hydrangenol
1H-2-benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)-
 
Notes:
allergen; an isocoumarin.
  • BOC Sciences
    • BOC Sciences
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      Product(s):
      480-47-7 Hydrangenol 98.5%
      Hydrangenol isolated from the herbs of Hydrangea hortensia. antiallergic effect.
       
       
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CAS Number: 480-47-7Picture of molecule3D/inchi
FDA UNII: TL8PI7PHV1
Nikkaji Web: J12.398F
MDL: MFCD01570286
XlogP3-AA: 3.20 (est)
Molecular Weight: 256.25744000
Formula: C15 H12 O4
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 528.00 to  529.00 °C. @ 760.00 mm Hg (est)
Flash Point: 404.00 °F. TCC ( 206.40 °C. ) (est)
logP (o/w): 2.339 (est)
Soluble in:
 water, 174.5 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
Hydrangenol 98.5%
Odor: characteristic
Use: Hydrangenol isolated from the herbs of Hydrangea hortensia. antiallergic effect.
Coompo
For experimental / research use only.
Hydrangenol from Plants ≥96%
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for hydrangenol usage levels up to:
 not for fragrance use.
 
Recommendation for hydrangenol flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 119199
National Institute of Allergy and Infectious Diseases: Data
 8-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one
Chemidplus: 0000480477
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References:
 8-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 119199
Pubchem (sid): 135073858
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C10262
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 antifungal 
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Occurrence (nature, food, other): note
 hydrangea serrata
Search Trop  Picture
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Synonyms:
1H-2-benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)-
3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1h-2-benzopyran-1-one
8-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one
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Articles:
PubMed: Search for new type of PPARγ agonist-like anti-diabetic compounds from medicinal plants.
PubMed: [Chemical constituents from Hydrangea macrophylla].
PubMed: Phenolic compounds from the roots of Jordanian viper's grass, Scorzonera judaica.
PubMed: Three new glycosides from the leaves of Hydrangea macrophylla subsp. serrata (THUNB.) MAKINO.
PubMed: New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium).
PubMed: Inhibitory effects of thunberginols A, B, and F on degranulations and releases of TNF-alpha and IL-4 in RBL-2H3 cells.
PubMed: Metabolic fate of orally administered phyllodulcin in rats.
PubMed: Stilbenecarboxylate biosynthesis: a new function in the family of chalcone synthase-related proteins.
PubMed: Allergic contact dermatitis from hydrangea--is it so rare?
PubMed: Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats.
PubMed: Structure-requirements of isocoumarins, phthalides, and stilbenes from Hydrangeae Dulcis Folium for inhibitory activity on histamine release from rat peritoneal mast cells.
PubMed: Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens.
PubMed: Development of bioactive functions in Hydrangeae Dulcis Folium. VII. Immunomodulatory activities of thunberginol A and related compounds on lymphocyte proliferation.
PubMed: Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats.
PubMed: Development of bioactive functions in Hydrangeae dulcis folium. VI. Syntheses of thunberginols A and F and their 3'-deoxy-derivatives using regiospecific lactonization of stilbene carboxylic acid: structures and inhibitory activity on histamine release of hydramacrophyllols A and B.
PubMed: Development of bioactive functions in hydrangeae dulcis folium. V. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (2). Thunberginols C, D, and E, thunberginol G 3'-O-glucoside, (-)-hydrangenol 4'-o-glucoside, and (+)-hydrangenol 4'-O-glucoside.
PubMed: Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats.
PubMed: Development of bioactive functions in hydrangeae dulcis folium. III. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (1). Thunberginols A, B, and F.
PubMed: [Development of bioactive functions in hydrangeae dulcis folium. II. Antiulcer, antiallergy, and cholagoic effects of the extract from hydrangeae dulcis folium].
PubMed: [Chemical constituents of Hydrangea macrophylla (Thunb.) Ser].
PubMed: [Quantitative analysis of dihydroisocoumarin constituents of Hydrangeae Dulcis Folium by means of high performance liquid chromatography. Chemical characterization of the processing, distribution in plant, and seasonal fluctuation].
PubMed: Thunberginols C, D, and E, new antiallergic and antimicrobial dihydroisocoumarins, and thunberginol G 3'-O-glucoside and (-)-hydrangenol 4'-O-glucoside, new dihydroisocoumarin glycosides, from Hydrangeae Dulcis Folium.
PubMed: Thunberginols A, B, and F, new antiallergic and antimicrobial principles from hydrangeae dulcis folium.
PubMed: Hydrangenol, a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae).
PubMed: Inhibitory effects of hydrangenol derivatives on the activation of hyaluronidase and their antiallergic activities.
PubMed: Allergic contact dermatitis to hydrangea.
PubMed: Antifungal activity of oosponol, oospolactone, phyllodulcin, hydrangenol, and some other related compounds.
PubMed: [High-speed liquid chromatographic analysis of drugs. IV. Speration analysis of phyllodulcin and hydrangenol in sweet hydrangea (author's transl)].
PubMed: Studies of hydrangenol in Hydrangea macrophylla Ser. II. Biosynthesis of hydrangenol from C14-labelled compounds.
PubMed: Enhancement of Gibberellin Growth-Promoting Activity by Hydrangenol Isolated from Leaves of Hydrangea Macrophylla.
PubMed: Studies of hydrangenol in hydrangea macrophylla Ser. I. Isolation, identification, and biosynthesis from C 14-labelled compounds.
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