beta-naphthol
2-hydroxynaphthalene
 
Notes:
Trace constit. of essential oils 2-Naphthol is a colorless crystalline solid and an isomer of 1-naphthol, differing by the location of the hydroxyl group on naphthalene. The naphthols are naphthalene homologues of phenol, with the hydroxyl group being more reactive than in the phenols. 2-Naphthol has several different uses including dyes, pigments, fats, oils, insecticides, pharmaceuticals, perfumes, antiseptics, synthesis of fungicides, and antioxidants for rubber. Detection of 2-Naphthol in urine usually results from long-term persistent exposure to pesticides such as chlorpyrifos, but also due to exposure to naphthalene in older types of mothballs, fires that produce polyaromatic hydrocarbons (PAHs), and tobacco smoke.; 2-Naphthol, or ?-naphthol, is a colorless crystalline solid with the formula C10H7OH. It is an isomer of 1-naphthol, differing by the location of the hydroxyl group on naphthalene. The naphthols are naphthalene homologues of phenol, with the hydroxyl group being more reactive than in the phenols. Both isomers are soluble in simple alcohols, ethers, and chloroform. They can be used in the production of dyes and in organic synthesis. For example, 2-naphthol reacts to form BINOL.
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      135-19-3 Tolnaflate Impurity A
      One of the impurities of Tolnaftate, which could be used as an Antifungal agent.
       
       
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      Product(s):
      NAPHTHOL, BETA-
       
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CAS Number: 135-19-3Picture of molecule3D/inchi
Other(deleted CASRN): 860440-31-9
ECHA EINECS - REACH Pre-Reg: 205-182-7
FDA UNII: P2Z71CIK5H
Nikkaji Web: J2.530E
Beilstein Number: 742134
MDL: MFCD00004067
XlogP3: 2.70 (est)
Molecular Weight: 144.17296000
Formula: C10 H8 O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
FDA Mainterm (IAUFC):135-19-3 ; BETA-NAPHTHOL
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Physical Properties:
Appearance: colorless crystalline solid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 122.30 °C. @ 760.00 mm Hg
Boiling Point: 285.00 to  286.00 °C. @ 760.00 mm Hg
Boiling Point: 145.00 to  146.00 °C. @ 10.00 mm Hg
Vapor Pressure: 0.002000 mmHg @ 25.00 °C. (est)
Flash Point: 291.00 °F. TCC ( 144.00 °C. ) (est)
logP (o/w): 2.700
Soluble in:
 water, 755 mg/L @ 25 °C (exp)
 water, 1512 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
Tolnaflate Impurity A
Odor: characteristic
Use: One of the impurities of Tolnaftate, which could be used as an Antifungal agent.
Charkit Chemical
NAPHTHOL, BETA-
EMD Millipore
For experimental / research use only.
beta-Naphthol for synthesis
ExtraSynthese
For experimental / research use only.
beta-Naphthol (GC) ≥99%
Glentham Life Sciences
2-Naphthol
Indenta Group
beta-Naphthol
Penta International
beta-NAPHTHOL
Santa Cruz Biotechnology
For experimental / research use only.
beta-Naphthol
Sigma-Aldrich: Aldrich
For experimental / research use only.
beta-Naphthol 99%
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-cat LDLo  100 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

oral-guinea pig LD50  1335 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 30(9), Pg. 22, 1965.

intraperitoneal-mouse LD50  97500 mg/kg
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 13, Pg. 381, 1978.

oral-mouse LDLo  100 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

oral-rabbit LDLo  3800 mg/kg
Yakkyoku. Pharmacy. Vol. 31, Pg. 1499, 1980.

unreported-rabbit LDLo  3800 mg/kg
Yakkyoku. Pharmacy. Vol. 32, Pg. 605, 1981.

oral-rat LD50  1960 mg/kg
Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. Vol. 8, Pg. 145, 1972.

Dermal Toxicity:
subcutaneous-guinea pig LDLo 2670 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 186, Pg. 195, 1937.

subcutaneous-mouse LDLo 100 mg/kg
Zeitschrift fuer Hygiene und Infektionskrankheiten. Vol. 64, Pg. 113, 1909.

skin-rabbit LD50 > 10000 mg/kg
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 26-4/1973

subcutaneous-rabbit LDLo 3000 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

subcutaneous-rat LDLo 2940 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SLEEP BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 186, Pg. 195, 1937.

Inhalation Toxicity:
inhalation-rat LC50 > 770 mg/m3/1H
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 26-4/1973

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Safety in Use Information:
Category: pharmaceuticals / chemical synthisis
Recommendation for beta-naphthol usage levels up to:
 not for fragrance use.
 
Recommendation for beta-naphthol flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
NIOSH International Chemical Safety Cards: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
EPA Substance Registry Services (TSCA): 135-19-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 8663
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 naphthalen-2-ol
Chemidplus: 0000135193
RTECS: 135-19-3
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References:
 naphthalen-2-ol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 135-19-3
Pubchem (cid): 8663
Pubchem (sid): 134975404
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C11713
HMDB (The Human Metabolome Database): HMDB12322
FooDB: FDB000877
Export Tariff Code: 2907.15.00.10
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
grade: technical, sublimed, resublimed
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 anticeptic 
 deodorants 
 germicid 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 azogen developer A
 betanaphthol
 C.I. azoic coupling component 1
 C.I. developer 5
 developer A
 developer BN
 developer NA
2-hydroxynaphthalene
b-hydroxynaphthalene
beta-hydroxynaphthalene
 microcidin
2-naftol
 naphthalen-2-ol
2-naphthalenol
2-naphthol
b-naphthol
 naphthol B
b-naphthyl alcohol
beta-naphthyl alcohol
beta-naphthyl hydroxide
2-napththol
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