symphytum officinale leaf extract
extract of the leaves of the comfrey, symphytum officinale l., boraginaceae
 
Notes:
Skin care and after shave preparations needing soothing properties. Contains allantonin that stimulates cell growth. perennial herb symphytum officinale, in the family boraginaceae, used topically for wound healing. it contains allantoin, carotene, essential oils ( oils, volatile); glycosides; mucilage, resin, saponins; tannins; triterpenoids, vitamin b12, and zinc. comfrey also contains pyrrolizidine alkaloids and is hepatotoxic if ingested.
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Name: symphytum officinale leaf extract
CAS Number: 84696-05-9 
ECHA EC Number: 283-625-3
Category: cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
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PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: brown liquid (est)
Assay: 4.00 to  6.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.00100 to 1.06000 @  25.00 °C.
Pounds per Gallon - (est).: 8.329 to  8.820
Boiling Point: 103.00 °C. @ 760.00 mm Hg
Soluble in:
 water
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Organoleptic Properties:
 
Odor Type: woody
 
Odor Strength: medium
 
 woody  rooty  
Odor Description:
at 100.00 %. 
mild woody rooty
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
Bio-Botanica®
Comfrey Leaf Symphytum Officinale Leaf Extract
Carrubba
comfrey leaf extract
Lipotec USA
Actiphyte® of Comfrey Leaf Extract
Vege Tech
comfrey extract
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic ingredient for skin conditioning
Recommendation for symphytum officinale leaf extract usage levels up to:
 not for fragrance use.
 
Recommendation for symphytum officinale leaf extract flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Outcome of the consultation with Member States and EFSA on the basic substance application for approval of Comfrey steeping to be used in plant protection as an insect repellent and plant elicitor in fruit trees, grass and vegetables
View page or View pdf
Daily Med: search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 symphytum officinale leaf extract
Chemidplus: 0084696059
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References:
 symphytum officinale leaf extract
Pubchem (sid): 135307585
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Other Information:
Export Tariff Code: 1302.19.0000
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 antidandruff agents 
 soothing agents 
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Occurrence (nature, food, other): note
 comfrey
Search Trop  Picture
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Synonyms:
 comfrey leaf extract
actiphyte of comfrey leaf extract
quaker comfrey leaf extract
 extract of the leaves of the comfrey, symphytum officinale l., boraginaceae
 symphytum officinalis leaf extract
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Articles:
PubMed: Single cell subtractive transcriptomics for identification of cell-specifically expressed candidate genes of pyrrolizidine alkaloid biosynthesis.
PubMed: Histological study of some Echium vulgare, Pulmonaria officinalis and Symphytum officinale populations.
PubMed: An outbreak of foxglove leaf poisoning.
PubMed: A rapid cleanup method for the isolation and concentration of pyrrolizidine alkaloids in comfrey root.
PubMed: Fructan Synthesis in Tissue Cultures of Symphytum officinale; L. Initiation, Differentiation, and Metabolic Activity.
PubMed: An evaluation of acetone extracts from six plants in the Ames mutagenicity test.
PubMed: The anatomy of the leaf of Symphytum officinale L.
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