chloroform
1,1,1-trichloromethane
 
Notes:
a commonly used laboratory solvent. it was previously used as an anesthetic, but was banned from use in the u.s. due to its suspected carcinogenicity. Indirect food additive arising from adhesives and polymers Chloroform is a common solvent in the laboratory because it is relatively unreactive, miscible with most organic liquids, and conveniently volatile. Chloroform is used as a solvent in the pharmaceutical industry and for producing dyes and pesticides. Chloroform is an effective solvent for alkaloids in their base form and thus plant material is commonly extracted with chloroform for pharmaceutical processing. For example, it is commercially used to extract morphine from poppies and scopolamine from Datura plants. Chloroform containing deuterium (heavy hydrogen), CDCl3, is a common solvent used in NMR spectroscopy. It can be used to bond pieces of acrylic glass (also known under the trade names Perspex and Plexiglas). A solvent of phenol:chloroform:isoamyl alcohol 25:24:1 is used to dissolve non-nucleic acid biomolecules in DNA and RNA extractions.; Chloroform is the organic compound with formula CHCl3. It does not undergo combustion in air, although it will burn when mixed with more flammable substances. It is a member of a group of compounds known as trihalomethanes. Chloroform has myriad uses as a reagent and a solvent. It is also considered an environmental hazard. Several million tons are produced annually.; The output of this process is a mixture of the four chloromethanes: chloromethane, dichloromethane, chloroform (trichloromethane), and carbon tetrachloride, which are then separated by distillation.
  • ECSA Chemicals
    • ECSA Chemicals
      Human Chemistry
      ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of the largest distributors worldwide.
      ECSA Chemicals is the largest Swiss-owned company in terms of warehouses for the distribution of chemical products. We have been distributing chemical products for over 100 years and we have a special interest in protecting the environment and in the safety of our facilities and collaborators.
      Established in 1913 as a small grocery store, in its over 100 years of activity ECSA Chemicals has become one of the most important Swiss-owned distributors of chemical products. The company, which is active in international distribution and trading, is organised into industrial segments that are managed by teams of specialists and experts. They guarantee professional and customised consultancy and services. With our experience, we can rapidly and safely connect you with the best suppliers on the market, providing you with a complete search, consulting and assistance service. The focus of our approach and operations is you, our customers. We strive every day to find the best products that satisfy your needs as quickly as possible. Your satisfaction is our greatest success. WHY CHOOSE ECSA? EXPERIENCE We have been working for 100 years. QUALITY We have obtained many certifications (ISO, SQAS, GDP, Responsible Care, Bio-Inspecta, RSPO, etc.). We guarantee full compliance with the current laws and continuous training for our staff. SAFETY We constantly carry out risk analyses for each infrastructure, defining safety levels and implementing corrective measures promptly wherever they are needed. WIDESPREAD DISTRIBUTION We have warehouses in strategic locations to supply goods to Switzerland and to the rest of the world. STORAGE CAPACITY The 3 ECSA-owned warehouses guarantee considerable storage area and capacity in each warehouse, with full availability of products (base chemicals and speciality chemicals). SPEED Presence all over the country, staff dedicated to sourcing raw materials and considerable storage capacity guarantee that goods are rapidly obtained and supplied. CONSULTANCY Our specialists - in-depth knowledge of the market and products allows us to provide full consulting services, from the purchase to the supply of raw materials.
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      Products List: View
      Product(s):
      RE-412652 CHLOROFORM RS-FOR HPLC-ISOCRATIC GRADE-STABI
      RE-438601 CHLOROFORM RPE-ISO-FOR ANALYSIS-STABILIZED W
       
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CAS Number: 67-66-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 200-663-8
FDA UNII: 7V31YC746X
Nikkaji Web: J2.366C
Beilstein Number: 1731042
MDL: MFCD00000826
XlogP3-AA: 2.30 (est)
Molecular Weight: 119.37497000
Formula: C H Cl3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: substances for use only as components of adhesives for food packaging, transporting, or holding food
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
FDA Mainterm (SATF):67-66-3 ; CHLOROFORM
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact Surfaces
Sec. 177.1580 Polycarbonate resins.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact Surfaces
Sec. 177.1585 Polyestercarbonate resins.
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: -64.00 to  -63.00 °C. @ 760.00 mm Hg
Boiling Point: 61.00 to  62.00 °C. @ 760.00 mm Hg
Boiling Point: 24.00 to  25.00 °C. @ 200.00 mm Hg
Vapor Pressure: 199.957001 mmHg @ 25.00 °C. (est)
Flash Point: -8.00 °F. TCC ( -22.00 °C. ) (est)
logP (o/w): 1.970
Soluble in:
 alcohol
 water, 2096 mg/L @ 25 °C (est)
 water, 7950 mg/L @ 25 °C (exp)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: not used anymore
solvents
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Suppliers:
ECSA Chemicals
CHLOROFORM RPE-ISO-FOR ANALYSIS-STABILIZED W
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
CHLOROFORM RS-FOR HPLC-ISOCRATIC GRADE-STABI
Rainbow Chemical
Chloroform
Santa Cruz Biotechnology
For experimental / research use only.
Chloroform ≥99.8%
Sigma-Aldrich: Sigma
For experimental / research use only.
Chloroform contains 100-200 ppm amylenes as stabilizer, ≥99.5%
Wedor Corporation
CHLOROFORM
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  695 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ATAXIA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Khigiena i Zdraveopazvane. Hygiene and Sanitation. Vol. 29(5), Pg. 39, 1986.

