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2-oxopentanedioic acid
Notes:
Flavouring ingredient
Alpha-ketoglutaric acid is an important biological compound and is a key intermediate in the Krebs cycle. Alpha-ketoglutaric acid occurs naturally within cells. One of its functions is to combine with ammonia to form glutamic acid and then glutamine. Another function is to combine with nitrogen released in the cell, therefore preventing nitrogen overload. (wikipedia)
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American International Chemical, Inc. Consistent sources North American supplier for globally sourced ingredients. AIC is a Westborough, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of Sales Representatives, along with our network of strategically located warehouses are ready to supply product when and where you need it. Email: Info Voice: (800) 238-0001 Facebook Twitter Linkedin Products List: View Product(s): 104855 Alpha-ketoglutaric Acid
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 328-50-7 a-ketoGlutaric Acid
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Charkit Chemical Corporation The Specialty Chemical Specialists Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you. about: Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals. Email: Sales Voice: 203-299-3220 Fax: 203-299-1355 Facebook Twitter Linkedin Latest News Events Blog Products List: View Product(s): ALPHA KETOGLUTARIC ACID
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Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GP9006 2-Ketoglutaric acid
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 15-81500 2-OXOPENTANEDIOIC ACID
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TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): K0005 2-Oxoglutaric Acid >99.0%(T)
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| CAS Number: | 328-50-7 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 206-330-3 | |
| FDA UNII: | 8ID597Z82X | |
| Nikkaji Web: | J11.847H | |
| Beilstein Number: | 1705689 | |
| MDL: | MFCD00004165 | |
| CoE Number: | 653 | |
| XlogP3-AA: | -0.90 (est) | |
| Molecular Weight: | 146.09882000 | |
| Formula: | C5 H6 O5 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 634 2-oxopentanedioic acid |
| DG SANTE Food Flavourings: | 08.037 2-oxo-glutaric acid |
| FEMA Number: | 3891 2-oxopentanedioic acid |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 328-50-7 ; 2-OXOPENTANEDIOIC ACID |
Physical Properties:
| Appearance: | white to pale yellow crystals (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 114.00 to 116.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 323.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.000010 mmHg @ 25.00 °C. (est) |
| Flash Point: | 351.00 °F. TCC ( 177.00 °C. ) (est) |
| logP (o/w): | -1.430 |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | refrigerate in tightly sealed containers. |
| Soluble in: | |
| water, 1e+006 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor Description: | odorless |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
deodorants |
Suppliers:
| AIDP |
| Alpha Keto Glutaric Acid (AKG) AKG 99% min |
| Alfa Biotechnology |
| For experimental / research use only. |
| 2-Ketoglutaric acid 98% |
| American International Chemical, LLC. |
| Alpha-ketoglutaric Acid |
| BOC Sciences |
| For experimental / research use only. |
| a-ketoGlutaric Acid |
| Carbosynth |
| For experimental / research use only. |
| a-Ketoglutaric acid |
| Charkit Chemical |
| ALPHA KETOGLUTARIC ACID |
| Glentham Life Sciences |
| 2-Ketoglutaric acid |
| Graham Chemical |
| alpha-ketoGlutaric Acid |
| Indis NV |
| For experimental / research use only. |
| Alpha-Ketoglutaric Acid / 2-Oxoglutaric Acid |
| Penta International |
| 2-OXOPENTANEDIOIC ACID |
| Prinova |
| alpha-ketoGlutaric Acid |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| alpha-ketoGlutaric Acid ≥98% |
| Sigma-Aldrich |
| For experimental / research use only. |
| a-Ketoglutaric acid puriss., ≥99.0% (T) |
| TCI AMERICA |
| For experimental / research use only. |
| 2-Oxoglutaric Acid >99.0%(T) |
Safety Information:
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
|
R 37/38 - Irritating to respiratory system and skin. R 41 - Risk of serious damage to eyes. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/39 - Wear suitable clothing and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavoring agents | ||
| Recommendation for alpha-ketoglutaric acid usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | ND (μg/capita/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 18 | |||
| Click here to view publication 18 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | - | |
| beverages(nonalcoholic): | 0.10000 | 5.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | 0.50000 | 5.00000 | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | 0.40000 | 5.00000 | |
| fish products: | - | - | |
| frozen dairy: | 1.00000 | 5.00000 | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | 0.50000 | 5.00000 | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | 0.10000 | 1.00000 | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | 0.10000 | 5.00000 | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf | |
| Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 View page or View pdf | |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 328-50-7 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 51 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 2-oxopentanedioic acid | |
| Chemidplus: | 0000328507 |
References:
| 2-oxopentanedioic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 328-50-7 |
| Pubchem (cid): | 51 |
| Pubchem (sid): | 134973455 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C00026 |
| HMDB (The Human Metabolome Database): | HMDB00208 |
| FooDB: | FDB007242 |
| YMDB (Yeast Metabolome Database): | YMDB00153 |
| Export Tariff Code: | 2918.30.9000 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| FAO: | 2-Oxopentanedioic acid |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| deodorants |
Occurrence (nature, food, other): note
| apple plant Search Trop Picture | |
| banana leaf Search Trop Picture | |
| barley Search Trop Picture | |
| barley seed Search Trop Picture | |
| carrot root Search Trop Picture | |
| cheese Search PMC Picture | |
| coffee Search PMC Picture | |
| oat hull husk Search Trop Picture | |
| peanut seed Search Trop Picture | |
| potato plant Search Trop Picture | |
| soybean seed Search Trop Picture | |
| star fruit fruit Search Trop Picture | |
| tamarind flower Search Trop Picture | |
| tamarind fruit Search Trop Picture | |
| tamarind leaf Search Trop Picture | |
| tamarind seed Search Trop Picture | |
| tomato fruit Search Trop Picture |
Synonyms:
| bis(L- | arginin)-2-oxoglutarate |
| bis(laevo- | arginin)-2-oxoglutarate |
| 2-keto | glutaric acid |
| 2-oxo | glutaric acid |
| 2-oxo- | glutaric acid |
| a-keto | glutaric acid |
| a-oxo | glutaric acid |
| alpha-oxo | glutaric acid |
| glutaric acid, 2-oxo- | |
| a- keto | lutaric acid |
| 2-oxo | pentane dioic acid |
| 2-oxo-1,5- | pentane dioic acid |
| 2-oxo | pentanedioic acid |
| 2-oxo-1,5- | pentanedioic acid |
| a-oxo | pentanedioic acid |
| pentanedioic acid, 2-oxo- | |
| 2-oxo | pentanedionic acid |