camptotheca acuminata seed

Articles:

PubMed:	Antitumor Effects and Biological Mechanism of Action of the Aqueous Extract of the Camptotheca acuminata Fruit in Human Endometrial Carcinoma Cells.
PubMed:	Oxidative stress and production of bioactive monoterpene indole alkaloids: biotechnological implications.
PubMed:	Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production.
PubMed:	Plant extracts for the topical management of psoriasis: a systematic review and meta-analysis.
PubMed:	Characterization and quantification of 10-hydroxycamptothecine in Camptotheca acuminate and its medicinal preparation by liquid chromatography-ion trap mass spectrometry.
PubMed:	New and highly efficient column chromatographic extraction and simple purification of camptothecin from Camptotheca acuminata and Nothapodytes pittosporoides.
PubMed:	Isolation and characterization of endophytic fungi from Camptotheca acuminata.
PubMed:	Blastococcus endophyticus sp. nov., an actinobacterium isolated from Camptotheca acuminata.
PubMed:	Development of transcriptomic resources for interrogating the biosynthesis of monoterpene indole alkaloids in medicinal plant species.
PubMed:	Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma.
PubMed:	The inhibitory effect of CIL-102 on the growth of human astrocytoma cells is mediated by the generation of reactive oxygen species and induction of ERK1/2 MAPK.
PubMed:	Anticancer drugs from traditional toxic Chinese medicines.
PubMed:	Camptothecin fails to induce apoptosis in tumor necrosis factor-alpha-treated HaCaT cells.
PubMed:	Delivery methods of camptothecin and its hydrosoluble analogue irinotecan for treatment of colorectal cancer.
PubMed:	Medicinal plants: a public resource for metabolomics and hypothesis development.
PubMed:	Plantactinospora endophytica sp. nov., an actinomycete isolated from Camptotheca acuminata Decne., reclassification of Actinaurispora siamensis as Plantactinospora siamensis comb. nov. and emended descriptions of the genus Plantactinospora and Plantactinospora mayteni.
PubMed:	Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport.
PubMed:	Examination of camptothecin and 10-hydroxycamptothecin in Camptotheca acuminata plant and cell culture, and the affected yields under several cell culture treatments.
PubMed:	Effect of artificial reconstitution of the interaction between the plant Camptotheca acuminata and the fungal endophyte Fusarium solani on camptothecin biosynthesis.
PubMed:	Nitrate reductase-mediated nitric oxide generation is essential for fungal elicitor-induced camptothecin accumulation of Camptotheca acuminata suspension cell cultures.
PubMed:	Correlations between camptothecin and related metabolites in Camptotheca acuminata reveal similar biosynthetic principles and in planta synergistic effects.
PubMed:	Correlation of camptothecin-producing ability and phylogenetic relationship in the genus Ophiorrhiza.
PubMed:	Evaluation of antimicrobial activity of endophytic fungi from Camptotheca acuminata (Nyssaceae).
PubMed:	Rhizobium kunmingense sp. nov., isolated from rhizosphere soil of Camptotheca acuminata Decne.
PubMed:	Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae).
PubMed:	10-Hydroxycamptothecin produced by a new endophytic Xylaria sp., M20, from Camptotheca acuminata.
PubMed:	Camptothecin production by in vitro cultures and plant regeneration in Ophiorrhiza species.
PubMed:	Metabolite fingerprinting of Camptotheca acuminata and the HPLC-ESI-MS/MS analysis of camptothecin and related alkaloids.
PubMed:	Novel camptothecin derivatives as topoisomerase I inhibitors.
PubMed:	[Isolation and purification of 10-hydroxycamptothecin and vincoside-lactam from Camptotheca acuminata seed by polyamide].
PubMed:	An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues.
PubMed:	Allene oxide cyclase from Camptotheca acuminata improves tolerance against low temperature and salt stress in tobacco and bacteria.
PubMed:	Molecular cloning, characterization and expression of a jasmonate biosynthetic pathway gene encoding allene oxide cyclase from Camptotheca acuminata.
PubMed:	[Effects of nitrogen forms on camptothecin content and its metabolism-related enzymes activities in Camptotheca acuminata seedlings].
PubMed:	[The study of dynamic acccumulation of camptothecin in Camptotheca acuminata fruit by TLCS].
