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disodium guanylate
Notes:
guanosine 5'-monophosphate. a guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature. Flavour enhancer
As it is a fairly expensive additive, it is not used independently of glutamic acid; if disodium guanylate is present in a list of ingredients but MSG does not appear to be, it is likely that glutamic acid is provided as part of another ingredient such as a processed soy protein complex. It is often added to foods in conjunction with disodium inosinate; the combination is known as disodium 5'-ribonucleotides.; Disodium guanylate (E627), also known as sodium 5'-guanylate and disodium 5'-guanylate, is the disodium salt of the flavor enhancer guanosine monophosphate (GMP). Disodium guanylate is a food additive and is commonly used in conjunction with glutamic acid (monosodium glutamate, MSG).
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 5550-12-9 Disodium 5'-guanylate 98%
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Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GE5826 Guanosine 5'-monophosphate disodium salt hydrate
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 04-85700 DISODIUM-5-GUANYLATE
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TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): G0172 Guanosine 5'-Monophosphate Disodium Salt Hydrate >98.0%(HPLC)(N)
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| CAS Number: | 5550-12-9 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 226-914-1 | |
| FDA UNII: | B768T44Q8V | |
| Beilstein Number: | 3586801 | |
| MDL: | MFCD00070575 | |
| CoE Number: | 11772 | |
| Molecular Weight: | 407.18754056 | |
| Formula: | C10 H12 N5 Na2 O8 P | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: flavor enhancers
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Additive: | Disodium 5'-Guanylate |
| GSFA Codex: | Disodium 5'-guanylate (627) |
| DG SANTE Food Additives: | disodium guanylate |
| FEMA Number: | 3668 disodium 5'-guanylate |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 5550-12-9 ; DISODIUM GUANYLATE |
| FDA Regulation: | |
| FDA PART 155 -- CANNED VEGETABLES Subpart B--Requirements for Specific Standardized Canned Vegetables Sec. 155.120 Canned green beans and canned wax beans. FDA PART 155 -- CANNED VEGETABLES Subpart B--Requirements for Specific Standardized Canned Vegetables Sec. 155.130 Canned corn. FDA PART 155 -- CANNED VEGETABLES Subpart B--Requirements for Specific Standardized Canned Vegetables Sec. 155.170 Canned peas. FDA PART 155 -- CANNED VEGETABLES Subpart B--Requirements for Specific Standardized Canned Vegetables Sec. 155.200 Certain other canned vegetables. FDA PART 155 -- CANNED VEGETABLES Subpart B--Requirements for Specific Standardized Canned Vegetables Sec. 155.201 Canned mushrooms. FDA PART 170 -- FOOD ADDITIVES Subpart C--Specific Administrative Rulings and Decisions Sec. 170.60 Nitrites and/or nitrates in curing premixes. FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart F--Flavoring Agents and Related Substances Sec. 172.530 Disodium guanylate. | |
Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 99.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 890.20 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 918.00 °F. TCC ( 492.20 °C. ) (est) |
| logP (o/w): | -0.423 (est) |
| Soluble in: | |
| water, 1e+006 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| alcohol | |
| ether | |
Organoleptic Properties:
| Odor Description: at 100.00 %. | odorless |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
humectants skin conditioning skin conditioning - emollient |
Suppliers:
| Ajinomoto USA |
| Ajitide™ Nucleotides
Flavor: characteristic A premium line of nucleotides with the Ajinomoto touch which unlocks the taste characteristics of foods synergy with glutamates and other flavor enhancers nucleotides have. |
| BOC Sciences |
| For experimental / research use only. |
| Disodium 5'-guanylate 98% |
| Carbosynth |
| For experimental / research use only. |
| Guanosine 5'-monophosphate disodium salt |
| Changzhou Longo Chemical |
| Guanosine 5'-monophosphate disodium salt |
| Glentham Life Sciences |
| Guanosine 5'-monophosphate disodium salt hydrate |
| Penta International |
| DISODIUM-5-GUANYLATE |
| Prinova |
| GMP |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Guanosine 5'-monophosphate disodium salt hydrate |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Guanosine 5'-monophosphate disodium salt hydrate from yeast, ≥99% |
| Sinofi Food Ingredients |
| Disodium Guanylate (E627 Flavour Enhancer)
Flavor: characteristic Flavour Enhancer, Instant Noodle, Pizza, Cheese, Snack Foods, Potato Chip, Crackers, Sauces, Fast Food, Baking Food, Ice Cream, Canned Food, Meats, Poultry, Sauces, Soups, Soft Candy, Puddings, Condiments, Seasonings. |
| TCI AMERICA |
| For experimental / research use only. |
| Guanosine 5'-Monophosphate Disodium Salt Hydrate >98.0%(HPLC)(N) |
Safety Information:
