Articles:
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2,4,6-trimethyl-1,3,5-trioxane
Notes:
a hypnotic and sedative with anticonvulsant effects. however, because of the hazards associated with its administration, its tendency to react with plastic, and the risks associated with its deterioration, it has largely been superseded by other agents. it is still occasionally used to control status epilepticus resistant to conventional treatment. (from martindale, the extra pharmacopoeia, 30th ed, p608-9) Used as a food additive [EAFUS]
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Beijing Lys Chemicals Co, LTD. From Grams to Tons Fine chemical high-tech company which contains R&D, production, and sales. BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services. Email: Mr. Jia Email: Mr. Guo Voice: 86-10-68418738 Fax: 86-10-68418739 Mr. Guo 86-10-68483445 Mr. Guo 86-10-68418739 News Product(s): 10401 Paraldehyde
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FCI SAS Inspired by Nature At FCI customer service is not a department it’s an attitude. Our team is composed of motivated professionals with great experience in the flavours and fragrances market. Our company has been serving this industry for more than 40 years and is ISO 9001 certified since 2009 . Whatever your question on flavour and fragrance ingredients: commercial, technical or regulatory – we will answer it very quickly. Email: Info Email: Philippe Faucher US Email: USA Sales Email: Germany Sales Email: Italy Sales Email: Japan Sales Voice: +33 (0)1 34 25 58 10 Fax: + 33 1 34 25 58 18 About Us Product(s): 13312 PARALDEHYDE
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 20-84500 2,4,6-TRIMETHYL-1,3,5-TRIOXANE
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Sunaux International Buy With Confidence We have industry leading processes and procedures to ensure nothing but the most reliable product. Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business. Email: John Felton Email: Stephen Zhou (Sales) Voice: 0512-57995626 Fax: 0512-57570299 Sales 0512-57995626 Sales 0512-57570299 News Product(s): A0132 Paraldehyde
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WholeChem, LLC Connecting Innovators To the Building Blocks Of the Universe Custom manufacturer and distributor of specialty ingredients. We make global local. SQF-Certified Supplier We owe our success to our integrity, our dedication to the industry, and our commitment to our clients. We invite your inquiries regarding our current product list and any other products you may be having trouble sourcing. Email: Info Email: Orders Voice: +1 (262) 995.8668 Certification Our Services Products List: View Product(s): Paraldehyde
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| CAS Number: | 123-63-7 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 204-639-8 | |
| FDA UNII: | S6M3YBG8QA | |
| Nikkaji Web: | J5.543C | |
| Beilstein Number: | 0080142 | |
| MDL: | MFCD00036208 | |
| CoE Number: | 594 | |
| XlogP3: | 0.70 (est) | |
| Molecular Weight: | 132.15924000 | |
| Formula: | C6 H12 O3 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: food contact phenolic resins in molded articles
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| DG SANTE Food Flavourings: | 05.053 2,4,6-trimethyl-1,3,5-trioxane |
| FEMA Number: | 4010 paraldehyde |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 123-63-7 ; PARALDEHYDE |
| FDA Regulation: | |
| FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use Sec. 177.2410 Phenolic resins in molded articles. | |
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 97.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.99400 @ 25.00 °C. |
| Refractive Index: | 1.40500 @ 20.00 °C. |
| Melting Point: | 11.00 to 13.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 123.00 to 124.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 15.693000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 4.57 ( Air = 1 ) |
| Flash Point: | 75.00 °F. TCC ( 23.89 °C. ) |
| logP (o/w): | 0.670 |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | store under nitrogen. |
| Storage: | refrigerate in tightly sealed containers. store under nitrogen. |
| Soluble in: | |
| alcohol | |
| water, 112000 mg/L @ 30 °C (exp) | |
Organoleptic Properties:
| Odor Description: at 0.10 % in propylene glycol. | sweet aromatic |
| Odor and/or flavor descriptions from others (if found). | |
| FCI SAS | |
| PARALDEHYDE | |
| Odor Description: | Strong, warm, sweet |
Cosmetic Information:
| None found |
Suppliers:
| Beijing Lys Chemicals |
| Paraldehyde |
| FCI SAS |
| PARALDEHYDE
Odor: Strong, warm, sweet |
| Godavari Biorefineries |
| Paraldehyde |
| Jinan Enlighten Chemical Technology(Wutong Aroma ) |
| Paraldehyde, Kosherk |
| Parchem |
| paraldehyde |
| Penta International |
| 2,4,6-TRIMETHYL-1,3,5-TRIOXANE |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Paraldehyde |
| Sunaux International |
| Paraldehyde |
| WholeChem |
| Paraldehyde |
Safety Information:
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| F - Highly flammable. | |
|
