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Category: herbicides / pesticides
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | light tan to brown solid (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 52.90 °C. @ 760.00 mm Hg
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| Boiling Point: | 302.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.001000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 5.82 ( Air = 1 ) |
| Flash Point: | 307.00 °F. TCC ( 152.80 °C. ) (est)
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| logP (o/w): | 3.500 |
| Soluble in: |
| | water, 53 mg/L @ 20 °C (exp) | | | water, 63.61 mg/L @ 25 °C (est) |
Organoleptic Properties:
Odor Description:
| sweet floral faint |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-guinea pig LD50 300 mg/kg Farm Chemicals Handbook. Vol. -, Pg. C112, 1991.
oral-mammal (species unspecified) LD50 3200 mg/kg LUNGS, THORAX, OR RESPIRATION: CYANOSIS Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 40(10), Pg. 114, 1975.
oral-mouse LD50 1230 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 104, 1999.
oral-rat LD50 1120 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 104, 1999.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | herbicides / pesticides |
| IFRA Critical Effect: | Toxicity and teratogenicity |
| IFRA: | View Standard |
| Recommendation for diphenyl amine usage levels up to: | | | PROHIBITED: Should not be used as a fragrance ingredient.
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| Recommendation for diphenyl amine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | aniline, N-phenyl- | | | benzenamine, N-phenyl- | | | benzene, (phenylamino)- | | | deccoscald 282 | | | diphenyl-amine | | | diphenylamine | | | naugalube 428L | | | no-scald | | ( | phenylamino)benzene | | N- | phenylaniline | | N- | phenylbenzenamine | | | scaldip | | | shield DPA |
Articles:
| PubMed: | Cell wall, cell membrane, and volatile metabolism are altered by antioxidant treatment, temperature shifts, and peel necrosis during apple fruit storage. |
| PubMed: | A method to detect diphenylamine contamination of apple fruit and storages using headspace solid phase micro-extraction and gas chromatography/mass spectroscopy. |
| PubMed: | Effect of metabolic inhibitors on growth and carotenoid production in Dunaliella bardawil. |
| PubMed: | Design, synthesis, and structure-activity relationship of novel aniline derivatives of chlorothalonil. |
| PubMed: | Hollow fiber liquid-phase microextraction with in situ derivatization combined with gas chromatography-mass spectrometry for the determination of root exudate phenylamine compounds in hot pepper ( Capsicum annuum L.). |
| PubMed: | Effects of route of administration and feeding schedule on pharmacokinetics of robenacoxib in cats. |
| PubMed: | Redox spectrophotometric method involving electrolytically generated manganese(III) sulphate with diphenylamine for the determination of ascorbic acid present in the samples of various fruits, commercial juices and sprouted food grains. |
| PubMed: | Cell wall, cell membrane, and volatile metabolism are altered by antioxidant treatment, temperature shifts, and peel necrosis during apple fruit storage. |
| PubMed: | A novel dsDNA/polydiphenylamine-4-sulfonic acid electrochemical biosensor for selective detection of the toxic catechol and related DNA damage. |
| PubMed: | Determination of fungicide residues in baby food by liquid chromatography-ion trap tandem mass spectrometry. |
| PubMed: | Micronucleus frequency in human lymphocytes after exposure to diphenylamine in vitro. |
| PubMed: | Diphenylamine residues in apples caused by contamination in fruit storage facilities. |
| PubMed: | Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway. |
| PubMed: | Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. |
| PubMed: | Ripening, storage temperature, ethylene action, and oxidative stress alter apple peel phytosterol metabolism. |
| PubMed: | Development of a quantitative high-performance thin-layer chromatographic method for sucralose in sewage effluent, surface water, and drinking water. |
| PubMed: | 'Diffuse skin browning' in 1-MCP-treated apples: etiology and systems of control. |
| PubMed: | Short anaerobiosis period prior to cold storage alleviates bitter pit and superficial scald in Granny Smith apples. |
| PubMed: | Screening of agrochemicals in foodstuffs using low-temperature plasma (LTP) ambient ionization mass spectrometry. |
| PubMed: | Profiling of compounds and degradation products from the postharvest treatment of pears and apples by ultra-high pressure liquid chromatography quadrupole-time-of-flight mass spectrometry. |
| PubMed: | Metabolomic change precedes apple superficial scald symptoms. |
| PubMed: | Trial offers early test case for personalized medicine. |
| PubMed: | Diphenylamine metabolism in 'braeburn' apples stored under conditions conducive to the development of internal browning. |