PubMed:	Micropropagation and production of Camptothecin from in vitro plants of Ophiorrhiza rugosa var. decumbens.
PubMed:	[Effect of nitrogen on camptothecin content in Camptotheca acuminata seedlings].
PubMed:	Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants.
PubMed:	Molecular cloning and characterization of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (CaHDR) from Camptotheca acuminata and its functional identification in Escherichia coli.
PubMed:	A new isopentenyl diphosphate isomerase gene from Camptotheca acuminata: cloning, characterization and functional expression in Escherichia coli.
PubMed:	Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies.
PubMed:	CPT accumulation in the fruit and during early phases of plant development in Camptotheca acuminata Decaisne (Nyssaceae).
PubMed:	[Callus induction and cultivation of Camptotheca acuminata].
PubMed:	Camptothecin: therapeutic potential and biotechnology.
PubMed:	Molecular target-guided tumor therapy with natural products derived from traditional Chinese medicine.
PubMed:	Characteristics of the microbial community in rhizosphere of Camptotheca acuminata cultured with exotic invasive plant Eupatorium adenophorum.
PubMed:	Molecular cloning, expression profiling and functional analysis of a DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Camptotheca acuminata.
PubMed:	Extraction and composition of three naturally occurring anti-cancer alkaloids in Camptotheca acuminata seed and leaf extracts.
PubMed:	[Effects of cu2+ on biosynthesis of camptothecin in cell cultures of Camptotheca acuminata].
PubMed:	Triterpenoids and ellagic acid derivatives from in vitro cultures of Camptotheca acuminata Decaisne.
PubMed:	Total synthesis and biological evaluation of 22-hydroxyacuminatine.
PubMed:	Molecular cloning and characterization of a novel stem-specific gene from Camptotheca acuminata.
PubMed:	Concise synthesis of 22-hydroxyacuminatine, cytotoxic camptothecinoid from Camptotheca acuminata, by pyridone benzannulation.
PubMed:	Laticifers in Camptotheca acuminata Decne: distribution and structure.
PubMed:	Wound-induced expression of the ferulate 5-hydroxylase gene in Camptotheca acuminata.
PubMed:	An ab initio quantum mechanics calculation that correlates with ligand orientation and DNA cleavage site selectivity in camptothecin-DNA-topoisomerase I ternary cleavage complexes.
PubMed:	Camptothecin and its analogues: a review on their chemotherapeutic potential.
PubMed:	The effect of growth regulators and sucrose on anthocyanin production in Camptotheca acuminata cell cultures.
PubMed:	Molecular characterization of two anthranilate synthase alpha subunit genes in Camptotheca acuminata.
PubMed:	New camptothecin and ellagic acid analogues from the root bark of Camptotheca acuminata.
PubMed:	Antifungal activity of camptothecin, trifolin, and hyperoside isolated from Camptotheca acuminata.
PubMed:	[Accumulation and localization of camptothecin in young shoot of Camptotheca acuminata].
PubMed:	Improvement of growth and camptothecin yield by altering nitrogen source supply in cell suspension cultures of Camptotheca acuminata.
PubMed:	Cellular localisation of the anti-cancer drug camptothecin in Camptotheca acuminata Decne (Nyssaceae).
PubMed:	Camptothecin, over four decades of surprising findings.
PubMed:	Rubitecan: 9-NC, 9-Nitro-20(S)-camptothecin, 9-nitro-camptothecin, 9-nitrocamptothecin, RFS 2000, RFS2000.
PubMed:	Pharmacology of irinotecan.
PubMed:	Camptothecin and taxol: historic achievements in natural products research.
PubMed:	Current treatment and future directions in neuroblastoma.
PubMed:	[Improved camptothecin production by cell lines of Camptotheca acuminata].
PubMed:	Camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots.
PubMed:	[Topotecan for pediatric patients with resistant and recurrent solid tumors].
PubMed:	The emerging role of irinotecan (CPT-11) in the treatment of malignant glioma in brain tumors.
PubMed:	Variations in the secondary metabolite camptothecin in relation to tissue age and season in Camptotheca acuminata.
PubMed:	Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants.
PubMed:	Bcmfs1, a novel major facilitator superfamily transporter from Botrytis cinerea, provides tolerance towards the natural toxic compounds camptothecin and cercosporin and towards fungicides.
