rebaudioside D
 
Notes:
Constit. of Stevia rebaudiana (stevia)
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      Product(s):
      63279-13-0 Rebaudioside D
       
  • CSA
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CAS Number: 63279-13-0Picture of molecule3D/inchi
FDA UNII: 1SU114WXBX
Nikkaji Web: J20.437D
MDL: MFCD11113790
XlogP3-AA: -4.40 (est)
Molecular Weight: 1129.16520000
Formula: C50 H80 O28
NMR Predictor: Predict (works with chrome or firefox)
EFSA/JECFA Comments: FEMA GRAS 29 : Rebaudioside D ≥95%; Total other steviol glycosides <3.5%
Category: sweeteners, flavor enhancers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 456 Rebaudioside D purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside D) View - notice PDF
GRN 548 High purity rebaudioside D View - notice PDF
GRN 715 Rebaudioside D View - notice PDF
GRN 764 Rebaudioside D View PDF
FEMA Number: 4921 rebaudioside D
FDA:No longer provide for the use of these seven synthetic flavoring substances
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -3.377 (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Alfa Biotechnology
For experimental / research use only.
Rebaudioside D 98%
BOC Sciences
For experimental / research use only.
Rebaudioside D
Carbosynth
For experimental / research use only.
Rebaudioside D
Layn Natural ingredients
Reb-D Series
PureCircle
Rebaudioside D
Sigma-Aldrich
For experimental / research use only.
Rebaudioside D analytical standard
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the CSA
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: sweeteners, flavor enhancers
Recommendation for rebaudioside D usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 29
Click here to view publication 29
 average usual ppmaverage maximum ppm
baked goods: 15.0000032.50000
beverages(nonalcoholic): 15.0000032.50000
beverages(alcoholic): 15.0000032.50000
breakfast cereal: 15.0000032.50000
cheese: --
chewing gum: 200.00000325.00000
condiments / relishes: 15.0000032.50000
confectionery froastings: 15.0000032.50000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 15.0000032.50000
fruit ices: 15.0000032.50000
gelatins / puddings: 15.0000032.50000
granulated sugar: --
gravies: --
hard candy: 15.0000032.50000
imitation dairy: 15.0000032.50000
instant coffee / tea: 15.0000032.50000
jams / jellies: 15.0000032.50000
meat products: --
milk products: 15.0000032.50000
nut products: 15.0000032.50000
other grains: 15.0000032.50000
poultry: --
processed fruits: 15.0000032.50000
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 15.0000032.50000
snack foods: 15.0000032.50000
soft candy: 15.0000032.50000
soups: 15.0000032.50000
sugar substitutes: --
sweet sauces: 15.0000032.50000
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Safety References:
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 71773169
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0063279130
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References:
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 71773169
Pubchem (sid): 172648804
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
HMDB (The Human Metabolome Database): HMDB34948
FooDB: FDB013541
FDA Listing of Food Additive Status: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 stevia rebaudiana
Search Trop  Picture
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Synonyms:
 KAUR-16-EN-18-oic acid, 13-((o-beta-D-glucopyranosyl-(1-&gt;2)-O-(beta-D-glucopyranosyl-(1-&gt;3))-beta-D-glucopyranosyl)oxy)-, 2-o-beta-D-glucopyranosyl-beta-D-glucopyranosyl ester, (4alpha)-
 rebaudioside D purified from the leaves of stevia rebaudiana (bertoni) bertoni (rebaudioside D)
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Articles:
PubMed: Isolation and Characterization of a Novel Rebaudioside M Isomer from a Bioconversion Reaction of Rebaudioside A and NMR Comparison Studies of Rebaudioside M Isolated from Stevia rebaudiana Bertoni and Stevia rebaudiana Morita.
PubMed: Rebaudioside A and Rebaudioside D bitterness do not covary with Acesulfame K bitterness or polymorphisms in TAS2R9 and TAS2R31.
PubMed: Hydrogenation of the exocyclic olefinic bond at C-16/C-17 position of ent-kaurane diterpene glycosides of Stevia rebaudiana using various catalysts.
PubMed: Metabolism and toxicity studies supporting the safety of rebaudioside D.
PubMed: Simultaneous analysis of steviol and steviol glycosides by liquid chromatography with ultraviolet detection on a mixed-mode column: application to Stevia plant material and Stevia-containing dietary supplements.
PubMed: Catalytic Hydrogenation of the Sweet Principles of Stevia rebaudiana, Rebaudioside B, Rebaudioside C, and Rebaudioside D and Sensory Evaluation of Their Reduced Derivatives.
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