| PubMed: | Pesticide residues in Italian Ready-Meals and dietary intake estimation. |
| PubMed: | Analyses of pesticide residues in fruit-based baby food by liquid chromatography/electrospray ionization time-of-flight mass spectrometry. |
| PubMed: | Development of a high-throughput screening method using a cell-based, lawn format assay for the identification of novel plant defense activators from combinatorial peptide libraries. |
| PubMed: | The indirect detection of bleach (sodium hypochlorite) in beverages as evidence of product tampering. |
| PubMed: | Analysis of sucrose esters--insecticides from the surface of tobacco plant leaves. |
| PubMed: | Oxidative remediation of diphenylamine in wastewater. |
| PubMed: | Influence of ethylene action, storage atmosphere, and storage duration on diphenylamine and diphenylamine derivative content of Granny Smith apple peel. |
| PubMed: | Rapid determination of diphenylamine residues in apples and pears with a single multicommuted fluorometric optosensor. |
| PubMed: | Relationship of superficial scald development and alpha-farnesene oxidation to reactions of diphenylamine and diphenylamine derivatives in Cv. Granny Smith apple peel. |
| PubMed: | 1-Methylcyclopropene interactions with diphenylamine on diphenylamine degradation, alpha-farnesene and conjugated trienol concentrations, and polyphenol oxidase and peroxidase activities in apple fruit. |
| PubMed: | Production of volatile compounds by Fuji apples following exposure to high CO2 or low O2. |
| PubMed: | Carbendazim and metalaxyl residues in post-harvest treated apples. |
| PubMed: | Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells. |
| PubMed: | Conjugated triene oxidation products of alpha-farnesene induce symptoms of superficial scald on stored apples. |
| PubMed: | Fate of apple peel phenolics during cool storage. |
| PubMed: | Fate of |
| PubMed: | Multivariate analysis of superficial scald susceptibility on Granny Smith apples dipped with different postharvest treatments. |
| PubMed: | Effect of superficial scald suppression by diphenylamine application on volatile evolution by stored Cortland apple fruit. |
| PubMed: | UVA-induced oxidative damage to rat liver nuclei: reduction of iron ions and the relationship between lipid peroxidation and DNA damage. |
| PubMed: | Monitoring of domestic and imported apples and rice by the U.S. Food and Drug Administration pesticide program. |
| PubMed: | Ascorbic acid inhibits lipid peroxidation but enhances DNA damage in rat liver nuclei incubated with iron ions. |
| PubMed: | Determination of o-phenylphenol, diphenylamine, and propargite pesticide residues in selected fruits and vegetables by gas chromatography/mass spectrometry. |
| PubMed: | Oxidative liver DNA damage in rats treated with pesticide mixtures. |
| PubMed: | Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival. |
| PubMed: | Investigation of regional glutathione levels in a model of chemically-induced renal papillary necrosis. |
| PubMed: | Cytogenetic effects on human lymphocytes of a mixture of fifteen pesticides commonly used in Italy. |
| PubMed: | Effect of Vicia faba and bran feeding on nitrosamine carcinogenesis and formation. |
| PubMed: | Genetic toxicity of a mixture of fifteen pesticides commonly found in the Italian diet. |
| PubMed: | Decreased incidence of diphenylamine-induced renal papillary necrosis in Syrian hamsters given dimethylsulphoxide. |
| PubMed: | Reverse-phase liquid chromatographic determination of clioquinol in cream and ointment preparations: collaborative study. |
| PubMed: | Monitoring Ontario-grown apples for pest control chemicals used in their production, 1978-86. |
| PubMed: | Determination of diphenylamine residues in apples, and 4-aminobiphenyl residues in diphenylamine, by high-performance liquid chromatography and electrochemical detection. |
| PubMed: | Conformation and configuration at the central amine nitrogen of a nucleotide adduct of the carcinogen 2-(acetylamino)fluorene as studied by 13C and 15N NMR spectroscopy. |
| PubMed: | Effect of anti-oxidants on growth and lactic acid production by Streptococcus mutans. |
| PubMed: | Effect of micronutrients, antioxidants and related compounds on the mutagenicity of 3,2'-dimethyl-4-aminobiphenyl, a colon and breast carcinogen. |
| PubMed: | Methods for the determination of diphenylamine residues in apples. |
| PubMed: | [Thin-layer chromatography of sugars (author's transl)]. |
| PubMed: | An Action Spectrum for Light-induced Primordium Formation in a Basidiomycete, Favolus arcularius (Fr) Ames. |
| PubMed: | Superficial scald, a functional disorder of stored apples. IV. Effect of variety, maturity, oiled wraps and diphenylamine on the concentration of alpha-farnesene in the fruit. |
| PubMed: | Superficial scald, a functional disorder of stored apples. 3. Concentration of diphenylamine in the fruit after treatment. |
| PubMed: | Metabolism of diphenylamine in the rat, rabbit and man. |
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