R 11 - Highly flammable. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 23 - Do not breath vapour. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 33 - Take precautionary measures against static discharge. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. S 38 - In case of insufficient ventlation, wear suitable respiratory equipment. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-mouse LD50 2750 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 19, 1957. oral-rabbit LD50 3304 mg/kg Proceedings of the Society for Experimental Biology and Medicine. Vol. 29, Pg. 730, 1932. oral-cat LDLo 3300 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. unreported-man LDLo 1462 mg/kg "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. intramuscular-man TDLo 568 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP British Journal of Psychiatry. Vol. 149, Pg. 650, 1986. intraperitoneal-mouse LD50 1257 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 19, 1957. oral-rat LD50 1530 mg/kg Union Carbide Data Sheet. Vol. 3/24/1970 intraperitoneal-rat LDLo 2100 mg/kg Toxicology and Applied Pharmacology. Vol. 1, Pg. 156, 1959. | |
| Dermal Toxicity: | |
|
subcutaneous-rat LDLo 1650 mg/kg Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 182, Pg. 348, 1936. skin-rabbit LD50 14100 uL/kg Union Carbide Data Sheet. Vol. 3/24/1970 | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | food contact phenolic resins in molded articles | ||
| Recommendation for paraldehyde usage levels up to: | |||
| not for fragrance use. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 20 | |||
| Click here to view publication 20 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 80.00000 | 200.00000 | |
| beverages(nonalcoholic): | 3.00000 | 20.00000 | |
| beverages(alcoholic): | 15.00000 | 40.00000 | |
| breakfast cereal: | 3.00000 | 12.00000 | |
| cheese: | - | - | |
| chewing gum: | 80.00000 | 200.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | 15.00000 | 100.00000 | |
| egg products: | 15.00000 | 100.00000 | |
| fats / oils: | 15.00000 | 100.00000 | |
| fish products: | - | - | |
| frozen dairy: | 10.00000 | 60.00000 | |
| fruit ices: | 8.00000 | 40.00000 | |
| gelatins / puddings: | 10.00000 | 50.00000 | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | 20.00000 | 89.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | 5.00000 | 30.00000 | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | 5.00000 | 40.00000 | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | 15.00000 | 50.00000 | |
| snack foods: | - | - | |
| soft candy: | 20.00000 | 60.00000 | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 3 (FGE.03); Acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated aldehydes, and a orthoester of formic acid, from chemical groups 1 and 2 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf | |
| Flavouring Group Evaluation 3, Revision 1 (FGE.03Rev1): Acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated or unsaturated aldehydes, an ester of a hemiacetal and an orthoester of formic acid, from chemical groups 1, 2 & 4 Commission Regulation (EC) No 1565/2000 of 18 July 2000) [1] - Scientific Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)on a request from the Commission View page or View pdf | |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| NIOSH International Chemical Safety Cards: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 123-63-7 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 31264 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WISER: | UN 1264 |
| WGK Germany: | 1 |
| 2,4,6-trimethyl-1,3,5-trioxane | |
| Chemidplus: | 0000123637 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 123-63-7 |
References:
| 2,4,6-trimethyl-1,3,5-trioxane | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 123-63-7 |
| Pubchem (cid): | 31264 |
| Pubchem (sid): | 134974572 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C07834 |
| HMDB (The Human Metabolome Database): | HMDB32456 |
| FooDB: | FDB010010 |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •grade: technical, usp. •paraldehyde: oral & rectal (liquid) paral (c-iv) from forest. •paraldehyde: parenteral (sterile) paraldehyde injection (c-iv) from cmc. •the british pharmacopeia specifies that it contains a suitable amount of an antioxidant; the usa pharmacopeia permits a suitable stabilizer. •paraldehyde draught (bpc 1973)] paraldehyde 4 ml, syrup 8 ml, liquorice liquid extract 3 ml, water to 50 ml. •paraldehyde enema (bpc 1973) paraldehyde 10 ml, sodium chloride solution to 100 ml. it must be freshly prepared. •paraldehyde injection (bp). sterile paraldehyde which has been sterilized by filtration; it contains no added antimicrobial preservatives. •paraldehyde mixture (apf). paraldehyde draught. paraldehyde 10 ml, liquorice liquid extract 10 ml, water to 100 ml. it should be recently prepared. separation occurs below 5 deg c and above 25 deg c. nord. p. has paraldehyde 10 g, methanol 10 mg, alcohol 20 g, acacia mucilage 30 g, liquorice liquid extract 5 g, & water 35 g. | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| p- | acetaldehyde |
| para- | acetaldehyde |
| acetaldehyde trimer | |
| acetaldehyde, trimer | |
| aldehyde (para) | |
| elaldehyde | |
| paral | |
| S- | trimethyl trioxymethylene |
| 2,4,6- | trimethyl-1,3,5-trioxacyclohexane |
| 2,6- | trimethyl-1,3,5-trioxacyclohexane |
| 2,4,6- | trimethyl-1,3,5-trioxane |
| 2,6- | trimethyl-1,3,5-trioxane |
| 1,3,5- | trimethyl-2,4,6-trioxane |
| 1,5- | trimethyl-2,4,6-trioxane |
| 2,4,6- | trimethyl-s-trioxane |
| S- | trimethyltrioxymethylene |
| 2,6- | trimetil-1,3,5-triossano |
| 1,3,5- | trioxane, 2,4,6-trimethyl- |
| 1,5- | trioxane, 2,4,6-trimethyl- |