PubMed:	Advances in cancer therapy with plant based natural products.
PubMed:	Rapid micro-assay of camptothecin in Camptotheca acuminata.
PubMed:	Cisplatin and irinotecan in upper gastrointestinal malignancies.
PubMed:	Therapeutic applications of medicinal plants in the treatment of breast cancer: a review of their pharmacology, efficacy and tolerability.
PubMed:	Anti-cancer drug discovery and development in Brazil: targeted plant collection as a rational strategy to acquire candidate anti-cancer compounds.
PubMed:	Apoptosis induction and cell cycle perturbation in human hepatoma hep G2 cells by 10-hydroxycamptothecin.
PubMed:	[Irinotecan (topoisomerase-I inhibitor) for the treatment of recurrent primary intracranial malignant lymphoma].
PubMed:	Cloning of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from terpenoid antibiotic-producing Streptomyces strains.
PubMed:	Tissue-specific expression of the beta-subunit of tryptophan synthase in Camptotheca acuminata, an indole alkaloid-producing plant.
PubMed:	The clinical pharmacology of topoisomerase I inhibitors.
PubMed:	Camptothecin and taxol: discovery to clinic.
PubMed:	Preclinical pharmacology of the natural product anticancer agent 10-hydroxycamptothecin, an inhibitor of topoisomerase I.
PubMed:	Topoisomerase I inhibitors: review and update.
PubMed:	Molecular characterization of three differentially expressed members of the Camptotheca acuminata 3-hydroxy-3-methylglutaryl CoA reductase (HMGR) gene family.
PubMed:	Antitumor activity and pharmacokinetics following oral administration of natural product DNA topoisomerase I inhibitors 10-hydroxycamptothecin and camptothecin in SCID mice bearing human breast cancer xenografts.
PubMed:	Tryptophan decarboxylase is encoded by two autonomously regulated genes in Camptotheca acuminata which are differentially expressed during development and stress.
PubMed:	Sustained harvest of camptothecin from the leaves of Camptotheca acuminata.
PubMed:	Regression of human colon cancer xenografts in SCID mice following oral administration of water-insoluble camptothecins.
PubMed:	[Determination of camptothecine in the fruit of Camptotheca acuminata Decne. by RP-HPLC].
PubMed:	Cloning and expression of a plant homologue of the small subunit of the Golgi-associated clathrin assembly protein AP19 from Camptotheca acuminata.
PubMed:	Reversed-phase high-performance liquid chromatography method for the simultaneous quantitation of the lactone and carboxylate forms of the novel natural product anticancer agent 10-hydroxycamptothecin in biological fluids and tissues.
PubMed:	[Camptothecin and derivatives: a new class of antitumor agents].
PubMed:	Camptothecin and taxol: from discovery to clinic.
PubMed:	Stimulation of interleukin-1beta-converting enzyme activity during growth inhibition by CPT-11 in the human myeloid leukemia cell line K562.
PubMed:	Preclinical evaluation of CPT-11 and its active metabolite SN-38.
PubMed:	Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites.
PubMed:	Camptothecin analogues in the treatment of non-small cell lung cancer.
PubMed:	Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture.
PubMed:	Sites of accumulation of the antitumor alkaloid camptothecin in Camptotheca acuminata.
PubMed:	Inhibition of phosphorylation of histone H1 and H3 induced by 10-hydroxycamptothecin, DNA topoisomerase I inhibitor, in murine ascites hepatoma cells.
PubMed:	Expression of a 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Camptotheca acuminata is differentially regulated by wounding and methyl jasmonate.
PubMed:	[Effects of 10-hydroxycamptothecin on induced chromosome aberrations in Chinese hamster ovary cells and micronuclei in mouse bone marrow and fetal liver].
PubMed:	DNA topoisomerase I as a site of action for 10-hydroxycamptothecin in human promyelocytic leukemia cells.
PubMed:	Tannins of cornaceous plants. I. Cornusiins A, B and C, dimeric monomeric and trimeric hydrolyzable tannins from Cornus officinalis, and orientation of valoneoyl group in related tannins.
PubMed:	Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.
PubMed:	Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata Decne: total synthesis and biological activity.
PubMed:	The effect of hydroxycamptothecin in the activity of RNA and DNA polymerases prepared from murine hepatoma cells.
PubMed:	Medicinal plants--old and new.