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Category: sweeteners, flavor enhancers
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 98.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 88.00 to 92.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 375.00 to 376.00 °C. @ 760.00 mm Hg
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| Flash Point: | 357.00 °F. TCC ( 180.56 °C. )
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| logP (o/w): | -1.701 (est) |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | None - None found. |
S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | sweeteners, flavor enhancers |
| Recommendation for dextro-ribose usage levels up to: | | | not for fragrance use.
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| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 16 |
| Click here to view publication 16 |
| | average usual ppm | average maximum ppm |
| baked goods: | 200.00000 | 1000.00000 |
| beverages(nonalcoholic): | - | - |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | 500.00000 | 1000.00000 |
| frozen dairy: | - | - |
| fruit ices: | - | - |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | 500.00000 | 1000.00000 |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | 500.00000 | 1000.00000 |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | 500.00000 | 1000.00000 |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | 200.00000 | 1000.00000 |
| soft candy: | - | - |
| soups: | 500.00000 | 1000.00000 |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Safety of d-ribose as a novel food pursuant to Regulation (EU) 2015/2283 View page or View pdf |
Statement on the safety of d-ribose View page or View pdf |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 50-69-1 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5779 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | (3R,4S,5R)-5-(hydroxymethyl)oxolane-2,3,4-triol |
| Chemidplus: | 0000050691 |
| RTECS: | VJ2275000 for cas# 50-69-1 |
References:
| | (3R,4S,5R)-5-(hydroxymethyl)oxolane-2,3,4-triol |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 50-69-1 |
| Pubchem (cid): | 5779 |
| Pubchem (sid): | 134971780 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (3R,4S,5R)-5-( | hydroxymethyl)oxolane-2,3,4-triol | | (3R,4S,5R)-5-( | hydroxymethyl)tetrahydrofuran-2,3,4-triol | | D- | ribo-2,3,4,5-tetrahydroxyvaleraldehyde | | dextro- | ribo-2,3,4,5-tetrahydroxyvaleraldehyde | | | ribo-2,3,4,5-tetrahydroxyvaleraldehyde, D- | | D- | ribofuranose | | a-D- | ribose | | D- | ribose | | D-(-)- | ribose | | D- | ribose granular | | D- | ribose powder | | dextro- | ribose natural | | | ribose FCC | | d- | ribose natural |
Articles:
| PubMed: | Antioxidant and antitumor effects of polysaccharides from the fungus Pleurotus abalonus. |
| PubMed: | Production of rare sugars from common sugars in subcritical aqueous ethanol. |
| PubMed: | Advanced glycation end products, physico-chemical and sensory characteristics of cooked lamb loins affected by cooking method and addition of flavour precursors. |
| PubMed: | Recognition of flavin mononucleotide, Haemophilus influenzae type b and its capsular polysaccharide vaccines by antibodies specific to D-ribitol-5-phosphate. |
| PubMed: | Alditols and monosaccharides from sorghum vinegar can attenuate platelet aggregation by inhibiting cyclooxygenase-1 and thromboxane-A2 synthase. |
| PubMed: | Recognition of riboflavin and the capsular polysaccharide of Haemophilus influenzae type b by antibodies generated to the haptenic epitope D-ribitol. |
| PubMed: | Synthesis of thymol glycosides under SCCO2 conditions using amyloglucosidase from Rhizopus mold. |
| PubMed: | Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. |
| PubMed: | Characterization and bioactivity of polysaccharides obtained from pine cones of Pinus koraiensis by graded ethanol precipitation. |
| PubMed: | Extracellular modulation of the silkmoth sex pheromone receptor activity by cyclic nucleotides. |
| PubMed: | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway. |
| PubMed: | Cellular protection during oxidative stress: a potential role for D-ribose and antioxidants. |
