cross-resistance between cyenopyrafen and pyridaben in the twospotted spider mite Tetranychus urticae (Acari: Tetranychidae). |
| PubMed: | Finding of pesticides in fashionable fruit juices by LC-MS/MS and GC-MS/MS. |
| PubMed: | Molecular characterization of two carboxylesterase genes of the citrus red mite, Panonychus citri (Acari: Tetranychidae). |
| PubMed: | [Determination of eight pesticide residues in tea by liquid chromatography-tandem mass spectrometry and its uncertainty evaluation]. |
| PubMed: | Investigation of pesticide residues in vegetables and fruits grown in various regions of Hatay, Turkey. |
| PubMed: | Simultaneous determination of procymidone, pyridaben and beta-cypermethrin residues in tea solution by GC-ECD. |
| PubMed: | Protocol for an electrospray ionization tandem mass spectral product ion library: development and application for identification of 240 pesticides in foods. |
| PubMed: | Transcriptome analysis of the citrus red mite, Panonychus citri, and its gene expression by exposure to insecticide/acaricide. |
| PubMed: | Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease. |
| PubMed: | Toxicity assessment of 45 pesticides to the epigeic earthworm Eisenia fetida. |
| PubMed: | The oxygen free radicals originating from mitochondrial complex I contribute to oxidative brain injury following hypoxia-ischemia in neonatal mice. |
| PubMed: | Synthesis and preliminary evaluation of 18F-labeled pyridaben analogues for myocardial perfusion imaging with PET. |
| PubMed: | Pollution level and human health risk assessment of some pesticides and polychlorinated biphenyls in Nantong of Southeast China. |
| PubMed: | Chemical control of the red palm mite, Raoiella indica (Acari: Tenuipalpidae) in banana and coconut. |
| PubMed: | Purification and partial characterization of glutathione S-transferases from three field populations of Panonychus citri (Acari: Tetranychidae). |
| PubMed: | Exploring the boundaries of additivity: mixtures of NADH: quinone oxidoreductase inhibitors. |
| PubMed: | Fumigant toxicity of lemon eucalyptus oil constituents to acaricide-susceptible and acaricide-resistant Tetranychus urticae. |
| PubMed: | Contact and fumigant toxicity of plant essential oils and efficacy of spray formulations containing the oils against B- and Q-biotypes of Bemisia tabaci. |
| PubMed: | Sublethal effects of fenpyroximate and pyridaben on two predatory mite species, Neoseiulus womersleyi and Phytoseiulus persimilis (Acari, Phytoseiidae). |
| PubMed: | Efficacy of selected pesticides against synanthropic mites under laboratory assay. |
| PubMed: | DJ-1 deficiency in astrocytes selectively enhances mitochondrial Complex I inhibitor-induced neurotoxicity. |
| PubMed: | Rate of loss of insecticides during soil solarization and soil biosolarization. |
| PubMed: | Effects of rotenone and pyridaben on complex I electron transfer and on mitochondrial nitric oxide synthase functional activity. |
| PubMed: | Toxicity of plant essential oils to acaricide-susceptible and -resistant Tetranychus urticae (Acari: Tetranychidae) and Neoseiulus californicus (Acari: Phytoseiidae). |
| PubMed: | Monitoring of resistance to spirodiclofen and five other acaricides in Panonychus citri collected from Chinese citrus orchards. |
| PubMed: | Rapid multiresidue determination for currently used pesticides in agricultural drainage waters and soils using gas chromatography-mass spectrometry. |
| PubMed: | Preparation and biodistribution of [18F]FP2OP as myocardial perfusion imaging agent for positron emission tomography. |
| PubMed: | Development of acaricide resistance in Pacific spider mite (Tetranychus pacificus) from California vineyards. |
| PubMed: | Insecticide resistance status of Bemisia tabaci Q-biotype in south-eastern Spain. |
| PubMed: | Evaluation of the novel myocardial perfusion positron-emission tomography tracer 18F-BMS-747158-02: comparison to 13N-ammonia and validation with microspheres in a pig model. |
| PubMed: | Mitochondrial dysfunction contributes to alveolar developmental arrest in hyperoxia-exposed mice. |
| PubMed: | Acaricides and predatory mites against the begonia mite, Polyphagotarsonemus latus (Acari: Tarsonemidae), on Hedera helix. |
| PubMed: | Resistance mechanisms to mitochondrial electron transport inhibitors in a field-collected strain of Tetranychus urticae Koch (Acari: Tetranychidae). |
| PubMed: | Comparison of hollow fiber liquid phase microextraction and dispersive liquid-liquid microextraction for the determination of organosulfur pesticides in environmental and beverage samples by gas chromatography with flame photometric detection. |
| PubMed: | Susceptibility of Aedes aegypti, Culex quinquefasciatus Say, and Anopheles quadrimaculatus Say to 19 pesticides with different modes of action. |
| PubMed: | BMS-747158-02: a novel PET myocardial perfusion imaging agent. |
| PubMed: | Mechanism of uptake and retention of F-18 BMS-747158-02 in cardiomyocytes: a novel PET myocardial imaging agent. |
| PubMed: | Effects of acaricides, pyrethroids and predator distributions on populations of Tetranychus urticae in apple orchards. |
| PubMed: | [Resistance of Brevipalpus phoenicis (Geijskes) (Acari: Tenuipalpidae) to acaricides that inhibit cellular respiration in citrus: cross-resistance and fitness cost]. |
