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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 280.00 to 282.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 311.00 to 312.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000299 mmHg @ 25.00 °C. (est) |
| Flash Point: | 288.00 °F. TCC ( 142.40 °C. ) (est)
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| logP (o/w): | 1.405 (est) |
| Soluble in: |
| | alcohol | | | water, 7279 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for bergaptol usage levels up to: | | | not for fragrance use.
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| Recommendation for bergaptol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 7H- | furo(3,2-g)(1)benzopyran-7-one, 4-hydroxy- | | 7H- | furo[3,2-g][1]benzopyran-7-one, 4-hydroxy- | | 4- | hydroxy-7H-furo(3,2-g)(1)benzopyran-7-one | | 4- | hydroxy-7H-furo[3,2-g]chromen-7-one | | 5- | hydroxyfuranocoumarin | | 4- | hydroxyfuro[3,2-g]chromen-7-one | | 5- | hydroxypsoralen |
Articles:
| PubMed: | [Chemical constituents contained in seeds of Notopterygium franchetii]. |
| PubMed: | Characterization of coumarin-specific prenyltransferase activities in Citrus limon peel. |
| PubMed: | Effect of maturity, processing, and storage on the furanocoumarin composition of grapefruit and grapefruit juice. |
| PubMed: | Biotransformations of 6',7'-dihydroxybergamottin and 6',7'-epoxybergamottin by the citrus-pathogenic fungi diminish cytochrome P450 3A4 inhibitory activity. |
| PubMed: | Major furocoumarins in grapefruit juice II: phototoxicity, photogenotoxicity, and inhibitory potency vs. cytochrome P450 3A4 activity. |
| PubMed: | Major furocoumarins in grapefruit juice I: levels and urinary metabolite(s). |
| PubMed: | Construction of a model to estimate the CYP3A inhibitory effect of grapefruit juice. |
| PubMed: | Coumarins from Seseli hartvigii. |
| PubMed: | Differentiation of four pairs of furocoumarin isomers by electrospray ionization tandem mass spectrometry. |
| PubMed: | Notopterygium forbesii Boiss extract and its active constituent phenethyl ferulate attenuate pro-inflammatory responses to lipopolysaccharide in RAW 264.7 macrophages. A "protective" role for oxidative stress? |
| PubMed: | Notopterygium forbesii boiss extract and its active constituents increase reactive species and heme oxygenase-1 in human fetal hepatocytes: mechanisms of action. |
| PubMed: | Development of a reversed-phase high-performance liquid chromatographic method for analyzing furanocoumarin components in citrus fruit juices and Chinese herbal medicines. |
| PubMed: | [Studies on chemical constituents in roots and rhizomes of Notopterygium incisum]. |
| PubMed: | Constitutive expression of bergaptol O-methyltransferase in Glehnia littoralis cell cultures. |
| PubMed: | Toxical effect of Peganum harmala L. leaves on the cotton leaf worm, Spodoptera littoralis Boisd and its parasitoids Microplitis rufiventris Kok. |
| PubMed: | [Contents of furanocoumarins in grapefruit juice and health foods]. |
| PubMed: | White and colored grapefruit juice produce similar pharmacokinetic interactions. |
| PubMed: | [A new coumarin glycoside from Glehnia littoralis]. |
| PubMed: | Aspergillus niger metabolism of citrus furanocoumarin inhibitors of human cytochrome P450 3A4. |
| PubMed: | Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins. |
| PubMed: | Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae). |
| PubMed: | Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. |
| PubMed: | The use of heat treatment to eliminate drug interactions due to grapefruit juice. |
| PubMed: | Metabolism of bergamottin by cytochromes P450 2B6 and 3A5. |
| PubMed: | UV-irradiated grapefruit juice loses pharmacokinetic interaction with nifedipine in rats. |
| PubMed: | [Effects of sweetie juice on nifedipine pharmacokinetics in rats]. |
| PubMed: | [Comprehensive determination of furanocoumarin derivatives in citrus juice by high performance liquid chromatography]. |
| PubMed: | The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5. |
| PubMed: | Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase. |
| PubMed: | Prenylated flavonoids, monoterpenoid furanocoumarins and other constituents from the twigs of Dorstenia elliptica (Moraceae). |
| PubMed: | Effects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats. |
| PubMed: | Furanocoumarins from the aerial parts of Dorstenia contrajerva. |
| PubMed: | Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4. |
| PubMed: | Photooxygenation of some potentially skin-photosensitizing hydroxyfurocoumarins. Part 2: Xanthotoxol and bergaptol. |
| PubMed: | Differential wound activation of members of the phenylalanine ammonia-lyase and 4-coumarate:CoA ligase gene families in various organs of parsley plants. |
| PubMed: | Isolation of two new coumarin glycosides from Notopterygium forbesii and evaluation of a Chinese crude drug, qiang-huo, the underground parts of N. incisum and N. forbesii, by high-performance liquid chromatography. |
| PubMed: | Temporal and Spatial Patterns of Gene Expression around Sites of Attempted Fungal Infection in Parsley Leaves. |
| PubMed: | Differential regulation and tissue-specific distribution of enzymes of phenylpropanoid pathways in developing parsley seedlings. |
| PubMed: | Biosynthesis of psoralens. Psoralen 5-monooxygenase activity from elicitor-treated Ammi majus cells. |
| PubMed: | Cellular localization of nonhost resistance reactions of parsley (Petroselinum crispum) to fungal infection. |
| PubMed: | Occurrence of phytoalexins and other putative defense-related substances in uninfected parsley plants. |
| PubMed: | Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography. |
| PubMed: | [Bergaptol ethers]. |
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