laureth-12
poly(oxy-1,2-ethanediyl), .alpha.-dodecyl-.omega.-hydroxy- (12 mol EO average molar ratio)
 
Notes:
None found
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CAS Number: 3056-00-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 221-286-5
Nikkaji Web: J205.363B
XlogP3: 3.50 (est)
Molecular Weight: 714.97538000
Formula: C36 H74 O13
NMR Predictor: Predict (works with chrome or firefox)
CAS Number: 9002-92-0Picture of molecule3D/inchi
Other(deleted CASRN): 101008-55-3
ECHA ELINCS - REACH Pre-Reg: 500-002-6
FDA UNII: J89TKQ5R54
Nikkaji Web: J92.963H
XlogP3: 5.10 (est)
Formula: (C2 H4 O)mult-C12 H26 O
NMR Predictor: Predict (works with chrome or firefox)
Category: emulsifiers, surfactants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 304.00 to  305.00 °C. @ 760.00 mm Hg (est)
Flash Point: > 220.00 °F. TCC ( > 104.44 °C. )
logP (o/w): 2.324 (est)
Soluble in:
 water, 11.31 mg/L @ 25 °C (est)
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Organoleptic Properties:
Odor Strength: none
 
Odor Description:
at 100.00 %. 
bland
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: surfactants
surfactant - emulsifying
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Suppliers:
Lipo Chemicals
Lipocol® L-12
Odor: characteristic
Use: Lipocol® L-12 is a solubilizer for shampoos, shower products, bubble baths, liquid hand soaps and other personal care cleansers. It is an effective emulsifier for depilatories, cleansing creams and lotions.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  8600 mg/kg
Soap, Perfumery & Cosmetics. Vol. 38, Pg. 47, 1965.

oral-rat LD50  4150 mg/kg
Toxicology and Applied Pharmacology. Vol. 2, Pg. 133, 1960.

oral-rat LD50  1000 mg/kg
Food and Cosmetics Toxicology. Vol. 8, Pg. 125, 1970.

intravenous-rat LD50  390 mg/kg
Toxicology and Applied Pharmacology. Vol. 2, Pg. 133, 1960.

intravenous-rat LD50  27 mg/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

intravenous-rat LD50  27 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

intravenous-rabbit LD50  36 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

oral-mouse LD50  4940 mg/kg
American Perfumer and Cosmetics. Vol. 77, Pg. 35, 1962.

oral-mouse LD50  3500 mg/kg
American Perfumer and Cosmetics. Vol. 77, Pg. 35, 1962.

oral-mouse LD50  1170 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

oral-mouse LD50  1170 mg/kg
Toxicology and Applied Pharmacology. Vol. 2, Pg. 133, 1960.

intravenous-mouse LD50  100 mg/kg
Toxicology and Applied Pharmacology. Vol. 7, Pg. 206, 1965.

intravenous-mouse LD50  100 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

intraperitoneal-mouse LD50  160 mg/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

intraperitoneal-mouse LD50  160 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

oral-guinea pig LD50  384 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

intravenous-guinea pig LD50  38 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

Dermal Toxicity:
subcutaneous-rat LD50 954 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

subcutaneous-rat LD50 953 mg/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

subcutaneous-mouse LD50 792.30 mg/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: emulsifiers, surfactants
Recommendation for laureth-12 usage levels up to:
 not for fragrance use.
 
Recommendation for laureth-12 flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 3056-00-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 76460
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Chemidplus: 0003056006
 2-dodecoxyethanol (peg-12)
Chemidplus: 0009002920
EPA/NOAA CAMEO: hazardous materials
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References:
 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 3056-00-6
Pubchem (cid): 76460
Pubchem (sid): 135035004
 2-dodecoxyethanol (peg-12)
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 9002-92-0
Pubchem (cid): 24750
Pubchem (sid): 134991393
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): D01539
HMDB (The Human Metabolome Database): Search
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 emulsifying agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
2-dodecoxyethanol (peg-12)
 lipocol L-12
 peg-12 lauryl ether
 poly(oxy-1,2-ethanediyl), .alpha.-dodecyl-.omega.-hydroxy- (12 mol EO average molar ratio)
 polyethylene glycol (12) lauryl ether
 polyethylene glycol (12) monolauryl ether
 polyoxyethylene (12) lauryl ether
 polyoxyethylene (12) monolauryl ether
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