| PubMed: | Assessing supercritical fluid extraction for the analysis of fipronil, kresoxim-methyl, acrinathrin, and pyridaben residues in melon. |
| PubMed: | Safe apples for baby-food production: survey of pesticide treatment regimes leaving minimum residues. |
| PubMed: | Photocatalytic degradation of pesticide pyridaben. 3. In surfactant/TiO2 aqueous dispersions. |
| PubMed: | Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease. |
| PubMed: | Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. |
| PubMed: | [Compatibility of two fungal biocontrol agents conidia with commercial chemical acaricides]. |
| PubMed: | Multiple resistance and biochemical mechanisms of pyridaben resistance in Tetranychus urticae (Acari: Tetranychidae). |
| PubMed: | Evaluation of resistance pattern to fenpyroximate and pyridaben in Tetranychus urticae collected from greenhouses and apple orchards using lethal concentration-slope relationship. |
| PubMed: | Acaricidal activity against Panonychus citri of a ginkgolic acid from the external seed coat of Ginkgo biloba. |
| PubMed: | Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. |
| PubMed: | Evaluation of epidemiologic and animal data associating pesticides with Parkinson's disease. |
| PubMed: | [Control effects of Mikania micrantha alcohol extract on citrus red mite Panonychus citri]. |
| PubMed: | Effect of household processing and unit-to-unit variability of pyrifenox, pyridaben, and tralomethrin residues in tomatoes. |
| PubMed: | Acaricide mode of action. |
| PubMed: | Fenpyroximate resistance in Tetranychus urticae (Acari: Tetranychidae): cross-resistance and biochemical resistance mechanisms. |
| PubMed: | [Acute toxicity and bio-concentration factor of three pesticides on Brachydanio rerio]. |
| PubMed: | Effects of fungicide residues on the survival, fecundity, and predation of the mites Tetranychus urticae (Acari: Tetranychidae) and Galendromus occidentalis (Acari: Phytoseiidae). |
| PubMed: | [Inhibitory effect of zinc on beta-hexosaminidase release from RBL-2H3 cells by synthetic chemicals]. |
| PubMed: | Application of liquid chromatography with electrospray tandem mass spectrometry to the determination of a new generation of pesticides in processed fruits and vegetables. |
| PubMed: | Soil photolysis in a moisture- and temperature-controlled environment. 2. Insecticides. |
| PubMed: | First detection of chlorfenapyr (Secure) resistance in two-spotted spider mite (Acari: Tetranychidae) from nectarines in an Australian orchard. |
| PubMed: | Action of major insecticide groups on insect cell lines of the beet armyworm, Spodoptera exigua, compared with larvicidal toxicity. |
| PubMed: | NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. |
| PubMed: | An index for selective toxicity of miticides to phytophagous mites and their predators based on orchard trials. |
| PubMed: | Reversal of Bcl-2-mediated resistance of the EW36 human B-cell lymphoma cell line to arsenite- and pesticide-induced apoptosis by PK11195, a ligand of the mitochondrial benzodiazepine receptor. |
| PubMed: | Characterization of resistance to clofentezine in populations of European red mite from orchards in Ontario. |
| PubMed: | Pesticide residue levels in peppers grown in a greenhouse after multiple applications of pyridaben and tralomethrin. |
| PubMed: | A single-subunit NADH-quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition. |
| PubMed: | Method development and fate determination of pesticide-treated hops and their subsequent usage in the production of beer. |
| PubMed: | [Effects of organonitrogen, carbamate pesticides and others on beta-hexosaminidase release from rat basophilic leukemia cells (RBL-2H3)]. |
| PubMed: | Cross-resistance, inheritance, and biochemistry of mitochondrial electron transport inhibitor-acaricide resistance in Tetranychus urticae (Acari: Tetranychidae). |
| PubMed: | Comparative residual toxicities of pesticides to the predator Agistemus industani (Acari: Stigmaeidae) on citrus in Florida. |
| PubMed: | The insecticide target in the PSST subunit of complex I. |
| PubMed: | Acaricide toxicity and resistance in larvae of different strains of Tetranychus urticae and Panonychus ulmi (Acari: Tetranychidae). |
| PubMed: | Functional coupling of PSST and ND1 subunits in NADH:ubiquinone oxidoreductase established by photoaffinity labeling. |
| PubMed: | Incidence and inheritance of resistance to METI-acaricides in European strains of the two-spotted spider mite (Tetranychus urticae) (Acari: Tetranychidae). |
| PubMed: | The use of outdoor freshwater pond microcosms. III. Responses of phytoplankton and periphyton to pyridaben. |
| PubMed: | Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I. |
| PubMed: | NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone. |
| PubMed: | NADH: ubiquinone oxidoreductase inhibitors block induction of ornithine decarboxylase activity in MCF-7 human breast cancer cells. |
| PubMed: | Anticancer action of cubé insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. |
| PubMed: | A laboratory-based method to measure relative pesticide and spray oil efficacy against broad mite, Polyphagotarsonemus latus (Banks)(Acari: Tarsonemidae). |
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