intraperitoneal-rat LD50  894 mg/kg
Environmental Research. Vol. 40, Pg. 411, 1986.

oral-mouse LD50  36 mg/kg
Archives of Toxicology, Supplement. Vol. 2, Pg. 371, 1979.

intraperitoneal-mouse LD50  623 mg/kg
Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 18, Pg. 109, 1960.

oral-guinea pig LD50  820 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(3), Pg. 10, 1983.

intraperitoneal-dog LD50  1000 mg/kg
LIVER: LIVER FUNCTION TESTS IMPAIRED
Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967.

intravenous-dog LDLo  75 mg/kg
Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.

oral-dog LDLo  1000 mg/kg
Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.

oral-man LDLo  2514 mg/kg
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) CARDIAC: OTHER CHANGES
American Journal of Emergency Medicine. Vol. 6, Pg. 507, 1988.

unreported-man LDLo  546 mg/kg
"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.

oral-rabbit LDLo  500 mg/kg
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 97, Pg. 86, 1923.

Dermal Toxicity:
skin-rabbit LD50 > 20000 mg/kg
National Technical Information Service. Vol. AD-A062-138

subcutaneous-mouse LD50 704 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 224, 1958.

subcutaneous-rabbit LDLo 800 mg/kg
Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.

Inhalation Toxicity:
inhalation-rat LC50 47702 mg/m3/4
Environmental Research. Vol. 40, Pg. 411, 1986.

inhalation-cat LCLo 35000 mg/m3/4H
BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING
Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936.

inhalation-dog LCLo 100000 mg/m3
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 230, 1966.

inhalation-frog LCLo 6000 mg/m3
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 97, Pg. 86, 1923.

inhalation-guinea pig LCLo 20000 ppm/2H
Fluorine Chemistry Reviews. Vol. 1, Pg. 197, 1967.

inhalation-human LCLo 25000 ppm/5M
Tabulae Biologicae. Vol. 3, Pg. 231, 1933.

inhalation-human TCLo 10 mg/m3/1Y
GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: NAUSEA OR VOMITING
Internationales Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 24, Pg. 127, 1967.

inhalation-human TCLo 5000 mg/m3/7M
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936.

inhalation-mammal (species unspecified) LCLo 25000 ppm/5M
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 138, Pg. 65, 1928.

inhalation-mouse LCLo 23000 mg/m3/56M
BEHAVIORAL: GENERAL ANESTHETIC PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Biochemische Zeitschrift. Vol. 115, Pg. 235, 1921.

inhalation-rabbit LCLo 59000 mg/m3
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 230, 1966.

inhalation-rat LC50 47702 mg/m3/4H
Environmental Research. Vol. 40, Pg. 411, 1986.

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Safety in Use Information:
Category: substances for use only as components of adhesives for food packaging, transporting, or holding food
Recommendation for chloroform usage levels up to:
 not for fragrance use.
 
Recommendation for chloroform flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ECHA (ESR): View
EPA-Iris: IRIS
NIOSH International Chemical Safety Cards: search
NIOSH Pocket Guide: search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA GENetic TOXicology: Search
EPA Substance Registry Services (TSCA): 67-66-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 6212
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 chloroform
Chemidplus: 0000067663
EPA/NOAA CAMEO: hazardous materials
RTECS: 67-66-3
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References:
 chloroform
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 67-66-3
Pubchem (cid): 6212
Pubchem (sid): 134970725
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI: View
CHEMBL: View
UM BBD: Search
KEGG (GenomeNet): C13827
HMDB (The Human Metabolome Database): HMDB29596
FooDB: FDB000760
Export Tariff Code: 2903.13.0000
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
•grade: technical, cp, acs, nf, reagent •very high purity grades; ar, nanograde, chromar, spectrar, hplc grades •at least one grain fumigant mixture contains chloroform (73.2%) with carbon disulfide (26.8%). •chloroform emulsion: chloroform 5 ml, quillaia liquid extract 0.1 ml, tragacanth mucilage 5 ml, water to 100 ml •chloroform spirit: chloroform 5% volvol in alcohol (90%) •chloroform water: chloroform 0.25% volvol in freshly boiled and cooled water •concentrated chloroform water: chloroform 10 ml, alcohol (90%) 60 ml, water to 100 ml •double-strength chloroform water: chloroform 0.5% volvol in freshly boiled and cooled water •chloroform and morphine tincture: chloroform 12.5 ml, morphine hydrochloride 229 mg, alcohol (90%) 12.5 ml, liquorice liquid extract 12.5 ml, treacle of commerce 12.5 ml, water 5 ml, anesthetic ether 3 ml, peppermint oil 0.1 ml, syrup to 100 ml. •chloroform contains not less than 99.0% and not more than 99.5% chloroform, the remainder consisting of alcohol. •technical, cp, acs, nf, reagent
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
 spearmint oil
Search Trop  Picture
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Synonyms:
 formyl trichloride
 methane trichloride
 methane, trichloro-
 methenyl chloride
 methenyl trichloride
 methyl trichloride
 methylidyne trichloride
 refrigerant R20
 TCM
 trichloroform
 trichloromethane
1,1,1-trichloromethane
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