| PubMed: | Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage. |
| PubMed: | Identification of H₂O₂ as a major antimicrobial component in coffee. |
| PubMed: | Characterization of a thermophilic L-rhamnose isomerase from Caldicellulosiruptor saccharolyticus ATCC 43494. |
| PubMed: | Isolation and characterization of lactic acid bacteria strains with ornithine producing capacity from natural sea salt. |
| PubMed: | Effect of high-pressure homogenization on the physical and antioxidant properties of Quercus resinosa infusions encapsulated by spray-drying. |
| PubMed: | Primary metabolism in Lactobacillus sakei food isolates by proteomic analysis. |
| PubMed: | Simultaneous detection of pro- and antioxidative effects in the variants of the deoxyribose degradation assay. |
| PubMed: | The role of ribose on oxidative stress during hypoxic exercise: a pilot study. |
| PubMed: | Xylose reductase activity in Debaryomyces hansenii UFV-170 cultivated in semi-synthetic medium and cotton husk hemicellulose hydrolyzate. |
| PubMed: | Protein glycation inhibitors from the fruiting body of Phellinus linteus. |
| PubMed: | Dose-dependent significance of monosaccharides on intracellular alpha-L-rhamnosidase activity from Pseudoalteromonas sp. |
| PubMed: | Myricetin, a naturally occurring flavonoid, prevents 2-deoxy-D-ribose induced dysfunction and oxidative damage in osteoblastic MC3T3-E1 cells. |
| PubMed: | Protective effect of caffeic acid phenethyl ester on tert-butyl hydroperoxide-induced oxidative hepatotoxicity and DNA damage. |
| PubMed: | D-ribose benefits heart failure patients. |
| PubMed: | Crystal structure and biochemical properties of the D-arabinose dehydrogenase from Sulfolobus solfataricus. |
| PubMed: | Syntheses of N-vanillyl-nonanamide glycosides using amyloglucosidase from Rhizopus and beta-glucosidase from sweet almond. |
| PubMed: | Coffee and Maillard products activate NF-kappaB in macrophages via H2O2 production. |
| PubMed: | Effects of heat-degraded sugars on survival and growth of Vibrio parahaemolyticus and other bacteria. |
| PubMed: | Lack of oral embryotoxicity/teratogenicity with D-ribose in Wistar rats. |
| PubMed: | Sub-chronic (13-week) oral toxicity study with D-ribose in Wistar rats. |
| PubMed: | D-ribose utilisation differentiates porcine Brachyspira pilosicoli from other porcine Brachyspira species. |
| PubMed: | Chemical composition and in vitro antioxidant evaluation of commercial water-soluble willow herb (Epilobium angustifolium L.) extracts. |
| PubMed: | Novel reactions of L-rhamnose isomerase from Pseudomonas stutzeri and its relation with D-xylose isomerase via substrate specificity. |
| PubMed: | Antioxidant properties of aqueous extracts from selected lamiaceae species grown in Turkey. |
| PubMed: | Analysis of reducing carbohydrates by reductive tryptamine derivatization prior to micellar electrokinetic capillary chromatography. |
| PubMed: | Staphylococcus equorum subsp. linens, subsp. nov., a starter culture component for surface ripened semi-hard cheeses. |
| PubMed: | Formation of 5-methyl-4-hydroxy-3[2H]-furanone in cytosolic extracts obtained from Zygosaccharomyces rouxii. |
| PubMed: | Antiradical activity of water soluble components in common diet vegetables. |
| PubMed: | The determination of phosphorus in Haemophilus influenzae type b conjugate vaccines by inductively coupled plasma-atomic emission spectrometry. |
| PubMed: | N(delta)-(5-hydroxy-4,6-dimethylpyrimidine-2-yl)-l-ornithine, a novel methylglyoxal-arginine modification in beer. |
| PubMed: | New Melanoidin-like Maillard Polymers from 2-Deoxypentoses. |
| PubMed: | Haloanaerobium fermentans sp. nov., a strictly anaerobic, fermentative halophile isolated from fermented puffer fish ovaries. |
| PubMed: | Chemical composition, nutritionally valuable minerals and functional properties of benniseed (Sesamum radiatum), pearl millet (Pennisetum typhoides) and quinoa (Chenopodium quinoa) flours. |
| PubMed: | Formation of malonaldehyde and acetaldehyde from the oxidation of 2'-deoxyribonucleosides. |
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