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| None - None found. | |
|
S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-rat LD50 3880 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Ajinomoto Co., Inc. Vol. -, Pg. -, 1973. oral-mouse LD50 15000 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA Ajinomoto Co., Inc. Vol. -, Pg. -, 1973. intravenous-mouse LD50 3580 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Ajinomoto Co., Inc. Vol. -, Pg. -, 1973. intraperitoneal-mouse LD50 5010 mg/kg GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Ajinomoto Co., Inc. Vol. -, Pg. -, 1973. intravenous-rat LD50 2720 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Ajinomoto Co., Inc. Vol. -, Pg. -, 1973. oral-rat LD50 > 17300 mg/kg Ajinomoto Co., Inc. Vol. -, Pg. -, 1973. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 5050 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA Ajinomoto Co., Inc. Vol. -, Pg. -, 1973. subcutaneous-rat LD50 3400 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Ajinomoto Co., Inc. Vol. -, Pg. -, 1973. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavor enhancers | ||
| Recommendation for disodium 5'-guanylate usage levels up to: | |||
| not for fragrance use. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 13 | |||
| Click here to view publication 13 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 143.00000 | |
| beverages(nonalcoholic): | - | 2000.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | 0.40000 | |
| chewing gum: | - | - | |
| condiments / relishes: | - | 3200.00000 | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | 2000.00000 | |
| fish products: | - | 10.00000 | |
| frozen dairy: | - | 3000.00000 | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | 2000.00000 | |
| granulated sugar: | - | - | |
| gravies: | - | 240.00000 | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | 200.00000 | |
| milk products: | - | 46.00000 | |
| nut products: | - | - | |
| other grains: | - | 240.00000 | |
| poultry: | - | 200.00000 | |
| processed fruits: | - | - | |
| processed vegetables: | - | 140.00000 | |
| reconstituted vegetables: | - | 150.00000 | |
| seasonings / flavors: | - | 1000.00000 | |
| snack foods: | - | 50.00000 | |
| soft candy: | - | 3000.00000 | |
| soups: | - | 720.00000 | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| European Food Safety Authority (EFSA) reference(s): | |
| Scientific Opinion on the safety and efficacy of disodium 5'-ribonucleotides, disodium 5'-guanylate, disodium 5'-inosinate for all animal species and categories View page or View pdf | |
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 5550-12-9 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 21712 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| disodium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate | |
| Chemidplus: | 0005550129 |
| RTECS: | MF9290000 for cas# 5550-12-9 |
References:
| disodium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 5550-12-9 |
| Pubchem (cid): | 21712 |
| Pubchem (sid): | 134987267 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| HMDB (The Human Metabolome Database): | Search |
| FooDB: | FDB001167 |
| Export Tariff Code: | 2934.99.9000 |
| FDA Listing of Food Additive Status: | View |
| ChemSpider: | View |
| Wikipedia: | View |
| EFSA Update of results on the monitoring of furan levels in food: | Read Report |
| EFSA Previous report: Results on the monitoring of furan levels in food: | Read Report |
| EFSA Report of the CONTAM Panel on provisional findings on furan in food: | Read Report |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| emollients | ||
| humectants | ||
| skin conditioning |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| ajitide nucleotides (guanylate) | |
| disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-imino-6-oxo-2,3,6,9-tetrahydro-1H-purin-9-yl)oxolan-2-yl]methyl phosphate | |
| disodium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate | |
| disodium 2-amino-9-(5-O-phosphonato-b-D-ribofuranosyl)-9H-purin-6-ol | |
| disodium 5'-GMP | |
| disodium 5'-O-phosphonatoguanosine | |
| disodium GMP | |
| disodium guanosine 5'-monophosphate | |
| disodium guanosine-5'-monophosphate | |
| disodium guanylate | |
| disodium-5-guanylate | |
| disodium-5'-guanylate | |
| GMP | |
| GMP disodium salt | |
| 5'- | GMP disodium salt |
| GMP sodium salt | |
| guanosine 5'-(disodium phosphate) | |
| guanosine 5'-monophosphate disodium salt | |
| guanosine 5'-monophosphate disodium salt hydrate | |
| guanosine 5'-monophosphate, disodium salt | |
| guanosine 5'-phosphate disodium salt | |
| guanosine 5'MP, disodium salt | |
| guanosine5'-monophosphatedisodiumsalt | |
| 5- | guanylic acid disodium salt |
| guanylic acid sodium salt | |
| 5'- | guanylic acid, sodium salt (1:2) |
| 9H- | purin-6-ol, 2-amino-9-(5-O-phosphono-β-D-ribofuranosyl)-, sodium salt (1:2) |
| ribotide | |
| sodium ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate |